(70 nodes) Progesterone-mediated oocyte maturation network (Leptonychotes weddellii)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	PRKACA	cAMP-dependent protein kinase catalytic subunit alpha isoform X1; Belongs to the protein kinase superfamily. (351 aa)
	LOC102731038	Adenylate cyclase type 9-like; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (564 aa)
	MAPK11	Mitogen-activated protein kinase. (254 aa)
	AP5S1	AP-5 complex subunit sigma-1 isoform X1. (200 aa)
	LOC102751021	Phosphatidylinositol 3-kinase regulatory subunit alpha-like isoform X1. (454 aa)
	ANAPC4	Anaphase-promoting complex subunit 4-like. (280 aa)
	STK10	Serine/threonine-protein kinase 10. (769 aa)
	SPDYC	Speedy protein C. (277 aa)
	RPS6KA6	Ribosomal protein S6 kinase. (744 aa)
	LOC102746125	LOW QUALITY PROTEIN: cyclin-A1-like; Belongs to the cyclin family. (463 aa)
	LOC102725945	Cyclin-dependent kinase 1-like isoform X1; Belongs to the protein kinase superfamily. (297 aa)
	REM1	GTP-binding protein; Belongs to the small GTPase superfamily. RGK family. (298 aa)
	KRAS	GTPase KRas isoform X2. (188 aa)
	LOC102726446	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform-like; Belongs to the PI3/PI4-kinase family. (235 aa)
	CDK3	Cyclin-dependent kinase 3; Belongs to the protein kinase superfamily. (305 aa)
	CDK2	Cyclin-dependent kinase 2 isoform X1; Belongs to the protein kinase superfamily. (346 aa)
	PIK3R3	Phosphatidylinositol 3-kinase regulatory subunit gamma. (461 aa)
	ADCY6	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1161 aa)
	MAPK10	Mitogen-activated protein kinase. (464 aa)
	GEM	GTP-binding protein; Belongs to the small GTPase superfamily. RGK family. (295 aa)
	PGR	Progesterone receptor. (827 aa)
	PLK1	Serine/threonine-protein kinase PLK. (604 aa)
	IGF1	Insulin-like growth factor I isoform X1. (153 aa)
	RRAD	GTP-binding protein; Belongs to the small GTPase superfamily. RGK family. (308 aa)
	LOC102726697	Guanine nucleotide-binding protein G(I) subunit alpha-1-like isoform X1. (354 aa)
	CPEB3	Cytoplasmic polyadenylation element-binding protein 3. (704 aa)
	LOC102747763	Speedy protein E4-like. (225 aa)
	CDC26	Anaphase-promoting complex subunit CDC26. (85 aa)
	MAPK12	Mitogen-activated protein kinase. (367 aa)
	ANAPC13	Anaphase-promoting complex subunit 13. (74 aa)
	PRKACB	cAMP-dependent protein kinase catalytic subunit beta isoform X1; Belongs to the protein kinase superfamily. (397 aa)
	ANAPC5	Anaphase-promoting complex subunit 5 isoform X1. (755 aa)
	AURKB	Aurora kinase B isoform X1; Belongs to the protein kinase superfamily. (344 aa)
	MAPK8	Mitogen-activated protein kinase. (427 aa)
	IGF1R	Insulin-like growth factor 1 receptor-like. (291 aa)
	AKT1	Non-specific serine/threonine protein kinase. (518 aa)
	FZR1	Fizzy-related protein homolog isoform X1. (496 aa)
	KIF22	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (660 aa)
	GNAI2	Guanine nucleotide-binding protein G(I) subunit alpha-2. (303 aa)
	ANAPC2	Anaphase-promoting complex subunit 2; Belongs to the cullin family. (818 aa)
	CDC25C	M-phase inducer phosphatase 3 isoform X1. (473 aa)
	CDC23	Cell division cycle protein 23 homolog. (597 aa)
	CCNB1	G2/mitotic-specific cyclin-B1; Belongs to the cyclin family. (427 aa)
	MOS	Proto-oncogene serine/threonine-protein kinase mos; Belongs to the protein kinase superfamily. (348 aa)
	LOC102749673	Insulin-like growth factor 1 receptor-like. (143 aa)
	AKT3	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (418 aa)
	RAF1	RAF proto-oncogene serine/threonine-protein kinase isoform X1. (648 aa)
	CCNB2	G2/mitotic-specific cyclin-B2; Belongs to the cyclin family. (299 aa)
	PTRHD1	Putative peptidyl-tRNA hydrolase PTRHD1. (140 aa)
	SPDYA	Speedy protein A. (285 aa)
	RPS6KA3	Ribosomal protein S6 kinase. (740 aa)
	CDC25B	M-phase inducer phosphatase 2 isoform X1. (516 aa)
	ANAPC11	Anaphase-promoting complex subunit 11 isoform X1. (84 aa)
	PDE3B	Phosphodiesterase. (1180 aa)
	MAPK1	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (326 aa)
	ANAPC10	Anaphase-promoting complex subunit 10; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle. (185 aa)
	ADCY9	Adenylate cyclase type 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (790 aa)
	LOC102746012	Adenylate cyclase type 3-like; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (311 aa)
	PIK3CD	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1043 aa)
	PIK3CA	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
	TMEM82	Transmembrane protein 82-like. (344 aa)
	LOC102732719	Ribosomal protein S6 kinase alpha-1-like. (200 aa)
	LOC102736516	Phosphatidylinositol 3-kinase regulatory subunit alpha-like. (138 aa)
	HSP90AB1	Heat shock protein HSP 90-beta. (464 aa)
	LOC102726367	Heat shock protein HSP 90-alpha-like. (262 aa)
	CDC16	Cell division cycle protein 16 homolog isoform X1. (620 aa)
	LOC102731850	Tyrosine-protein kinase receptor. (757 aa)
	INS	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (110 aa)
	LOC102735556	Mitogen-activated protein kinase 9-like. (134 aa)
	ANAPC7	Anaphase-promoting complex subunit 7. (461 aa)

