(37 nodes) Intestinal immune network for IgA production network (Leptonychotes weddellii)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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co-expression

protein homology

Your Input:
	CCL25	LOW QUALITY PROTEIN: c-C motif chemokine 25. (146 aa)
	CD80	LOW QUALITY PROTEIN: T-lymphocyte activation antigen CD80. (295 aa)
	FAIM3	Fas apoptotic inhibitory molecule 3. (338 aa)
	PIGR	Polymeric immunoglobulin receptor. (757 aa)
	FCAMR	High affinity immunoglobulin alpha and immunoglobulin mu Fc receptor. (524 aa)
	TREML2	Trem-like transcript 2 protein. (332 aa)
	CXCL12	Stromal cell-derived factor 1 isoform X1; Belongs to the intercrine alpha (chemokine CxC) family. (119 aa)
	CD300A	CMRF35-like molecule 8. (309 aa)
	LOC102746728	CMRF35-like molecule 1-like. (167 aa)
	LOC102745863	Mucosal addressin cell adhesion molecule 1-like. (205 aa)
	CCR9	c-C chemokine receptor type 9; Belongs to the G-protein coupled receptor 1 family. (369 aa)
	LOC102734456	HLA class II histocompatibility antigen, DO alpha chain-like; Belongs to the MHC class II family. (250 aa)
	LOC102740348	Tumor necrosis factor ligand superfamily member 13B-like. (164 aa)
	TGFB1	Transforming growth factor beta-1. (261 aa)
	CD28	T-cell-specific surface glycoprotein CD28. (209 aa)
	ICOS	Inducible T-cell costimulator. (209 aa)
	LOC102727257	Tumor necrosis factor receptor superfamily member 13B-like. (270 aa)
	CD40LG	CD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching. (260 aa)
	LOC102743741	Interleukin; Belongs to the IL-15/IL-21 family. (162 aa)
	IL6	Interleukin-6 isoform X1. (212 aa)
	LOC102747594	c-X-C chemokine receptor type 4-like; Belongs to the G-protein coupled receptor 1 family. (353 aa)
	ITGB7	Integrin beta; Belongs to the integrin beta chain family. (763 aa)
	ITGA4	Integrin alpha-4; Belongs to the integrin alpha chain family. (1033 aa)
	CD40	Tumor necrosis factor receptor superfamily member 5. (272 aa)
	TNFSF13	Tumor necrosis factor ligand superfamily member 13 isoform X1; Belongs to the tumor necrosis factor family. (250 aa)
	IL2	Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family. (154 aa)
	LOC102750166	HLA class II histocompatibility antigen, DM beta chain-like. (263 aa)
	LOC102750454	HLA class II histocompatibility antigen, DM alpha chain-like; Belongs to the MHC class II family. (261 aa)
	LOC102748462	HLA class II histocompatibility antigen, DO beta chain-like. (273 aa)
	LOC102747485	HLA class II histocompatibility antigen, DQ beta 2 chain-like isoform X2. (329 aa)
	LOC102741082	DLA class II histocompatibility antigen, DR-1 beta chain-like. (266 aa)
	LOC102740784	HLA class II histocompatibility antigen, DR alpha chain-like; Belongs to the MHC class II family. (254 aa)
	LTBR	Tumor necrosis factor receptor superfamily member 3 isoform X1. (421 aa)
	MAP3K14	Mitogen-activated protein kinase kinase kinase 14. (955 aa)
	IL5	Interleukin-5; Factor that induces terminal differentiation of late- developing B-cells to immunoglobulin secreting cells. (134 aa)
	IL4	Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Belongs to the IL-4/IL-13 family. (131 aa)
	IL10	Interleukin-10. (178 aa)

Your Current Organism:

Leptonychotes weddellii

NCBI taxonomy Id: 9713
Other names: L. weddellii, Leptonychotes weddelli, Weddell seal

