STRINGSTRING
TNF TNF CYGB CYGB VCAM1 VCAM1 IDO1 IDO1 HBM HBM HBQ1 HBQ1 LOC102731149 LOC102731149 LOC102739871 LOC102739871 LOC102740167 LOC102740167 AADAC AADAC AADACL2 AADACL2 IL18 IL18 IL10 IL10 LOC102745146 LOC102745146 F2RL1 F2RL1 NPPA NPPA APOA1 APOA1 LOC102728820 LOC102728820 LOC102747458 LOC102747458 LOC102741463 LOC102741463 TWF2 TWF2 NGB NGB MYD88 MYD88 LOC102730715 LOC102730715 LOC102727570 LOC102727570 ICAM1 ICAM1 PLCB3 PLCB3 LOC102729468 LOC102729468 IL1B IL1B KNG1 KNG1 IL6 IL6 HP HP IL12A IL12A IL12B IL12B IFNG IFNG SELE SELE LOC102726231 LOC102726231 FASLG FASLG HBB HBB HBA_LEPWE HBA_LEPWE
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
CYGBCytoglobin; Belongs to the globin family. (190 aa)
VCAM1Vascular cell adhesion protein 1. (377 aa)
IDO1Indoleamine 2,3-dioxygenase 1. (394 aa)
HBMHemoglobin subunit mu; Belongs to the globin family. (141 aa)
HBQ1Hemoglobin subunit theta-1; Belongs to the globin family. (142 aa)
LOC102731149Hemoglobin subunit alpha-1/2-like; Belongs to the globin family. (142 aa)
LOC102739871Hemoglobin subunit epsilon-2-like; Belongs to the globin family. (147 aa)
LOC102740167Hemoglobin subunit epsilon-like; Belongs to the globin family. (147 aa)
AADACArylacetamide deacetylase. (399 aa)
AADACL2LOW QUALITY PROTEIN: arylacetamide deacetylase-like 2. (400 aa)
IL18Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (193 aa)
IL10Interleukin-10. (178 aa)
LOC102745146Tumor necrosis factor ligand superfamily member 6-like; Belongs to the tumor necrosis factor family. (173 aa)
F2RL1Proteinase-activated receptor 2. (415 aa)
NPPANatriuretic peptides A. (150 aa)
APOA1Truncated apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility; Belongs to the apolipoprotein A1/A4/E family. (266 aa)
LOC102728820Hemoglobin subunit beta-like; Belongs to the globin family. (76 aa)
LOC102747458Hemoglobin subunit zeta-like; Belongs to the globin family. (142 aa)
LOC102741463Vascular cell adhesion protein 1-like. (318 aa)
TWF2Toll-like receptor 9-like isoform X1. (1331 aa)
NGBNeuroglobin; Belongs to the globin family. (151 aa)
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (296 aa)
LOC1027307151-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2-like. (231 aa)
LOC102727570Indoleamine 2,3-dioxygenase 2-like. (239 aa)
ICAM1Intercellular adhesion molecule 1. (533 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1100 aa)
LOC102729468Apolipoprotein L3-like. (223 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (270 aa)
KNG1Kininogen-1 isoform X1. (652 aa)
IL6Interleukin-6 isoform X1. (212 aa)
HPHaptoglobin; As a result of hemolysis, hemoglobin is found to accumulate in the kidney and is secreted in the urine. Haptoglobin captures, and combines with free plasma hemoglobin to allow hepatic recycling of heme iron and to prevent kidney damage. Haptoglobin also acts as an antioxidant, has antibacterial activity and plays a role in modulating many aspects of the acute phase response. Hemoglobin/haptoglobin complexes are rapidly cleared by the macrophage CD163 scavenger receptor expressed on the surface of liver Kupfer cells through an endocytic lysosomal degradation pathway. (347 aa)
IL12AInterleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC. (222 aa)
IL12BInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (279 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (166 aa)
SELEE-selectin. (609 aa)
LOC10272623160S ribosomal protein L32-like. (135 aa)
FASLGTumor necrosis factor ligand superfamily member 6. (130 aa)
HBBHemoglobin subunit beta; Involved in oxygen transport from the lung to the various peripheral tissues. (146 aa)
HBA_LEPWEHemoglobin subunit alpha-1/2; Involved in oxygen transport from the lung to the various peripheral tissues; Belongs to the globin family. (141 aa)
Your Current Organism:
Leptonychotes weddellii
NCBI taxonomy Id: 9713
Other names: L. weddellii, Leptonychotes weddelli, Weddell seal
Server load: medium (42%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.