STRINGSTRING
LOC102735070 LOC102735070 LOC102734470 LOC102734470 LOC102748045 LOC102748045 LOC102751019 LOC102751019 LOC102736146 LOC102736146 LOC102735556 LOC102735556 LOC102750801 LOC102750801 LOC102736444 LOC102736444 LOC102742564 LOC102742564 LOC102728297 LOC102728297 MYLK3 MYLK3 DIAPH1 DIAPH1 LOC102736544 LOC102736544 LAMA5 LAMA5 LAMB2 LAMB2 LOC102745316 LOC102745316 LOC102740057 LOC102740057 LOC102731850 LOC102731850 BIRC2 BIRC2 PAK6 PAK6 LOC102729499 LOC102729499 LOC102729200 LOC102729200 GPATCH8 GPATCH8 PPP1CA PPP1CA LOC102750303 LOC102750303 COMP COMP ZYX ZYX LOC102729189 LOC102729189 ACTL8 ACTL8 BIRC3 BIRC3 LOC102750394 LOC102750394 PDGFRA PDGFRA LOC102735329 LOC102735329 LOC102736516 LOC102736516 LOC102737030 LOC102737030 PDGFB PDGFB PARVB PARVB VEGFB VEGFB VAV2 VAV2 ARHGAP35 ARHGAP35 GP2 GP2 COL6A1 COL6A1 PIK3CA PIK3CA COL6A2 COL6A2 PGF PGF PIK3CD PIK3CD LOC102741220 LOC102741220 CCND1 CCND1 CRKL CRKL MST1 MST1 CDC42 CDC42 LOC102729978 LOC102729978 TLN1 TLN1 MAPK1 MAPK1 VWA2 VWA2 LRRC45 LRRC45 LOC102747503 LOC102747503 PAK2 PAK2 XIAP XIAP MYL9 MYL9 RAC2 RAC2 GSK3B GSK3B TLN2 TLN2 THBS1 THBS1 COL4A4 COL4A4 PPP1CB PPP1CB MFF MFF IBSP IBSP SPP1 SPP1 HGF HGF PDGFC PDGFC MYL12B MYL12B LOC102738234 LOC102738234 LOC102726446 LOC102726446 PIP5K1A PIP5K1A LPXN LPXN ITGA5 ITGA5 ITGA7 ITGA7 CAV2 CAV2 PIK3R3 PIK3R3 LAMC1 LAMC1 CAV1 CAV1 CCND3 CCND3 COL2A1 COL2A1 DHX9 DHX9 LOC102742552 LOC102742552 COL9A1 COL9A1 ARHGAP5 ARHGAP5 MAPK10 MAPK10 TGFB1I1 TGFB1I1 ITGA10 ITGA10 LOC102727373 LOC102727373 COL1A2 COL1A2 LOC102740357 LOC102740357 IGF1 IGF1 VTN VTN COL4A1 COL4A1 ILK ILK PTEN PTEN PAK7 PAK7 LOC102734862 LOC102734862 VCL VCL SRC SRC PIP5K1B PIP5K1B ACTB ACTB ITGB3 ITGB3 LOC102731565 LOC102731565 THBS3 THBS3 SHC1 SHC1 OTOGL OTOGL FN1 FN1 ACTN1 ACTN1 VWF VWF CAV3 CAV3 VAV3 VAV3 SHC4 SHC4 CEP152 CEP152 PPP1CC PPP1CC MYL2 MYL2 LOC102745156 LOC102745156 COL9A2 COL9A2 ITGB1 ITGB1 COL9A3 COL9A3 NEDD9 NEDD9 MAPK8 MAPK8 IGF1R IGF1R AKT1 AKT1 VASP VASP LOC102749767 LOC102749767 ACTN4 ACTN4 PAK4 PAK4 FLNA FLNA JUN JUN PAK1 PAK1 LOC102749673 LOC102749673 VEGFC VEGFC ROCK2 ROCK2 AKT3 AKT3 RAP1B RAP1B RAF1 RAF1 LOC102744445 LOC102744445 LOC102742903 LOC102742903 CHAD CHAD LOC102743414 LOC102743414 ITGA4 ITGA4 LOC102739404 LOC102739404 ITGA9 ITGA9 MESDC1 MESDC1 CRK CRK ITGB7 ITGB7 ACTG1 ACTG1 CAPN8 CAPN8 LOC102730129 LOC102730129 LOC102751021 LOC102751021 LOC102726881 LOC102726881
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LOC102735070Dedicator of cytokinesis protein 5-like; Belongs to the DOCK family. (294 aa)
LOC102734470ETS domain-containing protein Elk-3-like. (237 aa)
LOC102748045Proto-oncogene vav-like. (140 aa)
LOC102751019Talin-1-like. (2016 aa)
LOC1027361463-phosphoinositide-dependent protein kinase 1-like. (216 aa)
LOC102735556Mitogen-activated protein kinase 9-like. (134 aa)
LOC102750801filamin-C-like. (2247 aa)
LOC102736444Uromodulin-like. (600 aa)
LOC102742564Rho-associated protein kinase 2-like. (530 aa)
LOC102728297Serine/threonine-protein kinase PAK 7-like. (225 aa)
