STRINGSTRING
NDUFB10 NDUFB10 LOC102735556 LOC102735556 LOC102741952 LOC102741952 DDIT3 DDIT3 LOC102730420 LOC102730420 LOC102739777 LOC102739777 LOC102748935 LOC102748935 LOC102729504 LOC102729504 INS INS GSK3A GSK3A PPARA PPARA LOC102728289 LOC102728289 FAM71E2 FAM71E2 CASP8 CASP8 LOC102733727 LOC102733727 LOC102726062 LOC102726062 NDUFA11 NDUFA11 LOC102736634 LOC102736634 RXRA RXRA LOC102729898 LOC102729898 LOC102738241 LOC102738241 LEP LEP LOC102728579 LOC102728579 KIAA1958 KIAA1958 TGFB1 TGFB1 LOC102737840 LOC102737840 LOC102749709 LOC102749709 SDHC SDHC LOC102736516 LOC102736516 LOC102737233 LOC102737233 NDUFA10 NDUFA10 LOC102743648 LOC102743648 LOC102743128 LOC102743128 LOC102746126 LOC102746126 LOC102731913 LOC102731913 PIK3CA PIK3CA NDUFB3 NDUFB3 NDUFB5 NDUFB5 FOS FOS PIK3CD PIK3CD LOC102726230 LOC102726230 IL1A IL1A IL1B IL1B CASP3 CASP3 NDUFA13 NDUFA13 CASP7 CASP7 YJEFN3 YJEFN3 CDC42 CDC42 NDUFS2 NDUFS2 IKBKB IKBKB NDUFV1 NDUFV1 LOC102746004 LOC102746004 LOC102739825 LOC102739825 ADIPOR1 ADIPOR1 LOC102729372 LOC102729372 IL6 IL6 LOC102748583 LOC102748583 SDHA SDHA PRKAG2 PRKAG2 NDUFV2 NDUFV2 LOC102747789 LOC102747789 GSK3B GSK3B NDUFA12 NDUFA12 LOC102726815 LOC102726815 EIF2AK3 EIF2AK3 NDUFA4L2 NDUFA4L2 AKT3 AKT3 LOC102750828 LOC102750828 NDUFA9 NDUFA9 NDUFC2 NDUFC2 JUN JUN PRKAB1 PRKAB1 NDUFS4 NDUFS4 LOC102747288 LOC102747288 TNF TNF AKT1 AKT1 LOC102744846 LOC102744846 MAPK8 MAPK8 NDUFB7 NDUFB7 NDUFC1 NDUFC1 TNFRSF1A TNFRSF1A FASLG FASLG NDUFA3 NDUFA3 LOC102746787 LOC102746787 LOC102750923 LOC102750923 IRS1 IRS1 LOC102739587 LOC102739587 LOC102750335 LOC102750335 LOC102745146 LOC102745146 PKLR PKLR LOC102748757 LOC102748757 SOCS3 SOCS3 LOC102728825 LOC102728825 PRKAA1 PRKAA1 SDHD SDHD LOC102725978 LOC102725978 NFKB1 NFKB1 NDUFA6 NDUFA6 NDUFB11 NDUFB11 NDUFB4 NDUFB4 NDUFA2 NDUFA2 LOC102746063 LOC102746063 LOC102725676 LOC102725676 LOC102740357 LOC102740357 NDUFAB1 NDUFAB1 LOC102729606 LOC102729606 NR1H3 NR1H3 ATF4 ATF4 LOC102729404 LOC102729404 IL8 IL8 LOC102750117 LOC102750117 MAPK10 MAPK10 LOC102735630 LOC102735630 LOC102751186 LOC102751186 PIK3R3 PIK3R3 LOC102727267 LOC102727267 LOC102726446 LOC102726446 LOC102732026 LOC102732026 NDUFA5 NDUFA5 LOC102737931 LOC102737931 LOC102726837 LOC102726837 LOC102729172 LOC102729172 LOC102730680 LOC102730680 LOC102748999 LOC102748999 COX2 COX2 COX3 COX3 COI COI LOC102741669 LOC102741669 LOC102734861 LOC102734861 PRKAG1 PRKAG1 LOC102742579 LOC102742579 LOC102751021 LOC102751021 LOC102738272 LOC102738272 LOC102731352 LOC102731352
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
NDUFB10NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10. (172 aa)
LOC102735556Mitogen-activated protein kinase 9-like. (134 aa)
LOC102741952Uncharacterized protein KIAA1958-like. (738 aa)
DDIT3DNA damage-inducible transcript 3 protein; Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer- binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression [...] (168 aa)
LOC102730420Cytochrome b-c1 complex subunit 1, mitochondrial-like isoform X1. (481 aa)
LOC102739777NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial-like isoform X1. (479 aa)
LOC102748935NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8-like. (110 aa)
LOC102729504Apoptosis regulator BAX-like. (212 aa)
INSInsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (110 aa)
GSK3AGlycogen synthase kinase-3 alpha; Belongs to the protein kinase superfamily. (419 aa)
PPARAPeroxisome proliferator-activated receptor alpha. (303 aa)
LOC102728289Cytochrome c oxidase subunit; Belongs to the cytochrome c oxidase subunit 6B. (88 aa)
FAM71E2DUF3699 domain-containing protein. (930 aa)
CASP8Caspase-8 isoform X1; Belongs to the peptidase C14A family. (486 aa)
LOC102733727Cytochrome b-c1 complex subunit Rieske, mitochondrial; Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis. (274 aa)
LOC102726062Uncharacterized protein C7orf31 homolog. (590 aa)
NDUFA11NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11. (141 aa)
LOC102736634NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial-like. (132 aa)
RXRARetinoic acid receptor RXR-alpha. (439 aa)
LOC102729898NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial-like; Belongs to the complex I 30 kDa subunit family. (162 aa)
LOC102738241Mitogen-activated protein kinase kinase kinase 5-like. (795 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (166 aa)
LOC102728579Cytochrome c oxidase subunit 7A2, mitochondrial-like. (82 aa)
