STRINGSTRING
PPP3R1 PPP3R1 LOC102751021 LOC102751021 MAPK11 MAPK11 LOC102748045 LOC102748045 LOC102736146 LOC102736146 CSF2 CSF2 LOC102735556 LOC102735556 PDCD1 PDCD1 LOC102728297 LOC102728297 PAK6 PAK6 NCK2 NCK2 NFKBIE NFKBIE LOC102736516 LOC102736516 CTLA4 CTLA4 CD28 CD28 ICOS ICOS VAV2 VAV2 LOC102725943 LOC102725943 NFATC1 NFATC1 PIK3CA PIK3CA FOS FOS PIK3CD PIK3CD CD40LG CD40LG CDC42 CDC42 IKBKB IKBKB MAPK1 MAPK1 PAK2 PAK2 RASGRP1 RASGRP1 GSK3B GSK3B CD3D CD3D LOC102734398 LOC102734398 LOC102730162 LOC102730162 CD8A CD8A CHUK CHUK BCL10 BCL10 TEC TEC RAF1 RAF1 CDK4 CDK4 IFNG IFNG AKT3 AKT3 PAK1 PAK1 JUN JUN PAK4 PAK4 NFKBIB NFKBIB IKBKG IKBKG MAP2K2 MAP2K2 TNF TNF ERAS ERAS AKT1 AKT1 MAPK8 MAPK8 IL2 IL2 CD4 CD4 VAV3 VAV3 MAP3K14 MAP3K14 MAP3K8 MAP3K8 CD247 CD247 LCP2 LCP2 MAPK12 MAPK12 PRKCQ PRKCQ IL5 IL5 IL4 IL4 IL10 IL10 LAT LAT ZAP70 ZAP70 MAP2K7 MAP2K7 PAK7 PAK7 NFKB1 NFKB1 NFKBIA NFKBIA LOC102740357 LOC102740357 LOC102749335 LOC102749335 ITK ITK NFATC3 NFATC3 CARD11 CARD11 MAP2K1 MAP2K1 MAPK10 MAPK10 PIK3R3 PIK3R3 CSDE1 CSDE1 NRAS NRAS CBLB CBLB LOC102726446 LOC102726446 NCK1 NCK1 KRAS KRAS PPP3R2 PPP3R2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PPP3R1Calcineurin subunit B type 1 isoform X1. (170 aa)
LOC102751021Phosphatidylinositol 3-kinase regulatory subunit alpha-like isoform X1. (454 aa)
MAPK11Mitogen-activated protein kinase. (254 aa)
LOC102748045Proto-oncogene vav-like. (140 aa)
LOC1027361463-phosphoinositide-dependent protein kinase 1-like. (216 aa)
CSF2Granulocyte-macrophage colony-stimulating factor. (153 aa)
LOC102735556Mitogen-activated protein kinase 9-like. (134 aa)
PDCD1Programmed cell death protein 1. (266 aa)
LOC102728297Serine/threonine-protein kinase PAK 7-like. (225 aa)
PAK6Non-specific serine/threonine protein kinase. (681 aa)
NCK2Cytoplasmic protein. (380 aa)
NFKBIENF-kappa-B inhibitor epsilon. (361 aa)
LOC102736516Phosphatidylinositol 3-kinase regulatory subunit alpha-like. (138 aa)
CTLA4Cytotoxic T-lymphocyte protein 4 isoform X1. (223 aa)
CD28T-cell-specific surface glycoprotein CD28. (209 aa)
ICOSInducible T-cell costimulator. (209 aa)
VAV2Guanine nucleotide exchange factor VAV2. (357 aa)
LOC102725943Nuclear factor of activated T-cells, cytoplasmic 2-like. (160 aa)
NFATC1Nuclear factor of activated T-cells, cytoplasmic 1. (221 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
FOSProto-oncogene c-Fos isoform X1. (380 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1043 aa)
CD40LGCD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching. (260 aa)
CDC42Cell division control protein 42 homolog. (160 aa)
IKBKBInhibitor of nuclear factor kappa-B kinase subunit beta isoform X1. (756 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (326 aa)
PAK2Non-specific serine/threonine protein kinase. (524 aa)
RASGRP1RAS guanyl-releasing protein 1-like isoform X1. (366 aa)
GSK3BGlycogen synthase kinase-3 beta isoform X1; Belongs to the protein kinase superfamily. (433 aa)
CD3DT-cell surface glycoprotein CD3 delta chain. (171 aa)
LOC102734398T-cell surface glycoprotein CD3 gamma chain-like. (167 aa)
LOC102730162T-cell surface glycoprotein CD3 gamma chain-like. (182 aa)
CD8AT-cell surface glycoprotein CD8 alpha chain. (213 aa)
