STRINGSTRING
NCEH1 NCEH1 FZD7 FZD7 FZD3 FZD3 FZD2 FZD2 LOC102737081 LOC102737081 PRKACB PRKACB MEN1 MEN1 WNT8A WNT8A LOC102745156 LOC102745156 GNAI2 GNAI2 E2F2 E2F2 ITPR2 ITPR2 DVL3 DVL3 CACNA1F CACNA1F ATF6B ATF6B CREB3L3 CREB3L3 MAP2K2 MAP2K2 TCF7L1 TCF7L1 DVL2 DVL2 CCNE1 CCNE1 PDE8A PDE8A KCNA5 KCNA5 RAP1B RAP1B CDK4 CDK4 WNT10B WNT10B LOC102731038 LOC102731038 LOC102726484 LOC102726484 PRKACA PRKACA CDKN1A CDKN1A LOC102730119 LOC102730119 STAR STAR ARSI ARSI CAMK2A CAMK2A AGT AGT AIPL1 AIPL1 KCNA1 KCNA1 LOC102730715 LOC102730715 LOC102727679 LOC102727679 LOC102743561 LOC102743561 WNT2B WNT2B LOC102729806 LOC102729806 LOC102732653 LOC102732653 ORAI1 ORAI1 LOC102732238 LOC102732238 LOC102750211 LOC102750211 LOC102742748 LOC102742748 LOC102739552 LOC102739552 CRH CRH CREB3L1 CREB3L1 E2F3 E2F3 FZD4 FZD4 FH FH PLCB3 PLCB3 LOC102732818 LOC102732818 LOC102726140 LOC102726140 CDKN2A CDKN2A CDKN2B CDKN2B LOC102746012 LOC102746012 MC2R MC2R GNA11 GNA11 LOC102731813 LOC102731813 RASD1 RASD1 CCND1 CCND1 ADCY9 ADCY9 WNT4 WNT4 LDLR LDLR PDE8B PDE8B FZD9 FZD9 ITPR3 ITPR3 LOC102750183 LOC102750183 WNT3 WNT3 WNT9B WNT9B MAPK1 MAPK1 WNT3A WNT3A WNT11 WNT11 WDR5B WDR5B KCNK3 KCNK3 WNT6 WNT6 WNT10A WNT10A LOC102742813 LOC102742813 WNT5B WNT5B GSK3B GSK3B ATF2 ATF2 ITPR1 ITPR1 SP1 SP1 PTRHD1 PTRHD1 USP8 USP8 WNT5A WNT5A CACNA1G CACNA1G RB1 RB1 LOC102743616 LOC102743616 FZD10 FZD10 LEF1 LEF1 WNT16 WNT16 ARNT ARNT CDK2 CDK2 KCNA4 KCNA4 WNT1 WNT1 ADCY6 ADCY6 AHR AHR MAP2K1 MAP2K1 CCNE2 CCNE2 ATF4 ATF4 ARMC5 ARMC5 LOC102745940 LOC102745940 CDKN2C CDKN2C AXIN1 AXIN1 DVL1 DVL1 LOC102737670 LOC102737670 KCNA3 KCNA3 LOC102726697 LOC102726697 POMC POMC CDKN1B CDKN1B CREB1 CREB1 FZD5 FZD5 CAMK2G CAMK2G
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
NCEH1Neutral cholesterol ester hydrolase 1 isoform X2. (408 aa)
FZD7Frizzled-7; Belongs to the G-protein coupled receptor Fz/Smo family. (574 aa)
FZD3Frizzled-3 isoform X2; Belongs to the G-protein coupled receptor Fz/Smo family. (666 aa)
FZD2Frizzled-2; Belongs to the G-protein coupled receptor Fz/Smo family. (565 aa)
LOC102737081Steroid 21-hydroxylase-like; Belongs to the cytochrome P450 family. (492 aa)
PRKACBcAMP-dependent protein kinase catalytic subunit beta isoform X1; Belongs to the protein kinase superfamily. (397 aa)
MEN1Menin. (616 aa)
WNT8AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa)
LOC102745156Catenin beta-1-like isoform X1. (216 aa)
GNAI2Guanine nucleotide-binding protein G(I) subunit alpha-2. (303 aa)
E2F2Transcription factor E2F2. (440 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2-like. (2701 aa)
DVL3Segment polarity protein dishevelled homolog DVL-3 isoform X1. (716 aa)
CACNA1FVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1983 aa)
ATF6BCyclic AMP-dependent transcription factor ATF-6 beta. (623 aa)
CREB3L3Cyclic AMP-responsive element-binding protein 3-like protein 3. (466 aa)
MAP2K2Dual specificity mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa)
TCF7L1Transcription factor 7-like 1. (438 aa)
DVL2Segment polarity protein dishevelled homolog DVL-2 isoform X1. (734 aa)
CCNE1G1/S-specific cyclin-E1; Belongs to the cyclin family. (410 aa)
PDE8AHigh affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A. (142 aa)
KCNA5Potassium voltage-gated channel subfamily A member 5; Belongs to the potassium channel family. (603 aa)
RAP1BRas-related protein Rap-1b isoform X1. (184 aa)
CDK4Cyclin-dependent kinase 4; Belongs to the protein kinase superfamily. (303 aa)
