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ITPR1 ITPR1 ATF2 ATF2 LOC102742813 LOC102742813 KCNK3 KCNK3 ITPR3 ITPR3 PDE8B PDE8B LDLR LDLR ADCY9 ADCY9 GNA11 GNA11 MC2R MC2R LOC102746012 LOC102746012 LOC102732818 LOC102732818 PLCB3 PLCB3 CREB3L1 CREB3L1 LOC102742748 LOC102742748 ORAI1 ORAI1 LOC102732653 LOC102732653 LOC102727679 LOC102727679 LOC102730715 LOC102730715 KCNA1 KCNA1 AGT AGT STAR STAR PRKACA PRKACA LOC102731038 LOC102731038 KCNA4 KCNA4 ADCY6 ADCY6 ATF4 ATF4 LOC102745940 LOC102745940 KCNA3 KCNA3 POMC POMC CREB1 CREB1 NCEH1 NCEH1 NR0B1 NR0B1 LOC102737081 LOC102737081 PRKACB PRKACB ITPR2 ITPR2 CACNA1F CACNA1F ATF6B ATF6B CREB3L3 CREB3L3 PDE8A PDE8A KCNA5 KCNA5 LOC102743616 LOC102743616 CACNA1G CACNA1G PTRHD1 PTRHD1 SP1 SP1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ITPR1Inositol 1,4,5-trisphosphate receptor type 1. (1244 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2 isoform X2. (505 aa)
LOC102742813Neuroendocrine secretory protein 55-like. (246 aa)
KCNK3Potassium channel subfamily K member 3; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. (433 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3. (557 aa)
PDE8BPhosphodiesterase. (445 aa)
LDLRLow-density lipoprotein receptor. (861 aa)
ADCY9Adenylate cyclase type 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (790 aa)
GNA11Guanine nucleotide-binding protein subunit alpha-11. (359 aa)
MC2RAdrenocorticotropic hormone receptor. (297 aa)
LOC102746012Adenylate cyclase type 3-like; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (311 aa)
LOC102732818Cytochrome P450 11B1, mitochondrial-like isoform X1; Belongs to the cytochrome P450 family. (503 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1100 aa)
CREB3L1Cyclic AMP-responsive element-binding protein 3-like protein 1. (474 aa)
LOC1027427483 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase-like. (288 aa)
ORAI1Calcium release-activated calcium channel protein 1. (302 aa)
LOC102732653Nuclear receptor subfamily 4 group A member 1-like. (306 aa)
LOC102727679Potassium voltage-gated channel subfamily A member 10-like; Belongs to the potassium channel family. (511 aa)
LOC1027307151-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2-like. (231 aa)
KCNA1Potassium voltage-gated channel subfamily A member 1-like; Belongs to the potassium channel family. (495 aa)
AGTAngiotensinogen; Belongs to the serpin family. (477 aa)
STARSteroidogenic acute regulatory protein, mitochondrial; Plays a key role in steroid hormone synthesis by enhancing the metabolism of cholesterol into pregnenolone. Mediates the transfer of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane where it is cleaved to pregnenolone. (281 aa)
PRKACAcAMP-dependent protein kinase catalytic subunit alpha isoform X1; Belongs to the protein kinase superfamily. (351 aa)
LOC102731038Adenylate cyclase type 9-like; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (564 aa)
KCNA4Potassium voltage-gated channel subfamily A member 4; Belongs to the potassium channel family. (654 aa)
ADCY6Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1161 aa)
ATF4Cyclic AMP-dependent transcription factor ATF-4. (351 aa)
LOC102745940Steroid 17-alpha-hydroxylase/17,20 lyase-like; Belongs to the cytochrome P450 family. (508 aa)
KCNA3Potassium voltage-gated channel subfamily A member 3; Belongs to the potassium channel family. (439 aa)
POMCPro-opiomelanocortin. (153 aa)
CREB1Cyclic AMP-responsive element-binding protein 1 isoform X1. (341 aa)
NCEH1Neutral cholesterol ester hydrolase 1 isoform X2. (408 aa)
NR0B1Nuclear receptor subfamily 0 group B member 1. (393 aa)
LOC102737081Steroid 21-hydroxylase-like; Belongs to the cytochrome P450 family. (492 aa)
PRKACBcAMP-dependent protein kinase catalytic subunit beta isoform X1; Belongs to the protein kinase superfamily. (397 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2-like. (2701 aa)
CACNA1FVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1983 aa)
ATF6BCyclic AMP-dependent transcription factor ATF-6 beta. (623 aa)
CREB3L3Cyclic AMP-responsive element-binding protein 3-like protein 3. (466 aa)
PDE8AHigh affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A. (142 aa)
KCNA5Potassium voltage-gated channel subfamily A member 5; Belongs to the potassium channel family. (603 aa)
LOC102743616Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...] (520 aa)
CACNA1GVoltage-dependent T-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This channel gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite ne [...] (2266 aa)
PTRHD1Putative peptidyl-tRNA hydrolase PTRHD1. (140 aa)
SP1Transcription factor Sp1 isoform X1. (786 aa)
Your Current Organism:
Leptonychotes weddellii
NCBI taxonomy Id: 9713
Other names: L. weddellii, Leptonychotes weddelli, Weddell seal
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