STRINGSTRING
PIK3CD PIK3CD LOC102751021 LOC102751021 LOC102742576 LOC102742576 LOC102748953 LOC102748953 PRKACA PRKACA CSF2 CSF2 LOC102739463 LOC102739463 LAMA5 LAMA5 LAMB2 LAMB2 LOC102734642 LOC102734642 LOC102730715 LOC102730715 LOC102729499 LOC102729499 LOC102729200 LOC102729200 LOC102751087 LOC102751087 LOC102750303 LOC102750303 GNAL GNAL TGFB3 TGFB3 TGFB1 TGFB1 SERPINB10 SERPINB10 SERPINB8 SERPINB8 LOC102736516 LOC102736516 LOC102744687 LOC102744687 PLCB3 PLCB3 PIK3CA PIK3CA SERPINB3 SERPINB3 SERPINB13 SERPINB13 GNA15 GNA15 GNA11 GNA11 IL1B IL1B CASP3 CASP3 SERPINB9 SERPINB9 IL6 IL6 LOC102742813 LOC102742813 C9 C9 RAB7A RAB7A IL12A IL12A COL4A4 COL4A4 MFF MFF IL12B IL12B LOC102732394 LOC102732394 LOC102742806 LOC102742806 LOC102738001 LOC102738001 CD1C CD1C LOC102738307 LOC102738307 LOC102742903 LOC102742903 IFNG IFNG ARG1 ARG1 ACTN4 ACTN4 ARG2 ARG2 RAB5C RAB5C TNF TNF TGFB2 TGFB2 C8A C8A IL1R2 IL1R2 PRKACB PRKACB ACTN1 ACTN1 FN1 FN1 LOC102731565 LOC102731565 IL10 IL10 HSPB1 HSPB1 SMTN SMTN VCL VCL COL4A1 COL4A1 NFKB1 NFKB1 LOC102751010 LOC102751010 LOC102744601 LOC102744601 GNA14 GNA14 PRDX2 PRDX2 COL1A2 COL1A2 RAB5A RAB5A ITGAM ITGAM IL8 IL8 LAMC1 LAMC1 PIK3R3 PIK3R3 PRDX1 PRDX1 RAB5B RAB5B LOC102726446 LOC102726446
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1043 aa)
LOC102751021Phosphatidylinositol 3-kinase regulatory subunit alpha-like isoform X1. (454 aa)
LOC102742576C-X-C motif chemokine. (107 aa)
LOC102748953Smoothelin-like protein 2-like. (320 aa)
PRKACAcAMP-dependent protein kinase catalytic subunit alpha isoform X1; Belongs to the protein kinase superfamily. (351 aa)
CSF2Granulocyte-macrophage colony-stimulating factor. (153 aa)
LOC102739463cytospin-A-like. (183 aa)
LAMA5Laminin subunit alpha-5-like. (1341 aa)
LAMB2Laminin subunit beta-2 isoform X1. (1801 aa)
LOC102734642Guanine nucleotide-binding protein G(Olf) subunit alpha-like. (209 aa)
LOC1027307151-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2-like. (231 aa)
LOC102729499Collagen alpha-1(IV) chain-like. (112 aa)
LOC102729200Collagen alpha-1(IV) chain-like. (863 aa)
LOC102751087Nitric oxide synthase, inducible-like. (430 aa)
LOC102750303Collagen alpha-1(I) chain-like. (395 aa)
GNALGuanine nucleotide-binding protein G(Olf) subunit alpha. (174 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
TGFB1Transforming growth factor beta-1. (261 aa)
SERPINB10Serpin B10; Belongs to the serpin family. (397 aa)
SERPINB8Serpin B8; Belongs to the serpin family. (374 aa)
LOC102736516Phosphatidylinositol 3-kinase regulatory subunit alpha-like. (138 aa)
LOC102744687TPR and ankyrin repeat-containing protein 1-like. (157 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1100 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
SERPINB3Serpin B3; Belongs to the serpin family. (389 aa)
SERPINB13Serpin B13; Belongs to the serpin family. (391 aa)
GNA15Guanine nucleotide-binding protein subunit alpha-15. (374 aa)
GNA11Guanine nucleotide-binding protein subunit alpha-11. (359 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (270 aa)
CASP3Caspase-3; Belongs to the peptidase C14A family. (302 aa)
SERPINB9Serpin B9 isoform X1; Belongs to the serpin family. (375 aa)
IL6Interleukin-6 isoform X1. (212 aa)
LOC102742813Neuroendocrine secretory protein 55-like. (246 aa)
C9Complement component C9. (217 aa)
RAB7ARas-related protein Rab-7a isoform X1. (207 aa)
IL12AInterleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC. (222 aa)
COL4A4Collagen alpha-4(IV) chain-like. (1589 aa)
MFFMitochondrial fission factor isoform X2. (342 aa)
IL12BInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (279 aa)
LOC102732394cytospin-A-like. (104 aa)
LOC102742806T-cell surface glycoprotein CD1b-like. (349 aa)
LOC102738001T-cell surface glycoprotein CD1a-like. (339 aa)
CD1CT-cell surface glycoprotein CD1c. (337 aa)
LOC102738307T-cell surface glycoprotein CD1a-like. (340 aa)
LOC102742903Collagen alpha-1(I) chain-like. (1116 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (166 aa)
ARG1Arginase. (322 aa)
ACTN4Alpha-actinin-4 isoform X1. (933 aa)
ARG2Arginase. (354 aa)
RAB5CRas-related protein Rab-5C. (158 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
C8AComplement component C8 alpha chain. (589 aa)
IL1R2Interleukin-1 receptor type 2. (414 aa)
PRKACBcAMP-dependent protein kinase catalytic subunit beta isoform X1; Belongs to the protein kinase superfamily. (397 aa)
ACTN1Alpha-actinin-1. (406 aa)
FN1Fibronectin isoform X1. (2476 aa)
LOC102731565Laminin subunit gamma-3-like. (231 aa)
IL10Interleukin-10. (178 aa)
HSPB1Heat shock protein beta-1; Belongs to the small heat shock protein (HSP20) family. (207 aa)
SMTNSmoothelin isoform X4. (947 aa)
VCLVinculin isoform X1. (1134 aa)
COL4A1Collagen alpha-1(IV) chain. (321 aa)
NFKB1Nuclear factor NF-kappa-B p105 subunit. (254 aa)
LOC102751010Nitric oxide synthase, inducible-like. (531 aa)
LOC102744601Serine/threonine-protein kinase DCLK2-like. (185 aa)
GNA14Guanine nucleotide-binding protein subunit alpha-14. (355 aa)
PRDX2Peroxiredoxin-2 isoform X1. (198 aa)
COL1A2Collagen alpha-2(I) chain. (1365 aa)
RAB5ARas-related protein Rab-5A isoform X1. (215 aa)
ITGAMIntegrin alpha-M isoform X1; Belongs to the integrin alpha chain family. (1154 aa)
IL8Multifunctional fusion protein; Belongs to the intercrine alpha (chemokine CxC) family. (104 aa)
LAMC1Laminin subunit gamma-1. (1608 aa)
PIK3R3Phosphatidylinositol 3-kinase regulatory subunit gamma. (461 aa)
PRDX1Peroxiredoxin-1. (199 aa)
RAB5BRas-related protein Rab-5B isoform X1. (215 aa)
LOC102726446Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform-like; Belongs to the PI3/PI4-kinase family. (235 aa)
Your Current Organism:
Leptonychotes weddellii
NCBI taxonomy Id: 9713
Other names: L. weddellii, Leptonychotes weddelli, Weddell seal
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