(44 nodes) Long-term potentiation network (Leptonychotes weddellii)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	RPS6KA3	Ribosomal protein S6 kinase. (740 aa)
	PPP1CB	Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (327 aa)
	RAF1	RAF proto-oncogene serine/threonine-protein kinase isoform X1. (648 aa)
	RAP1B	Ras-related protein Rap-1b isoform X1. (184 aa)
	MAP2K2	Dual specificity mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa)
	ERAS	GTPase ERas. (233 aa)
	ITPR2	Inositol 1,4,5-trisphosphate receptor type 2-like. (2701 aa)
	GRIN1	Glutamate receptor ionotropic, NMDA 1 isoform X1. (943 aa)
	PPP1CC	Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (337 aa)
	PRKACB	cAMP-dependent protein kinase catalytic subunit beta isoform X1; Belongs to the protein kinase superfamily. (397 aa)
	GRM1	Metabotropic glutamate receptor 1. (887 aa)
	GRIN2A	Glutamate receptor ionotropic, NMDA 2A. (1308 aa)
	CAMK2G	Calcium/calmodulin-dependent protein kinase type II subunit gamma. (574 aa)
	GRIA2	Glutamate receptor 2 isoform X1. (940 aa)
	LOC102738071	Calmodulin-like; Belongs to the calmodulin family. (113 aa)
	EP300	Histone acetyltransferase p300. (2425 aa)
	PPP3R1	Calcineurin subunit B type 1 isoform X1. (170 aa)
	ATF4	Cyclic AMP-dependent transcription factor ATF-4. (351 aa)
	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1 isoform X1; Belongs to the protein kinase superfamily. (393 aa)
	PPP1R1A	Protein phosphatase 1 regulatory subunit 1A isoform X4. (171 aa)
	CSDE1	Cold shock domain-containing protein E1 isoform X1. (845 aa)
	NRAS	GTPase NRas. (189 aa)
	KRAS	GTPase KRas isoform X2. (188 aa)
	PPP3R2	Calcineurin subunit B type 2. (170 aa)
	LOC102736922	Calmodulin-like; Belongs to the calmodulin family. (223 aa)
	RPS6KA6	Ribosomal protein S6 kinase. (744 aa)
	CALML4	LOW QUALITY PROTEIN: calmodulin-like 4. (199 aa)
	LOC102733954	Calmodulin-like protein 4-like. (119 aa)
	PRKACA	cAMP-dependent protein kinase catalytic subunit alpha isoform X1; Belongs to the protein kinase superfamily. (351 aa)
	ARSI	Arylsulfatase I. (575 aa)
	CAMK2A	Calcium/calmodulin-dependent protein kinase type II subunit alpha. (476 aa)
	LOC102746549	Glutamate receptor ionotropic, NMDA 2C-like. (348 aa)
	CAMK4	Calcium/calmodulin-dependent protein kinase type IV. (360 aa)
	LOC102730715	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2-like. (231 aa)
	PPP1CA	Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (330 aa)
	GRIA1	Glutamate receptor 1-like; Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. (528 aa)
	CREBBP	CREB-binding protein-like. (1411 aa)
	LOC102732719	Ribosomal protein S6 kinase alpha-1-like. (200 aa)
	PLCB3	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1100 aa)
	GRIN2D	Glutamate receptor ionotropic, NMDA 2D. (840 aa)
	CALM3	Calmodulin isoform X1; Belongs to the calmodulin family. (149 aa)
	ITPR3	Inositol 1,4,5-trisphosphate receptor type 3. (557 aa)
	MAPK1	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (326 aa)
	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1. (1244 aa)

Your Current Organism:

Leptonychotes weddellii

NCBI taxonomy Id: 9713
Other names: L. weddellii, Leptonychotes weddelli, Weddell seal

