62 items (Leptonychotes weddellii) - STRING interaction network

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	MAPK10	Mitogen-activated protein kinase. (464 aa)
	PPP3R2	Calcineurin subunit B type 2. (170 aa)
	NFKBIB	NF-kappa-B inhibitor beta isoform X2. (354 aa)
	JUN	Transcription factor AP-1; Belongs to the bZIP family. (335 aa)
	DLL1	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (724 aa)
	IKBKB	Inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1. (756 aa)
	MAPK1	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (326 aa)
	DLL4	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (685 aa)
	IL2RB	Interleukin-2 receptor subunit beta. (552 aa)
	IL12A	Interleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC. (222 aa)
	CD3D	T-cell surface glycoprotein CD3 delta chain. (171 aa)
	LOC102734398	T-cell surface glycoprotein CD3 gamma chain-like. (167 aa)
	IL12B	Interleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (279 aa)
	LOC102730162	T-cell surface glycoprotein CD3 gamma chain-like. (182 aa)
	GATA3	Trans-acting T-cell-specific transcription factor GATA-3 isoform X1. (444 aa)
	CHUK	Inhibitor of nuclear factor kappa-B kinase subunit alpha. (745 aa)
	IFNG	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (166 aa)
	MAML1	Mastermind-like protein 1. (948 aa)
	LOC102734456	HLA class II histocompatibility antigen, DO alpha chain-like; Belongs to the MHC class II family. (250 aa)
	JAK3	Tyrosine-protein kinase. (1139 aa)
	IL4R	Interleukin-4 receptor subunit alpha isoform X1. (797 aa)
	NOTCH2	Neurogenic locus notch homolog protein 2. (1238 aa)
	NFKBIE	NF-kappa-B inhibitor epsilon. (361 aa)
	TYK2	Non-receptor tyrosine-protein kinase TYK2-like. (767 aa)
	LOC102725943	Nuclear factor of activated T-cells, cytoplasmic 2-like. (160 aa)
	NFATC1	Nuclear factor of activated T-cells, cytoplasmic 1. (221 aa)
	FOS	Proto-oncogene c-Fos isoform X1. (380 aa)
	TBX21	T-box transcription factor TBX21. (535 aa)
	IKBKG	NF-kappa-B essential modulator isoform X2. (419 aa)
	STAT5B	Signal transducer and activator of transcription 5B. (508 aa)
	MAPK8	Mitogen-activated protein kinase. (427 aa)
	IL2	Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family. (154 aa)
	LOC102750166	HLA class II histocompatibility antigen, DM beta chain-like. (263 aa)
	LOC102750454	HLA class II histocompatibility antigen, DM alpha chain-like; Belongs to the MHC class II family. (261 aa)
	LOC102748462	HLA class II histocompatibility antigen, DO beta chain-like. (273 aa)
	CD4	T-cell surface glycoprotein CD4. (462 aa)
	JAK2	Tyrosine-protein kinase. (952 aa)
	JAG1	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1218 aa)
	IFNGR2	Interferon gamma receptor 2. (115 aa)
	LOC102741082	DLA class II histocompatibility antigen, DR-1 beta chain-like. (266 aa)
	LOC102740784	HLA class II histocompatibility antigen, DR alpha chain-like; Belongs to the MHC class II family. (254 aa)
	CD247	T-cell surface glycoprotein CD3 zeta chain. (166 aa)
	IL12RB2	Interleukin-12 receptor subunit beta-2. (851 aa)
	STAT5A	Signal transducer and activator of transcription 5A. (464 aa)
	MAPK12	Mitogen-activated protein kinase. (367 aa)
	RBPJL	Recombining binding protein suppressor of hairless-like protein. (517 aa)
	PRKCQ	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (706 aa)
	IL13	Interleukin-13. (133 aa)
	IL5	Interleukin-5; Factor that induces terminal differentiation of late- developing B-cells to immunoglobulin secreting cells. (134 aa)
	IL4	Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Belongs to the IL-4/IL-13 family. (131 aa)
	LAT	Linker for activation of T-cells family member 1. (256 aa)
	ZAP70	Tyrosine-protein kinase. (616 aa)
	NFKB1	Nuclear factor NF-kappa-B p105 subunit. (254 aa)
	NFKBIA	NF-kappa-B inhibitor alpha isoform X2. (314 aa)
	NFATC3	Nuclear factor of activated T-cells, cytoplasmic 3 isoform X1. (1075 aa)
	PPP3R1	Calcineurin subunit B type 1 isoform X1. (170 aa)
	LOC102731864	Signal transducer and activator of transcription 5B-like. (353 aa)
	MAPK11	Mitogen-activated protein kinase. (254 aa)
	LOC102729516	Mastermind-like protein 2-like. (421 aa)
	LOC102749847	Tyrosine-protein kinase JAK1-like. (444 aa)
	LOC102735556	Mitogen-activated protein kinase 9-like. (134 aa)
	RUNX3	Runt-related transcription factor 3-like. (283 aa)