WNT10BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa)
LOC102731038Adenylate cyclase type 9-like; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (564 aa)
LOC102726484Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (207 aa)
PRKACAcAMP-dependent protein kinase catalytic subunit alpha isoform X1; Belongs to the protein kinase superfamily. (351 aa)
CDKN1ACyclin-dependent kinase inhibitor 1 isoform X1. (161 aa)
LOC102730119set1/Ash2 histone methyltransferase complex subunit ASH2-like. (220 aa)
STARSteroidogenic acute regulatory protein, mitochondrial; Plays a key role in steroid hormone synthesis by enhancing the metabolism of cholesterol into pregnenolone. Mediates the transfer of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane where it is cleaved to pregnenolone. (281 aa)
ARSIArylsulfatase I. (575 aa)
CAMK2ACalcium/calmodulin-dependent protein kinase type II subunit alpha. (476 aa)
AGTAngiotensinogen; Belongs to the serpin family. (477 aa)
AIPL1Aryl-hydrocarbon-interacting protein-like 1. (328 aa)
KCNA1Potassium voltage-gated channel subfamily A member 1-like; Belongs to the potassium channel family. (495 aa)
LOC1027307151-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2-like. (231 aa)
LOC102727679Potassium voltage-gated channel subfamily A member 10-like; Belongs to the potassium channel family. (511 aa)
LOC102743561Corticotropin-releasing factor receptor 2-like. (76 aa)
WNT2BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (393 aa)
LOC102729806WD repeat-containing protein 5-like. (334 aa)
LOC102732653Nuclear receptor subfamily 4 group A member 1-like. (306 aa)
ORAI1Calcium release-activated calcium channel protein 1. (302 aa)
LOC102732238Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (265 aa)
LOC102750211Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (154 aa)
LOC1027427483 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase-like. (288 aa)
LOC102739552Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
CRHCorticoliberin. (196 aa)
CREB3L1Cyclic AMP-responsive element-binding protein 3-like protein 1. (474 aa)
E2F3Transcription factor E2F3-like isoform X1. (465 aa)
FZD4Frizzled-4; Belongs to the G-protein coupled receptor Fz/Smo family. (537 aa)
FHFumarate hydratase, mitochondrial. (508 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1100 aa)
LOC102732818Cytochrome P450 11B1, mitochondrial-like isoform X1; Belongs to the cytochrome P450 family. (503 aa)
LOC102726140Frizzled-1-like; Belongs to the G-protein coupled receptor Fz/Smo family. (647 aa)
CDKN2ACyclin-dependent kinase inhibitor 2A, isoforms 1/2/3. (152 aa)
CDKN2BCyclin-dependent kinase 4 inhibitor B. (138 aa)
LOC102746012Adenylate cyclase type 3-like; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (311 aa)
MC2RAdrenocorticotropic hormone receptor. (297 aa)
GNA11Guanine nucleotide-binding protein subunit alpha-11. (359 aa)
LOC102731813Frizzled-6-like; Belongs to the G-protein coupled receptor Fz/Smo family. (400 aa)
RASD1Dexamethasone-induced Ras-related protein 1. (313 aa)
CCND1G1/S-specific cyclin-D1; Belongs to the cyclin family. (214 aa)
ADCY9Adenylate cyclase type 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (790 aa)
WNT4Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (296 aa)
LDLRLow-density lipoprotein receptor. (861 aa)
PDE8BPhosphodiesterase. (445 aa)
FZD9Frizzled-9; Belongs to the G-protein coupled receptor Fz/Smo family. (407 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3. (557 aa)
