STRINGSTRING
ITGAM ITGAM HSF4 HSF4 VCP VCP HSPA2 HSPA2 LOC102734190 LOC102734190 TNF TNF HSPA1L HSPA1L LOC102748768 LOC102748768 HBS1L HBS1L EEF1A2 EEF1A2 LOC102750923 LOC102750923 LOC102744217 LOC102744217 CLK2 CLK2 APAF1 APAF1 CLK4 CLK4 SAR1B SAR1B NLRC4 NLRC4 LOC102726691 LOC102726691 NFKBIA NFKBIA NFKB1 NFKB1 LOC102728215 LOC102728215 IL18 IL18 LOC102725978 LOC102725978 CLK1 CLK1 LOC102741456 LOC102741456 NFKB2 NFKB2 LOC102742576 LOC102742576 LOC102739283 LOC102739283 TLR5 TLR5 HSF1 HSF1 OTUD3 OTUD3 RAB1A RAB1A LOC102726062 LOC102726062 CASP9 CASP9 CASP8 CASP8 CLK3 CLK3 SAR1A SAR1A MYD88 MYD88 LOC102725545 LOC102725545 IL1B IL1B CASP3 CASP3 CASP7 CASP7 LOC102750470 LOC102750470 ARF1 ARF1 IL6 IL6 IL12A IL12A IL12B IL12B LOC102731213 LOC102731213 HSF2 HSF2 HSPD1 HSPD1 EEF1A1 EEF1A1 LOC102739252 LOC102739252 IL8 IL8 PYCARD PYCARD
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ITGAMIntegrin alpha-M isoform X1; Belongs to the integrin alpha chain family. (1154 aa)
HSF4Heat shock factor protein 4 isoform X1. (493 aa)
VCPTransitional endoplasmic reticulum ATPase isoform X1; Belongs to the AAA ATPase family. (806 aa)
HSPA2Heat shock-related 70 kDa protein 2; Belongs to the heat shock protein 70 family. (636 aa)
LOC102734190Heat shock 70 kDa protein 1-like; Belongs to the heat shock protein 70 family. (641 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
HSPA1LHeat shock 70 kDa protein 1-like; Belongs to the heat shock protein 70 family. (641 aa)
LOC102748768Uncharacterized protein LOC102748768. (634 aa)
HBS1LHBS1-like protein. (162 aa)
EEF1A2Elongation factor 1-alpha; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis. (463 aa)
LOC102750923Cytochrome c-like; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
LOC102744217Heat shock factor protein 5-like. (278 aa)
CLK2Dual specificity protein kinase CLK2; Belongs to the protein kinase superfamily. (500 aa)
APAF1Apoptotic protease-activating factor 1. (511 aa)
CLK4Dual specificity protein kinase CLK4; Belongs to the protein kinase superfamily. (481 aa)
SAR1BGTP-binding protein SAR1b; Belongs to the small GTPase superfamily. SAR1 family. (198 aa)
NLRC4LOW QUALITY PROTEIN: NLR family CARD domain-containing protein 4. (908 aa)
LOC102726691BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like isoform X2. (194 aa)
NFKBIANF-kappa-B inhibitor alpha isoform X2. (314 aa)
NFKB1Nuclear factor NF-kappa-B p105 subunit. (254 aa)
LOC102728215Complement C3-like. (768 aa)
IL18Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (193 aa)
LOC102725978Cytochrome c 2-like; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (109 aa)
CLK1Dual specificity protein kinase CLK1; Belongs to the protein kinase superfamily. (484 aa)
LOC102741456Heat shock factor protein 5-like. (256 aa)
NFKB2Nuclear factor NF-kappa-B p100 subunit. (900 aa)
LOC102742576C-X-C motif chemokine. (107 aa)
LOC102739283Heat shock cognate 71 kDa protein-like. (196 aa)
TLR5LOW QUALITY PROTEIN: toll-like receptor 5; Belongs to the Toll-like receptor family. (834 aa)
HSF1Heat shock factor protein 1. (527 aa)
OTUD3OTU domain-containing protein 3. (395 aa)
RAB1ARas-related protein Rab-1A isoform X1. (205 aa)
LOC102726062Uncharacterized protein C7orf31 homolog. (590 aa)
CASP9Caspase-9. (171 aa)
CASP8Caspase-8 isoform X1; Belongs to the peptidase C14A family. (486 aa)
CLK3Dual specificity protein kinase CLK3 isoform X1; Belongs to the protein kinase superfamily. (490 aa)
SAR1AGTP-binding protein SAR1a; Belongs to the small GTPase superfamily. SAR1 family. (198 aa)
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (296 aa)
LOC102725545Caspase-9-like; Belongs to the peptidase C14A family. (275 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (270 aa)
CASP3Caspase-3; Belongs to the peptidase C14A family. (302 aa)
CASP7Caspase-7; Belongs to the peptidase C14A family. (301 aa)
LOC102750470ADP-ribosylation factor 2-like isoform X2; Belongs to the small GTPase superfamily. Arf family. (181 aa)
ARF1ADP-ribosylation factor 1; Belongs to the small GTPase superfamily. Arf family. (181 aa)
IL6Interleukin-6 isoform X1. (212 aa)
IL12AInterleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC. (222 aa)
IL12BInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (279 aa)
LOC102731213Heat shock cognate 71 kDa protein-like isoform X1; Belongs to the heat shock protein 70 family. (646 aa)
HSF2Heat shock factor protein 2. (517 aa)
HSPD160 kDa heat shock protein, mitochondrial isoform X1; Belongs to the chaperonin (HSP60) family. (573 aa)
EEF1A1Elongation factor 1-alpha; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis. (462 aa)
LOC102739252Heat shock cognate 71 kDa protein-like. (395 aa)
IL8Multifunctional fusion protein; Belongs to the intercrine alpha (chemokine CxC) family. (104 aa)
PYCARDApoptosis-associated speck-like protein containing a CARD isoform X1. (194 aa)
Your Current Organism:
Leptonychotes weddellii
NCBI taxonomy Id: 9713
Other names: L. weddellii, Leptonychotes weddelli, Weddell seal
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