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PHKG2 PHKG2 FOXO1 FOXO1 PPP1R3C PPP1R3C INS INS EIF4E2 EIF4E2 G6PC2 G6PC2 PPP1CA PPP1CA LOC102734935 LOC102734935 GYS1 GYS1 LOC102736516 LOC102736516 PPARGC1A PPARGC1A PIK3CA PIK3CA INPPL1 INPPL1 PIK3CD PIK3CD PYGB PYGB CALM3 CALM3 LOC102726827 LOC102726827 CRKL CRKL INPP5A INPP5A TBCA TBCA FBP2 FBP2 FBP1 FBP1 WBSCR22 WBSCR22 MKNK2 MKNK2 IKBKB IKBKB MAPK1 MAPK1 PDE3B PDE3B FASN FASN LOC102748583 LOC102748583 PRKAG2 PRKAG2 GSK3B GSK3B PRKAR1A PRKAR1A RPS6 RPS6 PPP1R3B PPP1R3B PPP1CB PPP1CB CRK CRK FLOT2 FLOT2 LOC102738071 LOC102738071 SREBF2 SREBF2 PRKCZ PRKCZ LOC102729427 LOC102729427 PRKAR2A PRKAR2A HK3 HK3 EIF4E1B EIF4E1B KIAA1671 KIAA1671 PRKAA1 PRKAA1 LOC102727909 LOC102727909 ALKBH4 ALKBH4 SOCS3 SOCS3 SHC1 SHC1 PKLR PKLR SORBS2 SORBS2 SOCS2 SOCS2 MTOR MTOR IRS1 IRS1 PRKCI PRKCI SOCS4 SOCS4 GCK GCK SHC4 SHC4 CEP152 CEP152 PRKACB PRKACB PPP1CC PPP1CC PYGM PYGM PRKAR1B PRKAR1B MKNK1 MKNK1 MAPK8 MAPK8 AKT1 AKT1 ERAS ERAS G6PC G6PC PCK2 PCK2 MAP2K2 MAP2K2 SLC2A4 SLC2A4 LOC102730047 LOC102730047 PRKAB1 PRKAB1 CBL CBL AKT3 AKT3 PTPRF PTPRF RAF1 RAF1 RPS6KB1 RPS6KB1 PPP1R3G PPP1R3G LOC102726446 LOC102726446 KRAS KRAS CALML4 CALML4 REM1 REM1 LOC102736922 LOC102736922 LOC102730944 LOC102730944 PRKAG1 PRKAG1 LOC102751021 LOC102751021 LOC102734470 LOC102734470 NRAS NRAS CBLB CBLB CSDE1 CSDE1 LOC102740749 LOC102740749 PIK3R3 PIK3R3 RHEBL1 RHEBL1 PPP1R3A PPP1R3A MAPK10 MAPK10 MAP2K1 MAP2K1 LOC102733547 LOC102733547 PHKG1 PHKG1 GEM GEM LOC102749335 LOC102749335 LOC102739066 LOC102739066 PYGL PYGL RRAD RRAD PRKAR2B PRKAR2B PHKA2 PHKA2 PCK1 PCK1 EFCAB13 EFCAB13 LOC102733954 LOC102733954 LOC102736146 LOC102736146 PRKACA PRKACA RPS6KB2 RPS6KB2 LOC102735556 LOC102735556
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PHKG2Phosphorylase b kinase gamma catalytic chain, liver/testis isoform. (352 aa)
FOXO1Forkhead box protein O1-like. (418 aa)
PPP1R3CProtein phosphatase 1 regulatory subunit 3C; Acts as a glycogen-targeting subunit for PP1 and regulates its activity. Activates glycogen synthase, reduces glycogen phosphorylase activity and limits glycogen breakdown. (317 aa)
INSInsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (110 aa)
EIF4E2Eukaryotic translation initiation factor 4E type 2; Belongs to the eukaryotic initiation factor 4E family. (192 aa)
G6PC2Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (356 aa)
PPP1CASerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (330 aa)
LOC102734935Cdc42-interacting protein 4-like. (230 aa)
GYS1Glycogen [starch] synthase; Transfers the glycosyl residue from UDP-Glc to the non- reducing end of alpha-1,4-glucan. (737 aa)
LOC102736516Phosphatidylinositol 3-kinase regulatory subunit alpha-like. (138 aa)
PPARGC1APeroxisome proliferator-activated receptor gamma coactivator 1-alpha-like isoform X2. (671 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
INPPL1Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2. (1249 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1043 aa)
PYGBAlpha-1,4 glucan phosphorylase; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. (843 aa)
CALM3Calmodulin isoform X1; Belongs to the calmodulin family. (149 aa)
LOC102726827Eukaryotic translation initiation factor 4E-like; Belongs to the eukaryotic initiation factor 4E family. (217 aa)
CRKLCrk-like protein. (303 aa)
INPP5AType I inositol 1,4,5-trisphosphate 5-phosphatase. (364 aa)
TBCATubulin-specific chaperone A; Belongs to the TBCA family. (103 aa)
