(30 nodes) Type II diabetes mellitus network (Leptonychotes weddellii)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC102726446	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform-like; Belongs to the PI3/PI4-kinase family. (235 aa)
	LOC102740749	Phosphotransferase; Belongs to the hexokinase family. (82 aa)
	PIK3R3	Phosphatidylinositol 3-kinase regulatory subunit gamma. (461 aa)
	MAPK10	Mitogen-activated protein kinase. (464 aa)
	PRKCZ	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (557 aa)
	HK3	Hexokinase-3. (954 aa)
	SOCS3	Suppressor of cytokine signaling 3. (225 aa)
	PKLR	Pyruvate kinase; Belongs to the pyruvate kinase family. (428 aa)
	SOCS2	Suppressor of cytokine signaling 2. (198 aa)
	MTOR	Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2550 aa)
	IRS1	Insulin receptor substrate 1-like isoform X1. (1236 aa)
	SOCS4	Suppressor of cytokine signaling 4. (440 aa)
	GCK	Phosphotransferase. (391 aa)
	MAPK8	Mitogen-activated protein kinase. (427 aa)
	TNF	Tumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
	SLC2A4	Solute carrier family 2, facilitated glucose transporter member 4 isoform X1; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (509 aa)
	CACNA1G	Voltage-dependent T-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This channel gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite ne [...] (2266 aa)
	MAPK1	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (326 aa)
	INS	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (110 aa)
	LOC102735556	Mitogen-activated protein kinase 9-like. (134 aa)
	LOC102751021	Phosphatidylinositol 3-kinase regulatory subunit alpha-like isoform X1. (454 aa)
	PARP8	Poly [ADP-ribose] polymerase. (656 aa)
	PIK3CD	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1043 aa)
	PIK3CA	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
	LOC102736516	Phosphatidylinositol 3-kinase regulatory subunit alpha-like. (138 aa)
	SLC2A2	Solute carrier family 2, facilitated glucose transporter member 2 isoform X1; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (524 aa)
	PDX1	Pancreas/duodenum homeobox protein 1. (283 aa)
	KCNJ11	ATP-sensitive inward rectifier potassium channel 11. (390 aa)
	IKBKB	Inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1. (756 aa)
	LOC102745703	Pyruvate kinase; Belongs to the pyruvate kinase family. (610 aa)

Your Current Organism:

Leptonychotes weddellii

NCBI taxonomy Id: 9713
Other names: L. weddellii, Leptonychotes weddelli, Weddell seal

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
GCK	HK3	A0A2U3XYJ4	A0A2U3XP23	Phosphotransferase.	Hexokinase-3.	0.862
GCK	INS	A0A2U3XYJ4	A0A2U3Z329	Phosphotransferase.	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.668
GCK	IRS1	A0A2U3XYJ4	A0A2U3XWD6	Phosphotransferase.	Insulin receptor substrate 1-like isoform X1.	0.406
GCK	KCNJ11	A0A2U3XYJ4	A0A2U3Z1B7	Phosphotransferase.	ATP-sensitive inward rectifier potassium channel 11.	0.618
GCK	LOC102740749	A0A2U3XYJ4	A0A2U3XBX6	Phosphotransferase.	Phosphotransferase; Belongs to the hexokinase family.	0.984
GCK	PDX1	A0A2U3XYJ4	A0A2U3YYZ7	Phosphotransferase.	Pancreas/duodenum homeobox protein 1.	0.708
GCK	PKLR	A0A2U3XYJ4	A0A2U3XU00	Phosphotransferase.	Pyruvate kinase; Belongs to the pyruvate kinase family.	0.626
GCK	SLC2A2	A0A2U3XYJ4	A0A2U3YYK3	Phosphotransferase.	Solute carrier family 2, facilitated glucose transporter member 2 isoform X1; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.	0.727
GCK	SLC2A4	A0A2U3XYJ4	A0A2U3Y5I7	Phosphotransferase.	Solute carrier family 2, facilitated glucose transporter member 4 isoform X1; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.	0.485
HK3	GCK	A0A2U3XP23	A0A2U3XYJ4	Hexokinase-3.	Phosphotransferase.	0.862
HK3	INS	A0A2U3XP23	A0A2U3Z329	Hexokinase-3.	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.540
HK3	LOC102740749	A0A2U3XP23	A0A2U3XBX6	Hexokinase-3.	Phosphotransferase; Belongs to the hexokinase family.	0.949
HK3	LOC102745703	A0A2U3XP23	A0A2U3X6H5	Hexokinase-3.	Pyruvate kinase; Belongs to the pyruvate kinase family.	0.588
HK3	SLC2A4	A0A2U3XP23	A0A2U3Y5I7	Hexokinase-3.	Solute carrier family 2, facilitated glucose transporter member 4 isoform X1; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.	0.542
IKBKB	INS	A0A2U3YJI5	A0A2U3Z329	Inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1.	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.581
IKBKB	IRS1	A0A2U3YJI5	A0A2U3XWD6	Inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1.	Insulin receptor substrate 1-like isoform X1.	0.941
IKBKB	MTOR	A0A2U3YJI5	A0A2U3XVT2	Inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1.	Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family.	0.599
IKBKB	TNF	A0A2U3YJI5	A0A2U3Y499	Inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1.	Tumor necrosis factor; Belongs to the tumor necrosis factor family.	0.987
INS	GCK	A0A2U3Z329	A0A2U3XYJ4	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Phosphotransferase.	0.668
INS	HK3	A0A2U3Z329	A0A2U3XP23	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Hexokinase-3.	0.540