(76 nodes) Th17 cell differentiation network (Leptonychotes weddellii)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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co-expression

protein homology

Your Input:
	CD3D	T-cell surface glycoprotein CD3 delta chain. (171 aa)
	IL2RB	Interleukin-2 receptor subunit beta. (552 aa)
	IL6	Interleukin-6 isoform X1. (212 aa)
	FOXP3	Forkhead box protein P3 isoform X1. (456 aa)
	MAPK1	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (326 aa)
	IKBKB	Inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1. (756 aa)
	IL1B	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (270 aa)
	TBX21	T-box transcription factor TBX21. (535 aa)
	FOS	Proto-oncogene c-Fos isoform X1. (380 aa)
	NFATC1	Nuclear factor of activated T-cells, cytoplasmic 1. (221 aa)
	LOC102725943	Nuclear factor of activated T-cells, cytoplasmic 2-like. (160 aa)
	RARA	Retinoic acid receptor alpha isoform X1. (462 aa)
	TYK2	Non-receptor tyrosine-protein kinase TYK2-like. (767 aa)
	IL21R	Interleukin-21 receptor. (542 aa)
	TGFB1	Transforming growth factor beta-1. (261 aa)
	HSP90AB1	Heat shock protein HSP 90-beta. (464 aa)
	NFKBIE	NF-kappa-B inhibitor epsilon. (361 aa)
	RXRA	Retinoic acid receptor RXR-alpha. (439 aa)
	IL17A	interleukin-17A. (155 aa)
	IL17F	interleukin-17F. (157 aa)
	LOC102726367	Heat shock protein HSP 90-alpha-like. (262 aa)
	IL4R	Interleukin-4 receptor subunit alpha isoform X1. (797 aa)
	JAK3	Tyrosine-protein kinase. (1139 aa)
	LOC102730318	Mothers against decapentaplegic homolog. (415 aa)
	LOC102734456	HLA class II histocompatibility antigen, DO alpha chain-like; Belongs to the MHC class II family. (250 aa)
	LOC102731864	Signal transducer and activator of transcription 5B-like. (353 aa)
	LAT	Linker for activation of T-cells family member 1. (256 aa)
	TGFBR2	TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (564 aa)
	ZAP70	Tyrosine-protein kinase. (616 aa)
	NFKB1	Nuclear factor NF-kappa-B p105 subunit. (254 aa)
	NFKBIA	NF-kappa-B inhibitor alpha isoform X2. (314 aa)
	STAT3	Signal transducer and activator of transcription 3-like. (424 aa)
	NFATC3	Nuclear factor of activated T-cells, cytoplasmic 3 isoform X1. (1075 aa)
	PPP3R1	Calcineurin subunit B type 1 isoform X1. (170 aa)
	MAPK10	Mitogen-activated protein kinase. (464 aa)
	AHR	Aryl hydrocarbon receptor. (843 aa)
	RORC	Nuclear receptor ROR-gamma isoform X1. (518 aa)
	PPP3R2	Calcineurin subunit B type 2. (170 aa)
	LOC102735556	Mitogen-activated protein kinase 9-like. (134 aa)
	STAT5A	Signal transducer and activator of transcription 5A. (464 aa)
	LOC102749847	Tyrosine-protein kinase JAK1-like. (444 aa)
	MAPK11	Mitogen-activated protein kinase. (254 aa)
	LOC102734398	T-cell surface glycoprotein CD3 gamma chain-like. (167 aa)
	LOC102730162	T-cell surface glycoprotein CD3 gamma chain-like. (182 aa)
	GATA3	Trans-acting T-cell-specific transcription factor GATA-3 isoform X1. (444 aa)
	CHUK	Inhibitor of nuclear factor kappa-B kinase subunit alpha. (745 aa)
	IL23A	Interleukin-23 subunit alpha. (210 aa)
	IFNG	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (166 aa)
	IL22	Interleukin-22 isoform X1. (179 aa)
	JUN	Transcription factor AP-1; Belongs to the bZIP family. (335 aa)
	NFKBIB	NF-kappa-B inhibitor beta isoform X2. (354 aa)
	IKBKG	NF-kappa-B essential modulator isoform X2. (419 aa)
	LOC102730764	Mothers against decapentaplegic homolog 2-like. (227 aa)
	STAT5B	Signal transducer and activator of transcription 5B. (508 aa)
	LOC102745161	Signal transducer and activator of transcription 3-like. (301 aa)
	HIF1A	Hypoxia-inducible factor 1-alpha isoform X1. (823 aa)
	MAPK8	Mitogen-activated protein kinase. (427 aa)
	IL21	Interleukin; Belongs to the IL-15/IL-21 family. (153 aa)
	IL2	Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family. (154 aa)
	LOC102750166	HLA class II histocompatibility antigen, DM beta chain-like. (263 aa)
	LOC102750454	HLA class II histocompatibility antigen, DM alpha chain-like; Belongs to the MHC class II family. (261 aa)
	LOC102748462	HLA class II histocompatibility antigen, DO beta chain-like. (273 aa)
	RXRB	Retinoic acid receptor RXR-beta isoform X1. (536 aa)
	CD4	T-cell surface glycoprotein CD4. (462 aa)
	JAK2	Tyrosine-protein kinase. (952 aa)
	IFNGR2	Interferon gamma receptor 2. (115 aa)
	LOC102741082	DLA class II histocompatibility antigen, DR-1 beta chain-like. (266 aa)
	LOC102740784	HLA class II histocompatibility antigen, DR alpha chain-like; Belongs to the MHC class II family. (254 aa)
	CD247	T-cell surface glycoprotein CD3 zeta chain. (166 aa)
	MTOR	Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2550 aa)
	IL23R	Interleukin-23 receptor. (631 aa)
	MAPK12	Mitogen-activated protein kinase. (367 aa)
	SMAD4	Mothers against decapentaplegic homolog. (552 aa)
	PRKCQ	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (706 aa)
	IL4	Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Belongs to the IL-4/IL-13 family. (131 aa)
	IRF4	Interferon regulatory factor 4 isoform X1. (451 aa)

