(50 nodes) Thyroid hormone synthesis network (Leptonychotes weddellii)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	GPX1	Glutathione peroxidase; Belongs to the glutathione peroxidase family. (209 aa)
	LOC102745942	Iodotyrosine dehalogenase 1-like. (123 aa)
	PRKACA	cAMP-dependent protein kinase catalytic subunit alpha isoform X1; Belongs to the protein kinase superfamily. (351 aa)
	DUOX2	Dual oxidase 2-like. (1225 aa)
	LOC102731038	Adenylate cyclase type 9-like; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (564 aa)
	DUOXA2	Dual oxidase maturation factor 2. (320 aa)
	TSHB	Thyrotropin subunit beta. (138 aa)
	ADCY6	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1161 aa)
	ALB	Serum albumin. (608 aa)
	ATF4	Cyclic AMP-dependent transcription factor ATF-4. (351 aa)
	GPX7	Glutathione peroxidase; Belongs to the glutathione peroxidase family. (186 aa)
	PDIA4	Protein disulfide-isomerase A4. (645 aa)
	ATP1A3	Sodium/potassium-transporting ATPase subunit alpha. (1027 aa)
	SERPINA7	Thyroxine-binding globulin; Belongs to the serpin family. (414 aa)
	GPX8	Glutathione peroxidase; Belongs to the glutathione peroxidase family. (209 aa)
	TSHR	Thyrotropin receptor; Receptor for the thyroid-stimulating hormone (TSH) or thyrotropin. Also acts as a receptor for the heterodimeric glycoprotein hormone (GPHA2:GPHB5) or thyrostimulin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Plays a central role in controlling thyroid cell metabolism. Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily. (764 aa)
	CREB1	Cyclic AMP-responsive element-binding protein 1 isoform X1. (341 aa)
	LOC102747672	Iodotyrosine dehalogenase 1-like. (168 aa)
	PRKACB	cAMP-dependent protein kinase catalytic subunit beta isoform X1; Belongs to the protein kinase superfamily. (397 aa)
	GPX5	Glutathione peroxidase; Belongs to the glutathione peroxidase family. (221 aa)
	GPX6	Glutathione peroxidase; Belongs to the glutathione peroxidase family. (233 aa)
	ATP1B3	Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (280 aa)
	ITPR2	Inositol 1,4,5-trisphosphate receptor type 2-like. (2701 aa)
	ATF6B	Cyclic AMP-dependent transcription factor ATF-6 beta. (623 aa)
	GPX2	Glutathione peroxidase; Belongs to the glutathione peroxidase family. (190 aa)
	CREB3L3	Cyclic AMP-responsive element-binding protein 3-like protein 3. (466 aa)
	ATP1B2	Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (290 aa)
	ASGR1	Asialoglycoprotein receptor 1. (284 aa)
	ATP1B1	Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (303 aa)
	CANX	Calnexin isoform X1. (594 aa)
	HSP90B1	Endoplasmin isoform X1. (803 aa)
	TTR	Transthyretin; Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain. (147 aa)
	PTRHD1	Putative peptidyl-tRNA hydrolase PTRHD1. (140 aa)
	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1. (1244 aa)
	ATF2	Cyclic AMP-dependent transcription factor ATF-2 isoform X2. (505 aa)
	LOC102742813	Neuroendocrine secretory protein 55-like. (246 aa)
	ATP1A2	Sodium/potassium-transporting ATPase subunit alpha. (1020 aa)
	ATP1A4	Sodium/potassium-transporting ATPase subunit alpha. (1030 aa)
	SERPINA9	Serpin A9; Belongs to the serpin family. (418 aa)
	ITPR3	Inositol 1,4,5-trisphosphate receptor type 3. (557 aa)
	HSPA5	78 kDa glucose-regulated protein isoform X2; Belongs to the heat shock protein 70 family. (654 aa)
	FXYD2	FXYD domain-containing ion transport regulator; Belongs to the FXYD family. (66 aa)
	ADCY9	Adenylate cyclase type 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (790 aa)
	LOC102746012	Adenylate cyclase type 3-like; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (311 aa)
	ATP1B4	Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (360 aa)
	PLCB3	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1100 aa)
	CREB3L1	Cyclic AMP-responsive element-binding protein 3-like protein 1. (474 aa)
	ATP1A1	Sodium/potassium-transporting ATPase subunit alpha. (673 aa)
	LOC102735730	Sodium/potassium-transporting ATPase subunit alpha-1-like; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. (346 aa)
	LOC102730715	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2-like. (231 aa)

