(46 nodes) Fc epsilon RI signaling pathway network (Leptonychotes weddellii)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

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protein homology

Your Input:
	KRAS	GTPase KRas isoform X2. (188 aa)
	LOC102726446	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform-like; Belongs to the PI3/PI4-kinase family. (235 aa)
	ALOX5	Arachidonate 5-lipoxygenase isoform X1. (674 aa)
	NRAS	GTPase NRas. (189 aa)
	CSDE1	Cold shock domain-containing protein E1 isoform X1. (845 aa)
	PIK3R3	Phosphatidylinositol 3-kinase regulatory subunit gamma. (461 aa)
	MAPK10	Mitogen-activated protein kinase. (464 aa)
	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1 isoform X1; Belongs to the protein kinase superfamily. (393 aa)
	PLA2G4D	Phospholipase A2. (817 aa)
	MAP2K6	Dual specificity mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (334 aa)
	MAP2K7	Dual specificity mitogen-activated protein kinase kinase 7 isoform X1. (435 aa)
	LAT	Linker for activation of T-cells family member 1. (256 aa)
	IL4	Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Belongs to the IL-4/IL-13 family. (131 aa)
	IL5	Interleukin-5; Factor that induces terminal differentiation of late- developing B-cells to immunoglobulin secreting cells. (134 aa)
	IL13	Interleukin-13. (133 aa)
	MAPK12	Mitogen-activated protein kinase. (367 aa)
	LCP2	Lymphocyte cytosolic protein 2. (533 aa)
	VAV3	Guanine nucleotide exchange factor VAV3 isoform X2. (847 aa)
	JMJD7	jmjC domain-containing protein 7. (316 aa)
	BTK	Tyrosine-protein kinase. (659 aa)
	MAPK8	Mitogen-activated protein kinase. (427 aa)
	AKT1	Non-specific serine/threonine protein kinase. (518 aa)
	ERAS	GTPase ERas. (233 aa)
	TNF	Tumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
	MAP2K2	Dual specificity mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa)
	AKT3	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (418 aa)
	RAF1	RAF proto-oncogene serine/threonine-protein kinase isoform X1. (648 aa)
	FCER1A	High affinity immunoglobulin epsilon receptor subunit alpha. (264 aa)
	RAC2	Ras-related C3 botulinum toxin substrate 2. (192 aa)
	MAPK1	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (326 aa)
	LOC102735415	Phosphoinositide phospholipase C. (309 aa)
	FCER1G	High affinity immunoglobulin epsilon receptor subunit gamma. (94 aa)
	PIK3CD	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1043 aa)
	PIK3CA	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
	VAV2	Guanine nucleotide exchange factor VAV2. (357 aa)
	MAP2K3	Dual specificity mitogen-activated protein kinase kinase 3; Belongs to the protein kinase superfamily. (347 aa)
	MS4A2	High affinity immunoglobulin epsilon receptor subunit beta. (242 aa)
	LOC102736516	Phosphatidylinositol 3-kinase regulatory subunit alpha-like. (138 aa)
	IL3	Interleukin-3. (143 aa)
	LOC102735556	Mitogen-activated protein kinase 9-like. (134 aa)
	CSF2	Granulocyte-macrophage colony-stimulating factor. (153 aa)
	LOC102748833	Tyrosine-protein kinase. (375 aa)
	LOC102736146	3-phosphoinositide-dependent protein kinase 1-like. (216 aa)
	LOC102748045	Proto-oncogene vav-like. (140 aa)
	MAPK11	Mitogen-activated protein kinase. (254 aa)
	LOC102751021	Phosphatidylinositol 3-kinase regulatory subunit alpha-like isoform X1. (454 aa)

Your Current Organism:

Leptonychotes weddellii

NCBI taxonomy Id: 9713
Other names: L. weddellii, Leptonychotes weddelli, Weddell seal

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AKT1	AKT3	A0A2U3Y3V3	A0A2U3Y8K7	Non-specific serine/threonine protein kinase.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.808
AKT1	IL4	A0A2U3Y3V3	A0A2U3XTG1	Non-specific serine/threonine protein kinase.	Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Belongs to the IL-4/IL-13 family.	0.485
AKT1	KRAS	A0A2U3Y3V3	A0A2U3X8L4	Non-specific serine/threonine protein kinase.	GTPase KRas isoform X2.	0.462
AKT1	LOC102726446	A0A2U3Y3V3	A0A2U3X957	Non-specific serine/threonine protein kinase.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform-like; Belongs to the PI3/PI4-kinase family.	0.896
AKT1	LOC102735415	A0A2U3Y3V3	A0A2U3YKX8	Non-specific serine/threonine protein kinase.	Phosphoinositide phospholipase C.	0.411
AKT1	LOC102736146	A0A2U3Y3V3	A0A2U3Z6N9	Non-specific serine/threonine protein kinase.	3-phosphoinositide-dependent protein kinase 1-like.	0.955
AKT1	LOC102736516	A0A2U3Y3V3	A0A2U3YU20	Non-specific serine/threonine protein kinase.	Phosphatidylinositol 3-kinase regulatory subunit alpha-like.	0.891
AKT1	LOC102751021	A0A2U3Y3V3	A0A2U3Z893	Non-specific serine/threonine protein kinase.	Phosphatidylinositol 3-kinase regulatory subunit alpha-like isoform X1.	0.551
AKT1	MAP2K2	A0A2U3Y3V3	A0A2U3Y596	Non-specific serine/threonine protein kinase.	Dual specificity mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily.	0.415
AKT1	MAPK1	A0A2U3Y3V3	A0A2U3YIW0	Non-specific serine/threonine protein kinase.	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	0.847
AKT1	MAPK11	A0A2U3Y3V3	A0A2U3Z7B5	Non-specific serine/threonine protein kinase.	Mitogen-activated protein kinase.	0.862
AKT1	MAPK12	A0A2U3Y3V3	A0A2U3XVF8	Non-specific serine/threonine protein kinase.	Mitogen-activated protein kinase.	0.851
AKT1	PIK3CA	A0A2U3Y3V3	A0A2U3YQH7	Non-specific serine/threonine protein kinase.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.913
AKT1	PIK3CD	A0A2U3Y3V3	A0A2U3YPT2	Non-specific serine/threonine protein kinase.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.871
AKT1	PIK3R3	A0A2U3Y3V3	A0A2U3XCA0	Non-specific serine/threonine protein kinase.	Phosphatidylinositol 3-kinase regulatory subunit gamma.	0.850
AKT1	RAC2	A0A2U3Y3V3	A0A2U3YFA7	Non-specific serine/threonine protein kinase.	Ras-related C3 botulinum toxin substrate 2.	0.483
AKT1	RAF1	A0A2U3Y3V3	A0A2U3Y9A9	Non-specific serine/threonine protein kinase.	RAF proto-oncogene serine/threonine-protein kinase isoform X1.	0.873
AKT3	AKT1	A0A2U3Y8K7	A0A2U3Y3V3	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Non-specific serine/threonine protein kinase.	0.808
AKT3	IL4	A0A2U3Y8K7	A0A2U3XTG1	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Belongs to the IL-4/IL-13 family.	0.485
AKT3	KRAS	A0A2U3Y8K7	A0A2U3X8L4	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	GTPase KRas isoform X2.	0.416