KIAA1958Uncharacterized protein KIAA1958 homolog. (292 aa)
TGFB1Transforming growth factor beta-1. (261 aa)
LOC102737840NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial-like. (212 aa)
LOC102749709CCAAT/enhancer-binding protein alpha-like. (165 aa)
SDHCSuccinate dehydrogenase cytochrome b560 subunit, mitochondrial isoform X1. (169 aa)
LOC102736516Phosphatidylinositol 3-kinase regulatory subunit alpha-like. (138 aa)
LOC102737233Cytochrome c oxidase subunit 5A, mitochondrial-like. (152 aa)
NDUFA10NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial. (267 aa)
LOC102743648NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. (139 aa)
LOC102743128Cytochrome c1, heme protein, mitochondrial-like. (266 aa)
LOC102746126Cytochrome c oxidase subunit 8A, mitochondrial-like. (69 aa)
LOC102731913Cytochrome b-c1 complex subunit 10-like. (56 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
NDUFB3NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3. (98 aa)
NDUFB5NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial isoform X1. (189 aa)
FOSProto-oncogene c-Fos isoform X1. (380 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1043 aa)
LOC102726230Cytochrome c oxidase subunit 6A, mitochondrial. (112 aa)
IL1AInterleukin-1; Belongs to the IL-1 family. (265 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (270 aa)
CASP3Caspase-3; Belongs to the peptidase C14A family. (302 aa)
NDUFA13NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13. (144 aa)
CASP7Caspase-7; Belongs to the peptidase C14A family. (301 aa)
YJEFN3yjeF N-terminal domain-containing protein 3. (250 aa)
CDC42Cell division control protein 42 homolog. (160 aa)
NDUFS2NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial. (242 aa)
IKBKBInhibitor of nuclear factor kappa-B kinase subunit beta isoform X1. (756 aa)
NDUFV1NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial; Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. (464 aa)
LOC102746004Bcl-2-like protein 11-like isoform X2. (140 aa)
LOC102739825Cytochrome c oxidase subunit; Belongs to the cytochrome c oxidase subunit 6B. (86 aa)
ADIPOR1Adiponectin receptor protein 1. (375 aa)
LOC102729372Cytochrome c oxidase subunit; Belongs to the cytochrome c oxidase subunit 6B. (86 aa)
IL6Interleukin-6 isoform X1. (212 aa)
LOC1027485835'-AMP-activated protein kinase subunit gamma-2-like. (129 aa)
SDHASuccinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial. (338 aa)
PRKAG25'-AMP-activated protein kinase subunit gamma-2-like isoform X2. (327 aa)
NDUFV2NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial isoform X1. (249 aa)
LOC102747789NADH dehydrogenase [ubiquinone] iron-sulfur protein 5-like. (107 aa)
GSK3BGlycogen synthase kinase-3 beta isoform X1; Belongs to the protein kinase superfamily. (433 aa)
NDUFA12NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. (145 aa)
LOC102726815Cytochrome c oxidase subunit 8A, mitochondrial-like. (69 aa)
EIF2AK3Eukaryotic translation initiation factor 2-alpha kinase 3 isoform X1. (1114 aa)
NDUFA4L2NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2. (87 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (418 aa)
LOC102750828Cytochrome b-c1 complex subunit 9-like. (64 aa)
NDUFA9NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial. (377 aa)
NDUFC2NADH dehydrogenase [ubiquinone] 1 subunit C2; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. (120 aa)
JUNTranscription factor AP-1; Belongs to the bZIP family. (335 aa)
PRKAB15'-AMP-activated protein kinase subunit beta-1. (270 aa)
NDUFS4NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial. (175 aa)
LOC102747288CCAAT/enhancer-binding protein alpha-like. (178 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
AKT1Non-specific serine/threonine protein kinase. (518 aa)
LOC102744846Cytochrome b-c1 complex subunit 2, mitochondrial-like; Belongs to the peptidase M16 family. (453 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
NDUFB7NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7. (137 aa)
NDUFC1NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial. (76 aa)
TNFRSF1ATumor necrosis factor receptor superfamily member 1A. (358 aa)
FASLGTumor necrosis factor ligand superfamily member 6. (130 aa)
NDUFA3NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3. (84 aa)
LOC102746787NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9-like. (139 aa)
LOC102750923Cytochrome c-like; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
