STRINGSTRING
TRADD TRADD CHUK CHUK AKT3 AKT3 PRKAB1 PRKAB1 NFKBIB NFKBIB IKBKG IKBKG SLC2A4 SLC2A4 PCK2 PCK2 G6PC G6PC LOC102745161 LOC102745161 TNF TNF AKT1 AKT1 SLC2A3 SLC2A3 MAPK8 MAPK8 RXRB RXRB TNFRSF1A TNFRSF1A JAK2 JAK2 ACSL4 ACSL4 CAMKK2 CAMKK2 PTPN11 PTPN11 IRS1 IRS1 MTOR MTOR CPT1B CPT1B PRKCQ PRKCQ CPT1A CPT1A PRKAG1 PRKAG1 SOCS3 SOCS3 PRKAA1 PRKAA1 POMC POMC NFKB1 NFKB1 NFKBIA NFKBIA MAPK10 MAPK10 NPY NPY LOC102727190 LOC102727190 PCK1 PCK1 LOC102735556 LOC102735556 STAT3 STAT3 PPARA PPARA G6PC2 G6PC2 AGRP AGRP ACSL3 ACSL3 PRKAG2 PRKAG2 ACSL5 ACSL5 LOC102748583 LOC102748583 ADIPOR1 ADIPOR1 ACSBG2 ACSBG2 IKBKB IKBKB ACSL1 ACSL1 PPARGC1A PPARGC1A LEP LEP NFKBIE NFKBIE RXRA RXRA
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TRADDTumor necrosis factor receptor type 1-associated DEATH domain protein. (312 aa)
CHUKInhibitor of nuclear factor kappa-B kinase subunit alpha. (745 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (418 aa)
PRKAB15'-AMP-activated protein kinase subunit beta-1. (270 aa)
NFKBIBNF-kappa-B inhibitor beta isoform X2. (354 aa)
IKBKGNF-kappa-B essential modulator isoform X2. (419 aa)
SLC2A4Solute carrier family 2, facilitated glucose transporter member 4 isoform X1; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (509 aa)
PCK2Phosphoenolpyruvate carboxykinase [GTP], mitochondrial isoform X2. (640 aa)
G6PCGlucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (357 aa)
LOC102745161Signal transducer and activator of transcription 3-like. (301 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
AKT1Non-specific serine/threonine protein kinase. (518 aa)
SLC2A3Solute carrier family 2, facilitated glucose transporter member 3; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (318 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
RXRBRetinoic acid receptor RXR-beta isoform X1. (536 aa)
TNFRSF1ATumor necrosis factor receptor superfamily member 1A. (358 aa)
JAK2Tyrosine-protein kinase. (952 aa)
ACSL4long-chain-fatty-acid--CoA ligase 4. (711 aa)
CAMKK2Calcium/calmodulin-dependent protein kinase kinase 2 isoform X1. (578 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (593 aa)
IRS1Insulin receptor substrate 1-like isoform X1. (1236 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2550 aa)
CPT1BCarnitine O-palmitoyltransferase 1, muscle isoform; Belongs to the carnitine/choline acetyltransferase family. (772 aa)
PRKCQProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (706 aa)
CPT1ACarnitine O-palmitoyltransferase 1, liver isoform-like. (429 aa)
PRKAG15'-AMP-activated protein kinase subunit gamma-1 isoform X1. (298 aa)
SOCS3Suppressor of cytokine signaling 3. (225 aa)
PRKAA1Non-specific serine/threonine protein kinase. (559 aa)
POMCPro-opiomelanocortin. (153 aa)
NFKB1Nuclear factor NF-kappa-B p105 subunit. (254 aa)
NFKBIANF-kappa-B inhibitor alpha isoform X2. (314 aa)
MAPK10Mitogen-activated protein kinase. (464 aa)
NPYPro-neuropeptide Y. (97 aa)
LOC102727190Serine/threonine-protein kinase STK11-like. (545 aa)
PCK1Phosphoenolpyruvate carboxykinase, cytosolic [GTP] isoform X2. (622 aa)
LOC102735556Mitogen-activated protein kinase 9-like. (134 aa)
STAT3Signal transducer and activator of transcription 3-like. (424 aa)
PPARAPeroxisome proliferator-activated receptor alpha. (303 aa)
G6PC2Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (356 aa)
AGRPAgouti-related protein. (132 aa)
ACSL3long-chain-fatty-acid--CoA ligase 3. (720 aa)
PRKAG25'-AMP-activated protein kinase subunit gamma-2-like isoform X2. (327 aa)
ACSL5long-chain-fatty-acid--CoA ligase 5 isoform X2. (683 aa)
LOC1027485835'-AMP-activated protein kinase subunit gamma-2-like. (129 aa)
ADIPOR1Adiponectin receptor protein 1. (375 aa)
ACSBG2long-chain-fatty-acid--CoA ligase ACSBG2-like. (653 aa)
IKBKBInhibitor of nuclear factor kappa-B kinase subunit beta isoform X1. (756 aa)
ACSL1long-chain-fatty-acid--CoA ligase 1 isoform X1. (686 aa)
PPARGC1APeroxisome proliferator-activated receptor gamma coactivator 1-alpha-like isoform X2. (671 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (166 aa)
NFKBIENF-kappa-B inhibitor epsilon. (361 aa)
RXRARetinoic acid receptor RXR-alpha. (439 aa)
Your Current Organism:
Leptonychotes weddellii
NCBI taxonomy Id: 9713
Other names: L. weddellii, Leptonychotes weddelli, Weddell seal
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