(37 nodes) Vasopressin-regulated water reabsorption network (Leptonychotes weddellii)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	RAB5A	Ras-related protein Rab-5A isoform X1. (215 aa)
	LOC102734471	Dynactin subunit 1-like. (1117 aa)
	LOC102731038	Adenylate cyclase type 9-like; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (564 aa)
	PRKACA	cAMP-dependent protein kinase catalytic subunit alpha isoform X1; Belongs to the protein kinase superfamily. (351 aa)
	LOC102736866	Cytoplasmic dynein 1 heavy chain 1-like. (856 aa)
	CREB3L1	Cyclic AMP-responsive element-binding protein 3-like protein 1. (474 aa)
	LOC102732933	Dynactin subunit 6-like. (127 aa)
	DYNC2LI1	Cytoplasmic dynein 2 light intermediate chain 1. (350 aa)
	AQP4	Aquaporin-4; Belongs to the MIP/aquaporin (TC 1.A.8) family. (301 aa)
	LOC102746012	Adenylate cyclase type 3-like; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (311 aa)
	DYNLL1	Dynein light chain. (89 aa)
	ADCY9	Adenylate cyclase type 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (790 aa)
	LOC102725834	Vesicle-fusing ATPase-like. (290 aa)
	NSF	Vesicle-fusing ATPase-like. (285 aa)
	AQP10	LOW QUALITY PROTEIN: aquaporin-10; Belongs to the MIP/aquaporin (TC 1.A.8) family. (297 aa)
	ARHGDIA	Rho GDP-dissociation inhibitor 1 isoform X1. (204 aa)
	LOC102742813	Neuroendocrine secretory protein 55-like. (246 aa)
	DYNC2H1	Cytoplasmic dynein 2 heavy chain 1. (386 aa)
	PTRHD1	Putative peptidyl-tRNA hydrolase PTRHD1. (140 aa)
	DCTN4	Dynactin subunit 4 isoform X2. (467 aa)
	DYNC1LI1	Dynein light intermediate chain; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes. (524 aa)
	DCTN2	Dynactin subunit 2 isoform X2. (405 aa)
	CREB3L3	Cyclic AMP-responsive element-binding protein 3-like protein 3. (466 aa)
	RAB5C	Ras-related protein Rab-5C. (158 aa)
	PRKACB	cAMP-dependent protein kinase catalytic subunit beta isoform X1; Belongs to the protein kinase superfamily. (397 aa)
	LOC102746878	Cytoplasmic dynein 1 intermediate chain 1-like. (158 aa)
	AQP3	Aquaporin-3; Belongs to the MIP/aquaporin (TC 1.A.8) family. (292 aa)
	RAB11B	Ras-related protein Rab-11B. (218 aa)
	CREB1	Cyclic AMP-responsive element-binding protein 1 isoform X1. (341 aa)
	ARHGDIG	Rho GDP-dissociation inhibitor 3. (220 aa)
	DYNC1LI2	Dynein light intermediate chain; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes. (472 aa)
	DYNC1I2	Cytoplasmic dynein 1 intermediate chain 2 isoform X1. (638 aa)
	DCTN5	Dynactin subunit 5. (182 aa)
	LOC102736746	Cytoplasmic dynein 1 intermediate chain 1-like. (396 aa)
	STX4	Syntaxin-4; Belongs to the syntaxin family. (297 aa)
	ADCY6	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1161 aa)
	RAB5B	Ras-related protein Rab-5B isoform X1. (215 aa)

Your Current Organism:

Leptonychotes weddellii

NCBI taxonomy Id: 9713
Other names: L. weddellii, Leptonychotes weddelli, Weddell seal

