STRINGSTRING
LOC102737260 LOC102737260 LOC102736922 LOC102736922 ATP6V0D2 ATP6V0D2 PPP3R2 PPP3R2 HSPD1 HSPD1 CTSS CTSS RAB5B RAB5B VDR VDR MAPK10 MAPK10 ITGAX ITGAX ITGAM ITGAM PPP3R1 PPP3R1 EP300 EP300 PIK3C3 PIK3C3 RAB5A RAB5A APAF1 APAF1 IRAK4 IRAK4 LOC102751010 LOC102751010 CEBPB CEBPB CLEC7A CLEC7A LOC102738071 LOC102738071 TLR6 TLR6 TLR1 TLR1 NFKB1 NFKB1 LOC102747757 LOC102747757 LOC102750324 LOC102750324 LOC102747471 LOC102747471 CAMP CAMP IFNB1 IFNB1 CORO1C CORO1C LOC102725978 LOC102725978 IL18 IL18 CREB1 CREB1 CAMK2G CAMK2G SRC SRC CLEC4G CLEC4G LOC102728215 LOC102728215 LOC102743181 LOC102743181 CORO1A CORO1A IL10 IL10 LOC102735079 LOC102735079 MAPK12 MAPK12 EEA1 EEA1 LOC102727514 LOC102727514 LOC102740784 LOC102740784 LOC102741082 LOC102741082 LOC102750923 LOC102750923 MRC1 MRC1 IFNGR2 IFNGR2 TRAF6 TRAF6 LOC102743194 LOC102743194 FADD FADD JAK2 JAK2 LOC102729240 LOC102729240 TNFRSF1A TNFRSF1A LOC102748462 LOC102748462 LOC102750454 LOC102750454 LOC102750166 LOC102750166 MAPK8 MAPK8 CLEC4A CLEC4A TGFB2 TGFB2 AKT1 AKT1 TNF TNF RAB5C RAB5C LOC102735873 LOC102735873 FCGR2B FCGR2B ATP6V0C ATP6V0C ATP6AP1 ATP6AP1 HSPA9 HSPA9 AKT3 AKT3 IFNG IFNG LOC102746290 LOC102746290 NFYB NFYB RAF1 RAF1 LOC102728244 LOC102728244 CORO6 CORO6 BCL10 BCL10 IL23A IL23A CD74 CD74 ATP6V0D1 ATP6V0D1 TRADD TRADD IL12B IL12B IFITM3 IFITM3 LOC102727117 LOC102727117 IL12A IL12A NOD2 NOD2 RAB7A RAB7A IL6 IL6 MAPK1 MAPK1 CORO1B CORO1B IL10RA IL10RA FCER1G FCER1G RFXANK RFXANK CASP3 CASP3 IL1B IL1B IL1A IL1A CARD9 CARD9 CALM3 CALM3 SPHK2 SPHK2 ATP6V1H ATP6V1H LOC102725545 LOC102725545 CREBBP CREBBP LOC102732223 LOC102732223 NFYC NFYC TGFB1 TGFB1 TGFB3 TGFB3 ARHGEF12 ARHGEF12 LOC102726062 LOC102726062 CASP9 CASP9 LOC102751087 LOC102751087 ATP6V0B ATP6V0B IL10RB IL10RB CASP8 CASP8 LOC102734456 LOC102734456 MYD88 MYD88 LOC102729504 LOC102729504 CAMK2A CAMK2A ARSI ARSI TWF2 TWF2 CTSD CTSD LOC102735556 LOC102735556 LOC102733954 LOC102733954 LOC102749847 LOC102749847 MAPK11 MAPK11 LOC102726878 LOC102726878 LOC102740172 LOC102740172 LOC102734861 LOC102734861 CALML4 CALML4 LOC102749739 LOC102749739 IFNA14 IFNA14 EFCAB13 EFCAB13
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
LOC102737260Macrophage mannose receptor 1-like. (457 aa)
LOC102736922Calmodulin-like; Belongs to the calmodulin family. (223 aa)
ATP6V0D2V-type proton ATPase subunit; Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. Belongs to the V-ATPase V0D/AC39 subunit family. (351 aa)
PPP3R2Calcineurin subunit B type 2. (170 aa)
HSPD160 kDa heat shock protein, mitochondrial isoform X1; Belongs to the chaperonin (HSP60) family. (573 aa)
CTSSCathepsin S isoform X1; Belongs to the peptidase C1 family. (340 aa)
RAB5BRas-related protein Rab-5B isoform X1. (215 aa)
VDRVitamin D3 receptor. (427 aa)
MAPK10Mitogen-activated protein kinase. (464 aa)
ITGAXIntegrin alpha-X; Belongs to the integrin alpha chain family. (1166 aa)
ITGAMIntegrin alpha-M isoform X1; Belongs to the integrin alpha chain family. (1154 aa)
PPP3R1Calcineurin subunit B type 1 isoform X1. (170 aa)
