(60 nodes) Natural killer cell mediated cytotoxicity network (Leptonychotes weddellii)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ZAP70	Tyrosine-protein kinase. (616 aa)
	LAT	Linker for activation of T-cells family member 1. (256 aa)
	SHC1	SHC-transforming protein 1 isoform X2. (583 aa)
	LOC102745146	Tumor necrosis factor ligand superfamily member 6-like; Belongs to the tumor necrosis factor family. (173 aa)
	LCP2	Lymphocyte cytosolic protein 2. (533 aa)
	CD247	T-cell surface glycoprotein CD3 zeta chain. (166 aa)
	PTPN11	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (593 aa)
	IFNGR2	Interferon gamma receptor 2. (115 aa)
	VAV3	Guanine nucleotide exchange factor VAV3 isoform X2. (847 aa)
	SHC4	SHC-transforming protein 4. (630 aa)
	CEP152	Centrosomal protein of 152 kDa isoform X1. (1723 aa)
	FASLG	Tumor necrosis factor ligand superfamily member 6. (130 aa)
	ITGAL	Integrin alpha-L; Belongs to the integrin alpha chain family. (1168 aa)
	ERAS	GTPase ERas. (233 aa)
	TNF	Tumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
	LOC102735873	Low affinity immunoglobulin gamma Fc region receptor III-like. (232 aa)
	MAP2K2	Dual specificity mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa)
	PAK1	Non-specific serine/threonine protein kinase. (544 aa)
	IFNG	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (166 aa)
	SH3BP2	SH3 domain-binding protein 2-like. (366 aa)
	RAF1	RAF proto-oncogene serine/threonine-protein kinase isoform X1. (648 aa)
	RAC2	Ras-related C3 botulinum toxin substrate 2. (192 aa)
	TYROBP	TYRO protein tyrosine kinase-binding protein isoform X1. (111 aa)
	HCST	Hematopoietic cell signal transducer. (79 aa)
	MAPK1	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (326 aa)
	LOC102735415	Phosphoinositide phospholipase C. (309 aa)
	FCER1G	High affinity immunoglobulin epsilon receptor subunit gamma. (94 aa)
	CASP3	Caspase-3; Belongs to the peptidase C14A family. (302 aa)
	PIK3CD	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1043 aa)
	PIK3CA	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
	NFATC1	Nuclear factor of activated T-cells, cytoplasmic 1. (221 aa)
	LOC102725943	Nuclear factor of activated T-cells, cytoplasmic 2-like. (160 aa)
	VAV2	Guanine nucleotide exchange factor VAV2. (357 aa)
	ICAM1	Intercellular adhesion molecule 1. (533 aa)
	LOC102736516	Phosphatidylinositol 3-kinase regulatory subunit alpha-like. (138 aa)
	PRF1	Perforin-1. (555 aa)
	LOC102732650	SH2 domain-containing protein 1A; Cytoplasmic adapter regulating receptors of the signaling lymphocytic activation molecule (SLAM) family such as SLAMF1, CD244, LY9, CD84, SLAMF6 and SLAMF7. In SLAM signaling seems to cooperate with SH2D1B/EAT-2. (128 aa)
	IFNAR1	Interferon alpha/beta receptor 1. (560 aa)
	ICAM2	Intercellular adhesion molecule 2. (264 aa)
	CSF2	Granulocyte-macrophage colony-stimulating factor. (153 aa)
	LOC102748045	Proto-oncogene vav-like. (140 aa)
	LOC102751021	Phosphatidylinositol 3-kinase regulatory subunit alpha-like isoform X1. (454 aa)
	LOC102730741	Natural killer cells antigen CD94-like. (162 aa)
	LOC102734861	BH3-interacting domain death agonist-like. (83 aa)
	LOC102750030	Protein-tyrosine kinase 2-beta-like. (125 aa)
	IFNA14	LOW QUALITY PROTEIN: interferon, alpha 14. (182 aa)
	SH2D1B	SH2 domain-containing protein 1B. (108 aa)
	PPP3R2	Calcineurin subunit B type 2. (170 aa)
	KRAS	GTPase KRas isoform X2. (188 aa)
	LOC102726446	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform-like; Belongs to the PI3/PI4-kinase family. (235 aa)
	NRAS	GTPase NRas. (189 aa)
	CSDE1	Cold shock domain-containing protein E1 isoform X1. (845 aa)
	PIK3R3	Phosphatidylinositol 3-kinase regulatory subunit gamma. (461 aa)
	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1 isoform X1; Belongs to the protein kinase superfamily. (393 aa)
	PPP3R1	Calcineurin subunit B type 1 isoform X1. (170 aa)
	KLRK1	NKG2-D type II integral membrane protein. (216 aa)
	LOC102747757	Interferon alpha-1/2-like. (187 aa)
	LOC102747471	Interferon alpha-1/2-like. (187 aa)
	IFNB1	Interferon beta. (182 aa)
	TNFSF10	Tumor necrosis factor ligand superfamily member 10; Belongs to the tumor necrosis factor family. (245 aa)