FBP2Fructose-1,6-bisphosphatase isozyme 2; Belongs to the FBPase class 1 family. (339 aa)
FBP1Fructose-1,6-bisphosphatase 1; Belongs to the FBPase class 1 family. (338 aa)
WBSCR22Ribosome biogenesis methyltransferase WBSCR22 isoform X2. (282 aa)
MKNK2MAP kinase-interacting serine/threonine-protein kinase 2 isoform X2; Belongs to the protein kinase superfamily. (463 aa)
IKBKBInhibitor of nuclear factor kappa-B kinase subunit beta isoform X1. (756 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (326 aa)
PDE3BPhosphodiesterase. (1180 aa)
FASNFatty acid synthase. (2519 aa)
LOC1027485835'-AMP-activated protein kinase subunit gamma-2-like. (129 aa)
PRKAG25'-AMP-activated protein kinase subunit gamma-2-like isoform X2. (327 aa)
GSK3BGlycogen synthase kinase-3 beta isoform X1; Belongs to the protein kinase superfamily. (433 aa)
PRKAR1AcAMP-dependent protein kinase type I-alpha regulatory subunit. (381 aa)
RPS640S ribosomal protein S6. (80 aa)
PPP1R3BProtein phosphatase 1 regulatory subunit. (285 aa)
PPP1CBSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (327 aa)
CRKAdapter molecule crk. (92 aa)
FLOT2Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily. (379 aa)
LOC102738071Calmodulin-like; Belongs to the calmodulin family. (113 aa)
SREBF2Sterol regulatory element-binding protein 2-like. (557 aa)
PRKCZProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (557 aa)
LOC10272942740S ribosomal protein S6; Belongs to the eukaryotic ribosomal protein eS6 family. (249 aa)
PRKAR2AcAMP-dependent protein kinase type II-alpha regulatory subunit. (391 aa)
HK3Hexokinase-3. (954 aa)
EIF4E1BEukaryotic translation initiation factor 4E type 1B; Belongs to the eukaryotic initiation factor 4E family. (215 aa)
KIAA1671Uncharacterized protein KIAA1671 homolog. (308 aa)
PRKAA1Non-specific serine/threonine protein kinase. (559 aa)
LOC102727909Cdc42-interacting protein 4-like. (302 aa)
ALKBH4Alpha-ketoglutarate-dependent dioxygenase alkB homolog 4. (302 aa)
SOCS3Suppressor of cytokine signaling 3. (225 aa)
SHC1SHC-transforming protein 1 isoform X2. (583 aa)
PKLRPyruvate kinase; Belongs to the pyruvate kinase family. (428 aa)
SORBS2Sorbin and SH3 domain-containing protein 2 isoform X2. (1095 aa)
SOCS2Suppressor of cytokine signaling 2. (198 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2550 aa)
IRS1Insulin receptor substrate 1-like isoform X1. (1236 aa)
PRKCIProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (543 aa)
SOCS4Suppressor of cytokine signaling 4. (440 aa)
GCKPhosphotransferase. (391 aa)
SHC4SHC-transforming protein 4. (630 aa)
CEP152Centrosomal protein of 152 kDa isoform X1. (1723 aa)
PRKACBcAMP-dependent protein kinase catalytic subunit beta isoform X1; Belongs to the protein kinase superfamily. (397 aa)
PPP1CCSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (337 aa)
PYGMAlpha-1,4 glucan phosphorylase; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. (625 aa)
PRKAR1BcAMP-dependent protein kinase type I-beta regulatory subunit. (145 aa)
MKNK1MAP kinase-interacting serine/threonine-protein kinase 1; Belongs to the protein kinase superfamily. (415 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
AKT1Non-specific serine/threonine protein kinase. (518 aa)
ERASGTPase ERas. (233 aa)
G6PCGlucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (357 aa)
PCK2Phosphoenolpyruvate carboxykinase [GTP], mitochondrial isoform X2. (640 aa)
MAP2K2Dual specificity mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa)