EP300Histone acetyltransferase p300. (2425 aa)
PIK3C3Phosphatidylinositol 3-kinase catalytic subunit type 3. (811 aa)
RAB5ARas-related protein Rab-5A isoform X1. (215 aa)
APAF1Apoptotic protease-activating factor 1. (511 aa)
IRAK4Interleukin-1 receptor-associated kinase 4 isoform X1. (459 aa)
LOC102751010Nitric oxide synthase, inducible-like. (531 aa)
CEBPBCCAAT/enhancer-binding protein. (345 aa)
CLEC7AC-type lectin domain family 7 member A. (248 aa)
LOC102738071Calmodulin-like; Belongs to the calmodulin family. (113 aa)
TLR6Toll-like receptor. (794 aa)
TLR1Toll-like receptor 1; Belongs to the Toll-like receptor family. (794 aa)
NFKB1Nuclear factor NF-kappa-B p105 subunit. (254 aa)
LOC102747757Interferon alpha-1/2-like. (187 aa)
LOC102750324Interferon alpha-2-like. (175 aa)
LOC102747471Interferon alpha-1/2-like. (187 aa)
CAMPCathelicidin antimicrobial peptide. (171 aa)
IFNB1Interferon beta. (182 aa)
CORO1Ccoronin-1C. (303 aa)
LOC102725978Cytochrome c 2-like; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (109 aa)
IL18Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (193 aa)
CREB1Cyclic AMP-responsive element-binding protein 1 isoform X1. (341 aa)
CAMK2GCalcium/calmodulin-dependent protein kinase type II subunit gamma. (574 aa)
SRCTyrosine-protein kinase. (536 aa)
CLEC4GC-type lectin domain family 4 member G. (293 aa)
LOC102728215Complement C3-like. (768 aa)
LOC102743181CD209 antigen-like protein 2-like isoform X1. (246 aa)
CORO1ACoronin; Belongs to the WD repeat coronin family. (461 aa)
IL10Interleukin-10. (178 aa)
LOC102735079Rho guanine nucleotide exchange factor 12-like. (163 aa)
MAPK12Mitogen-activated protein kinase. (367 aa)
EEA1Early endosome antigen 1. (1155 aa)
LOC102727514Early endosome antigen 1-like. (255 aa)
LOC102740784HLA class II histocompatibility antigen, DR alpha chain-like; Belongs to the MHC class II family. (254 aa)
LOC102741082DLA class II histocompatibility antigen, DR-1 beta chain-like. (266 aa)
LOC102750923Cytochrome c-like; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
MRC1Macrophage mannose receptor 1. (1000 aa)
IFNGR2Interferon gamma receptor 2. (115 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (541 aa)
LOC102743194V-type proton ATPase subunit d 2-like. (302 aa)
FADDFAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (218 aa)
JAK2Tyrosine-protein kinase. (952 aa)
LOC102729240CCAAT/enhancer-binding protein gamma-like. (145 aa)
TNFRSF1ATumor necrosis factor receptor superfamily member 1A. (358 aa)
LOC102748462HLA class II histocompatibility antigen, DO beta chain-like. (273 aa)
LOC102750454HLA class II histocompatibility antigen, DM alpha chain-like; Belongs to the MHC class II family. (261 aa)
LOC102750166HLA class II histocompatibility antigen, DM beta chain-like. (263 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
CLEC4ALOW QUALITY PROTEIN: C-type lectin domain family 4 member A. (236 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
AKT1Non-specific serine/threonine protein kinase. (518 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
