STRINGSTRING
MAPK15 MAPK15 IL1B IL1B FOS FOS JUND JUND IL25 IL25 HSP90AB1 HSP90AB1 S100A9 S100A9 FOSB FOSB TNF TNF MAPK8 MAPK8 ANAPC5 ANAPC5 FADD FADD TRAF6 TRAF6 TRAF3IP2 TRAF3IP2 MAPK12 MAPK12 TNFAIP3 TNFAIP3 IL13 IL13 IL5 IL5 IL4 IL4 TAB3 TAB3 ELAVL1 ELAVL1 NFKB1 NFKB1 NFKBIA NFKBIA CEBPB CEBPB MAPK7 MAPK7 PTGS2 PTGS2 CXCL6 CXCL6 IL8 IL8 MAPK10 MAPK10 CCL17 CCL17 IL17A IL17A IL17F IL17F LOC102726367 LOC102726367 CASP8 CASP8 CSF3 CSF3 SRSF1 SRSF1 CCL20 CCL20 LOC102735556 LOC102735556 CSF2 CSF2 LOC102741358 LOC102741358 MAPK11 MAPK11 LOC102742576 LOC102742576 LOC102732112 LOC102732112 CASP3 CASP3 LOC102730789 LOC102730789 CXCL10 CXCL10 LOC102740611 LOC102740611 IKBKB IKBKB MAPK1 MAPK1 IL6 IL6 LOC102729256 LOC102729256 USP25 USP25 GSK3B GSK3B LOC102748381 LOC102748381 CCL7 CCL7 TRADD TRADD MMP13 MMP13 MMP3 MMP3 CHUK CHUK LOC102728754 LOC102728754 HSP90B1 HSP90B1 IFNG IFNG MMP9 MMP9 JUN JUN IKBKG IKBKG
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MAPK15Mitogen-activated protein kinase. (559 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (270 aa)
FOSProto-oncogene c-Fos isoform X1. (380 aa)
JUNDTranscription factor jun-D. (298 aa)
IL25Interleukin-25. (169 aa)
HSP90AB1Heat shock protein HSP 90-beta. (464 aa)
S100A9Protein S100; Belongs to the S-100 family. (140 aa)
FOSBProtein fosB isoform X1. (335 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
ANAPC5Anaphase-promoting complex subunit 5 isoform X1. (755 aa)
FADDFAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (218 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (541 aa)
TRAF3IP2Adapter protein CIKS isoform X1. (563 aa)
MAPK12Mitogen-activated protein kinase. (367 aa)
TNFAIP3Tumor necrosis factor alpha-induced protein 3. (790 aa)
IL13Interleukin-13. (133 aa)
IL5Interleukin-5; Factor that induces terminal differentiation of late- developing B-cells to immunoglobulin secreting cells. (134 aa)
IL4Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Belongs to the IL-4/IL-13 family. (131 aa)
TAB3TGF-beta-activated kinase 1 and MAP3K7-binding protein 3-like. (717 aa)
ELAVL1ELAV-like protein; Belongs to the RRM elav family. (326 aa)
NFKB1Nuclear factor NF-kappa-B p105 subunit. (254 aa)
NFKBIANF-kappa-B inhibitor alpha isoform X2. (314 aa)
CEBPBCCAAT/enhancer-binding protein. (345 aa)
MAPK7Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (814 aa)
PTGS2Prostaglandin G/H synthase 2. (470 aa)
CXCL6C-X-C motif chemokine. (113 aa)
IL8Multifunctional fusion protein; Belongs to the intercrine alpha (chemokine CxC) family. (104 aa)
MAPK10Mitogen-activated protein kinase. (464 aa)
CCL17c-C motif chemokine 17. (99 aa)
IL17Ainterleukin-17A. (155 aa)
IL17Finterleukin-17F. (157 aa)
LOC102726367Heat shock protein HSP 90-alpha-like. (262 aa)
CASP8Caspase-8 isoform X1; Belongs to the peptidase C14A family. (486 aa)
CSF3Granulocyte colony-stimulating factor. (195 aa)
SRSF1Serine/arginine-rich splicing factor 1 isoform X1. (248 aa)
CCL20C-C motif chemokine. (89 aa)
LOC102735556Mitogen-activated protein kinase 9-like. (134 aa)
CSF2Granulocyte-macrophage colony-stimulating factor. (153 aa)
LOC102741358Protein S100; Belongs to the S-100 family. (89 aa)
MAPK11Mitogen-activated protein kinase. (254 aa)
LOC102742576C-X-C motif chemokine. (107 aa)
LOC102732112interleukin-17B-like. (76 aa)
CASP3Caspase-3; Belongs to the peptidase C14A family. (302 aa)
LOC102730789TNF receptor-associated factor 3-like. (295 aa)
CXCL10C-X-C motif chemokine. (98 aa)
LOC102740611TNF receptor-associated factor. (490 aa)
IKBKBInhibitor of nuclear factor kappa-B kinase subunit beta isoform X1. (756 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (326 aa)
IL6Interleukin-6 isoform X1. (212 aa)
LOC102729256TNF receptor-associated factor 3-like. (283 aa)
USP25Ubiquitin carboxyl-terminal hydrolase 25-like isoform X1; Belongs to the peptidase C19 family. (1123 aa)
GSK3BGlycogen synthase kinase-3 beta isoform X1; Belongs to the protein kinase superfamily. (433 aa)
LOC102748381Inhibitor of nuclear factor kappa-B kinase subunit epsilon-like. (618 aa)
CCL7LOW QUALITY PROTEIN: c-C motif chemokine 7. (99 aa)
TRADDTumor necrosis factor receptor type 1-associated DEATH domain protein. (312 aa)
MMP13Collagenase 3. (470 aa)
MMP3Stromelysin-1. (476 aa)
CHUKInhibitor of nuclear factor kappa-B kinase subunit alpha. (745 aa)
LOC102728754interleukin-17B-like. (104 aa)
HSP90B1Endoplasmin isoform X1. (803 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (166 aa)
MMP9Matrix metalloproteinase-9. (704 aa)
JUNTranscription factor AP-1; Belongs to the bZIP family. (335 aa)
IKBKGNF-kappa-B essential modulator isoform X2. (419 aa)
Your Current Organism:
Leptonychotes weddellii
NCBI taxonomy Id: 9713
Other names: L. weddellii, Leptonychotes weddelli, Weddell seal
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