IRS1Insulin receptor substrate 1-like isoform X1. (1236 aa)
LOC102739587Cytochrome c oxidase subunit 4 isoform 1, mitochondrial-like. (148 aa)
LOC102750335NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5-like isoform X2. (86 aa)
LOC102745146Tumor necrosis factor ligand superfamily member 6-like; Belongs to the tumor necrosis factor family. (173 aa)
PKLRPyruvate kinase; Belongs to the pyruvate kinase family. (428 aa)
LOC102748757Cytochrome b-c1 complex subunit 8-like isoform X1. (82 aa)
SOCS3Suppressor of cytokine signaling 3. (225 aa)
LOC102728825Cytochrome c oxidase subunit 5B, mitochondrial-like. (129 aa)
PRKAA1Non-specific serine/threonine protein kinase. (559 aa)
SDHDSuccinate dehydrogenase [ubiquinone] cytochrome b small subunit; Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q); Belongs to the CybS family. (159 aa)
LOC102725978Cytochrome c 2-like; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (109 aa)
NFKB1Nuclear factor NF-kappa-B p105 subunit. (254 aa)
NDUFA6NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed to be not involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. (128 aa)
NDUFB11NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial. (153 aa)
NDUFB4NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4. (129 aa)
NDUFA2NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. (99 aa)
LOC102746063Cytochrome c oxidase subunit 7A1, mitochondrial-like. (80 aa)
LOC102725676NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. (172 aa)
LOC102740357Cell division control protein 42 homolog. (191 aa)
NDUFAB1Acyl carrier protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis. (154 aa)
LOC102729606NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1-like. (70 aa)
NR1H3Oxysterols receptor LXR-alpha isoform X1. (456 aa)
ATF4Cyclic AMP-dependent transcription factor ATF-4. (351 aa)
LOC102729404Cytochrome c oxidase subunit 6A, mitochondrial. (97 aa)
IL8Multifunctional fusion protein; Belongs to the intercrine alpha (chemokine CxC) family. (104 aa)
LOC102750117Cytochrome c oxidase subunit 7A2, mitochondrial-like isoform X2. (82 aa)
MAPK10Mitogen-activated protein kinase. (464 aa)
LOC102735630Cytochrome b-c1 complex subunit 6; This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. This protein may mediate formation of the complex between cytochromes c and c1. Belongs to the UQCRH/QCR6 family. (91 aa)
LOC102751186Cytochrome c oxidase subunit 7C, mitochondrial-like. (63 aa)
PIK3R3Phosphatidylinositol 3-kinase regulatory subunit gamma. (461 aa)
LOC102727267Succinate dehydrogenase cytochrome b560 subunit, mitochondrial-like. (167 aa)
LOC102726446Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform-like; Belongs to the PI3/PI4-kinase family. (235 aa)
LOC102732026Cytochrome c oxidase subunit 7C, mitochondrial-like. (78 aa)
NDUFA5NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 isoform X1. (116 aa)
LOC102737931Cytochrome b-c1 complex subunit 7; Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain; Belongs to the UQCRB/QCR7 family. (79 aa)
LOC102726837Cytochrome c oxidase subunit 4 isoform 2, mitochondrial-like isoform X1. (171 aa)
LOC102729172NADH dehydrogenase [ubiquinone] iron-sulfur protein 5-like. (106 aa)
LOC102730680NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like. (82 aa)
LOC102748999Cytochrome c oxidase subunit 7B, mitochondrial-like isoform X1. (80 aa)
COX2Cytochrome c oxidase subunit 2; Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1. (227 aa)
COX3Cytochrome c oxidase subunit 3; Subunits I, II and III form the functional core of the enzyme complex. (261 aa)
COICytochrome c oxidase subunit 1; Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B. (514 aa)
LOC102741669Cytochrome c oxidase subunit 6A, mitochondrial. (59 aa)
LOC102734861BH3-interacting domain death agonist-like. (83 aa)
PRKAG15'-AMP-activated protein kinase subunit gamma-1 isoform X1. (298 aa)
LOC102742579Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial-like. (248 aa)
LOC102751021Phosphatidylinositol 3-kinase regulatory subunit alpha-like isoform X1. (454 aa)
LOC102738272Cytochrome c oxidase subunit 7B2, mitochondrial-like. (80 aa)
LOC102731352Serine/threonine-protein kinase/endoribonuclease IRE1-like. (414 aa)
Your Current Organism:
Leptonychotes weddellii
NCBI taxonomy Id: 9713
Other names: L. weddellii, Leptonychotes weddelli, Weddell seal
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