STRINGSTRING
VCAM1 VCAM1 LOC102730129 LOC102730129 LOC102751021 LOC102751021 LOC102731864 LOC102731864 LOC102740880 LOC102740880 MAPK11 MAPK11 LOC102735556 LOC102735556 LOC102741463 LOC102741463 FOXO1 FOXO1 STAT3 STAT3 STAT5A STAT5A DIAPH1 DIAPH1 AGT AGT LOC102729504 LOC102729504 LOC102730318 LOC102730318 PLCD1 PLCD1 LOC102740057 LOC102740057 LOC102730715 LOC102730715 LOC102729499 LOC102729499 LOC102729200 LOC102729200 LOC102750303 LOC102750303 TGFB3 TGFB3 TGFB1 TGFB1 LOC102736516 LOC102736516 ICAM1 ICAM1 PLCB3 PLCB3 VEGFB VEGFB NFATC1 NFATC1 PIK3CA PIK3CA PIK3CD PIK3CD IL1A IL1A LOC102730373 LOC102730373 IL1B IL1B CASP3 CASP3 CCND1 CCND1 CDC42 CDC42 LOC102735415 LOC102735415 NOX1 NOX1 MAPK1 MAPK1 NOX3 NOX3 IL6 IL6 COL4A4 COL4A4 MFF MFF THBD THBD LOC102740305 LOC102740305 LOC102742903 LOC102742903 CDK4 CDK4 AKT3 AKT3 VEGFC VEGFC SELE SELE JUN JUN LOC102730764 LOC102730764 STAT5B STAT5B LOC102745161 LOC102745161 TNF TNF ERAS ERAS AKT1 AKT1 TGFB2 TGFB2 MAPK8 MAPK8 LOC102748068 LOC102748068 JAK2 JAK2 EGR1 EGR1 AGER AGER PLCD3 PLCD3 PLCE1 PLCE1 MAPK12 MAPK12 FN1 FN1 SMAD4 SMAD4 PIM1 PIM1 TGFBR2 TGFBR2 SERPINE1 SERPINE1 CDKN1B CDKN1B COL4A1 COL4A1 NFKB1 NFKB1 PRKCZ PRKCZ LOC102740357 LOC102740357 COL1A2 COL1A2 IL8 IL8 MAPK10 MAPK10 PIK3R3 PIK3R3 CSDE1 CSDE1 NRAS NRAS LOC102726446 LOC102726446 KRAS KRAS
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
VCAM1Vascular cell adhesion protein 1. (377 aa)
LOC102730129Uncharacterized protein LOC102730129. (471 aa)
LOC102751021Phosphatidylinositol 3-kinase regulatory subunit alpha-like isoform X1. (454 aa)
LOC102731864Signal transducer and activator of transcription 5B-like. (353 aa)
LOC102740880Nitric oxide synthase, endothelial-like. (619 aa)
MAPK11Mitogen-activated protein kinase. (254 aa)
LOC102735556Mitogen-activated protein kinase 9-like. (134 aa)
LOC102741463Vascular cell adhesion protein 1-like. (318 aa)
FOXO1Forkhead box protein O1-like. (418 aa)
STAT3Signal transducer and activator of transcription 3-like. (424 aa)
STAT5ASignal transducer and activator of transcription 5A. (464 aa)
DIAPH1Protein diaphanous homolog 1. (850 aa)
AGTAngiotensinogen; Belongs to the serpin family. (477 aa)
LOC102729504Apoptosis regulator BAX-like. (212 aa)
LOC102730318Mothers against decapentaplegic homolog. (415 aa)
PLCD1Phosphoinositide phospholipase C. (597 aa)
LOC102740057Vascular endothelial growth factor A-like isoform X1; Belongs to the PDGF/VEGF growth factor family. (186 aa)
LOC1027307151-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2-like. (231 aa)
LOC102729499Collagen alpha-1(IV) chain-like. (112 aa)
LOC102729200Collagen alpha-1(IV) chain-like. (863 aa)
LOC102750303Collagen alpha-1(I) chain-like. (395 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
TGFB1Transforming growth factor beta-1. (261 aa)
LOC102736516Phosphatidylinositol 3-kinase regulatory subunit alpha-like. (138 aa)
ICAM1Intercellular adhesion molecule 1. (533 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1100 aa)
VEGFBVascular endothelial growth factor B isoform X1; Belongs to the PDGF/VEGF growth factor family. (207 aa)
NFATC1Nuclear factor of activated T-cells, cytoplasmic 1. (221 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1043 aa)
