STRINGSTRING
IL10RB IL10RB BCL2L1 BCL2L1 LOC102731213 LOC102731213 ALOX5 ALOX5 LOC102739252 LOC102739252 LAMC1 LAMC1 MAPK10 MAPK10 IRAK4 IRAK4 LOC102751010 LOC102751010 MAP2K6 MAP2K6 NFKBIA NFKBIA NFKB1 NFKB1 LOC102726697 LOC102726697 LOC102725978 LOC102725978 IL10 IL10 LOC102731565 LOC102731565 PPIF PPIF MAPK12 MAPK12 LOC102740784 LOC102740784 LOC102741082 LOC102741082 LOC102750923 LOC102750923 IFNGR2 IFNGR2 TRAF6 TRAF6 LY96 LY96 JAK2 JAK2 GNAI2 GNAI2 ITGB1 ITGB1 TNFRSF1A TNFRSF1A BIRC7 BIRC7 LOC102748462 LOC102748462 LOC102750454 LOC102750454 LOC102750166 LOC102750166 MAPK8 MAPK8 TGFB2 TGFB2 AKT1 AKT1 HSPA1L HSPA1L TNF TNF LOC102734190 LOC102734190 LOC102745161 LOC102745161 HSPA2 HSPA2 IKBKG IKBKG NFKBIB NFKBIB CD40 CD40 AKT3 AKT3 IFNG IFNG LOC102728244 LOC102728244 CHUK CHUK IL12B IL12B IL12A IL12A XIAP XIAP MAPK1 MAPK1 IKBKB IKBKB LDLR LDLR IL10RA IL10RA CASP3 CASP3 CD40LG CD40LG LOC102725545 LOC102725545 MAP2K3 MAP2K3 TYK2 TYK2 GNAO1 GNAO1 TGFB1 TGFB1 BIRC3 BIRC3 TGFB3 TGFB3 LOC102726062 LOC102726062 CASP9 CASP9 LOC102751087 LOC102751087 CASP8 CASP8 BIRC2 BIRC2 LAMB2 LAMB2 LOC102734456 LOC102734456 MYD88 MYD88 LOC102740654 LOC102740654 LAMA5 LAMA5 STAT3 STAT3 CCR5 CCR5 LOC102735556 LOC102735556 LOC102736146 LOC102736146 LOC102749847 LOC102749847 MAPK11 MAPK11 LOC102739283 LOC102739283
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
IL10RBInterleukin-10 receptor subunit beta. (375 aa)
BCL2L1Bcl-2-like protein 1 isoform X1. (233 aa)
LOC102731213Heat shock cognate 71 kDa protein-like isoform X1; Belongs to the heat shock protein 70 family. (646 aa)
ALOX5Arachidonate 5-lipoxygenase isoform X1. (674 aa)
LOC102739252Heat shock cognate 71 kDa protein-like. (395 aa)
LAMC1Laminin subunit gamma-1. (1608 aa)
MAPK10Mitogen-activated protein kinase. (464 aa)
IRAK4Interleukin-1 receptor-associated kinase 4 isoform X1. (459 aa)
LOC102751010Nitric oxide synthase, inducible-like. (531 aa)
MAP2K6Dual specificity mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (334 aa)
NFKBIANF-kappa-B inhibitor alpha isoform X2. (314 aa)
NFKB1Nuclear factor NF-kappa-B p105 subunit. (254 aa)
LOC102726697Guanine nucleotide-binding protein G(I) subunit alpha-1-like isoform X1. (354 aa)
LOC102725978Cytochrome c 2-like; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (109 aa)
IL10Interleukin-10. (178 aa)
LOC102731565Laminin subunit gamma-3-like. (231 aa)
PPIFPeptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (210 aa)
MAPK12Mitogen-activated protein kinase. (367 aa)
LOC102740784HLA class II histocompatibility antigen, DR alpha chain-like; Belongs to the MHC class II family. (254 aa)
LOC102741082DLA class II histocompatibility antigen, DR-1 beta chain-like. (266 aa)
LOC102750923Cytochrome c-like; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
IFNGR2Interferon gamma receptor 2. (115 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (541 aa)
LY96Lymphocyte antigen 96 isoform X1. (160 aa)
JAK2Tyrosine-protein kinase. (952 aa)
GNAI2Guanine nucleotide-binding protein G(I) subunit alpha-2. (303 aa)
ITGB1Integrin beta; Belongs to the integrin beta chain family. (798 aa)
TNFRSF1ATumor necrosis factor receptor superfamily member 1A. (358 aa)
BIRC7Baculoviral IAP repeat-containing protein 7. (287 aa)
LOC102748462HLA class II histocompatibility antigen, DO beta chain-like. (273 aa)
LOC102750454HLA class II histocompatibility antigen, DM alpha chain-like; Belongs to the MHC class II family. (261 aa)