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ARSI	CALM3	A0A2U3Z4M7	A0A2U3YN48	Arylsulfatase I.	Calmodulin isoform X1; Belongs to the calmodulin family.	0.770
ARSI	CALML4	A0A2U3Z4M7	A0A2U3Z8V7	Arylsulfatase I.	LOW QUALITY PROTEIN: calmodulin-like 4.	0.785
ARSI	LOC102730715	A0A2U3Z4M7	A0A2U3Z1L9	Arylsulfatase I.	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2-like.	0.786
ARSI	LOC102738071	A0A2U3Z4M7	A0A2U3XLG6	Arylsulfatase I.	Calmodulin-like; Belongs to the calmodulin family.	0.770
ARSI	PLCB3	A0A2U3Z4M7	A0A2U3YRT9	Arylsulfatase I.	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.	0.786
ATF4	CAMK2A	A0A2U3XET2	A0A2U3Z4L3	Cyclic AMP-dependent transcription factor ATF-4.	Calcium/calmodulin-dependent protein kinase type II subunit alpha.	0.819
ATF4	CAMK2G	A0A2U3XET2	A0A2U3XQ41	Cyclic AMP-dependent transcription factor ATF-4.	Calcium/calmodulin-dependent protein kinase type II subunit gamma.	0.814
ATF4	CAMK4	A0A2U3XET2	A0A2U3Z2E8	Cyclic AMP-dependent transcription factor ATF-4.	Calcium/calmodulin-dependent protein kinase type IV.	0.898
ATF4	CREBBP	A0A2U3XET2	A0A2U3YT32	Cyclic AMP-dependent transcription factor ATF-4.	CREB-binding protein-like.	0.953
ATF4	EP300	A0A2U3XET2	A0A2U3XF65	Cyclic AMP-dependent transcription factor ATF-4.	Histone acetyltransferase p300.	0.953
ATF4	LOC102732719	A0A2U3XET2	A0A2U3YSJ8	Cyclic AMP-dependent transcription factor ATF-4.	Ribosomal protein S6 kinase alpha-1-like.	0.900
ATF4	MAPK1	A0A2U3XET2	A0A2U3YIW0	Cyclic AMP-dependent transcription factor ATF-4.	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	0.810
ATF4	PRKACA	A0A2U3XET2	A0A2U3Z6A9	Cyclic AMP-dependent transcription factor ATF-4.	cAMP-dependent protein kinase catalytic subunit alpha isoform X1; Belongs to the protein kinase superfamily.	0.903
ATF4	PRKACB	A0A2U3XET2	A0A2U3XZU0	Cyclic AMP-dependent transcription factor ATF-4.	cAMP-dependent protein kinase catalytic subunit beta isoform X1; Belongs to the protein kinase superfamily.	0.903
ATF4	RPS6KA3	A0A2U3XET2	A0A2U3YDK5	Cyclic AMP-dependent transcription factor ATF-4.	Ribosomal protein S6 kinase.	0.908
ATF4	RPS6KA6	A0A2U3XET2	A0A2U3X694	Cyclic AMP-dependent transcription factor ATF-4.	Ribosomal protein S6 kinase.	0.886
CALM3	ARSI	A0A2U3YN48	A0A2U3Z4M7	Calmodulin isoform X1; Belongs to the calmodulin family.	Arylsulfatase I.	0.770
CALM3	CALML4	A0A2U3YN48	A0A2U3Z8V7	Calmodulin isoform X1; Belongs to the calmodulin family.	LOW QUALITY PROTEIN: calmodulin-like 4.	0.870
CALM3	CAMK2A	A0A2U3YN48	A0A2U3Z4L3	Calmodulin isoform X1; Belongs to the calmodulin family.	Calcium/calmodulin-dependent protein kinase type II subunit alpha.	0.979
CALM3	CAMK2G	A0A2U3YN48	A0A2U3XQ41	Calmodulin isoform X1; Belongs to the calmodulin family.	Calcium/calmodulin-dependent protein kinase type II subunit gamma.	0.911