STRINGSTRING
PRKAG1 PRKAG1 RPS6KA3 RPS6KA3 RPS6KA6 RPS6KA6 SLC27A6 SLC27A6 LOC102726446 LOC102726446 PIK3R3 PIK3R3 PPP1R3A PPP1R3A MAPK10 MAPK10 NFU1 NFU1 NR1H3 NR1H3 MGEA5 MGEA5 PYGL PYGL NFKBIA NFKBIA PRKCZ PRKCZ NFKB1 NFKB1 PTEN PTEN PRKAA1 PRKAA1 CREB1 CREB1 TBC1D4 TBC1D4 SOCS3 SOCS3 PRKCQ PRKCQ CPT1B CPT1B MTOR MTOR IRS1 IRS1 PTPN11 PTPN11 PPP1CC PPP1CC PYGM PYGM TNFRSF1A TNFRSF1A MAPK8 MAPK8 AKT1 AKT1 TNF TNF LOC102745161 LOC102745161 G6PC G6PC PCK2 PCK2 CREB3L3 CREB3L3 SLC2A4 SLC2A4 PRKAB1 PRKAB1 AKT3 AKT3 PTPRF PTPRF RPS6KB1 RPS6KB1 PPP1R3G PPP1R3G PPP1R3B PPP1R3B GSK3B GSK3B PRKAG2 PRKAG2 LOC102748583 LOC102748583 IL6 IL6 CRTC2 CRTC2 IKBKB IKBKB LOC102746417 LOC102746417 PYGB PYGB PIK3CD PIK3CD PIK3CA PIK3CA PPARGC1A PPARGC1A LOC102732719 LOC102732719 LOC102736516 LOC102736516 GYS1 GYS1 SLC27A5 SLC27A5 CREB3L1 CREB3L1 SLC2A2 SLC2A2 CPT1A CPT1A NR1H2 NR1H2 PPP1CA PPP1CA OGT OGT G6PC2 G6PC2 PPARA PPARA INS INS AGT AGT STAT3 STAT3 PPP1R3C PPP1R3C FOXO1 FOXO1 LOC102735556 LOC102735556 RPS6KB2 RPS6KB2 LOC102736146 LOC102736146 PCK1 PCK1 LOC102740880 LOC102740880 LOC102750518 LOC102750518 PPP1CB PPP1CB LOC102751021 LOC102751021
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PRKAG15'-AMP-activated protein kinase subunit gamma-1 isoform X1. (298 aa)
RPS6KA3Ribosomal protein S6 kinase. (740 aa)
RPS6KA6Ribosomal protein S6 kinase. (744 aa)
SLC27A6Long-chain fatty acid transport protein 6. (619 aa)
LOC102726446Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform-like; Belongs to the PI3/PI4-kinase family. (235 aa)
PIK3R3Phosphatidylinositol 3-kinase regulatory subunit gamma. (461 aa)
PPP1R3AProtein phosphatase 1 regulatory subunit 3A. (1122 aa)
MAPK10Mitogen-activated protein kinase. (464 aa)
NFU1NFU1 iron-sulfur cluster scaffold homolog, mitochondrial. (196 aa)
NR1H3Oxysterols receptor LXR-alpha isoform X1. (456 aa)
MGEA5Bifunctional protein NCOAT. (539 aa)
PYGLAlpha-1,4 glucan phosphorylase; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. (851 aa)
NFKBIANF-kappa-B inhibitor alpha isoform X2. (314 aa)
PRKCZProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (557 aa)
NFKB1Nuclear factor NF-kappa-B p105 subunit. (254 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
PRKAA1Non-specific serine/threonine protein kinase. (559 aa)
CREB1Cyclic AMP-responsive element-binding protein 1 isoform X1. (341 aa)
TBC1D4TBC1 domain family member 4 isoform X6. (1300 aa)
SOCS3Suppressor of cytokine signaling 3. (225 aa)
PRKCQProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (706 aa)
CPT1BCarnitine O-palmitoyltransferase 1, muscle isoform; Belongs to the carnitine/choline acetyltransferase family. (772 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2550 aa)
IRS1Insulin receptor substrate 1-like isoform X1. (1236 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (593 aa)
PPP1CCSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (337 aa)
PYGMAlpha-1,4 glucan phosphorylase; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. (625 aa)
TNFRSF1ATumor necrosis factor receptor superfamily member 1A. (358 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
AKT1Non-specific serine/threonine protein kinase. (518 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
LOC102745161Signal transducer and activator of transcription 3-like. (301 aa)
G6PCGlucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (357 aa)
PCK2Phosphoenolpyruvate carboxykinase [GTP], mitochondrial isoform X2. (640 aa)
CREB3L3Cyclic AMP-responsive element-binding protein 3-like protein 3. (466 aa)
