STRINGSTRING
XKRX XKRX LOC102740611 LOC102740611 TXN TXN LOC102737114 LOC102737114 LOC102740920 LOC102740920 LOC102730789 LOC102730789 LOC102743429 LOC102743429 IL1B IL1B LOC102750659 LOC102750659 LOC102730373 LOC102730373 LOC102750324 LOC102750324 LOC102747471 LOC102747471 CAMP CAMP IFNB1 IFNB1 IL18 IL18 TRIP6 TRIP6 LOC102748960 LOC102748960 VCPIP1 VCPIP1 NLRP13 NLRP13 MNDA MNDA LRRC71 LRRC71 NEK6 NEK6 LOC102726367 LOC102726367 ARRDC4 ARRDC4 LOC102731633 LOC102731633 LOC102746542 LOC102746542 IFNAR1 IFNAR1 CASP8 CASP8 ARRDC2 ARRDC2 LOC102735634 LOC102735634 LOC102730715 LOC102730715 VDAC2 VDAC2 BIRC2 BIRC2 LOC102747151 LOC102747151 LOC102748489 LOC102748489 CARD9 CARD9 ARHGEF33 ARHGEF33 LOC102733606 LOC102733606 ATL3 ATL3 ANTXR2 ANTXR2 LPP LPP TXN2 TXN2 SHARPIN SHARPIN PLCB3 PLCB3 TONSL TONSL TYK2 TYK2 LOC102749512 LOC102749512 BIRC3 BIRC3 DHX33 DHX33 HSP90AB1 HSP90AB1 LRRC7 LRRC7 LOC102742054 LOC102742054 MYD88 MYD88 LOC102736039 LOC102736039 LOC102735556 LOC102735556 LOC102744509 LOC102744509 LOC102749847 LOC102749847 MAPK11 MAPK11 LOC102742576 LOC102742576 LOC102740882 LOC102740882 LOC102734169 LOC102734169 LOC102729524 LOC102729524 IFNA14 IFNA14 NLRP9 NLRP9 BCL2L1 BCL2L1 CCDC109B CCDC109B IKBKE IKBKE DNM1L DNM1L LOC102749618 LOC102749618 CTSB CTSB NEK7 NEK7 MAPK10 MAPK10 IL8 IL8 PYCARD PYCARD TXNIP TXNIP IRAK4 IRAK4 TMEM173 TMEM173 GIMAP2 GIMAP2 GIMAP8 GIMAP8 CEP78 CEP78 GIMAP6 GIMAP6 ATL1 ATL1 NLRC4 NLRC4 NFKBIA NFKBIA GABARAPL1 GABARAPL1 ERBB2IP ERBB2IP NFKB1 NFKB1 LOC102747757 LOC102747757 LOC102751218 LOC102751218 TAB3 TAB3 GPRC6A GPRC6A TNFAIP3 TNFAIP3 MAPK12 MAPK12 TANK TANK LOC102726710 LOC102726710 LOC102750157 LOC102750157 TRAF6 TRAF6 FADD FADD ATG12 ATG12 NOD1 NOD1 BRCC3 BRCC3 P2RX7 P2RX7 NLRP12 NLRP12 ARRDC1 ARRDC1 LOC102748068 LOC102748068 ITPR2 ITPR2 PKN1 PKN1 MAPK8 MAPK8 TNF TNF PKN2 PKN2 RNF31 RNF31 IRF9 IRF9 GABARAP GABARAP IKBKG IKBKG ATG5 ATG5 NFKBIB NFKBIB JUN JUN OAS2 OAS2 OAS1 OAS1 NLRX1 NLRX1 LOC102745369 LOC102745369 STAT2 STAT2 CHUK CHUK TRPM7 TRPM7 PANX1 PANX1 IRF7 IRF7 ARRDC3 ARRDC3 LOC102748381 LOC102748381 NLRP6 NLRP6 ITPR1 ITPR1 LOC102731085 LOC102731085 PSTPIP1 PSTPIP1 NOD2 NOD2 NLRP10 NLRP10 OTUD7A OTUD7A TXNDC2 TXNDC2 MAVS MAVS XIAP XIAP LOC102729256 LOC102729256 IL6 IL6 TRIM14 TRIM14 NLRC3 NLRC3 CASR CASR MAPK1 MAPK1 ITPR3 ITPR3 VDAC3 VDAC3 IKBKB IKBKB LOC102750756 LOC102750756
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
XKRXXK-related protein. (449 aa)
LOC102740611TNF receptor-associated factor. (490 aa)
TXNThioredoxin; Belongs to the thioredoxin family. (105 aa)
LOC102737114Leucine-rich repeat-containing protein 31-like. (211 aa)
LOC102740920C-C motif chemokine. (91 aa)
LOC102730789TNF receptor-associated factor 3-like. (295 aa)
LOC102743429Leucine-rich repeat-containing protein LOC400891-like. (392 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (270 aa)
LOC102750659Tonsoku-like protein-like. (490 aa)
