(26 nodes) Type I diabetes mellitus network (Leptonychotes weddellii)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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protein homology

Your Input:
	PRF1	Perforin-1. (555 aa)
	LOC102734456	HLA class II histocompatibility antigen, DO alpha chain-like; Belongs to the MHC class II family. (250 aa)
	INS	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (110 aa)
	CPE	Carboxypeptidase E. (440 aa)
	HSPD1	60 kDa heat shock protein, mitochondrial isoform X1; Belongs to the chaperonin (HSP60) family. (573 aa)
	CD80	LOW QUALITY PROTEIN: T-lymphocyte activation antigen CD80. (295 aa)
	LOC102731758	Glutamate decarboxylase 1-like. (404 aa)
	GAD1	Glutamate decarboxylase 1. (460 aa)
	LOC102745146	Tumor necrosis factor ligand superfamily member 6-like; Belongs to the tumor necrosis factor family. (173 aa)
	IL12B	Interleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (279 aa)
	LOC102740784	HLA class II histocompatibility antigen, DR alpha chain-like; Belongs to the MHC class II family. (254 aa)
	LOC102741082	DLA class II histocompatibility antigen, DR-1 beta chain-like. (266 aa)
	FASLG	Tumor necrosis factor ligand superfamily member 6. (130 aa)
	LOC102748462	HLA class II histocompatibility antigen, DO beta chain-like. (273 aa)
	LOC102750454	HLA class II histocompatibility antigen, DM alpha chain-like; Belongs to the MHC class II family. (261 aa)
	LOC102750166	HLA class II histocompatibility antigen, DM beta chain-like. (263 aa)
	IL2	Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family. (154 aa)
	LTA	Lymphotoxin-alpha; Belongs to the tumor necrosis factor family. (204 aa)
	TNF	Tumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
	LOC102746195	DLA class I histocompatibility antigen, A9/A9 alpha chain-like. (189 aa)
	IFNG	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (166 aa)
	LOC102734859	Glutamate decarboxylase 1-like. (133 aa)
	IL12A	Interleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC. (222 aa)
	IL1B	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (270 aa)
	IL1A	Interleukin-1; Belongs to the IL-1 family. (265 aa)
	CD28	T-cell-specific surface glycoprotein CD28. (209 aa)

Your Current Organism:

Leptonychotes weddellii

NCBI taxonomy Id: 9713
Other names: L. weddellii, Leptonychotes weddelli, Weddell seal

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CD28	CD80	A0A2U3YTM8	A0A2U3XGM7	T-cell-specific surface glycoprotein CD28.	LOW QUALITY PROTEIN: T-lymphocyte activation antigen CD80.	0.984
CD28	IFNG	A0A2U3YTM8	A0A2U3Y8N2	T-cell-specific surface glycoprotein CD28.	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	0.449
CD28	IL2	A0A2U3YTM8	A0A2U3Y3E4	T-cell-specific surface glycoprotein CD28.	Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family.	0.560
CD80	CD28	A0A2U3XGM7	A0A2U3YTM8	LOW QUALITY PROTEIN: T-lymphocyte activation antigen CD80.	T-cell-specific surface glycoprotein CD28.	0.984
CD80	FASLG	A0A2U3XGM7	A0A2U3Y1M8	LOW QUALITY PROTEIN: T-lymphocyte activation antigen CD80.	Tumor necrosis factor ligand superfamily member 6.	0.435
CD80	IFNG	A0A2U3XGM7	A0A2U3Y8N2	LOW QUALITY PROTEIN: T-lymphocyte activation antigen CD80.	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	0.747
CD80	IL1A	A0A2U3XGM7	A0A2U3YMJ2	LOW QUALITY PROTEIN: T-lymphocyte activation antigen CD80.	Interleukin-1; Belongs to the IL-1 family.	0.535
CD80	IL1B	A0A2U3XGM7	A0A2U3YM52	LOW QUALITY PROTEIN: T-lymphocyte activation antigen CD80.	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family.	0.652
CD80	IL2	A0A2U3XGM7	A0A2U3Y3E4	LOW QUALITY PROTEIN: T-lymphocyte activation antigen CD80.	Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family.	0.675
CD80	INS	A0A2U3XGM7	A0A2U3Z329	LOW QUALITY PROTEIN: T-lymphocyte activation antigen CD80.	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.453
CD80	LOC102740784	A0A2U3XGM7	A0A2U3XXW2	LOW QUALITY PROTEIN: T-lymphocyte activation antigen CD80.	HLA class II histocompatibility antigen, DR alpha chain-like; Belongs to the MHC class II family.	0.634
CD80	LOC102746195	A0A2U3XGM7	A0A2U3Y4L7	LOW QUALITY PROTEIN: T-lymphocyte activation antigen CD80.	DLA class I histocompatibility antigen, A9/A9 alpha chain-like.	0.462
CD80	TNF	A0A2U3XGM7	A0A2U3Y499	LOW QUALITY PROTEIN: T-lymphocyte activation antigen CD80.	Tumor necrosis factor; Belongs to the tumor necrosis factor family.	0.722
CPE	INS	A0A2U3X755	A0A2U3Z329	Carboxypeptidase E.	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.739
FASLG	CD80	A0A2U3Y1M8	A0A2U3XGM7	Tumor necrosis factor ligand superfamily member 6.	LOW QUALITY PROTEIN: T-lymphocyte activation antigen CD80.	0.435
FASLG	IFNG	A0A2U3Y1M8	A0A2U3Y8N2	Tumor necrosis factor ligand superfamily member 6.	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	0.714
FASLG	IL1B	A0A2U3Y1M8	A0A2U3YM52	Tumor necrosis factor ligand superfamily member 6.	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family.	0.471
FASLG	IL2	A0A2U3Y1M8	A0A2U3Y3E4	Tumor necrosis factor ligand superfamily member 6.	Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family.	0.501
FASLG	LOC102745146	A0A2U3Y1M8	A0A2U3XU33	Tumor necrosis factor ligand superfamily member 6.	Tumor necrosis factor ligand superfamily member 6-like; Belongs to the tumor necrosis factor family.	0.934
FASLG	PRF1	A0A2U3Y1M8	A0A2U3YUQ2	Tumor necrosis factor ligand superfamily member 6.	Perforin-1.	0.682