STRINGSTRING
KITLG KITLG SIGLEC10 SIGLEC10 CD7 CD7 ANPEP ANPEP LOC102738307 LOC102738307 CD1C CD1C LOC102738001 LOC102738001 LOC102742806 LOC102742806 ITGA4 ITGA4 CD8A CD8A LOC102730162 LOC102730162 CSF1R CSF1R LOC102734398 LOC102734398 TFRC TFRC CD3D CD3D IL6 IL6 MS4A1 MS4A1 EPOR EPOR IL1B IL1B IL1A IL1A CSF1 CSF1 IL3RA IL3RA FLT3 FLT3 CPN2 CPN2 LOC102728378 LOC102728378 LRRC15 LRRC15 CD37 CD37 IL4R IL4R FLT3LG FLT3LG CD59 CD59 LOC102730926 LOC102730926 IL11 IL11 CSF3 CSF3 LOC102734456 LOC102734456 LOC102747745 LOC102747745 IL3 IL3 CSF2 CSF2 DGCR6 DGCR6 LOC102742177 LOC102742177 FCGBP FCGBP THPO THPO LOC102750166 LOC102750166 TNF TNF LOC102749767 LOC102749767 IL7 IL7 ITGA5 ITGA5 ITGAM ITGAM CD22 CD22 ZAN ZAN CD19 CD19 ITGB3 ITGB3 IL4 IL4 IL5 IL5 GYPA GYPA LOC102733973 LOC102733973 CD9 CD9 LOC102740784 LOC102740784 LOC102741082 LOC102741082 CSF3R CSF3R IL1R2 IL1R2 CD4 CD4 LOC102748462 LOC102748462 LOC102750454 LOC102750454
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
KITLGKit ligand; Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. Belongs to the SCF family. (274 aa)
SIGLEC10Sialic acid-binding Ig-like lectin 10. (692 aa)
CD7T-cell antigen CD7. (209 aa)
ANPEPAminopeptidase. (962 aa)
LOC102738307T-cell surface glycoprotein CD1a-like. (340 aa)
CD1CT-cell surface glycoprotein CD1c. (337 aa)
LOC102738001T-cell surface glycoprotein CD1a-like. (339 aa)
LOC102742806T-cell surface glycoprotein CD1b-like. (349 aa)
ITGA4Integrin alpha-4; Belongs to the integrin alpha chain family. (1033 aa)
CD8AT-cell surface glycoprotein CD8 alpha chain. (213 aa)
LOC102730162T-cell surface glycoprotein CD3 gamma chain-like. (182 aa)
CSF1RMacrophage colony-stimulating factor 1 receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (961 aa)
LOC102734398T-cell surface glycoprotein CD3 gamma chain-like. (167 aa)
TFRCTransferrin receptor protein 1 isoform X1. (770 aa)
CD3DT-cell surface glycoprotein CD3 delta chain. (171 aa)
IL6Interleukin-6 isoform X1. (212 aa)
MS4A1B-lymphocyte antigen CD20. (297 aa)
EPORErythropoietin receptor; Receptor for erythropoietin. (509 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (270 aa)
IL1AInterleukin-1; Belongs to the IL-1 family. (265 aa)
CSF1Macrophage colony-stimulating factor 1; Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female [...] (547 aa)
IL3RAInterleukin-3 receptor subunit alpha. (376 aa)
FLT3Receptor-type tyrosine-protein kinase FLT3; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (984 aa)
CPN2Carboxypeptidase N subunit 2. (547 aa)
LOC102728378Granulocyte colony-stimulating factor receptor-like. (493 aa)
LRRC15Leucine-rich repeat-containing protein 15. (580 aa)
CD37Tetraspanin. (281 aa)
IL4RInterleukin-4 receptor subunit alpha isoform X1. (797 aa)
FLT3LGFms-related tyrosine kinase 3 ligand. (290 aa)
CD59CD59 glycoprotein. (120 aa)
LOC102730926Granulocyte-macrophage colony-stimulating factor receptor subunit alpha-like. (345 aa)
IL11Interleukin-11. (120 aa)
CSF3Granulocyte colony-stimulating factor. (195 aa)
LOC102734456HLA class II histocompatibility antigen, DO alpha chain-like; Belongs to the MHC class II family. (250 aa)
LOC102747745Interleukin-9 receptor-like. (175 aa)
IL3Interleukin-3. (143 aa)
CSF2Granulocyte-macrophage colony-stimulating factor. (153 aa)
DGCR6Protein DGCR6. (105 aa)
LOC102742177Mast/stem cell growth factor receptor Kit-like. (217 aa)
FCGBPLOW QUALITY PROTEIN: Fc of IgG binding protein. (2990 aa)
THPOLOW QUALITY PROTEIN: thrombopoietin. (352 aa)
LOC102750166HLA class II histocompatibility antigen, DM beta chain-like. (263 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
LOC102749767Integrin alpha-IIb-like. (534 aa)
IL7Interleukin-7; Hematopoietic growth factor capable of stimulating the proliferation of lymphoid progenitors. It is important for proliferation during certain stages of B-cell maturation. Belongs to the IL-7/IL-9 family. (158 aa)
ITGA5Integrin alpha-5; Belongs to the integrin alpha chain family. (1054 aa)
ITGAMIntegrin alpha-M isoform X1; Belongs to the integrin alpha chain family. (1154 aa)
CD22B-cell receptor CD22 isoform X1. (844 aa)
ZANZonadhesin. (2627 aa)
CD19B-lymphocyte antigen CD19. (559 aa)
ITGB3Integrin beta; Belongs to the integrin beta chain family. (852 aa)
IL4Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Belongs to the IL-4/IL-13 family. (131 aa)
IL5Interleukin-5; Factor that induces terminal differentiation of late- developing B-cells to immunoglobulin secreting cells. (134 aa)
GYPAglycophorin-A. (122 aa)
LOC102733973Interleukin-5 receptor subunit alpha-like. (310 aa)
CD9Tetraspanin. (226 aa)
LOC102740784HLA class II histocompatibility antigen, DR alpha chain-like; Belongs to the MHC class II family. (254 aa)
LOC102741082DLA class II histocompatibility antigen, DR-1 beta chain-like. (266 aa)
CSF3RGranulocyte colony-stimulating factor receptor. (430 aa)
IL1R2Interleukin-1 receptor type 2. (414 aa)
CD4T-cell surface glycoprotein CD4. (462 aa)
LOC102748462HLA class II histocompatibility antigen, DO beta chain-like. (273 aa)
LOC102750454HLA class II histocompatibility antigen, DM alpha chain-like; Belongs to the MHC class II family. (261 aa)
Your Current Organism:
Leptonychotes weddellii
NCBI taxonomy Id: 9713
Other names: L. weddellii, Leptonychotes weddelli, Weddell seal
Server load: low (34%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.