IL1AInterleukin-1; Belongs to the IL-1 family. (265 aa)
LOC102730373Cytochrome b-245 heavy chain-like. (550 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (270 aa)
CASP3Caspase-3; Belongs to the peptidase C14A family. (302 aa)
CCND1G1/S-specific cyclin-D1; Belongs to the cyclin family. (214 aa)
CDC42Cell division control protein 42 homolog. (160 aa)
LOC102735415Phosphoinositide phospholipase C. (309 aa)
NOX1NADPH oxidase 1 isoform X1. (564 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (326 aa)
NOX3NADPH oxidase 3. (566 aa)
IL6Interleukin-6 isoform X1. (212 aa)
COL4A4Collagen alpha-4(IV) chain-like. (1589 aa)
MFFMitochondrial fission factor isoform X2. (342 aa)
THBDThrombomodulin. (577 aa)
LOC1027403051-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1-like. (211 aa)
LOC102742903Collagen alpha-1(I) chain-like. (1116 aa)
CDK4Cyclin-dependent kinase 4; Belongs to the protein kinase superfamily. (303 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (418 aa)
VEGFCVascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (419 aa)
SELEE-selectin. (609 aa)
JUNTranscription factor AP-1; Belongs to the bZIP family. (335 aa)
LOC102730764Mothers against decapentaplegic homolog 2-like. (227 aa)
STAT5BSignal transducer and activator of transcription 5B. (508 aa)
LOC102745161Signal transducer and activator of transcription 3-like. (301 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
ERASGTPase ERas. (233 aa)
AKT1Non-specific serine/threonine protein kinase. (518 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
LOC102748068Cytochrome b-245 heavy chain-like. (135 aa)
JAK2Tyrosine-protein kinase. (952 aa)
EGR1Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (542 aa)
AGERAdvanced glycosylation end product-specific receptor. (397 aa)
PLCD3Phosphoinositide phospholipase C. (778 aa)
PLCE1Phosphoinositide phospholipase C. (2299 aa)
MAPK12Mitogen-activated protein kinase. (367 aa)
FN1Fibronectin isoform X1. (2476 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
PIM1Serine/threonine-protein kinase; Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily. (313 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (564 aa)
SERPINE1Plasminogen activator inhibitor 1; Belongs to the serpin family. (402 aa)
CDKN1BCyclin-dependent kinase inhibitor 1B. (198 aa)
COL4A1Collagen alpha-1(IV) chain. (321 aa)
NFKB1Nuclear factor NF-kappa-B p105 subunit. (254 aa)
PRKCZProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (557 aa)
LOC102740357Cell division control protein 42 homolog. (191 aa)
COL1A2Collagen alpha-2(I) chain. (1365 aa)
IL8Multifunctional fusion protein; Belongs to the intercrine alpha (chemokine CxC) family. (104 aa)
MAPK10Mitogen-activated protein kinase. (464 aa)
PIK3R3Phosphatidylinositol 3-kinase regulatory subunit gamma. (461 aa)
CSDE1Cold shock domain-containing protein E1 isoform X1. (845 aa)
NRASGTPase NRas. (189 aa)
LOC102726446Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform-like; Belongs to the PI3/PI4-kinase family. (235 aa)
KRASGTPase KRas isoform X2. (188 aa)
Your Current Organism:
Leptonychotes weddellii
NCBI taxonomy Id: 9713
Other names: L. weddellii, Leptonychotes weddelli, Weddell seal
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