STRINGSTRING
IL8 IL8 SPP1 SPP1 LOC102726446 LOC102726446 IKBKE IKBKE PIK3R3 PIK3R3 MAPK10 MAPK10 MAP2K1 MAP2K1 IRAK4 IRAK4 CD80 CD80 MAP2K6 MAP2K6 NFKBIA NFKBIA TLR6 TLR6 TLR1 TLR1 NFKB1 NFKB1 LOC102725792 LOC102725792 LOC102747757 LOC102747757 LOC102750324 LOC102750324 LOC102747471 LOC102747471 IFNB1 IFNB1 TLR7 TLR7 MAP2K7 MAP2K7 MAPK12 MAPK12 MAP3K8 MAP3K8 TRAF6 TRAF6 FADD FADD TMED7 TMED7 TICAM2 TICAM2 LY96 LY96 MAPK8 MAPK8 AKT1 AKT1 TNF TNF MAP2K2 MAP2K2 IKBKG IKBKG JUN JUN CD40 CD40 AKT3 AKT3 LOC102728244 LOC102728244 CHUK CHUK IL12B IL12B LOC102727117 LOC102727117 IRF7 IRF7 LOC102748381 LOC102748381 IL12A IL12A LOC102729256 LOC102729256 IL6 IL6 MAPK1 MAPK1 IKBKB IKBKB CXCL9 CXCL9 CXCL10 CXCL10 LOC102740920 LOC102740920 CXCL11 CXCL11 LOC102730789 LOC102730789 IL1B IL1B PIK3CD PIK3CD FOS FOS PIK3CA PIK3CA MAP2K3 MAP2K3 LOC102732223 LOC102732223 LOC102736516 LOC102736516 LOC102735431 LOC102735431 IFNAR1 IFNAR1 CASP8 CASP8 MYD88 MYD88 TWF2 TWF2 LOC102735556 LOC102735556 MAPK11 MAPK11 LOC102744116 LOC102744116 LOC102751021 LOC102751021 LOC102740172 LOC102740172 TLR5 TLR5 IFNA14 IFNA14
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
IL8Multifunctional fusion protein; Belongs to the intercrine alpha (chemokine CxC) family. (104 aa)
SPP1Osteopontin isoform X1. (299 aa)
LOC102726446Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform-like; Belongs to the PI3/PI4-kinase family. (235 aa)
IKBKEInhibitor of nuclear factor kappa-B kinase subunit epsilon. (106 aa)
PIK3R3Phosphatidylinositol 3-kinase regulatory subunit gamma. (461 aa)
MAPK10Mitogen-activated protein kinase. (464 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1 isoform X1; Belongs to the protein kinase superfamily. (393 aa)
IRAK4Interleukin-1 receptor-associated kinase 4 isoform X1. (459 aa)
CD80LOW QUALITY PROTEIN: T-lymphocyte activation antigen CD80. (295 aa)
MAP2K6Dual specificity mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (334 aa)
NFKBIANF-kappa-B inhibitor alpha isoform X2. (314 aa)
TLR6Toll-like receptor. (794 aa)
TLR1Toll-like receptor 1; Belongs to the Toll-like receptor family. (794 aa)
NFKB1Nuclear factor NF-kappa-B p105 subunit. (254 aa)
LOC102725792C-C motif chemokine. (92 aa)
LOC102747757Interferon alpha-1/2-like. (187 aa)
LOC102750324Interferon alpha-2-like. (175 aa)
LOC102747471Interferon alpha-1/2-like. (187 aa)
IFNB1Interferon beta. (182 aa)
TLR7Toll-like receptor 7; Belongs to the Toll-like receptor family. (1050 aa)
MAP2K7Dual specificity mitogen-activated protein kinase kinase 7 isoform X1. (435 aa)
MAPK12Mitogen-activated protein kinase. (367 aa)
MAP3K8Mitogen-activated protein kinase kinase kinase 8. (467 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (541 aa)
FADDFAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (218 aa)
TMED7Transmembrane emp24 domain-containing protein 7. (224 aa)
TICAM2TIR domain-containing adapter molecule 2. (238 aa)
LY96Lymphocyte antigen 96 isoform X1. (160 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
AKT1Non-specific serine/threonine protein kinase. (518 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
MAP2K2Dual specificity mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa)
IKBKGNF-kappa-B essential modulator isoform X2. (419 aa)
JUNTranscription factor AP-1; Belongs to the bZIP family. (335 aa)
CD40Tumor necrosis factor receptor superfamily member 5. (272 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (418 aa)
LOC102728244Interleukin-1 receptor-associated kinase 1-like. (299 aa)
CHUKInhibitor of nuclear factor kappa-B kinase subunit alpha. (745 aa)
IL12BInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (279 aa)
LOC102727117Toll-like receptor 10-like; Belongs to the Toll-like receptor family. (809 aa)
IRF7Interferon regulatory factor 7. (470 aa)
LOC102748381Inhibitor of nuclear factor kappa-B kinase subunit epsilon-like. (618 aa)
IL12AInterleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC. (222 aa)
LOC102729256TNF receptor-associated factor 3-like. (283 aa)
IL6Interleukin-6 isoform X1. (212 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (326 aa)
IKBKBInhibitor of nuclear factor kappa-B kinase subunit beta isoform X1. (756 aa)
CXCL9C-X-C motif chemokine. (126 aa)
CXCL10C-X-C motif chemokine. (98 aa)
LOC102740920C-C motif chemokine. (91 aa)
CXCL11c-X-C motif chemokine 11. (100 aa)
LOC102730789TNF receptor-associated factor 3-like. (295 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (270 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1043 aa)
FOSProto-oncogene c-Fos isoform X1. (380 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
MAP2K3Dual specificity mitogen-activated protein kinase kinase 3; Belongs to the protein kinase superfamily. (347 aa)
LOC102732223Toll/interleukin-1 receptor domain-containing adapter protein-like. (226 aa)
LOC102736516Phosphatidylinositol 3-kinase regulatory subunit alpha-like. (138 aa)
LOC102735431C-C motif chemokine. (93 aa)
IFNAR1Interferon alpha/beta receptor 1. (560 aa)
CASP8Caspase-8 isoform X1; Belongs to the peptidase C14A family. (486 aa)
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (296 aa)
TWF2Toll-like receptor 9-like isoform X1. (1331 aa)
LOC102735556Mitogen-activated protein kinase 9-like. (134 aa)
MAPK11Mitogen-activated protein kinase. (254 aa)
LOC102744116Interferon regulatory factor 6-like. (227 aa)
LOC102751021Phosphatidylinositol 3-kinase regulatory subunit alpha-like isoform X1. (454 aa)
LOC102740172Lipopolysaccharide-binding protein-like. (97 aa)
TLR5LOW QUALITY PROTEIN: toll-like receptor 5; Belongs to the Toll-like receptor family. (834 aa)
IFNA14LOW QUALITY PROTEIN: interferon, alpha 14. (182 aa)
Your Current Organism:
Leptonychotes weddellii
NCBI taxonomy Id: 9713
Other names: L. weddellii, Leptonychotes weddelli, Weddell seal
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