SLC2A4Solute carrier family 2, facilitated glucose transporter member 4 isoform X1; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (509 aa)
LOC102730047Tuberin-like. (353 aa)
PRKAB15'-AMP-activated protein kinase subunit beta-1. (270 aa)
CBLE3 ubiquitin-protein ligase CBL. (910 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (418 aa)
PTPRFReceptor-type tyrosine-protein phosphatase F. (687 aa)
RAF1RAF proto-oncogene serine/threonine-protein kinase isoform X1. (648 aa)
RPS6KB1Non-specific serine/threonine protein kinase. (445 aa)
PPP1R3GProtein phosphatase 1 regulatory subunit 3G. (351 aa)
LOC102726446Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform-like; Belongs to the PI3/PI4-kinase family. (235 aa)
KRASGTPase KRas isoform X2. (188 aa)
CALML4LOW QUALITY PROTEIN: calmodulin-like 4. (199 aa)
REM1GTP-binding protein; Belongs to the small GTPase superfamily. RGK family. (298 aa)
LOC102736922Calmodulin-like; Belongs to the calmodulin family. (223 aa)
LOC102730944Phosphorylase b kinase regulatory subunit; Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. Belongs to the phosphorylase b kinase regulatory chain family. (90 aa)
PRKAG15'-AMP-activated protein kinase subunit gamma-1 isoform X1. (298 aa)
LOC102751021Phosphatidylinositol 3-kinase regulatory subunit alpha-like isoform X1. (454 aa)
LOC102734470ETS domain-containing protein Elk-3-like. (237 aa)
NRASGTPase NRas. (189 aa)
CBLBE3 ubiquitin-protein ligase CBL-B-like. (832 aa)
CSDE1Cold shock domain-containing protein E1 isoform X1. (845 aa)
LOC102740749Phosphotransferase; Belongs to the hexokinase family. (82 aa)
PIK3R3Phosphatidylinositol 3-kinase regulatory subunit gamma. (461 aa)
RHEBL1GTPase RhebL1. (183 aa)
PPP1R3AProtein phosphatase 1 regulatory subunit 3A. (1122 aa)
MAPK10Mitogen-activated protein kinase. (464 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1 isoform X1; Belongs to the protein kinase superfamily. (393 aa)
LOC102733547S-adenosylmethionine sensor upstream of mTORC1; S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 s [...] (405 aa)
PHKG1Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform isoform X1; Belongs to the protein kinase superfamily. (387 aa)
GEMGTP-binding protein; Belongs to the small GTPase superfamily. RGK family. (295 aa)
LOC102749335E3 ubiquitin-protein ligase CBL-B-like. (139 aa)
LOC102739066GTP-binding protein Rheb-like. (142 aa)
PYGLAlpha-1,4 glucan phosphorylase; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. (851 aa)
RRADGTP-binding protein; Belongs to the small GTPase superfamily. RGK family. (308 aa)
PRKAR2BcAMP-dependent protein kinase type II-beta regulatory subunit. (417 aa)
PHKA2Phosphorylase b kinase regulatory subunit; Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. Belongs to the phosphorylase b kinase regulatory chain family. (617 aa)
PCK1Phosphoenolpyruvate carboxykinase, cytosolic [GTP] isoform X2. (622 aa)
EFCAB13LOW QUALITY PROTEIN: EF-hand calcium binding domain 13. (905 aa)
LOC102733954Calmodulin-like protein 4-like. (119 aa)
LOC1027361463-phosphoinositide-dependent protein kinase 1-like. (216 aa)
PRKACAcAMP-dependent protein kinase catalytic subunit alpha isoform X1; Belongs to the protein kinase superfamily. (351 aa)
RPS6KB2Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (482 aa)
LOC102735556Mitogen-activated protein kinase 9-like. (134 aa)
Your Current Organism:
Leptonychotes weddellii
NCBI taxonomy Id: 9713
Other names: L. weddellii, Leptonychotes weddelli, Weddell seal
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