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NPPA NPPA CALML4 CALML4 LOC102731038 LOC102731038 LOC102733954 LOC102733954 PRKACA PRKACA STAR STAR ARSI ARSI CAMK2A CAMK2A AGT AGT CAMK4 CAMK4 LOC102730715 LOC102730715 LOC102732653 LOC102732653 ORAI1 ORAI1 LOC102735730 LOC102735730 ATP1A1 ATP1A1 LOC102742748 LOC102742748 NPR1 NPR1 CREB3L1 CREB3L1 DAGLB DAGLB PLCB3 PLCB3 LOC102737831 LOC102737831 ATP1B4 ATP1B4 LOC102746012 LOC102746012 CALM3 CALM3 MC2R MC2R GNA11 GNA11 ADCY9 ADCY9 LDLR LDLR ITPR3 ITPR3 ATP1A4 ATP1A4 ATP1A2 ATP1A2 KCNK3 KCNK3 LOC102742813 LOC102742813 ATF2 ATF2 ITPR1 ITPR1 PTRHD1 PTRHD1 CACNA1G CACNA1G LOC102743616 LOC102743616 ATP1B1 ATP1B1 ATP1B2 ATP1B2 CREB3L3 CREB3L3 ATF6B ATF6B CACNA1F CACNA1F ITPR2 ITPR2 PRKD3 PRKD3 ATP1B3 ATP1B3 PRKACB PRKACB LOC102737081 LOC102737081 ATF1 ATF1 KCNK9 KCNK9 CAMK1G CAMK1G CAMK2G CAMK2G CREB1 CREB1 POMC POMC LOC102738071 LOC102738071 ATP1A3 ATP1A3 NR4A2 NR4A2 KCNJ5 KCNJ5 PDE2A PDE2A ATF4 ATF4 ADCY6 ADCY6 LOC102736922 LOC102736922
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
NPPANatriuretic peptides A. (150 aa)
CALML4LOW QUALITY PROTEIN: calmodulin-like 4. (199 aa)
LOC102731038Adenylate cyclase type 9-like; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (564 aa)
LOC102733954Calmodulin-like protein 4-like. (119 aa)
PRKACAcAMP-dependent protein kinase catalytic subunit alpha isoform X1; Belongs to the protein kinase superfamily. (351 aa)
STARSteroidogenic acute regulatory protein, mitochondrial; Plays a key role in steroid hormone synthesis by enhancing the metabolism of cholesterol into pregnenolone. Mediates the transfer of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane where it is cleaved to pregnenolone. (281 aa)
ARSIArylsulfatase I. (575 aa)
CAMK2ACalcium/calmodulin-dependent protein kinase type II subunit alpha. (476 aa)
AGTAngiotensinogen; Belongs to the serpin family. (477 aa)
CAMK4Calcium/calmodulin-dependent protein kinase type IV. (360 aa)
LOC1027307151-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2-like. (231 aa)
LOC102732653Nuclear receptor subfamily 4 group A member 1-like. (306 aa)
ORAI1Calcium release-activated calcium channel protein 1. (302 aa)
LOC102735730Sodium/potassium-transporting ATPase subunit alpha-1-like; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. (346 aa)
ATP1A1Sodium/potassium-transporting ATPase subunit alpha. (673 aa)
LOC1027427483 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase-like. (288 aa)
NPR1Atrial natriuretic peptide receptor 1; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (242 aa)
CREB3L1Cyclic AMP-responsive element-binding protein 3-like protein 1. (474 aa)
DAGLBSn1-specific diacylglycerol lipase beta. (671 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1100 aa)
LOC102737831Serine/threonine-protein kinase D2-like. (246 aa)
ATP1B4Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (360 aa)
LOC102746012Adenylate cyclase type 3-like; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (311 aa)
CALM3Calmodulin isoform X1; Belongs to the calmodulin family. (149 aa)
MC2RAdrenocorticotropic hormone receptor. (297 aa)
GNA11Guanine nucleotide-binding protein subunit alpha-11. (359 aa)
ADCY9Adenylate cyclase type 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (790 aa)
LDLRLow-density lipoprotein receptor. (861 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3. (557 aa)
ATP1A4Sodium/potassium-transporting ATPase subunit alpha. (1030 aa)
ATP1A2Sodium/potassium-transporting ATPase subunit alpha. (1020 aa)
KCNK3Potassium channel subfamily K member 3; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. (433 aa)
LOC102742813Neuroendocrine secretory protein 55-like. (246 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2 isoform X2. (505 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1. (1244 aa)
PTRHD1Putative peptidyl-tRNA hydrolase PTRHD1. (140 aa)
CACNA1GVoltage-dependent T-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This channel gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite ne [...] (2266 aa)
LOC102743616Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...] (520 aa)
ATP1B1Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (303 aa)
ATP1B2Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (290 aa)
CREB3L3Cyclic AMP-responsive element-binding protein 3-like protein 3. (466 aa)
ATF6BCyclic AMP-dependent transcription factor ATF-6 beta. (623 aa)
CACNA1FVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1983 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2-like. (2701 aa)
PRKD3Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (890 aa)
ATP1B3Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (280 aa)
PRKACBcAMP-dependent protein kinase catalytic subunit beta isoform X1; Belongs to the protein kinase superfamily. (397 aa)
LOC102737081Steroid 21-hydroxylase-like; Belongs to the cytochrome P450 family. (492 aa)
ATF1Cyclic AMP-dependent transcription factor ATF-1 isoform X2. (270 aa)
KCNK9Potassium channel subfamily K member 9. (264 aa)
CAMK1GCalcium/calmodulin-dependent protein kinase type 1G. (220 aa)
CAMK2GCalcium/calmodulin-dependent protein kinase type II subunit gamma. (574 aa)
CREB1Cyclic AMP-responsive element-binding protein 1 isoform X1. (341 aa)
POMCPro-opiomelanocortin. (153 aa)
LOC102738071Calmodulin-like; Belongs to the calmodulin family. (113 aa)
ATP1A3Sodium/potassium-transporting ATPase subunit alpha. (1027 aa)
NR4A2Nuclear receptor subfamily 4 group A member 2 isoform X2. (598 aa)
KCNJ5G protein-activated inward rectifier potassium channel 4. (430 aa)
PDE2APhosphodiesterase. (943 aa)
ATF4Cyclic AMP-dependent transcription factor ATF-4. (351 aa)
ADCY6Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1161 aa)
LOC102736922Calmodulin-like; Belongs to the calmodulin family. (223 aa)
Your Current Organism:
Leptonychotes weddellii
NCBI taxonomy Id: 9713
Other names: L. weddellii, Leptonychotes weddelli, Weddell seal
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