Your Current Organism:

Leptonychotes weddellii

NCBI taxonomy Id: 9713
Other names: L. weddellii, Leptonychotes weddelli, Weddell seal

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADCY6	ADCY9	A0A2U3XDB9	A0A2U3YLR7	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	0.920
ADCY6	HSP90B1	A0A2U3XDB9	A0A2U3Y995	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Endoplasmin isoform X1.	0.446
ADCY6	LOC102731038	A0A2U3XDB9	A0A2U3Z797	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 9-like; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	0.842
ADCY6	LOC102742813	A0A2U3XDB9	A0A2U3YGK0	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Neuroendocrine secretory protein 55-like.	0.810
ADCY6	LOC102746012	A0A2U3XDB9	A0A2U3YPK1	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 3-like; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	0.895
ADCY6	PLCB3	A0A2U3XDB9	A0A2U3YRT9	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.	0.500
ADCY6	PRKACA	A0A2U3XDB9	A0A2U3Z6A9	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	cAMP-dependent protein kinase catalytic subunit alpha isoform X1; Belongs to the protein kinase superfamily.	0.919
ADCY6	PRKACB	A0A2U3XDB9	A0A2U3XZU0	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	cAMP-dependent protein kinase catalytic subunit beta isoform X1; Belongs to the protein kinase superfamily.	0.928
ADCY6	PTRHD1	A0A2U3XDB9	A0A2U3YCC1	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Putative peptidyl-tRNA hydrolase PTRHD1.	0.797
ADCY9	ADCY6	A0A2U3YLR7	A0A2U3XDB9	Adenylate cyclase type 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.920
ADCY9	LOC102731038	A0A2U3YLR7	A0A2U3Z797	Adenylate cyclase type 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	Adenylate cyclase type 9-like; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	0.921
ADCY9	LOC102742813	A0A2U3YLR7	A0A2U3YGK0	Adenylate cyclase type 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	Neuroendocrine secretory protein 55-like.	0.896
ADCY9	LOC102746012	A0A2U3YLR7	A0A2U3YPK1	Adenylate cyclase type 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	Adenylate cyclase type 3-like; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	0.992
ADCY9	PRKACA	A0A2U3YLR7	A0A2U3Z6A9	Adenylate cyclase type 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	cAMP-dependent protein kinase catalytic subunit alpha isoform X1; Belongs to the protein kinase superfamily.	0.938
ADCY9	PRKACB	A0A2U3YLR7	A0A2U3XZU0	Adenylate cyclase type 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	cAMP-dependent protein kinase catalytic subunit beta isoform X1; Belongs to the protein kinase superfamily.	0.937
ADCY9	PTRHD1	A0A2U3YLR7	A0A2U3YCC1	Adenylate cyclase type 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	Putative peptidyl-tRNA hydrolase PTRHD1.	0.815
ALB	ATF4	A0A2U3XEF9	A0A2U3XET2	Serum albumin.	Cyclic AMP-dependent transcription factor ATF-4.	0.454
ALB	CANX	A0A2U3XEF9	A0A2U3Y8B6	Serum albumin.	Calnexin isoform X1.	0.669
ALB	CREB1	A0A2U3XEF9	A0A2U3XPQ5	Serum albumin.	Cyclic AMP-responsive element-binding protein 1 isoform X1.	0.553
ALB	GPX1	A0A2U3XEF9	A0A2U3Z8Z4	Serum albumin.	Glutathione peroxidase; Belongs to the glutathione peroxidase family.	0.586