STRINGSTRING
LOC102734862 LOC102734862 LOC102726697 LOC102726697 LOC102740357 LOC102740357 ITK ITK LOC102738651 LOC102738651 ITGAM ITGAM ARHGAP5 ARHGAP5 NCF2 NCF2 PIK3R3 PIK3R3 CTNND1 CTNND1 LPXN LPXN VCAM1 VCAM1 LOC102738933 LOC102738933 RASSF5 RASSF5 CXCL12 CXCL12 LOC102726446 LOC102726446 CLDN18 CLDN18 LOC102738234 LOC102738234 MYL12B MYL12B LOC102749407 LOC102749407 MAPK12 MAPK12 PTPN11 PTPN11 ACTN1 ACTN1 CLDN11 CLDN11 VAV3 VAV3 MYL2 MYL2 LOC102745156 LOC102745156 GNAI2 GNAI2 ITGB1 ITGB1 LOC102748068 LOC102748068 ITGAL ITGAL VASP VASP CLDN7 CLDN7 OCLN OCLN ACTN4 ACTN4 THY1 THY1 MMP9 MMP9 CTNNA1 CTNNA1 ROCK2 ROCK2 RAP1B RAP1B CLDN16 CLDN16 CLDN1 CLDN1 ITGA4 ITGA4 LOC102733200 LOC102733200 LOC102728451 LOC102728451 RAPGEF4 RAPGEF4 RAC2 RAC2 LOC102747594 LOC102747594 MYL9 MYL9 NCF1 NCF1 CLDN2 CLDN2 LOC102735415 LOC102735415 LOC102729978 LOC102729978 F11R F11R CDC42 CDC42 LOC102730373 LOC102730373 CLDN14 CLDN14 PIK3CD PIK3CD PIK3CA PIK3CA ARHGAP35 ARHGAP35 VAV2 VAV2 ICAM1 ICAM1 LOC102736516 LOC102736516 ACTL8 ACTL8 CLDN19 CLDN19 CLDN24 CLDN24 LOC102740157 LOC102740157 CLDN4 CLDN4 NCF4 NCF4 LOC102742564 LOC102742564 LOC102741463 LOC102741463 LOC102731549 LOC102731549 LOC102748045 LOC102748045 MAPK11 MAPK11 LOC102730737 LOC102730737 LOC102730434 LOC102730434 LOC102743809 LOC102743809 LOC102726881 LOC102726881 LOC102751021 LOC102751021 LOC102750030 LOC102750030 CLDN5 CLDN5 CLDN22 CLDN22 ACTG1 ACTG1 MSN MSN VCL VCL CLDN10 CLDN10 CLDN15 CLDN15 LOC102748960 LOC102748960 ACTB ACTB CLDN25 CLDN25
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LOC102734862Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1354 aa)
LOC102726697Guanine nucleotide-binding protein G(I) subunit alpha-1-like isoform X1. (354 aa)
LOC102740357Cell division control protein 42 homolog. (191 aa)
ITKTyrosine-protein kinase. (486 aa)
LOC102738651Afadin-like. (267 aa)
ITGAMIntegrin alpha-M isoform X1; Belongs to the integrin alpha chain family. (1154 aa)
ARHGAP5Rho GTPase-activating protein 5 isoform X1. (1503 aa)
NCF2Neutrophil cytosol factor 2 isoform X1. (526 aa)
PIK3R3Phosphatidylinositol 3-kinase regulatory subunit gamma. (461 aa)
CTNND1Catenin delta-1 isoform X2. (1022 aa)
LPXNLeupaxin; Belongs to the paxillin family. (386 aa)
VCAM1Vascular cell adhesion protein 1. (377 aa)
LOC102738933Catenin alpha-3-like. (530 aa)
RASSF5Ras association domain-containing protein 5. (194 aa)
CXCL12Stromal cell-derived factor 1 isoform X1; Belongs to the intercrine alpha (chemokine CxC) family. (119 aa)
LOC102726446Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform-like; Belongs to the PI3/PI4-kinase family. (235 aa)
CLDN18Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (261 aa)
LOC102738234Myosin regulatory light polypeptide 9-like isoform X2. (172 aa)
MYL12BMyosin regulatory light chain 12B isoform X1. (172 aa)
LOC102749407Catenin alpha-2-like. (304 aa)
MAPK12Mitogen-activated protein kinase. (367 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (593 aa)
ACTN1Alpha-actinin-1. (406 aa)
CLDN11Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (207 aa)
VAV3Guanine nucleotide exchange factor VAV3 isoform X2. (847 aa)
MYL2Myosin regulatory light chain 2, ventricular/cardiac muscle isoform isoform X1. (166 aa)
LOC102745156Catenin beta-1-like isoform X1. (216 aa)
GNAI2Guanine nucleotide-binding protein G(I) subunit alpha-2. (303 aa)
ITGB1Integrin beta; Belongs to the integrin beta chain family. (798 aa)
LOC102748068Cytochrome b-245 heavy chain-like. (135 aa)
ITGALIntegrin alpha-L; Belongs to the integrin alpha chain family. (1168 aa)
VASPVasodilator-stimulated phosphoprotein isoform X1; Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance, lamellipodial and filopodial dynamics, platelet activation and cell migration. Belongs to the Ena/VASP family. (382 aa)