LOC102730373Cytochrome b-245 heavy chain-like. (550 aa)
LOC102750324Interferon alpha-2-like. (175 aa)
LOC102747471Interferon alpha-1/2-like. (187 aa)
CAMPCathelicidin antimicrobial peptide. (171 aa)
IFNB1Interferon beta. (182 aa)
IL18Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (193 aa)
TRIP6Thyroid receptor-interacting protein 6. (478 aa)
LOC102748960Cytochrome b-245 light chain-like. (196 aa)
VCPIP1Deubiquitinating protein VCIP135. (1218 aa)
NLRP13NACHT, LRR and PYD domains-containing protein 13. (991 aa)
MNDAMyeloid cell nuclear differentiation antigen. (436 aa)
LRRC71Leucine-rich repeat-containing protein 71. (559 aa)
NEK6Serine/threonine-protein kinase Nek6. (100 aa)
LOC102726367Heat shock protein HSP 90-alpha-like. (262 aa)
ARRDC4Arrestin domain-containing protein 4-like. (412 aa)
LOC102731633Rho guanine nucleotide exchange factor 10-like. (410 aa)
LOC102746542Transient receptor potential cation channel subfamily M member 2-like. (677 aa)
IFNAR1Interferon alpha/beta receptor 1. (560 aa)
CASP8Caspase-8 isoform X1; Belongs to the peptidase C14A family. (486 aa)
ARRDC2Arrestin domain-containing protein 2 isoform X1. (407 aa)
LOC102735634Lipoma-preferred partner-like. (263 aa)
LOC1027307151-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2-like. (231 aa)
VDAC2Voltage-dependent anion-selective channel protein 2 isoform X1. (294 aa)
BIRC2Baculoviral IAP repeat-containing protein 2-like. (619 aa)
LOC102747151OTU domain-containing protein 7B-like. (220 aa)
LOC102748489Serine/threonine-protein kinase Nek6-like. (146 aa)
CARD9Caspase recruitment domain-containing protein 9-like. (536 aa)
ARHGEF33Rho guanine nucleotide exchange factor 33. (690 aa)
LOC1027336061-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3-like. (156 aa)
ATL3Atlastin-3. (540 aa)
ANTXR2Anthrax toxin receptor; Belongs to the ATR family. (498 aa)
LPPLipoma-preferred partner-like. (332 aa)
TXN2Thioredoxin, mitochondrial. (163 aa)
SHARPINSharpin isoform X1. (283 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1100 aa)
TONSLTonsoku-like protein. (879 aa)
TYK2Non-receptor tyrosine-protein kinase TYK2-like. (767 aa)
LOC102749512Protein NLRC3-like. (756 aa)
BIRC3Baculoviral IAP repeat-containing protein 3. (604 aa)
DHX33Putative ATP-dependent RNA helicase DHX33-like isoform X1. (534 aa)
HSP90AB1Heat shock protein HSP 90-beta. (464 aa)
LRRC7Leucine-rich repeat-containing protein 7. (1537 aa)
LOC102742054Ubiquitin thioesterase ZRANB1-like. (329 aa)
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (296 aa)
LOC102736039Thioredoxin domain-containing protein 6-like. (271 aa)
LOC102735556Mitogen-activated protein kinase 9-like. (134 aa)
LOC102744509Autophagy protein 5-like. (78 aa)
LOC102749847Tyrosine-protein kinase JAK1-like. (444 aa)
MAPK11Mitogen-activated protein kinase. (254 aa)
LOC102742576C-X-C motif chemokine. (107 aa)
LOC102740882LOW QUALITY PROTEIN: GTPase IMAP family member 7-like. (300 aa)