SLC2A4Solute carrier family 2, facilitated glucose transporter member 4 isoform X1; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (509 aa)
PRKAB15'-AMP-activated protein kinase subunit beta-1. (270 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (418 aa)
PTPRFReceptor-type tyrosine-protein phosphatase F. (687 aa)
RPS6KB1Non-specific serine/threonine protein kinase. (445 aa)
PPP1R3GProtein phosphatase 1 regulatory subunit 3G. (351 aa)
PPP1R3BProtein phosphatase 1 regulatory subunit. (285 aa)
GSK3BGlycogen synthase kinase-3 beta isoform X1; Belongs to the protein kinase superfamily. (433 aa)
PRKAG25'-AMP-activated protein kinase subunit gamma-2-like isoform X2. (327 aa)
LOC1027485835'-AMP-activated protein kinase subunit gamma-2-like. (129 aa)
IL6Interleukin-6 isoform X1. (212 aa)
CRTC2CREB-regulated transcription coactivator 2. (695 aa)
IKBKBInhibitor of nuclear factor kappa-B kinase subunit beta isoform X1. (756 aa)
LOC102746417Long-chain fatty acid transport protein 4-like. (346 aa)
PYGBAlpha-1,4 glucan phosphorylase; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. (843 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1043 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
PPARGC1APeroxisome proliferator-activated receptor gamma coactivator 1-alpha-like isoform X2. (671 aa)
LOC102732719Ribosomal protein S6 kinase alpha-1-like. (200 aa)
LOC102736516Phosphatidylinositol 3-kinase regulatory subunit alpha-like. (138 aa)
GYS1Glycogen [starch] synthase; Transfers the glycosyl residue from UDP-Glc to the non- reducing end of alpha-1,4-glucan. (737 aa)
SLC27A5Bile acyl-CoA synthetase. (687 aa)
CREB3L1Cyclic AMP-responsive element-binding protein 3-like protein 1. (474 aa)
SLC2A2Solute carrier family 2, facilitated glucose transporter member 2 isoform X1; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (524 aa)
CPT1ACarnitine O-palmitoyltransferase 1, liver isoform-like. (429 aa)
NR1H2Oxysterols receptor LXR-beta. (457 aa)
PPP1CASerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (330 aa)
OGTUDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit isoform X1. (1046 aa)
G6PC2Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (356 aa)
PPARAPeroxisome proliferator-activated receptor alpha. (303 aa)
INSInsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (110 aa)
AGTAngiotensinogen; Belongs to the serpin family. (477 aa)
STAT3Signal transducer and activator of transcription 3-like. (424 aa)
PPP1R3CProtein phosphatase 1 regulatory subunit 3C; Acts as a glycogen-targeting subunit for PP1 and regulates its activity. Activates glycogen synthase, reduces glycogen phosphorylase activity and limits glycogen breakdown. (317 aa)
FOXO1Forkhead box protein O1-like. (418 aa)
LOC102735556Mitogen-activated protein kinase 9-like. (134 aa)
RPS6KB2Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (482 aa)
LOC1027361463-phosphoinositide-dependent protein kinase 1-like. (216 aa)
PCK1Phosphoenolpyruvate carboxykinase, cytosolic [GTP] isoform X2. (622 aa)
LOC102740880Nitric oxide synthase, endothelial-like. (619 aa)
LOC102750518Tribbles homolog 3-like. (215 aa)
PPP1CBSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (327 aa)
LOC102751021Phosphatidylinositol 3-kinase regulatory subunit alpha-like isoform X1. (454 aa)
Your Current Organism:
Leptonychotes weddellii
NCBI taxonomy Id: 9713
Other names: L. weddellii, Leptonychotes weddelli, Weddell seal
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