MYLK3Myosin light chain kinase 3. (99 aa)
DIAPH1Protein diaphanous homolog 1. (850 aa)
LOC102736544Thrombospondin-4-like. (685 aa)
LAMA5Laminin subunit alpha-5-like. (1341 aa)
LAMB2Laminin subunit beta-2 isoform X1. (1801 aa)
LOC102745316Von Willebrand factor-like. (532 aa)
LOC102740057Vascular endothelial growth factor A-like isoform X1; Belongs to the PDGF/VEGF growth factor family. (186 aa)
LOC102731850Tyrosine-protein kinase receptor. (757 aa)
BIRC2Baculoviral IAP repeat-containing protein 2-like. (619 aa)
PAK6Non-specific serine/threonine protein kinase. (681 aa)
LOC102729499Collagen alpha-1(IV) chain-like. (112 aa)
LOC102729200Collagen alpha-1(IV) chain-like. (863 aa)
GPATCH8G patch domain-containing protein 8 isoform X1. (1425 aa)
PPP1CASerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (330 aa)
LOC102750303Collagen alpha-1(I) chain-like. (395 aa)
COMPCartilage oligomeric matrix protein. (728 aa)
ZYXZyxin. (579 aa)
LOC102729189Dedicator of cytokinesis protein 5-like. (273 aa)
ACTL8Actin-like protein 8; Belongs to the actin family. (366 aa)
BIRC3Baculoviral IAP repeat-containing protein 3. (604 aa)
LOC102750394Dedicator of cytokinesis protein 1-like. (237 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1090 aa)
LOC102735329Vascular endothelial growth factor receptor 1-like. (351 aa)
LOC102736516Phosphatidylinositol 3-kinase regulatory subunit alpha-like. (138 aa)
LOC102737030Receptor tyrosine-protein kinase erbB-2-like; Belongs to the protein kinase superfamily. Tyr protein kinase family. (627 aa)
PDGFBPlatelet-derived growth factor subunit B isoform X1; Belongs to the PDGF/VEGF growth factor family. (241 aa)
PARVBBeta-parvin. (327 aa)
VEGFBVascular endothelial growth factor B isoform X1; Belongs to the PDGF/VEGF growth factor family. (207 aa)
VAV2Guanine nucleotide exchange factor VAV2. (357 aa)
ARHGAP35Rho GTPase-activating protein 35. (1500 aa)
GP2Pancreatic secretory granule membrane major glycoprotein GP2. (502 aa)
COL6A1Collagen alpha-1(VI) chain. (1027 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
COL6A2Collagen alpha-2(VI) chain. (1021 aa)
PGFPlacenta growth factor; Belongs to the PDGF/VEGF growth factor family. (170 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1043 aa)
LOC102741220Integrin alpha-9-like. (114 aa)
CCND1G1/S-specific cyclin-D1; Belongs to the cyclin family. (214 aa)
CRKLCrk-like protein. (303 aa)
MST1Hepatocyte growth factor-like protein; Belongs to the peptidase S1 family. Plasminogen subfamily. (711 aa)
CDC42Cell division control protein 42 homolog. (160 aa)
LOC102729978Beta-actin-like protein 2-like isoform X1. (376 aa)
TLN1Talin-1. (549 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (326 aa)
VWA2Von Willebrand factor A domain-containing protein 2. (804 aa)
LRRC45Leucine-rich repeat-containing protein 45. (670 aa)
LOC102747503Collagen alpha-6(VI) chain-like. (1244 aa)
PAK2Non-specific serine/threonine protein kinase. (524 aa)
XIAPE3 ubiquitin-protein ligase XIAP-like isoform X1. (497 aa)