LOC102734169Gamma-aminobutyric acid receptor-associated protein-like 2-like. (117 aa)
LOC102729524Transient receptor potential cation channel subfamily M member 7-like. (129 aa)
IFNA14LOW QUALITY PROTEIN: interferon, alpha 14. (182 aa)
NLRP9LOW QUALITY PROTEIN: NLR family, pyrin domain containing 9. (667 aa)
BCL2L1Bcl-2-like protein 1 isoform X1. (233 aa)
CCDC109BMitochondrial calcium uniporter regulatory subunit MCUb. (84 aa)
IKBKEInhibitor of nuclear factor kappa-B kinase subunit epsilon. (106 aa)
DNM1LDynamin-1-like protein isoform X1; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (749 aa)
LOC102749618Toll-like receptor 4-like; Belongs to the Toll-like receptor family. (793 aa)
CTSBCathepsin B; Belongs to the peptidase C1 family. (339 aa)
NEK7Serine/threonine-protein kinase Nek7; Belongs to the protein kinase superfamily. (285 aa)
MAPK10Mitogen-activated protein kinase. (464 aa)
IL8Multifunctional fusion protein; Belongs to the intercrine alpha (chemokine CxC) family. (104 aa)
PYCARDApoptosis-associated speck-like protein containing a CARD isoform X1. (194 aa)
TXNIPThioredoxin-interacting protein-like. (391 aa)
IRAK4Interleukin-1 receptor-associated kinase 4 isoform X1. (459 aa)
TMEM173Stimulator of interferon genes protein. (378 aa)
GIMAP2GTPase IMAP family member 2. (338 aa)
GIMAP8GTPase IMAP family member 8. (657 aa)
CEP78Centrosomal protein of 78 kDa isoform X1. (801 aa)
GIMAP6GTPase IMAP family member 6. (350 aa)
ATL1Atlastin-1 isoform X1. (558 aa)
NLRC4LOW QUALITY PROTEIN: NLR family CARD domain-containing protein 4. (908 aa)
NFKBIANF-kappa-B inhibitor alpha isoform X2. (314 aa)
GABARAPL1Gamma-aminobutyric acid receptor-associated protein-like 1 isoform X1. (117 aa)
ERBB2IPProtein LAP2 isoform X1. (1460 aa)
NFKB1Nuclear factor NF-kappa-B p105 subunit. (254 aa)
LOC102747757Interferon alpha-1/2-like. (187 aa)
LOC102751218Voltage-dependent anion-selective channel protein 1-like. (280 aa)
TAB3TGF-beta-activated kinase 1 and MAP3K7-binding protein 3-like. (717 aa)
GPRC6AG-protein coupled receptor family C group 6 member A isoform X1. (928 aa)
TNFAIP3Tumor necrosis factor alpha-induced protein 3. (790 aa)
MAPK12Mitogen-activated protein kinase. (367 aa)
TANKTRAF family member-associated NF-kappa-B activator isoform X2. (426 aa)
LOC102726710Beta-defensin 103A-like. (67 aa)
LOC102750157Leucine-rich repeat-containing protein 31-like. (523 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (541 aa)
FADDFAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (218 aa)
ATG12Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family. (140 aa)
NOD1Nucleotide-binding oligomerization domain-containing protein 1. (953 aa)
BRCC3Lys-63-specific deubiquitinase BRCC36 isoform X1. (316 aa)
P2RX7P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (591 aa)
NLRP12NACHT, LRR and PYD domains-containing protein 12. (1059 aa)