CLDN7Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (211 aa)
OCLNOccludin. (271 aa)
ACTN4Alpha-actinin-4 isoform X1. (933 aa)
THY1Thy-1 membrane glycoprotein. (161 aa)
MMP9Matrix metalloproteinase-9. (704 aa)
CTNNA1Catenin alpha-1 isoform X1. (906 aa)
ROCK2Rho-associated protein kinase 2. (850 aa)
RAP1BRas-related protein Rap-1b isoform X1. (184 aa)
CLDN16Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (235 aa)
CLDN1Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (211 aa)
ITGA4Integrin alpha-4; Belongs to the integrin alpha chain family. (1033 aa)
LOC102733200Claudin-9-like. (206 aa)
LOC102728451Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (293 aa)
RAPGEF4Rap guanine nucleotide exchange factor 4 isoform X1. (858 aa)
RAC2Ras-related C3 botulinum toxin substrate 2. (192 aa)
LOC102747594c-X-C chemokine receptor type 4-like; Belongs to the G-protein coupled receptor 1 family. (353 aa)
MYL9Myosin regulatory light polypeptide 9 isoform X1. (172 aa)
NCF1Neutrophil cytosol factor 1. (380 aa)
CLDN2Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (230 aa)
LOC102735415Phosphoinositide phospholipase C. (309 aa)
LOC102729978Beta-actin-like protein 2-like isoform X1. (376 aa)
F11RJunctional adhesion molecule A. (298 aa)
CDC42Cell division control protein 42 homolog. (160 aa)
LOC102730373Cytochrome b-245 heavy chain-like. (550 aa)
CLDN14Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (237 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1043 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
ARHGAP35Rho GTPase-activating protein 35. (1500 aa)
VAV2Guanine nucleotide exchange factor VAV2. (357 aa)
ICAM1Intercellular adhesion molecule 1. (533 aa)
LOC102736516Phosphatidylinositol 3-kinase regulatory subunit alpha-like. (138 aa)
ACTL8Actin-like protein 8; Belongs to the actin family. (366 aa)
CLDN19Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (224 aa)
CLDN24Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (220 aa)
LOC102740157Cadherin-5-like; Cadherins are calcium-dependent cell adhesion proteins. (464 aa)
CLDN4Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (209 aa)
NCF4Neutrophil cytosol factor 4. (342 aa)
LOC102742564Rho-associated protein kinase 2-like. (530 aa)
LOC102741463Vascular cell adhesion protein 1-like. (318 aa)
LOC102731549GA-binding protein alpha chain-like. (204 aa)
LOC102748045Proto-oncogene vav-like. (140 aa)
MAPK11Mitogen-activated protein kinase. (254 aa)
LOC102730737Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (221 aa)
LOC102730434Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (217 aa)
LOC102743809Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (224 aa)
LOC102726881Breast cancer anti-estrogen resistance protein 1-like. (695 aa)
LOC102751021Phosphatidylinositol 3-kinase regulatory subunit alpha-like isoform X1. (454 aa)
LOC102750030Protein-tyrosine kinase 2-beta-like. (125 aa)
CLDN5Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (309 aa)
CLDN22Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (220 aa)
ACTG1LOW QUALITY PROTEIN: actin, gamma 1. (411 aa)
MSNLOW QUALITY PROTEIN: moesin. (546 aa)
VCLVinculin isoform X1. (1134 aa)
CLDN10Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (231 aa)
CLDN15Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (232 aa)
LOC102748960Cytochrome b-245 light chain-like. (196 aa)
ACTBActin, cytoplasmic 1. (375 aa)
CLDN25Putative claudin-25. (228 aa)
Your Current Organism:
Leptonychotes weddellii
NCBI taxonomy Id: 9713
Other names: L. weddellii, Leptonychotes weddelli, Weddell seal
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