41 items (Leptonychotes weddellii) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC102746195	DLA class I histocompatibility antigen, A9/A9 alpha chain-like. (189 aa)
	LOC102734190	Heat shock 70 kDa protein 1-like; Belongs to the heat shock protein 70 family. (641 aa)
	TNF	Tumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
	HSPA1L	Heat shock 70 kDa protein 1-like; Belongs to the heat shock protein 70 family. (641 aa)
	LOC102750166	HLA class II histocompatibility antigen, DM beta chain-like. (263 aa)
	LOC102750454	HLA class II histocompatibility antigen, DM alpha chain-like; Belongs to the MHC class II family. (261 aa)
	LOC102748462	HLA class II histocompatibility antigen, DO beta chain-like. (273 aa)
	TAP1	Antigen peptide transporter 1. (750 aa)
	CD4	T-cell surface glycoprotein CD4. (462 aa)
	LOC102741082	DLA class II histocompatibility antigen, DR-1 beta chain-like. (266 aa)
	LOC102740784	HLA class II histocompatibility antigen, DR alpha chain-like; Belongs to the MHC class II family. (254 aa)
	HSPA4	Heat shock 70 kDa protein 4 isoform X1. (839 aa)
	CREB1	Cyclic AMP-responsive element-binding protein 1 isoform X1. (341 aa)
	LOC102743896	Thioredoxin; Belongs to the thioredoxin family. (121 aa)
	CALR	Calreticulin. (417 aa)
	CTSB	Cathepsin B; Belongs to the peptidase C1 family. (339 aa)
	LOC102739252	Heat shock cognate 71 kDa protein-like. (395 aa)
	CTSS	Cathepsin S isoform X1; Belongs to the peptidase C1 family. (340 aa)
	LOC102731213	Heat shock cognate 71 kDa protein-like isoform X1; Belongs to the heat shock protein 70 family. (646 aa)
	LOC102733223	Protein disulfide-isomerase A3-like; Belongs to the protein disulfide isomerase family. (294 aa)
	B2M	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. (118 aa)
	RFXANK	DNA-binding protein RFXANK. (260 aa)
	LOC102749901	Gamma-interferon-inducible-lysosomal thiol reductase-like. (252 aa)
	NFYC	Nuclear transcription factor Y subunit gamma isoform X1. (439 aa)
	HSP90AB1	Heat shock protein HSP 90-beta. (464 aa)
	LOC102726367	Heat shock protein HSP 90-alpha-like. (262 aa)
	LOC102733853	Antigen peptide transporter 2-like. (411 aa)
	LOC102734456	HLA class II histocompatibility antigen, DO alpha chain-like; Belongs to the MHC class II family. (250 aa)
	LOC102730741	Natural killer cells antigen CD94-like. (162 aa)
	LOC102739283	Heat shock cognate 71 kDa protein-like. (196 aa)
	CD74	HLA class II histocompatibility antigen gamma chain. (279 aa)
	HSPA5	78 kDa glucose-regulated protein isoform X2; Belongs to the heat shock protein 70 family. (654 aa)
	CD8A	T-cell surface glycoprotein CD8 alpha chain. (213 aa)
	NFYB	Nuclear transcription factor Y subunit beta. (169 aa)
	IFNG	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (166 aa)
	CANX	Calnexin isoform X1. (594 aa)
	LOC102727326	Cathepsin L1-like isoform X1; Belongs to the peptidase C1 family. (334 aa)
	PSME3	Proteasome activator complex subunit 3 isoform X3. (254 aa)
	PSME2	Proteasome activator complex subunit 2 isoform X1. (239 aa)
	PSME1	Proteasome activator complex subunit 1 isoform X1. (249 aa)
	HSPA2	Heat shock-related 70 kDa protein 2; Belongs to the heat shock protein 70 family. (636 aa)

Your Current Organism:

Leptonychotes weddellii

NCBI taxonomy Id: 9713
Other names: L. weddellii, Leptonychotes weddelli, Weddell seal

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
B2M	CALR	A0A2U3X7R0	A0A2U3XH12	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	Calreticulin.	0.763
B2M	CD4	A0A2U3X7R0	A0A2U3Y2Q1	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	T-cell surface glycoprotein CD4.	0.401
B2M	CD8A	A0A2U3X7R0	A0A2U3YBZ1	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	T-cell surface glycoprotein CD8 alpha chain.	0.811
B2M	LOC102730741	A0A2U3X7R0	A0A2U3Z8F5	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	Natural killer cells antigen CD94-like.	0.473
B2M	LOC102733223	A0A2U3X7R0	A0A2U3X7U7	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	Protein disulfide-isomerase A3-like; Belongs to the protein disulfide isomerase family.	0.709
B2M	LOC102734456	A0A2U3X7R0	A0A2U3Z2X5	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	HLA class II histocompatibility antigen, DO alpha chain-like; Belongs to the MHC class II family.	0.567
B2M	LOC102740784	A0A2U3X7R0	A0A2U3XXW2	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	HLA class II histocompatibility antigen, DR alpha chain-like; Belongs to the MHC class II family.	0.592
B2M	LOC102741082	A0A2U3X7R0	A0A2U3XXW7	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	DLA class II histocompatibility antigen, DR-1 beta chain-like.	0.600
B2M	LOC102743896	A0A2U3X7R0	A0A2U3XJV3	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	Thioredoxin; Belongs to the thioredoxin family.	0.709
B2M	LOC102746195	A0A2U3X7R0	A0A2U3Y4L7	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	DLA class I histocompatibility antigen, A9/A9 alpha chain-like.	0.997
B2M	LOC102748462	A0A2U3X7R0	A0A2U3Y332	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	HLA class II histocompatibility antigen, DO beta chain-like.	0.600
B2M	LOC102750166	A0A2U3X7R0	A0A2U3Y3B4	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	HLA class II histocompatibility antigen, DM beta chain-like.	0.597
B2M	LOC102750454	A0A2U3X7R0	A0A2U3Y337	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	HLA class II histocompatibility antigen, DM alpha chain-like; Belongs to the MHC class II family.	0.540
B2M	PSME2	A0A2U3X7R0	A0A2U3Y4T3	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	Proteasome activator complex subunit 2 isoform X1.	0.417
CALR	B2M	A0A2U3XH12	A0A2U3X7R0	Calreticulin.	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	0.763
CALR	CANX	A0A2U3XH12	A0A2U3Y8B6	Calreticulin.	Calnexin isoform X1.	0.981
CALR	CD4	A0A2U3XH12	A0A2U3Y2Q1	Calreticulin.	T-cell surface glycoprotein CD4.	0.534
CALR	HSP90AB1	A0A2U3XH12	A0A2U3YWF8	Calreticulin.	Heat shock protein HSP 90-beta.	0.715
CALR	HSPA1L	A0A2U3XH12	A0A2U3Y468	Calreticulin.	Heat shock 70 kDa protein 1-like; Belongs to the heat shock protein 70 family.	0.572
CALR	HSPA4	A0A2U3XH12	A0A2U3XTJ8	Calreticulin.	Heat shock 70 kDa protein 4 isoform X1.	0.509