ARRDC1Arrestin domain-containing protein 1. (431 aa)
LOC102748068Cytochrome b-245 heavy chain-like. (135 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2-like. (2701 aa)
PKN1Serine/threonine-protein kinase N1. (796 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
PKN2Serine/threonine-protein kinase N2 isoform X1. (984 aa)
RNF31E3 ubiquitin-protein ligase RNF31 isoform X1. (1080 aa)
IRF9Interferon regulatory factor 9 isoform X1. (445 aa)
GABARAPGamma-aminobutyric acid receptor-associated protein. (117 aa)
IKBKGNF-kappa-B essential modulator isoform X2. (419 aa)
ATG5Autophagy protein 5; Involved in autophagic vesicle formation. (255 aa)
NFKBIBNF-kappa-B inhibitor beta isoform X2. (354 aa)
JUNTranscription factor AP-1; Belongs to the bZIP family. (335 aa)
OAS22'-5'-oligoadenylate synthase 2. (685 aa)
OAS12'-5'-oligoadenylate synthase 1. (420 aa)
NLRX1NLR family member X1. (975 aa)
LOC102745369Arrestin domain-containing protein 5-like. (186 aa)
STAT2Signal transducer and activator of transcription. (854 aa)
CHUKInhibitor of nuclear factor kappa-B kinase subunit alpha. (745 aa)
TRPM7Transient receptor potential cation channel subfamily M member 7. (1731 aa)
PANX1Pannexin; Structural component of the gap junctions and the hemichannels. (427 aa)
IRF7Interferon regulatory factor 7. (470 aa)
ARRDC3Arrestin domain-containing protein 3-like. (414 aa)
LOC102748381Inhibitor of nuclear factor kappa-B kinase subunit epsilon-like. (618 aa)
NLRP6NACHT, LRR and PYD domains-containing protein 6. (893 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1. (1244 aa)
LOC102731085RBR-type E3 ubiquitin transferase. (856 aa)
PSTPIP1Proline-serine-threonine phosphatase-interacting protein 1. (416 aa)
NOD2Nucleotide-binding oligomerization domain-containing protein 2. (1013 aa)
NLRP10LOW QUALITY PROTEIN: NACHT, LRR and PYD domains-containing protein 10. (640 aa)
OTUD7AOTU domain-containing protein 7A. (479 aa)
TXNDC2Thioredoxin domain-containing protein 2. (527 aa)
MAVSLOW QUALITY PROTEIN: mitochondrial antiviral-signaling protein. (522 aa)
XIAPE3 ubiquitin-protein ligase XIAP-like isoform X1. (497 aa)
LOC102729256TNF receptor-associated factor 3-like. (283 aa)
IL6Interleukin-6 isoform X1. (212 aa)
TRIM14Tripartite motif-containing protein 14. (285 aa)
NLRC3Protein NLRC3. (330 aa)
CASRExtracellular calcium-sensing receptor. (1074 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (326 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3. (557 aa)
VDAC3Voltage-dependent anion-selective channel protein 3 isoform X1. (284 aa)
IKBKBInhibitor of nuclear factor kappa-B kinase subunit beta isoform X1. (756 aa)
LOC10275075614-3-3 protein epsilon-like; Belongs to the 14-3-3 family. (233 aa)
Your Current Organism:
Leptonychotes weddellii
NCBI taxonomy Id: 9713
Other names: L. weddellii, Leptonychotes weddelli, Weddell seal
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