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CCL25	CCR9	A0A2U3XR07	A0A2U3Z6R6	LOW QUALITY PROTEIN: c-C motif chemokine 25.	c-C chemokine receptor type 9; Belongs to the G-protein coupled receptor 1 family.	0.807
CCL25	LOC102747594	A0A2U3XR07	A0A2U3YFN5	LOW QUALITY PROTEIN: c-C motif chemokine 25.	c-X-C chemokine receptor type 4-like; Belongs to the G-protein coupled receptor 1 family.	0.426
CCR9	CCL25	A0A2U3Z6R6	A0A2U3XR07	c-C chemokine receptor type 9; Belongs to the G-protein coupled receptor 1 family.	LOW QUALITY PROTEIN: c-C motif chemokine 25.	0.807
CCR9	CD80	A0A2U3Z6R6	A0A2U3XGM7	c-C chemokine receptor type 9; Belongs to the G-protein coupled receptor 1 family.	LOW QUALITY PROTEIN: T-lymphocyte activation antigen CD80.	0.578
CCR9	CXCL12	A0A2U3Z6R6	A0A2U3X9U4	c-C chemokine receptor type 9; Belongs to the G-protein coupled receptor 1 family.	Stromal cell-derived factor 1 isoform X1; Belongs to the intercrine alpha (chemokine CxC) family.	0.914
CCR9	ITGB7	A0A2U3Z6R6	A0A2U3YD77	c-C chemokine receptor type 9; Belongs to the G-protein coupled receptor 1 family.	Integrin beta; Belongs to the integrin beta chain family.	0.460
CCR9	LOC102745863	A0A2U3Z6R6	A0A2U3Z8P2	c-C chemokine receptor type 9; Belongs to the G-protein coupled receptor 1 family.	Mucosal addressin cell adhesion molecule 1-like.	0.539
CCR9	LOC102747594	A0A2U3Z6R6	A0A2U3YFN5	c-C chemokine receptor type 9; Belongs to the G-protein coupled receptor 1 family.	c-X-C chemokine receptor type 4-like; Belongs to the G-protein coupled receptor 1 family.	0.628
CD28	CD40	A0A2U3YTM8	A0A2U3Y7Z8	T-cell-specific surface glycoprotein CD28.	Tumor necrosis factor receptor superfamily member 5.	0.460
CD28	CD40LG	A0A2U3YTM8	A0A2U3YMY4	T-cell-specific surface glycoprotein CD28.	CD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching.	0.615
CD28	CD80	A0A2U3YTM8	A0A2U3XGM7	T-cell-specific surface glycoprotein CD28.	LOW QUALITY PROTEIN: T-lymphocyte activation antigen CD80.	0.984
CD28	ICOS	A0A2U3YTM8	A0A2U3YTM1	T-cell-specific surface glycoprotein CD28.	Inducible T-cell costimulator.	0.739
CD28	IL10	A0A2U3YTM8	A0A2U3XRS9	T-cell-specific surface glycoprotein CD28.	Interleukin-10.	0.401
CD28	IL2	A0A2U3YTM8	A0A2U3Y3E4	T-cell-specific surface glycoprotein CD28.	Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family.	0.560
CD28	IL4	A0A2U3YTM8	A0A2U3XTG1	T-cell-specific surface glycoprotein CD28.	Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Belongs to the IL-4/IL-13 family.	0.415
CD300A	FCAMR	A0A2U3X9N2	A0A2U3XG60	CMRF35-like molecule 8.	High affinity immunoglobulin alpha and immunoglobulin mu Fc receptor.	0.499
CD40	CD28	A0A2U3Y7Z8	A0A2U3YTM8	Tumor necrosis factor receptor superfamily member 5.	T-cell-specific surface glycoprotein CD28.	0.460
CD40	CD40LG	A0A2U3Y7Z8	A0A2U3YMY4	Tumor necrosis factor receptor superfamily member 5.	CD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching.	0.999
CD40	CD80	A0A2U3Y7Z8	A0A2U3XGM7	Tumor necrosis factor receptor superfamily member 5.	LOW QUALITY PROTEIN: T-lymphocyte activation antigen CD80.	0.880
CD40	ICOS	A0A2U3Y7Z8	A0A2U3YTM1	Tumor necrosis factor receptor superfamily member 5.	Inducible T-cell costimulator.	0.788