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADCY6	ADCY9	A0A2U3XDB9	A0A2U3YLR7	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	0.920
ADCY6	LOC102731038	A0A2U3XDB9	A0A2U3Z797	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 9-like; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	0.842
ADCY6	LOC102742813	A0A2U3XDB9	A0A2U3YGK0	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Neuroendocrine secretory protein 55-like.	0.810
ADCY6	LOC102746012	A0A2U3XDB9	A0A2U3YPK1	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 3-like; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	0.895
ADCY6	PRKACA	A0A2U3XDB9	A0A2U3Z6A9	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	cAMP-dependent protein kinase catalytic subunit alpha isoform X1; Belongs to the protein kinase superfamily.	0.919
ADCY6	PRKACB	A0A2U3XDB9	A0A2U3XZU0	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	cAMP-dependent protein kinase catalytic subunit beta isoform X1; Belongs to the protein kinase superfamily.	0.928
ADCY6	PTRHD1	A0A2U3XDB9	A0A2U3YCC1	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Putative peptidyl-tRNA hydrolase PTRHD1.	0.797
ADCY9	ADCY6	A0A2U3YLR7	A0A2U3XDB9	Adenylate cyclase type 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.920
ADCY9	LOC102731038	A0A2U3YLR7	A0A2U3Z797	Adenylate cyclase type 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	Adenylate cyclase type 9-like; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	0.921
ADCY9	LOC102742813	A0A2U3YLR7	A0A2U3YGK0	Adenylate cyclase type 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	Neuroendocrine secretory protein 55-like.	0.896
ADCY9	LOC102746012	A0A2U3YLR7	A0A2U3YPK1	Adenylate cyclase type 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	Adenylate cyclase type 3-like; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	0.992
ADCY9	PRKACA	A0A2U3YLR7	A0A2U3Z6A9	Adenylate cyclase type 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	cAMP-dependent protein kinase catalytic subunit alpha isoform X1; Belongs to the protein kinase superfamily.	0.938
ADCY9	PRKACB	A0A2U3YLR7	A0A2U3XZU0	Adenylate cyclase type 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	cAMP-dependent protein kinase catalytic subunit beta isoform X1; Belongs to the protein kinase superfamily.	0.937
ADCY9	PTRHD1	A0A2U3YLR7	A0A2U3YCC1	Adenylate cyclase type 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	Putative peptidyl-tRNA hydrolase PTRHD1.	0.815
AQP10	AQP3	A0A2U3YIJ7	A0A2U3XT82	LOW QUALITY PROTEIN: aquaporin-10; Belongs to the MIP/aquaporin (TC 1.A.8) family.	Aquaporin-3; Belongs to the MIP/aquaporin (TC 1.A.8) family.	0.415
AQP10	AQP4	A0A2U3YIJ7	A0A2U3YPU6	LOW QUALITY PROTEIN: aquaporin-10; Belongs to the MIP/aquaporin (TC 1.A.8) family.	Aquaporin-4; Belongs to the MIP/aquaporin (TC 1.A.8) family.	0.812
AQP3	AQP10	A0A2U3XT82	A0A2U3YIJ7	Aquaporin-3; Belongs to the MIP/aquaporin (TC 1.A.8) family.	LOW QUALITY PROTEIN: aquaporin-10; Belongs to the MIP/aquaporin (TC 1.A.8) family.	0.415
AQP3	AQP4	A0A2U3XT82	A0A2U3YPU6	Aquaporin-3; Belongs to the MIP/aquaporin (TC 1.A.8) family.	Aquaporin-4; Belongs to the MIP/aquaporin (TC 1.A.8) family.	0.656
AQP4	AQP10	A0A2U3YPU6	A0A2U3YIJ7	Aquaporin-4; Belongs to the MIP/aquaporin (TC 1.A.8) family.	LOW QUALITY PROTEIN: aquaporin-10; Belongs to the MIP/aquaporin (TC 1.A.8) family.	0.812
AQP4	AQP3	A0A2U3YPU6	A0A2U3XT82	Aquaporin-4; Belongs to the MIP/aquaporin (TC 1.A.8) family.	Aquaporin-3; Belongs to the MIP/aquaporin (TC 1.A.8) family.	0.656