Your Current Organism:

Leptonychotes weddellii

NCBI taxonomy Id: 9713
Other names: L. weddellii, Leptonychotes weddelli, Weddell seal

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AHR	HSP90AB1	A0A2U3XDZ1	A0A2U3YWF8	Aryl hydrocarbon receptor.	Heat shock protein HSP 90-beta.	0.999
AHR	LOC102726367	A0A2U3XDZ1	A0A2U3YZ27	Aryl hydrocarbon receptor.	Heat shock protein HSP 90-alpha-like.	0.998
CD247	CD3D	A0A2U3XW81	A0A2U3YDJ4	T-cell surface glycoprotein CD3 zeta chain.	T-cell surface glycoprotein CD3 delta chain.	0.997
CD247	CD4	A0A2U3XW81	A0A2U3Y2Q1	T-cell surface glycoprotein CD3 zeta chain.	T-cell surface glycoprotein CD4.	0.726
CD247	IL2RB	A0A2U3XW81	A0A2U3YEY9	T-cell surface glycoprotein CD3 zeta chain.	Interleukin-2 receptor subunit beta.	0.835
CD247	JAK3	A0A2U3XW81	A0A2U3Z0Y0	T-cell surface glycoprotein CD3 zeta chain.	Tyrosine-protein kinase.	0.421
CD247	LAT	A0A2U3XW81	A0A2U3XRH3	T-cell surface glycoprotein CD3 zeta chain.	Linker for activation of T-cells family member 1.	0.608
CD247	LOC102730162	A0A2U3XW81	A0A2U3YD51	T-cell surface glycoprotein CD3 zeta chain.	T-cell surface glycoprotein CD3 gamma chain-like.	0.998
CD247	LOC102734398	A0A2U3XW81	A0A2U3YD98	T-cell surface glycoprotein CD3 zeta chain.	T-cell surface glycoprotein CD3 gamma chain-like.	0.998
CD247	LOC102734456	A0A2U3XW81	A0A2U3Z2X5	T-cell surface glycoprotein CD3 zeta chain.	HLA class II histocompatibility antigen, DO alpha chain-like; Belongs to the MHC class II family.	0.803
CD247	LOC102740784	A0A2U3XW81	A0A2U3XXW2	T-cell surface glycoprotein CD3 zeta chain.	HLA class II histocompatibility antigen, DR alpha chain-like; Belongs to the MHC class II family.	0.830
CD247	LOC102741082	A0A2U3XW81	A0A2U3XXW7	T-cell surface glycoprotein CD3 zeta chain.	DLA class II histocompatibility antigen, DR-1 beta chain-like.	0.823
CD247	LOC102748462	A0A2U3XW81	A0A2U3Y332	T-cell surface glycoprotein CD3 zeta chain.	HLA class II histocompatibility antigen, DO beta chain-like.	0.823
CD247	LOC102750166	A0A2U3XW81	A0A2U3Y3B4	T-cell surface glycoprotein CD3 zeta chain.	HLA class II histocompatibility antigen, DM beta chain-like.	0.809
CD247	LOC102750454	A0A2U3XW81	A0A2U3Y337	T-cell surface glycoprotein CD3 zeta chain.	HLA class II histocompatibility antigen, DM alpha chain-like; Belongs to the MHC class II family.	0.815
CD247	PRKCQ	A0A2U3XW81	A0A2U3XTI0	T-cell surface glycoprotein CD3 zeta chain.	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.	0.415
CD247	ZAP70	A0A2U3XW81	A0A2U3XR38	T-cell surface glycoprotein CD3 zeta chain.	Tyrosine-protein kinase.	0.999
CD3D	CD247	A0A2U3YDJ4	A0A2U3XW81	T-cell surface glycoprotein CD3 delta chain.	T-cell surface glycoprotein CD3 zeta chain.	0.997
CD3D	CD4	A0A2U3YDJ4	A0A2U3Y2Q1	T-cell surface glycoprotein CD3 delta chain.	T-cell surface glycoprotein CD4.	0.646
CD3D	IFNG	A0A2U3YDJ4	A0A2U3Y8N2	T-cell surface glycoprotein CD3 delta chain.	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	0.408