STRINGSTRING
PPP2R2A PPP2R2A FADD FADD GNAI2 GNAI2 FASLG FASLG TNFRSF1A TNFRSF1A IL2 IL2 MAPK8 MAPK8 TGFB2 TGFB2 C1QB C1QB C1QC C1QC AKT1 AKT1 TNF TNF IL12B IL12B LOC102734398 LOC102734398 CD3D CD3D IL12A IL12A LOC102742813 LOC102742813 IL6 IL6 KNG1 KNG1 PPP2R2C PPP2R2C MAPK1 MAPK1 IKBKB IKBKB LOC102740920 LOC102740920 IL1B IL1B GNA11 GNA11 GNA15 GNA15 PIK3CD PIK3CD FOS FOS PIK3CA PIK3CA PLCB3 PLCB3 LOC102736516 LOC102736516 LOC102732031 LOC102732031 GNAO1 GNAO1 TGFB1 TGFB1 TGFB3 TGFB3 LOC102730764 LOC102730764 LOC102735431 LOC102735431 GNAL GNAL LOC102751087 LOC102751087 CASP8 CASP8 LOC102730715 LOC102730715 LOC102734642 LOC102734642 MYD88 MYD88 LOC102730629 LOC102730629 TWF2 TWF2 LOC102735556 LOC102735556 MAPK11 MAPK11 LOC102751021 LOC102751021 IKBKG IKBKG JUN JUN AKT3 AKT3 IFNG IFNG LOC102728244 LOC102728244 ACE ACE CHUK CHUK LOC102730162 LOC102730162 IFNGR2 IFNGR2 TRAF6 TRAF6 BDKRB2 BDKRB2 CD247 CD247 MAPK12 MAPK12 LOC102745146 LOC102745146 IL10 IL10 TGFBR2 TGFBR2 LOC102728215 LOC102728215 SERPINE1 SERPINE1 AADACL2 AADACL2 AADAC AADAC IFNB1 IFNB1 LOC102726697 LOC102726697 NFKB1 NFKB1 TLR6 TLR6 NFKBIA NFKBIA PPP2CB PPP2CB LOC102751010 LOC102751010 GNA14 GNA14 CALR CALR IRAK4 IRAK4 IL8 IL8 MAPK10 MAPK10 PIK3R3 PIK3R3 LOC102726446 LOC102726446
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PPP2R2ASerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (447 aa)
FADDFAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (218 aa)
GNAI2Guanine nucleotide-binding protein G(I) subunit alpha-2. (303 aa)
FASLGTumor necrosis factor ligand superfamily member 6. (130 aa)
TNFRSF1ATumor necrosis factor receptor superfamily member 1A. (358 aa)
IL2Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family. (154 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
C1QBComplement C1q subcomponent subunit B. (249 aa)
C1QCComplement C1q subcomponent subunit C. (245 aa)
AKT1Non-specific serine/threonine protein kinase. (518 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
IL12BInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (279 aa)
LOC102734398T-cell surface glycoprotein CD3 gamma chain-like. (167 aa)
CD3DT-cell surface glycoprotein CD3 delta chain. (171 aa)
IL12AInterleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC. (222 aa)
LOC102742813Neuroendocrine secretory protein 55-like. (246 aa)
IL6Interleukin-6 isoform X1. (212 aa)
KNG1Kininogen-1 isoform X1. (652 aa)
PPP2R2CSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B gamma isoform. (231 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (326 aa)
IKBKBInhibitor of nuclear factor kappa-B kinase subunit beta isoform X1. (756 aa)
LOC102740920C-C motif chemokine. (91 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (270 aa)
GNA11Guanine nucleotide-binding protein subunit alpha-11. (359 aa)
GNA15Guanine nucleotide-binding protein subunit alpha-15. (374 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1043 aa)
FOSProto-oncogene c-Fos isoform X1. (380 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1100 aa)
LOC102736516Phosphatidylinositol 3-kinase regulatory subunit alpha-like. (138 aa)
LOC102732031Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform-like. (407 aa)
GNAO1Guanine nucleotide-binding protein G(O) subunit alpha. (311 aa)
