(67 nodes) Morphine addiction network (Leptonychotes weddellii)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	GRK6	G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. (582 aa)
	GNB5	Guanine nucleotide-binding protein subunit beta-5. (345 aa)
	GNG10	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
	GABRR2	Gamma-aminobutyric acid receptor subunit rho-2; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (507 aa)
	GABRR1	Gamma-aminobutyric acid receptor subunit rho-1; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (456 aa)
	GNB2	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 isoform X1. (340 aa)
	OPRM1	Mu-type opioid receptor isoform X1; Belongs to the G-protein coupled receptor 1 family. (403 aa)
	GABRP	Gamma-aminobutyric acid receptor subunit pi; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (440 aa)
	PDE4B	cAMP-specific 3',5'-cyclic phosphodiesterase 4B. (284 aa)
	GABRE	Gamma-aminobutyric acid receptor subunit epsilon-like; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (493 aa)
	PRKACB	cAMP-dependent protein kinase catalytic subunit beta isoform X1; Belongs to the protein kinase superfamily. (397 aa)
	GNG5	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
	GNAI2	Guanine nucleotide-binding protein G(I) subunit alpha-2. (303 aa)
	GNB3	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3. (340 aa)
	PDE7B	Phosphodiesterase. (446 aa)
	GNG13	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13. (67 aa)
	PDE8A	High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A. (142 aa)
	SLC32A1	Vesicular inhibitory amino acid transporter. (526 aa)
	LOC102745475	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1-like isoform X1. (340 aa)
	LOC102734981	Gamma-aminobutyric acid receptor subunit beta-1-like; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (295 aa)
	PDE4A	Phosphodiesterase. (843 aa)
	PDE7A	Phosphodiesterase. (483 aa)
	PTRHD1	Putative peptidyl-tRNA hydrolase PTRHD1. (140 aa)
	GNGT2	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (69 aa)
	LOC102742813	Neuroendocrine secretory protein 55-like. (246 aa)
	PDE3B	Phosphodiesterase. (1180 aa)
	ADRBK1	G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. (647 aa)
	PDE8B	Phosphodiesterase. (445 aa)
	ADCY9	Adenylate cyclase type 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (790 aa)
	GNG8	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (70 aa)
	LOC102746012	Adenylate cyclase type 3-like; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (311 aa)
	LOC102736718	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (72 aa)
	GNG4	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
	GNG2	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (71 aa)
	KCNJ9	G protein-activated inward rectifier potassium channel 3. (385 aa)
	GNAO1	Guanine nucleotide-binding protein G(O) subunit alpha. (311 aa)
	KCNJ6	G protein-activated inward rectifier potassium channel 2-like. (407 aa)
	LOC102747137	G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. (140 aa)
	GNB4	Guanine nucleotide-binding protein subunit beta-4. (340 aa)
	LOC102748147	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (72 aa)
	GABRQ	Gamma-aminobutyric acid receptor subunit theta-like; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (628 aa)
	PRKACA	cAMP-dependent protein kinase catalytic subunit alpha isoform X1; Belongs to the protein kinase superfamily. (351 aa)
	LOC102745857	Phosphodiesterase. (503 aa)
	LOC102731038	Adenylate cyclase type 9-like; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (564 aa)
	GABRD	Gamma-aminobutyric acid receptor subunit delta-like; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (452 aa)
	GABRA2	Gamma-aminobutyric acid receptor subunit alpha-2; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (451 aa)
	GABRA4	Gamma-aminobutyric acid receptor subunit alpha-4 isoform X1; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (555 aa)
	GABRG1	Gamma-aminobutyric acid receptor subunit gamma-1 isoform X1; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (472 aa)
	LOC102743643	Gamma-aminobutyric acid receptor subunit beta-1-like; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (209 aa)
	PDE4D	Phosphodiesterase. (811 aa)
	GABRB3	Gamma-aminobutyric acid receptor subunit beta-3-like; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (388 aa)
	GABRA5	Gamma-aminobutyric acid receptor subunit alpha-5; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (463 aa)
	PDE1B	Phosphodiesterase. (535 aa)
	ADCY6	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1161 aa)
	PDE10A	Phosphodiesterase. (794 aa)
	GNG3	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
	PDE2A	Phosphodiesterase. (943 aa)
	GABRB2	Gamma-aminobutyric acid receptor subunit beta-2; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (364 aa)
	GABRA6	Gamma-aminobutyric acid receptor subunit alpha-6; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (453 aa)
	GABRA1	Gamma-aminobutyric acid receptor subunit alpha-1 isoform X1; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (456 aa)
	GABRG2	Gamma-aminobutyric acid receptor subunit gamma-2 isoform X2; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (475 aa)
	KCNJ5	G protein-activated inward rectifier potassium channel 4. (430 aa)
	KCNJ3	G protein-activated inward rectifier potassium channel 1 isoform X1. (501 aa)
	DRD1	D(1A) dopamine receptor; Belongs to the G-protein coupled receptor 1 family. (446 aa)
	GNGT1	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (74 aa)
	GNG11	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (73 aa)
	LOC102726697	Guanine nucleotide-binding protein G(I) subunit alpha-1-like isoform X1. (354 aa)

