(48 nodes) Malaria network (Leptonychotes weddellii)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC102726231	60S ribosomal protein L32-like. (135 aa)
	HBB	Hemoglobin subunit beta; Involved in oxygen transport from the lung to the various peripheral tissues. (146 aa)
	HBA_LEPWE	Hemoglobin subunit alpha-1/2; Involved in oxygen transport from the lung to the various peripheral tissues; Belongs to the globin family. (141 aa)
	LOC102728820	Hemoglobin subunit beta-like; Belongs to the globin family. (76 aa)
	LOC102747458	Hemoglobin subunit zeta-like; Belongs to the globin family. (142 aa)
	LOC102741463	Vascular cell adhesion protein 1-like. (318 aa)
	TWF2	Toll-like receptor 9-like isoform X1. (1331 aa)
	NGB	Neuroglobin; Belongs to the globin family. (151 aa)
	LOC102736544	Thrombospondin-4-like. (685 aa)
	MYD88	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (296 aa)
	CSF3	Granulocyte colony-stimulating factor. (195 aa)
	SDC1	Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family. (307 aa)
	COMP	Cartilage oligomeric matrix protein. (728 aa)
	TGFB3	Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
	LOC102725560	Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family. (225 aa)
	TGFB1	Transforming growth factor beta-1. (261 aa)
	ICAM1	Intercellular adhesion molecule 1. (533 aa)
	NID1	Nidogen-1. (1241 aa)
	CD40LG	CD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching. (260 aa)
	IL1B	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (270 aa)
	IL6	Interleukin-6 isoform X1. (212 aa)
	IL12A	Interleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC. (222 aa)
	THBS1	Thrombospondin-1 isoform X1. (1170 aa)
	DARC	Duffy antigen/chemokine receptor isoform X1. (331 aa)
	LOC102743414	Thrombospondin-2-like. (463 aa)
	IFNG	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (166 aa)
	CD40	Tumor necrosis factor receptor superfamily member 5. (272 aa)
	SELE	E-selectin. (609 aa)
	TNF	Tumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
	TGFB2	Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
	ITGAL	Integrin alpha-L; Belongs to the integrin alpha chain family. (1168 aa)
	GYPA	glycophorin-A. (122 aa)
	THBS3	Thrombospondin-3 isoform X1. (956 aa)
	IL10	Interleukin-10. (178 aa)
	IL18	Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (193 aa)
	LOC102740167	Hemoglobin subunit epsilon-like; Belongs to the globin family. (147 aa)
	CLEC12A	C-type lectin domain family 12 member A. (271 aa)
	KLRB1	Killer cell lectin-like receptor subfamily B member 1. (250 aa)
	LOC102739871	Hemoglobin subunit epsilon-2-like; Belongs to the globin family. (147 aa)
	KLRF1	Killer cell lectin-like receptor subfamily F member 1. (237 aa)
	KLRK1	NKG2-D type II integral membrane protein. (216 aa)
	LOC102731149	Hemoglobin subunit alpha-1/2-like; Belongs to the globin family. (142 aa)
	HBQ1	Hemoglobin subunit theta-1; Belongs to the globin family. (142 aa)
	HBM	Hemoglobin subunit mu; Belongs to the globin family. (141 aa)
	IL8	Multifunctional fusion protein; Belongs to the intercrine alpha (chemokine CxC) family. (104 aa)
	VCAM1	Vascular cell adhesion protein 1. (377 aa)
	CYGB	Cytoglobin; Belongs to the globin family. (190 aa)
	HGF	Hepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. (730 aa)

Your Current Organism:

Leptonychotes weddellii

NCBI taxonomy Id: 9713
Other names: L. weddellii, Leptonychotes weddelli, Weddell seal

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CD40	CD40LG	A0A2U3Y7Z8	A0A2U3YMY4	Tumor necrosis factor receptor superfamily member 5.	CD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching.	0.999
CD40	CSF3	A0A2U3Y7Z8	A0A2U3Z1Q3	Tumor necrosis factor receptor superfamily member 5.	Granulocyte colony-stimulating factor.	0.438
CD40	ICAM1	A0A2U3Y7Z8	A0A2U3YSH4	Tumor necrosis factor receptor superfamily member 5.	Intercellular adhesion molecule 1.	0.725
CD40	IFNG	A0A2U3Y7Z8	A0A2U3Y8N2	Tumor necrosis factor receptor superfamily member 5.	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	0.786
CD40	IL10	A0A2U3Y7Z8	A0A2U3XRS9	Tumor necrosis factor receptor superfamily member 5.	Interleukin-10.	0.725
CD40	IL18	A0A2U3Y7Z8	A0A2U3XPG8	Tumor necrosis factor receptor superfamily member 5.	Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family.	0.531
CD40	IL1B	A0A2U3Y7Z8	A0A2U3YM52	Tumor necrosis factor receptor superfamily member 5.	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family.	0.619
CD40	IL6	A0A2U3Y7Z8	A0A2U3YGL7	Tumor necrosis factor receptor superfamily member 5.	Interleukin-6 isoform X1.	0.716
CD40	IL8	A0A2U3Y7Z8	A0A2U3XEG2	Tumor necrosis factor receptor superfamily member 5.	Multifunctional fusion protein; Belongs to the intercrine alpha (chemokine CxC) family.	0.411
CD40	ITGAL	A0A2U3Y7Z8	A0A2U3Y2T7	Tumor necrosis factor receptor superfamily member 5.	Integrin alpha-L; Belongs to the integrin alpha chain family.	0.472
CD40	MYD88	A0A2U3Y7Z8	A0A2U3Z302	Tumor necrosis factor receptor superfamily member 5.	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.	0.694
CD40	SDC1	A0A2U3Y7Z8	A0A2U3Z1N3	Tumor necrosis factor receptor superfamily member 5.	Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family.	0.491
CD40	TGFB1	A0A2U3Y7Z8	A0A2U3YVA3	Tumor necrosis factor receptor superfamily member 5.	Transforming growth factor beta-1.	0.479
CD40	TNF	A0A2U3Y7Z8	A0A2U3Y499	Tumor necrosis factor receptor superfamily member 5.	Tumor necrosis factor; Belongs to the tumor necrosis factor family.	0.846
CD40	TWF2	A0A2U3Y7Z8	A0A2U3Z4Z0	Tumor necrosis factor receptor superfamily member 5.	Toll-like receptor 9-like isoform X1.	0.613
CD40	VCAM1	A0A2U3Y7Z8	A0A2U3XA76	Tumor necrosis factor receptor superfamily member 5.	Vascular cell adhesion protein 1.	0.523
CD40LG	CD40	A0A2U3YMY4	A0A2U3Y7Z8	CD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching.	Tumor necrosis factor receptor superfamily member 5.	0.999
CD40LG	CSF3	A0A2U3YMY4	A0A2U3Z1Q3	CD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching.	Granulocyte colony-stimulating factor.	0.571
CD40LG	ICAM1	A0A2U3YMY4	A0A2U3YSH4	CD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching.	Intercellular adhesion molecule 1.	0.504
CD40LG	IFNG	A0A2U3YMY4	A0A2U3Y8N2	CD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching.	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	0.765