CHUKInhibitor of nuclear factor kappa-B kinase subunit alpha. (745 aa)
BCL10B-cell lymphoma/leukemia 10 isoform X1. (233 aa)
TECTyrosine-protein kinase. (630 aa)
RAF1RAF proto-oncogene serine/threonine-protein kinase isoform X1. (648 aa)
CDK4Cyclin-dependent kinase 4; Belongs to the protein kinase superfamily. (303 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (166 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (418 aa)
PAK1Non-specific serine/threonine protein kinase. (544 aa)
JUNTranscription factor AP-1; Belongs to the bZIP family. (335 aa)
PAK4Non-specific serine/threonine protein kinase. (441 aa)
NFKBIBNF-kappa-B inhibitor beta isoform X2. (354 aa)
IKBKGNF-kappa-B essential modulator isoform X2. (419 aa)
MAP2K2Dual specificity mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
ERASGTPase ERas. (233 aa)
AKT1Non-specific serine/threonine protein kinase. (518 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
IL2Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family. (154 aa)
CD4T-cell surface glycoprotein CD4. (462 aa)
VAV3Guanine nucleotide exchange factor VAV3 isoform X2. (847 aa)
MAP3K14Mitogen-activated protein kinase kinase kinase 14. (955 aa)
MAP3K8Mitogen-activated protein kinase kinase kinase 8. (467 aa)
CD247T-cell surface glycoprotein CD3 zeta chain. (166 aa)
LCP2Lymphocyte cytosolic protein 2. (533 aa)
MAPK12Mitogen-activated protein kinase. (367 aa)
PRKCQProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (706 aa)
IL5Interleukin-5; Factor that induces terminal differentiation of late- developing B-cells to immunoglobulin secreting cells. (134 aa)
IL4Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Belongs to the IL-4/IL-13 family. (131 aa)
IL10Interleukin-10. (178 aa)
LATLinker for activation of T-cells family member 1. (256 aa)
ZAP70Tyrosine-protein kinase. (616 aa)
MAP2K7Dual specificity mitogen-activated protein kinase kinase 7 isoform X1. (435 aa)
PAK7Serine/threonine-protein kinase PAK 7. (474 aa)
NFKB1Nuclear factor NF-kappa-B p105 subunit. (254 aa)
NFKBIANF-kappa-B inhibitor alpha isoform X2. (314 aa)
LOC102740357Cell division control protein 42 homolog. (191 aa)
LOC102749335E3 ubiquitin-protein ligase CBL-B-like. (139 aa)
ITKTyrosine-protein kinase. (486 aa)
NFATC3Nuclear factor of activated T-cells, cytoplasmic 3 isoform X1. (1075 aa)
CARD11Caspase recruitment domain-containing protein 11. (1146 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1 isoform X1; Belongs to the protein kinase superfamily. (393 aa)
MAPK10Mitogen-activated protein kinase. (464 aa)
PIK3R3Phosphatidylinositol 3-kinase regulatory subunit gamma. (461 aa)
CSDE1Cold shock domain-containing protein E1 isoform X1. (845 aa)
NRASGTPase NRas. (189 aa)
CBLBE3 ubiquitin-protein ligase CBL-B-like. (832 aa)
LOC102726446Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform-like; Belongs to the PI3/PI4-kinase family. (235 aa)
NCK1Cytoplasmic protein. (377 aa)
KRASGTPase KRas isoform X2. (188 aa)
PPP3R2Calcineurin subunit B type 2. (170 aa)
Your Current Organism:
Leptonychotes weddellii
NCBI taxonomy Id: 9713
Other names: L. weddellii, Leptonychotes weddelli, Weddell seal
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