MYL9Myosin regulatory light polypeptide 9 isoform X1. (172 aa)
RAC2Ras-related C3 botulinum toxin substrate 2. (192 aa)
GSK3BGlycogen synthase kinase-3 beta isoform X1; Belongs to the protein kinase superfamily. (433 aa)
TLN2Talin-2-like isoform X1. (2542 aa)
THBS1Thrombospondin-1 isoform X1. (1170 aa)
COL4A4Collagen alpha-4(IV) chain-like. (1589 aa)
PPP1CBSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (327 aa)
MFFMitochondrial fission factor isoform X2. (342 aa)
IBSPBone sialoprotein 2. (318 aa)
SPP1Osteopontin isoform X1. (299 aa)
HGFHepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. (730 aa)
PDGFCPlatelet-derived growth factor C-like; Belongs to the PDGF/VEGF growth factor family. (345 aa)
MYL12BMyosin regulatory light chain 12B isoform X1. (172 aa)
LOC102738234Myosin regulatory light polypeptide 9-like isoform X2. (172 aa)
LOC102726446Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform-like; Belongs to the PI3/PI4-kinase family. (235 aa)
PIP5K1APhosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X1. (549 aa)
LPXNLeupaxin; Belongs to the paxillin family. (386 aa)
ITGA5Integrin alpha-5; Belongs to the integrin alpha chain family. (1054 aa)
ITGA7Integrin alpha-7; Belongs to the integrin alpha chain family. (1181 aa)
CAV2Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (162 aa)
PIK3R3Phosphatidylinositol 3-kinase regulatory subunit gamma. (461 aa)
LAMC1Laminin subunit gamma-1. (1608 aa)
CAV1Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (178 aa)
CCND3G1/S-specific cyclin-D3 isoform X1; Belongs to the cyclin family. (291 aa)
COL2A1Collagen alpha-1(II) chain isoform X1. (1487 aa)
DHX9ATP-dependent RNA helicase A. (1276 aa)
LOC102742552Platelet-derived growth factor D-like isoform X1. (370 aa)
COL9A1Collagen alpha-1(IX) chain. (885 aa)
ARHGAP5Rho GTPase-activating protein 5 isoform X1. (1503 aa)
MAPK10Mitogen-activated protein kinase. (464 aa)
TGFB1I1Transforming growth factor beta-1-induced transcript 1 protein isoform X2; Belongs to the paxillin family. (447 aa)
ITGA10LOW QUALITY PROTEIN: integrin alpha-10; Belongs to the integrin alpha chain family. (1165 aa)
LOC102727373Integrin alpha-10-like. (374 aa)
COL1A2Collagen alpha-2(I) chain. (1365 aa)
LOC102740357Cell division control protein 42 homolog. (191 aa)
IGF1Insulin-like growth factor I isoform X1. (153 aa)
VTNVitronectin. (456 aa)
COL4A1Collagen alpha-1(IV) chain. (321 aa)
ILKIntegrin-linked protein kinase isoform X1. (452 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
PAK7Serine/threonine-protein kinase PAK 7. (474 aa)
LOC102734862Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1354 aa)
VCLVinculin isoform X1. (1134 aa)
SRCTyrosine-protein kinase. (536 aa)
PIP5K1BPhosphatidylinositol 4-phosphate 5-kinase type-1 beta. (154 aa)
ACTBActin, cytoplasmic 1. (375 aa)
ITGB3Integrin beta; Belongs to the integrin beta chain family. (852 aa)
LOC102731565Laminin subunit gamma-3-like. (231 aa)
THBS3Thrombospondin-3 isoform X1. (956 aa)