TGFB1Transforming growth factor beta-1. (261 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
LOC102730764Mothers against decapentaplegic homolog 2-like. (227 aa)
LOC102735431C-C motif chemokine. (93 aa)
GNALGuanine nucleotide-binding protein G(Olf) subunit alpha. (174 aa)
LOC102751087Nitric oxide synthase, inducible-like. (430 aa)
CASP8Caspase-8 isoform X1; Belongs to the peptidase C14A family. (486 aa)
LOC1027307151-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2-like. (231 aa)
LOC102734642Guanine nucleotide-binding protein G(Olf) subunit alpha-like. (209 aa)
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (296 aa)
LOC102730629Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (288 aa)
TWF2Toll-like receptor 9-like isoform X1. (1331 aa)
LOC102735556Mitogen-activated protein kinase 9-like. (134 aa)
MAPK11Mitogen-activated protein kinase. (254 aa)
LOC102751021Phosphatidylinositol 3-kinase regulatory subunit alpha-like isoform X1. (454 aa)
IKBKGNF-kappa-B essential modulator isoform X2. (419 aa)
JUNTranscription factor AP-1; Belongs to the bZIP family. (335 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (418 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (166 aa)
LOC102728244Interleukin-1 receptor-associated kinase 1-like. (299 aa)
ACEAngiotensin-converting enzyme. (1311 aa)
CHUKInhibitor of nuclear factor kappa-B kinase subunit alpha. (745 aa)
LOC102730162T-cell surface glycoprotein CD3 gamma chain-like. (182 aa)
IFNGR2Interferon gamma receptor 2. (115 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (541 aa)
BDKRB2B2 bradykinin receptor; Belongs to the G-protein coupled receptor 1 family. (392 aa)
CD247T-cell surface glycoprotein CD3 zeta chain. (166 aa)
MAPK12Mitogen-activated protein kinase. (367 aa)
LOC102745146Tumor necrosis factor ligand superfamily member 6-like; Belongs to the tumor necrosis factor family. (173 aa)
IL10Interleukin-10. (178 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (564 aa)
LOC102728215Complement C3-like. (768 aa)
SERPINE1Plasminogen activator inhibitor 1; Belongs to the serpin family. (402 aa)
AADACL2LOW QUALITY PROTEIN: arylacetamide deacetylase-like 2. (400 aa)
AADACArylacetamide deacetylase. (399 aa)
IFNB1Interferon beta. (182 aa)
LOC102726697Guanine nucleotide-binding protein G(I) subunit alpha-1-like isoform X1. (354 aa)
NFKB1Nuclear factor NF-kappa-B p105 subunit. (254 aa)
TLR6Toll-like receptor. (794 aa)
NFKBIANF-kappa-B inhibitor alpha isoform X2. (314 aa)
PPP2CBSerine/threonine-protein phosphatase. (308 aa)
LOC102751010Nitric oxide synthase, inducible-like. (531 aa)
GNA14Guanine nucleotide-binding protein subunit alpha-14. (355 aa)
CALRCalreticulin. (417 aa)
IRAK4Interleukin-1 receptor-associated kinase 4 isoform X1. (459 aa)
IL8Multifunctional fusion protein; Belongs to the intercrine alpha (chemokine CxC) family. (104 aa)
MAPK10Mitogen-activated protein kinase. (464 aa)
PIK3R3Phosphatidylinositol 3-kinase regulatory subunit gamma. (461 aa)
LOC102726446Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform-like; Belongs to the PI3/PI4-kinase family. (235 aa)
Your Current Organism:
Leptonychotes weddellii
NCBI taxonomy Id: 9713
Other names: L. weddellii, Leptonychotes weddelli, Weddell seal
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