Your Current Organism:

Leptonychotes weddellii

NCBI taxonomy Id: 9713
Other names: L. weddellii, Leptonychotes weddelli, Weddell seal

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CASP3	FASLG	A0A2U3YM46	A0A2U3Y1M8	Caspase-3; Belongs to the peptidase C14A family.	Tumor necrosis factor ligand superfamily member 6.	0.641
CASP3	ICAM1	A0A2U3YM46	A0A2U3YSH4	Caspase-3; Belongs to the peptidase C14A family.	Intercellular adhesion molecule 1.	0.493
CASP3	IFNG	A0A2U3YM46	A0A2U3Y8N2	Caspase-3; Belongs to the peptidase C14A family.	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	0.644
CASP3	KRAS	A0A2U3YM46	A0A2U3X8L4	Caspase-3; Belongs to the peptidase C14A family.	GTPase KRas isoform X2.	0.560
CASP3	LOC102734861	A0A2U3YM46	A0A2U3Z8M2	Caspase-3; Belongs to the peptidase C14A family.	BH3-interacting domain death agonist-like.	0.719
CASP3	LOC102745146	A0A2U3YM46	A0A2U3XU33	Caspase-3; Belongs to the peptidase C14A family.	Tumor necrosis factor ligand superfamily member 6-like; Belongs to the tumor necrosis factor family.	0.641
CASP3	LOC102750030	A0A2U3YM46	A0A2U3Z8N4	Caspase-3; Belongs to the peptidase C14A family.	Protein-tyrosine kinase 2-beta-like.	0.605
CASP3	MAPK1	A0A2U3YM46	A0A2U3YIW0	Caspase-3; Belongs to the peptidase C14A family.	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	0.948
CASP3	PAK1	A0A2U3YM46	A0A2U3Y773	Caspase-3; Belongs to the peptidase C14A family.	Non-specific serine/threonine protein kinase.	0.905
CASP3	PIK3CA	A0A2U3YM46	A0A2U3YQH7	Caspase-3; Belongs to the peptidase C14A family.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.494
CASP3	RAF1	A0A2U3YM46	A0A2U3Y9A9	Caspase-3; Belongs to the peptidase C14A family.	RAF proto-oncogene serine/threonine-protein kinase isoform X1.	0.530
CASP3	TNF	A0A2U3YM46	A0A2U3Y499	Caspase-3; Belongs to the peptidase C14A family.	Tumor necrosis factor; Belongs to the tumor necrosis factor family.	0.763
CASP3	TNFSF10	A0A2U3YM46	A0A2U3XQC2	Caspase-3; Belongs to the peptidase C14A family.	Tumor necrosis factor ligand superfamily member 10; Belongs to the tumor necrosis factor family.	0.557
CD247	FCER1G	A0A2U3XW81	A0A2U3YL68	T-cell surface glycoprotein CD3 zeta chain.	High affinity immunoglobulin epsilon receptor subunit gamma.	0.422
CD247	HCST	A0A2U3XW81	A0A2U3YH36	T-cell surface glycoprotein CD3 zeta chain.	Hematopoietic cell signal transducer.	0.444
CD247	KLRK1	A0A2U3XW81	A0A2U3XL39	T-cell surface glycoprotein CD3 zeta chain.	NKG2-D type II integral membrane protein.	0.483
CD247	LAT	A0A2U3XW81	A0A2U3XRH3	T-cell surface glycoprotein CD3 zeta chain.	Linker for activation of T-cells family member 1.	0.608
CD247	LCP2	A0A2U3XW81	A0A2U3XVM1	T-cell surface glycoprotein CD3 zeta chain.	Lymphocyte cytosolic protein 2.	0.738
CD247	LOC102732650	A0A2U3XW81	A0A2U3YYQ0	T-cell surface glycoprotein CD3 zeta chain.	SH2 domain-containing protein 1A; Cytoplasmic adapter regulating receptors of the signaling lymphocytic activation molecule (SLAM) family such as SLAMF1, CD244, LY9, CD84, SLAMF6 and SLAMF7. In SLAM signaling seems to cooperate with SH2D1B/EAT-2.	0.596
CD247	LOC102735415	A0A2U3XW81	A0A2U3YKX8	T-cell surface glycoprotein CD3 zeta chain.	Phosphoinositide phospholipase C.	0.579