(44 nodes) Cytosolic DNA-sensing pathway network (Leptonychotes weddellii)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	POLR3E	DNA-directed RNA polymerase III subunit RPC5 isoform X1. (710 aa)
	IKBKE	Inhibitor of nuclear factor kappa-B kinase subunit epsilon. (106 aa)
	MB21D1	Cyclic GMP-AMP synthase. (522 aa)
	PYCARD	Apoptosis-associated speck-like protein containing a CARD isoform X1. (194 aa)
	POLR3C	RNA polymerase III subunit C3; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (508 aa)
	TMEM173	Stimulator of interferon genes protein. (378 aa)
	POLR3F	DNA-directed RNA polymerase III subunit RPC6; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs; Belongs to the eukaryotic RPC34/RPC39 RNA polymerase subunit family. (316 aa)
	POLR3G	DNA-directed RNA polymerase III subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. (223 aa)
	NFKBIA	NF-kappa-B inhibitor alpha isoform X2. (314 aa)
	NFKB1	Nuclear factor NF-kappa-B p105 subunit. (254 aa)
	LOC102747757	Interferon alpha-1/2-like. (187 aa)
	LOC102750324	Interferon alpha-2-like. (175 aa)
	LOC102747471	Interferon alpha-1/2-like. (187 aa)
	IFNB1	Interferon beta. (182 aa)
	IL18	Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (193 aa)
	ADAR	Double-stranded RNA-specific adenosine deaminase. (1145 aa)
	POLR2H	DNA-directed RNA polymerases I, II, and III subunit RPABC3 isoform X1. (114 aa)
	IKBKG	NF-kappa-B essential modulator isoform X2. (419 aa)
	NFKBIB	NF-kappa-B inhibitor beta isoform X2. (354 aa)
	POLR2K	DNA-directed RNA polymerases I, II, and III subunit RPABC4. (58 aa)
	POLR3H	DNA-directed RNA polymerase III subunit RPC8 isoform X1. (204 aa)
	POLR2E	DNA-directed RNA polymerases I, II, and III subunit RPABC1 isoform X1. (210 aa)
	CHUK	Inhibitor of nuclear factor kappa-B kinase subunit alpha. (745 aa)
	POLR2L	DNA-directed RNA polymerases I, II, and III subunit RPABC5. (67 aa)
	IRF7	Interferon regulatory factor 7. (470 aa)
	LOC102748381	Inhibitor of nuclear factor kappa-B kinase subunit epsilon-like. (618 aa)
	LOC102749969	Interleukin-33-like. (267 aa)
	MAVS	LOW QUALITY PROTEIN: mitochondrial antiviral-signaling protein. (522 aa)
	IL6	Interleukin-6 isoform X1. (212 aa)
	LOC102728857	Probable ATP-dependent RNA helicase DDX58-like. (294 aa)
	IKBKB	Inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1. (756 aa)
	CXCL10	C-X-C motif chemokine. (98 aa)
	LOC102740920	C-C motif chemokine. (91 aa)
	IL1B	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (270 aa)
	POLR3D	DNA-directed RNA polymerase III subunit RPC4 isoform X1. (398 aa)
	PIWIL2	Piwi-like protein 2; Belongs to the argonaute family. (970 aa)
	POLR2F	DNA-directed RNA polymerases I, II, and III subunit RPABC2. (127 aa)
	POLR1C	DNA-directed RNA polymerases I and III subunit RPAC1. (346 aa)
	LOC102746545	DNA-directed RNA polymerases I and III subunit RPAC2-like. (133 aa)
	TREX1	Three prime repair exonuclease 1. (314 aa)
	LOC102748034	DNA-directed RNA polymerase III subunit RPC2-like; Belongs to the RNA polymerase beta chain family. (527 aa)
	POLR3K	DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family. (108 aa)
	LOC102741776	DNA-directed RNA polymerase III subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. (218 aa)
	IFNA14	LOW QUALITY PROTEIN: interferon, alpha 14. (182 aa)

Your Current Organism:

Leptonychotes weddellii

NCBI taxonomy Id: 9713
Other names: L. weddellii, Leptonychotes weddelli, Weddell seal

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADAR	IRF7	A0A2U3XTV3	A0A2U3YDR6	Double-stranded RNA-specific adenosine deaminase.	Interferon regulatory factor 7.	0.527
ADAR	LOC102728857	A0A2U3XTV3	A0A2U3YH50	Double-stranded RNA-specific adenosine deaminase.	Probable ATP-dependent RNA helicase DDX58-like.	0.589
CHUK	IFNB1	A0A2U3YBY3	A0A2U3XNU1	Inhibitor of nuclear factor kappa-B kinase subunit alpha.	Interferon beta.	0.412
CHUK	IKBKB	A0A2U3YBY3	A0A2U3YJI5	Inhibitor of nuclear factor kappa-B kinase subunit alpha.	Inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1.	0.999
CHUK	IKBKG	A0A2U3YBY3	A0A2U3Y6Q4	Inhibitor of nuclear factor kappa-B kinase subunit alpha.	NF-kappa-B essential modulator isoform X2.	0.999
CHUK	IL1B	A0A2U3YBY3	A0A2U3YM52	Inhibitor of nuclear factor kappa-B kinase subunit alpha.	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family.	0.584
CHUK	IL6	A0A2U3YBY3	A0A2U3YGL7	Inhibitor of nuclear factor kappa-B kinase subunit alpha.	Interleukin-6 isoform X1.	0.577
CHUK	IRF7	A0A2U3YBY3	A0A2U3YDR6	Inhibitor of nuclear factor kappa-B kinase subunit alpha.	Interferon regulatory factor 7.	0.929
CHUK	LOC102740920	A0A2U3YBY3	A0A2U3YKC3	Inhibitor of nuclear factor kappa-B kinase subunit alpha.	C-C motif chemokine.	0.406
CHUK	LOC102748381	A0A2U3YBY3	A0A2U3YDT3	Inhibitor of nuclear factor kappa-B kinase subunit alpha.	Inhibitor of nuclear factor kappa-B kinase subunit epsilon-like.	0.513
CHUK	MAVS	A0A2U3YBY3	A0A2U3YG15	Inhibitor of nuclear factor kappa-B kinase subunit alpha.	LOW QUALITY PROTEIN: mitochondrial antiviral-signaling protein.	0.961
CHUK	NFKB1	A0A2U3YBY3	A0A2U3XMD9	Inhibitor of nuclear factor kappa-B kinase subunit alpha.	Nuclear factor NF-kappa-B p105 subunit.	0.980
CHUK	NFKBIA	A0A2U3YBY3	A0A2U3XLC0	Inhibitor of nuclear factor kappa-B kinase subunit alpha.	NF-kappa-B inhibitor alpha isoform X2.	0.997
CHUK	NFKBIB	A0A2U3YBY3	A0A2U3Y6U2	Inhibitor of nuclear factor kappa-B kinase subunit alpha.	NF-kappa-B inhibitor beta isoform X2.	0.950
CHUK	TMEM173	A0A2U3YBY3	A0A2U3XH30	Inhibitor of nuclear factor kappa-B kinase subunit alpha.	Stimulator of interferon genes protein.	0.792
CXCL10	IFNB1	A0A2U3YK42	A0A2U3XNU1	C-X-C motif chemokine.	Interferon beta.	0.593
CXCL10	IL18	A0A2U3YK42	A0A2U3XPG8	C-X-C motif chemokine.	Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family.	0.706
CXCL10	IL1B	A0A2U3YK42	A0A2U3YM52	C-X-C motif chemokine.	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family.	0.754
CXCL10	IL6	A0A2U3YK42	A0A2U3YGL7	C-X-C motif chemokine.	Interleukin-6 isoform X1.	0.803
CXCL10	IRF7	A0A2U3YK42	A0A2U3YDR6	C-X-C motif chemokine.	Interferon regulatory factor 7.	0.680