STRINGSTRING
LOC102743616 LOC102743616 LHCGR LHCGR LOC102731038 LOC102731038 LOC102732257 LOC102732257 PRKACA PRKACA STAR STAR LOC102731762 LOC102731762 LHB LHB INS INS LOC102731850 LOC102731850 LOC102739666 LOC102739666 HSD17B7 HSD17B7 LOC102742748 LOC102742748 LOC102731614 LOC102731614 LOC102732116 LOC102732116 LOC102746012 LOC102746012 BMP6 BMP6 ADCY9 ADCY9 LDLR LDLR LOC102742813 LOC102742813 LOC102747983 LOC102747983 PTRHD1 PTRHD1 LOC102734979 LOC102734979 LOC102749673 LOC102749673 IGF1R IGF1R LOC102742596 LOC102742596 PRKACB PRKACB JMJD7 JMJD7 LOC102748964 LOC102748964 LOC102748666 LOC102748666 PLA2G4D PLA2G4D IGF1 IGF1 LOC102735642 LOC102735642 PTGS2 PTGS2 LOC102745940 LOC102745940 ACOT2 ACOT2 ACOT4 ACOT4 ADCY6 ADCY6 LOC102745211 LOC102745211 ALOX5 ALOX5
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
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experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
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Your Input:
LOC102743616Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...] (520 aa)
LHCGRLutropin-choriogonadotropic hormone receptor; Receptor for lutropin-choriogonadotropic hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase; Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily. (483 aa)
LOC102731038Adenylate cyclase type 9-like; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (564 aa)
LOC102732257Follicle-stimulating hormone receptor; G protein-coupled receptor for follitropin, the follicle- stimulating hormone. Through cAMP production activates the downstream PI3K-AKT and ERK1/ERK2 signaling pathways. (469 aa)
PRKACAcAMP-dependent protein kinase catalytic subunit alpha isoform X1; Belongs to the protein kinase superfamily. (351 aa)
STARSteroidogenic acute regulatory protein, mitochondrial; Plays a key role in steroid hormone synthesis by enhancing the metabolism of cholesterol into pregnenolone. Mediates the transfer of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane where it is cleaved to pregnenolone. (281 aa)
LOC102731762Bone morphogenetic protein 15-like. (393 aa)
LHBLutropin subunit beta. (141 aa)
INSInsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (110 aa)
LOC102731850Tyrosine-protein kinase receptor. (757 aa)
LOC102739666Cytochrome P450 1A1-like; Belongs to the cytochrome P450 family. (519 aa)
HSD17B73-keto-steroid reductase. (159 aa)
LOC1027427483 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase-like. (288 aa)
LOC102731614Aromatase-like isoform X1; Belongs to the cytochrome P450 family. (503 aa)
LOC102732116Follicle-stimulating hormone receptor-like. (181 aa)
LOC102746012Adenylate cyclase type 3-like; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (311 aa)
BMP6Bone morphogenetic protein 6. (189 aa)
ADCY9Adenylate cyclase type 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (790 aa)
LDLRLow-density lipoprotein receptor. (861 aa)
LOC102742813Neuroendocrine secretory protein 55-like. (246 aa)
LOC102747983Cytochrome P450 2J2-like; Belongs to the cytochrome P450 family. (445 aa)
PTRHD1Putative peptidyl-tRNA hydrolase PTRHD1. (140 aa)
LOC102734979Cytochrome P450 1B1-like; Belongs to the cytochrome P450 family. (543 aa)
LOC102749673Insulin-like growth factor 1 receptor-like. (143 aa)
IGF1RInsulin-like growth factor 1 receptor-like. (291 aa)
LOC102742596Cytochrome P450 2W1-like; Belongs to the cytochrome P450 family. (501 aa)
PRKACBcAMP-dependent protein kinase catalytic subunit beta isoform X1; Belongs to the protein kinase superfamily. (397 aa)
JMJD7jmjC domain-containing protein 7. (316 aa)
LOC102748964LOW QUALITY PROTEIN: prostaglandin F synthase 1-like. (324 aa)
LOC102748666Aldo-keto reductase family 1 member C1 homolog. (327 aa)
PLA2G4DPhospholipase A2. (817 aa)
IGF1Insulin-like growth factor I isoform X1. (153 aa)
LOC102735642Acyl-coenzyme A thioesterase 6-like isoform X1. (421 aa)
PTGS2Prostaglandin G/H synthase 2. (470 aa)
LOC102745940Steroid 17-alpha-hydroxylase/17,20 lyase-like; Belongs to the cytochrome P450 family. (508 aa)
ACOT2Acyl-coenzyme A thioesterase 2, mitochondrial. (282 aa)
ACOT4Acyl-coenzyme A thioesterase 4. (420 aa)
ADCY6Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1161 aa)
LOC102745211Follitropin subunit beta-like. (129 aa)
ALOX5Arachidonate 5-lipoxygenase isoform X1. (674 aa)
Your Current Organism:
Leptonychotes weddellii
NCBI taxonomy Id: 9713
Other names: L. weddellii, Leptonychotes weddelli, Weddell seal
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