SHC1SHC-transforming protein 1 isoform X2. (583 aa)
OTOGLOtogelin-like protein. (2344 aa)
FN1Fibronectin isoform X1. (2476 aa)
ACTN1Alpha-actinin-1. (406 aa)
VWFVon Willebrand factor. (2285 aa)
CAV3Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (151 aa)
VAV3Guanine nucleotide exchange factor VAV3 isoform X2. (847 aa)
SHC4SHC-transforming protein 4. (630 aa)
CEP152Centrosomal protein of 152 kDa isoform X1. (1723 aa)
PPP1CCSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (337 aa)
MYL2Myosin regulatory light chain 2, ventricular/cardiac muscle isoform isoform X1. (166 aa)
LOC102745156Catenin beta-1-like isoform X1. (216 aa)
COL9A2Collagen alpha-2(IX) chain. (595 aa)
ITGB1Integrin beta; Belongs to the integrin beta chain family. (798 aa)
COL9A3Collagen alpha-3(IX) chain. (681 aa)
NEDD9Enhancer of filamentation 1 isoform X1. (834 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
IGF1RInsulin-like growth factor 1 receptor-like. (291 aa)
AKT1Non-specific serine/threonine protein kinase. (518 aa)
VASPVasodilator-stimulated phosphoprotein isoform X1; Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance, lamellipodial and filopodial dynamics, platelet activation and cell migration. Belongs to the Ena/VASP family. (382 aa)
LOC102749767Integrin alpha-IIb-like. (534 aa)
ACTN4Alpha-actinin-4 isoform X1. (933 aa)
PAK4Non-specific serine/threonine protein kinase. (441 aa)
FLNAfilamin-A-like. (1685 aa)
JUNTranscription factor AP-1; Belongs to the bZIP family. (335 aa)
PAK1Non-specific serine/threonine protein kinase. (544 aa)
LOC102749673Insulin-like growth factor 1 receptor-like. (143 aa)
VEGFCVascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (419 aa)
ROCK2Rho-associated protein kinase 2. (850 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (418 aa)
RAP1BRas-related protein Rap-1b isoform X1. (184 aa)
RAF1RAF proto-oncogene serine/threonine-protein kinase isoform X1. (648 aa)
LOC102744445Integrin beta; Belongs to the integrin beta chain family. (197 aa)
LOC102742903Collagen alpha-1(I) chain-like. (1116 aa)
CHADChondroadherin isoform X1. (359 aa)
LOC102743414Thrombospondin-2-like. (463 aa)
ITGA4Integrin alpha-4; Belongs to the integrin alpha chain family. (1033 aa)
LOC102739404Integrin alpha-9-like. (152 aa)
ITGA9Integrin alpha-9-like. (470 aa)
MESDC1Mesoderm development candidate 1. (362 aa)
CRKAdapter molecule crk. (92 aa)
ITGB7Integrin beta; Belongs to the integrin beta chain family. (763 aa)
ACTG1LOW QUALITY PROTEIN: actin, gamma 1. (411 aa)
CAPN8LOW QUALITY PROTEIN: calpain 8; Belongs to the peptidase C2 family. (566 aa)
LOC102730129Uncharacterized protein LOC102730129. (471 aa)
LOC102751021Phosphatidylinositol 3-kinase regulatory subunit alpha-like isoform X1. (454 aa)
LOC102726881Breast cancer anti-estrogen resistance protein 1-like. (695 aa)
Your Current Organism:
Leptonychotes weddellii
NCBI taxonomy Id: 9713
Other names: L. weddellii, Leptonychotes weddelli, Weddell seal
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