Your Current Organism:

Leptonychotes weddellii

NCBI taxonomy Id: 9713
Other names: L. weddellii, Leptonychotes weddelli, Weddell seal

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADCY6	ADCY9	A0A2U3XDB9	A0A2U3YLR7	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	0.920
ADCY6	GNAI2	A0A2U3XDB9	A0A2U3Y188	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Guanine nucleotide-binding protein G(I) subunit alpha-2.	0.826
ADCY6	GNAO1	A0A2U3XDB9	A0A2U3YV57	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Guanine nucleotide-binding protein G(O) subunit alpha.	0.923
ADCY6	GNB2	A0A2U3XDB9	A0A2U3XQS7	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 isoform X1.	0.820
ADCY6	GNB3	A0A2U3XDB9	A0A2U3Y2J3	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3.	0.820
ADCY6	GNB4	A0A2U3XDB9	A0A2U3Z2R3	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Guanine nucleotide-binding protein subunit beta-4.	0.802
ADCY6	GNB5	A0A2U3XDB9	A0A2U3XPJ8	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Guanine nucleotide-binding protein subunit beta-5.	0.820
ADCY6	GNG10	A0A2U3XDB9	A0A2U3XQ47	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	0.822
ADCY6	GNG11	A0A2U3XDB9	A0A2U3XNE9	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	0.817
ADCY6	GNG13	A0A2U3XDB9	A0A2U3Y623	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13.	0.820
ADCY6	GNG2	A0A2U3XDB9	A0A2U3YSQ4	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	0.817
ADCY6	GNG3	A0A2U3XDB9	A0A2U3XFZ3	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	0.816
ADCY6	GNG4	A0A2U3XDB9	A0A2U3YRJ3	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	0.817
ADCY6	GNG5	A0A2U3XDB9	A0A2U3XZW5	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	0.813
ADCY6	GNG8	A0A2U3XDB9	A0A2U3YMQ8	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	0.813
ADCY6	GNGT1	A0A2U3XDB9	A0A2U3XNE6	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	0.817
ADCY6	GNGT2	A0A2U3XDB9	A0A2U3YCQ1	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	0.813
ADCY6	KCNJ9	A0A2U3XDB9	A0A2U3YUC3	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	G protein-activated inward rectifier potassium channel 3.	0.482
ADCY6	LOC102726697	A0A2U3XDB9	A0A2U3XNG2	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Guanine nucleotide-binding protein G(I) subunit alpha-1-like isoform X1.	0.826
ADCY6	LOC102731038	A0A2U3XDB9	A0A2U3Z797	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 9-like; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	0.842