Your Current Organism:

Leptonychotes weddellii

NCBI taxonomy Id: 9713
Other names: L. weddellii, Leptonychotes weddelli, Weddell seal

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CD247	CD3D	A0A2U3XW81	A0A2U3YDJ4	T-cell surface glycoprotein CD3 zeta chain.	T-cell surface glycoprotein CD3 delta chain.	0.997
CD247	CD4	A0A2U3XW81	A0A2U3Y2Q1	T-cell surface glycoprotein CD3 zeta chain.	T-cell surface glycoprotein CD4.	0.726
CD247	IL2RB	A0A2U3XW81	A0A2U3YEY9	T-cell surface glycoprotein CD3 zeta chain.	Interleukin-2 receptor subunit beta.	0.835
CD247	JAK3	A0A2U3XW81	A0A2U3Z0Y0	T-cell surface glycoprotein CD3 zeta chain.	Tyrosine-protein kinase.	0.421
CD247	LAT	A0A2U3XW81	A0A2U3XRH3	T-cell surface glycoprotein CD3 zeta chain.	Linker for activation of T-cells family member 1.	0.608
CD247	LOC102730162	A0A2U3XW81	A0A2U3YD51	T-cell surface glycoprotein CD3 zeta chain.	T-cell surface glycoprotein CD3 gamma chain-like.	0.998
CD247	LOC102734398	A0A2U3XW81	A0A2U3YD98	T-cell surface glycoprotein CD3 zeta chain.	T-cell surface glycoprotein CD3 gamma chain-like.	0.998
CD247	LOC102734456	A0A2U3XW81	A0A2U3Z2X5	T-cell surface glycoprotein CD3 zeta chain.	HLA class II histocompatibility antigen, DO alpha chain-like; Belongs to the MHC class II family.	0.803
CD247	LOC102740784	A0A2U3XW81	A0A2U3XXW2	T-cell surface glycoprotein CD3 zeta chain.	HLA class II histocompatibility antigen, DR alpha chain-like; Belongs to the MHC class II family.	0.830
CD247	LOC102741082	A0A2U3XW81	A0A2U3XXW7	T-cell surface glycoprotein CD3 zeta chain.	DLA class II histocompatibility antigen, DR-1 beta chain-like.	0.823
CD247	LOC102748462	A0A2U3XW81	A0A2U3Y332	T-cell surface glycoprotein CD3 zeta chain.	HLA class II histocompatibility antigen, DO beta chain-like.	0.823
CD247	LOC102750166	A0A2U3XW81	A0A2U3Y3B4	T-cell surface glycoprotein CD3 zeta chain.	HLA class II histocompatibility antigen, DM beta chain-like.	0.809
CD247	LOC102750454	A0A2U3XW81	A0A2U3Y337	T-cell surface glycoprotein CD3 zeta chain.	HLA class II histocompatibility antigen, DM alpha chain-like; Belongs to the MHC class II family.	0.815
CD247	PRKCQ	A0A2U3XW81	A0A2U3XTI0	T-cell surface glycoprotein CD3 zeta chain.	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.	0.415
CD247	ZAP70	A0A2U3XW81	A0A2U3XR38	T-cell surface glycoprotein CD3 zeta chain.	Tyrosine-protein kinase.	0.999
CD3D	CD247	A0A2U3YDJ4	A0A2U3XW81	T-cell surface glycoprotein CD3 delta chain.	T-cell surface glycoprotein CD3 zeta chain.	0.997
CD3D	CD4	A0A2U3YDJ4	A0A2U3Y2Q1	T-cell surface glycoprotein CD3 delta chain.	T-cell surface glycoprotein CD4.	0.646
CD3D	IFNG	A0A2U3YDJ4	A0A2U3Y8N2	T-cell surface glycoprotein CD3 delta chain.	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	0.408
CD3D	IL2	A0A2U3YDJ4	A0A2U3Y3E4	T-cell surface glycoprotein CD3 delta chain.	Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family.	0.438
CD3D	IL2RB	A0A2U3YDJ4	A0A2U3YEY9	T-cell surface glycoprotein CD3 delta chain.	Interleukin-2 receptor subunit beta.	0.502