LOC102750183Corticotropin-releasing factor receptor 1-like; Belongs to the G-protein coupled receptor 2 family. (357 aa)
WNT3Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (338 aa)
WNT9BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (218 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (326 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
WDR5BWD repeat-containing protein 5B. (306 aa)
KCNK3Potassium channel subfamily K member 3; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. (433 aa)
WNT6Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (362 aa)
WNT10AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (261 aa)
LOC102742813Neuroendocrine secretory protein 55-like. (246 aa)
WNT5BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (358 aa)
GSK3BGlycogen synthase kinase-3 beta isoform X1; Belongs to the protein kinase superfamily. (433 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2 isoform X2. (505 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1. (1244 aa)
SP1Transcription factor Sp1 isoform X1. (786 aa)
PTRHD1Putative peptidyl-tRNA hydrolase PTRHD1. (140 aa)
USP8Ubiquitin carboxyl-terminal hydrolase 8 isoform X1; Belongs to the peptidase C19 family. (1116 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
CACNA1GVoltage-dependent T-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This channel gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite ne [...] (2266 aa)
RB1Retinoblastoma-associated protein. (846 aa)
LOC102743616Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...] (520 aa)
FZD10Frizzled-10; Belongs to the G-protein coupled receptor Fz/Smo family. (581 aa)
LEF1Lymphoid enhancer-binding factor 1 isoform X1. (399 aa)
WNT16Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (149 aa)
ARNTAryl hydrocarbon receptor nuclear translocator isoform X1. (786 aa)
CDK2Cyclin-dependent kinase 2 isoform X1; Belongs to the protein kinase superfamily. (346 aa)
KCNA4Potassium voltage-gated channel subfamily A member 4; Belongs to the potassium channel family. (654 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
ADCY6Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1161 aa)
AHRAryl hydrocarbon receptor. (843 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1 isoform X1; Belongs to the protein kinase superfamily. (393 aa)
CCNE2G1/S-specific cyclin-E2; Belongs to the cyclin family. (344 aa)
ATF4Cyclic AMP-dependent transcription factor ATF-4. (351 aa)
ARMC5Armadillo repeat-containing protein 5. (943 aa)
LOC102745940Steroid 17-alpha-hydroxylase/17,20 lyase-like; Belongs to the cytochrome P450 family. (508 aa)
CDKN2CCyclin-dependent kinase 4 inhibitor C. (168 aa)
AXIN1Axin-1 isoform X1. (867 aa)
DVL1Segment polarity protein dishevelled homolog DVL-1 isoform X1. (693 aa)
LOC102737670Cyclin-dependent kinase 6-like. (322 aa)
KCNA3Potassium voltage-gated channel subfamily A member 3; Belongs to the potassium channel family. (439 aa)
LOC102726697Guanine nucleotide-binding protein G(I) subunit alpha-1-like isoform X1. (354 aa)
POMCPro-opiomelanocortin. (153 aa)
CDKN1BCyclin-dependent kinase inhibitor 1B. (198 aa)
CREB1Cyclic AMP-responsive element-binding protein 1 isoform X1. (341 aa)
FZD5Frizzled-5; Belongs to the G-protein coupled receptor Fz/Smo family. (574 aa)
CAMK2GCalcium/calmodulin-dependent protein kinase type II subunit gamma. (574 aa)
Your Current Organism:
Leptonychotes weddellii
NCBI taxonomy Id: 9713
Other names: L. weddellii, Leptonychotes weddelli, Weddell seal
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