LOC102750166HLA class II histocompatibility antigen, DM beta chain-like. (263 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
AKT1Non-specific serine/threonine protein kinase. (518 aa)
HSPA1LHeat shock 70 kDa protein 1-like; Belongs to the heat shock protein 70 family. (641 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
LOC102734190Heat shock 70 kDa protein 1-like; Belongs to the heat shock protein 70 family. (641 aa)
LOC102745161Signal transducer and activator of transcription 3-like. (301 aa)
HSPA2Heat shock-related 70 kDa protein 2; Belongs to the heat shock protein 70 family. (636 aa)
IKBKGNF-kappa-B essential modulator isoform X2. (419 aa)
NFKBIBNF-kappa-B inhibitor beta isoform X2. (354 aa)
CD40Tumor necrosis factor receptor superfamily member 5. (272 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (418 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (166 aa)
LOC102728244Interleukin-1 receptor-associated kinase 1-like. (299 aa)
CHUKInhibitor of nuclear factor kappa-B kinase subunit alpha. (745 aa)
IL12BInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (279 aa)
IL12AInterleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC. (222 aa)
XIAPE3 ubiquitin-protein ligase XIAP-like isoform X1. (497 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (326 aa)
IKBKBInhibitor of nuclear factor kappa-B kinase subunit beta isoform X1. (756 aa)
LDLRLow-density lipoprotein receptor. (861 aa)
IL10RAInterleukin-10 receptor subunit alpha. (575 aa)
CASP3Caspase-3; Belongs to the peptidase C14A family. (302 aa)
CD40LGCD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching. (260 aa)
LOC102725545Caspase-9-like; Belongs to the peptidase C14A family. (275 aa)
MAP2K3Dual specificity mitogen-activated protein kinase kinase 3; Belongs to the protein kinase superfamily. (347 aa)
TYK2Non-receptor tyrosine-protein kinase TYK2-like. (767 aa)
GNAO1Guanine nucleotide-binding protein G(O) subunit alpha. (311 aa)
TGFB1Transforming growth factor beta-1. (261 aa)
BIRC3Baculoviral IAP repeat-containing protein 3. (604 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
LOC102726062Uncharacterized protein C7orf31 homolog. (590 aa)
CASP9Caspase-9. (171 aa)
LOC102751087Nitric oxide synthase, inducible-like. (430 aa)
CASP8Caspase-8 isoform X1; Belongs to the peptidase C14A family. (486 aa)
BIRC2Baculoviral IAP repeat-containing protein 2-like. (619 aa)
LAMB2Laminin subunit beta-2 isoform X1. (1801 aa)
LOC102734456HLA class II histocompatibility antigen, DO alpha chain-like; Belongs to the MHC class II family. (250 aa)
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (296 aa)
LOC102740654Phosphoinositide 3-kinase regulatory subunit 5-like. (111 aa)
LAMA5Laminin subunit alpha-5-like. (1341 aa)
STAT3Signal transducer and activator of transcription 3-like. (424 aa)
CCR5c-C chemokine receptor type 5; Belongs to the G-protein coupled receptor 1 family. (352 aa)
LOC102735556Mitogen-activated protein kinase 9-like. (134 aa)
LOC1027361463-phosphoinositide-dependent protein kinase 1-like. (216 aa)
LOC102749847Tyrosine-protein kinase JAK1-like. (444 aa)
MAPK11Mitogen-activated protein kinase. (254 aa)
LOC102739283Heat shock cognate 71 kDa protein-like. (196 aa)
Your Current Organism:
Leptonychotes weddellii
NCBI taxonomy Id: 9713
Other names: L. weddellii, Leptonychotes weddelli, Weddell seal
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