(43 nodes) Long-term depression network (Leptonychotes weddellii)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC102748833	Tyrosine-protein kinase. (375 aa)
	LOC102726335	Glutamate receptor ionotropic, delta-2-like isoform X1. (787 aa)
	GUCY1B3	Guanylate cyclase soluble subunit beta-1 isoform X1; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (619 aa)
	GUCY1A3	Guanylate cyclase soluble subunit alpha-3; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (690 aa)
	KRAS	GTPase KRas isoform X2. (188 aa)
	PRKG1	cGMP-dependent protein kinase 1. (193 aa)
	NRAS	GTPase NRas. (189 aa)
	CSDE1	Cold shock domain-containing protein E1 isoform X1. (845 aa)
	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1 isoform X1; Belongs to the protein kinase superfamily. (393 aa)
	GNA12	Guanine nucleotide-binding protein subunit alpha-12 isoform X1. (305 aa)
	IGF1	Insulin-like growth factor I isoform X1. (153 aa)
	PPP2CB	Serine/threonine-protein phosphatase. (308 aa)
	PLA2G4D	Phospholipase A2. (817 aa)
	GRIA2	Glutamate receptor 2 isoform X1. (940 aa)
	LOC102726697	Guanine nucleotide-binding protein G(I) subunit alpha-1-like isoform X1. (354 aa)
	GRID2	Glutamate receptor ionotropic, delta-2. (211 aa)
	GRM1	Metabotropic glutamate receptor 1. (887 aa)
	JMJD7	jmjC domain-containing protein 7. (316 aa)
	GNAI2	Guanine nucleotide-binding protein G(I) subunit alpha-2. (303 aa)
	PRKG2	cGMP-dependent protein kinase 2. (553 aa)
	ITPR2	Inositol 1,4,5-trisphosphate receptor type 2-like. (2701 aa)
	IGF1R	Insulin-like growth factor 1 receptor-like. (291 aa)
	ERAS	GTPase ERas. (233 aa)
	MAP2K2	Dual specificity mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa)
	LOC102749673	Insulin-like growth factor 1 receptor-like. (143 aa)
	LOC102736905	Glutamate receptor 3-like. (89 aa)
	RAF1	RAF proto-oncogene serine/threonine-protein kinase isoform X1. (648 aa)
	GNAZ	Guanine nucleotide-binding protein G(Z) subunit alpha. (355 aa)
	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1. (1244 aa)
	PPP1R17	Protein phosphatase 1 regulatory subunit 17. (155 aa)
	LOC102742813	Neuroendocrine secretory protein 55-like. (246 aa)
	MAPK1	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (326 aa)
	LOC102750183	Corticotropin-releasing factor receptor 1-like; Belongs to the G-protein coupled receptor 2 family. (357 aa)
	ITPR3	Inositol 1,4,5-trisphosphate receptor type 3. (557 aa)
	GNA11	Guanine nucleotide-binding protein subunit alpha-11. (359 aa)
	LOC102738224	LOW QUALITY PROTEIN: guanylate cyclase soluble subunit beta-2-like. (612 aa)
	PLCB3	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1100 aa)
	LOC102732031	Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform-like. (407 aa)
	GNAO1	Guanine nucleotide-binding protein G(O) subunit alpha. (311 aa)
	GRIA1	Glutamate receptor 1-like; Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. (528 aa)
	CRH	Corticoliberin. (196 aa)
	LOC102730715	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2-like. (231 aa)
	LOC102731850	Tyrosine-protein kinase receptor. (757 aa)

Your Current Organism:

Leptonychotes weddellii

NCBI taxonomy Id: 9713
Other names: L. weddellii, Leptonychotes weddelli, Weddell seal

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CRH	LOC102750183	A0A2U3YWI0	A0A2U3YJ45	Corticoliberin.	Corticotropin-releasing factor receptor 1-like; Belongs to the G-protein coupled receptor 2 family.	0.997
CSDE1	GNA11	A0A2U3XB03	A0A2U3YMA5	Cold shock domain-containing protein E1 isoform X1.	Guanine nucleotide-binding protein subunit alpha-11.	0.419
CSDE1	GNAI2	A0A2U3XB03	A0A2U3Y188	Cold shock domain-containing protein E1 isoform X1.	Guanine nucleotide-binding protein G(I) subunit alpha-2.	0.418
CSDE1	GNAO1	A0A2U3XB03	A0A2U3YV57	Cold shock domain-containing protein E1 isoform X1.	Guanine nucleotide-binding protein G(O) subunit alpha.	0.418
CSDE1	LOC102726697	A0A2U3XB03	A0A2U3XNG2	Cold shock domain-containing protein E1 isoform X1.	Guanine nucleotide-binding protein G(I) subunit alpha-1-like isoform X1.	0.418
CSDE1	LOC102748833	A0A2U3XB03	A0A2U3Z676	Cold shock domain-containing protein E1 isoform X1.	Tyrosine-protein kinase.	0.408
CSDE1	MAP2K1	A0A2U3XB03	A0A2U3XED8	Cold shock domain-containing protein E1 isoform X1.	Dual specificity mitogen-activated protein kinase kinase 1 isoform X1; Belongs to the protein kinase superfamily.	0.524
CSDE1	MAP2K2	A0A2U3XB03	A0A2U3Y596	Cold shock domain-containing protein E1 isoform X1.	Dual specificity mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily.	0.524
CSDE1	MAPK1	A0A2U3XB03	A0A2U3YIW0	Cold shock domain-containing protein E1 isoform X1.	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	0.532
CSDE1	PPP2CB	A0A2U3XB03	A0A2U3XJS7	Cold shock domain-containing protein E1 isoform X1.	Serine/threonine-protein phosphatase.	0.416
CSDE1	PRKG1	A0A2U3XB03	A0A2U3YC82	Cold shock domain-containing protein E1 isoform X1.	cGMP-dependent protein kinase 1.	0.433
CSDE1	PRKG2	A0A2U3XB03	A0A2U3Y1D0	Cold shock domain-containing protein E1 isoform X1.	cGMP-dependent protein kinase 2.	0.433
CSDE1	RAF1	A0A2U3XB03	A0A2U3Y9A9	Cold shock domain-containing protein E1 isoform X1.	RAF proto-oncogene serine/threonine-protein kinase isoform X1.	0.846
ERAS	GNA11	A0A2U3Y423	A0A2U3YMA5	GTPase ERas.	Guanine nucleotide-binding protein subunit alpha-11.	0.469
ERAS	GNAI2	A0A2U3Y423	A0A2U3Y188	GTPase ERas.	Guanine nucleotide-binding protein G(I) subunit alpha-2.	0.478
ERAS	GNAO1	A0A2U3Y423	A0A2U3YV57	GTPase ERas.	Guanine nucleotide-binding protein G(O) subunit alpha.	0.418
ERAS	LOC102726697	A0A2U3Y423	A0A2U3XNG2	GTPase ERas.	Guanine nucleotide-binding protein G(I) subunit alpha-1-like isoform X1.	0.478
ERAS	LOC102748833	A0A2U3Y423	A0A2U3Z676	GTPase ERas.	Tyrosine-protein kinase.	0.408
ERAS	MAP2K1	A0A2U3Y423	A0A2U3XED8	GTPase ERas.	Dual specificity mitogen-activated protein kinase kinase 1 isoform X1; Belongs to the protein kinase superfamily.	0.550
ERAS	MAP2K2	A0A2U3Y423	A0A2U3Y596	GTPase ERas.	Dual specificity mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily.	0.550