Your Current Organism:

Leptonychotes weddellii

NCBI taxonomy Id: 9713
Other names: L. weddellii, Leptonychotes weddelli, Weddell seal

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADCY6	ADCY9	A0A2U3XDB9	A0A2U3YLR7	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	0.920
ADCY6	AKT1	A0A2U3XDB9	A0A2U3Y3V3	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Non-specific serine/threonine protein kinase.	0.819
ADCY6	AKT3	A0A2U3XDB9	A0A2U3Y8K7	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.866
ADCY6	GNAI2	A0A2U3XDB9	A0A2U3Y188	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Guanine nucleotide-binding protein G(I) subunit alpha-2.	0.826
ADCY6	LOC102726697	A0A2U3XDB9	A0A2U3XNG2	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Guanine nucleotide-binding protein G(I) subunit alpha-1-like isoform X1.	0.826
ADCY6	LOC102731038	A0A2U3XDB9	A0A2U3Z797	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 9-like; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	0.842
ADCY6	LOC102746012	A0A2U3XDB9	A0A2U3YPK1	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 3-like; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	0.895
ADCY6	PDE3B	A0A2U3XDB9	A0A2U3YI06	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Phosphodiesterase.	0.864
ADCY6	PRKACA	A0A2U3XDB9	A0A2U3Z6A9	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	cAMP-dependent protein kinase catalytic subunit alpha isoform X1; Belongs to the protein kinase superfamily.	0.919
ADCY6	PRKACB	A0A2U3XDB9	A0A2U3XZU0	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	cAMP-dependent protein kinase catalytic subunit beta isoform X1; Belongs to the protein kinase superfamily.	0.928
ADCY6	PTRHD1	A0A2U3XDB9	A0A2U3YCC1	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Putative peptidyl-tRNA hydrolase PTRHD1.	0.797
ADCY9	ADCY6	A0A2U3YLR7	A0A2U3XDB9	Adenylate cyclase type 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.920
ADCY9	AKT1	A0A2U3YLR7	A0A2U3Y3V3	Adenylate cyclase type 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	Non-specific serine/threonine protein kinase.	0.817
ADCY9	AKT3	A0A2U3YLR7	A0A2U3Y8K7	Adenylate cyclase type 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.813
ADCY9	GNAI2	A0A2U3YLR7	A0A2U3Y188	Adenylate cyclase type 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	Guanine nucleotide-binding protein G(I) subunit alpha-2.	0.848
ADCY9	LOC102726697	A0A2U3YLR7	A0A2U3XNG2	Adenylate cyclase type 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	Guanine nucleotide-binding protein G(I) subunit alpha-1-like isoform X1.	0.848
ADCY9	LOC102731038	A0A2U3YLR7	A0A2U3Z797	Adenylate cyclase type 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	Adenylate cyclase type 9-like; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	0.921
ADCY9	LOC102746012	A0A2U3YLR7	A0A2U3YPK1	Adenylate cyclase type 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	Adenylate cyclase type 3-like; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	0.992
ADCY9	PDE3B	A0A2U3YLR7	A0A2U3YI06	Adenylate cyclase type 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	Phosphodiesterase.	0.830
ADCY9	PRKACA	A0A2U3YLR7	A0A2U3Z6A9	Adenylate cyclase type 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	cAMP-dependent protein kinase catalytic subunit alpha isoform X1; Belongs to the protein kinase superfamily.	0.938