RAB5CRas-related protein Rab-5C. (158 aa)
LOC102735873Low affinity immunoglobulin gamma Fc region receptor III-like. (232 aa)
FCGR2BLow affinity immunoglobulin gamma Fc region receptor II-b isoform X1. (314 aa)
ATP6V0CV-type proton ATPase proteolipid subunit; Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (155 aa)
ATP6AP1V-type proton ATPase subunit S1. (464 aa)
HSPA9Stress-70 protein, mitochondrial; Belongs to the heat shock protein 70 family. (679 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (418 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (166 aa)
LOC10274629025-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial-like; Belongs to the cytochrome P450 family. (508 aa)
NFYBNuclear transcription factor Y subunit beta. (169 aa)
RAF1RAF proto-oncogene serine/threonine-protein kinase isoform X1. (648 aa)
LOC102728244Interleukin-1 receptor-associated kinase 1-like. (299 aa)
CORO6Coronin; Belongs to the WD repeat coronin family. (472 aa)
BCL10B-cell lymphoma/leukemia 10 isoform X1. (233 aa)
IL23AInterleukin-23 subunit alpha. (210 aa)
CD74HLA class II histocompatibility antigen gamma chain. (279 aa)
ATP6V0D1V-type proton ATPase subunit; Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. Belongs to the V-ATPase V0D/AC39 subunit family. (351 aa)
TRADDTumor necrosis factor receptor type 1-associated DEATH domain protein. (312 aa)
IL12BInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (279 aa)
IFITM3Interferon-induced transmembrane protein 3. (146 aa)
LOC102727117Toll-like receptor 10-like; Belongs to the Toll-like receptor family. (809 aa)
IL12AInterleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC. (222 aa)
NOD2Nucleotide-binding oligomerization domain-containing protein 2. (1013 aa)
RAB7ARas-related protein Rab-7a isoform X1. (207 aa)
IL6Interleukin-6 isoform X1. (212 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (326 aa)
CORO1BCoronin; Belongs to the WD repeat coronin family. (489 aa)
IL10RAInterleukin-10 receptor subunit alpha. (575 aa)
FCER1GHigh affinity immunoglobulin epsilon receptor subunit gamma. (94 aa)
RFXANKDNA-binding protein RFXANK. (260 aa)
CASP3Caspase-3; Belongs to the peptidase C14A family. (302 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (270 aa)
IL1AInterleukin-1; Belongs to the IL-1 family. (265 aa)
CARD9Caspase recruitment domain-containing protein 9-like. (536 aa)
CALM3Calmodulin isoform X1; Belongs to the calmodulin family. (149 aa)
SPHK2Sphingosine kinase 2 isoform X1. (656 aa)
ATP6V1HV-type proton ATPase subunit H; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit H activates ATPase activity of the enzyme and couples ATPase activity to proton flow. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. (470 aa)
LOC102725545Caspase-9-like; Belongs to the peptidase C14A family. (275 aa)
CREBBPCREB-binding protein-like. (1411 aa)
LOC102732223Toll/interleukin-1 receptor domain-containing adapter protein-like. (226 aa)
NFYCNuclear transcription factor Y subunit gamma isoform X1. (439 aa)
TGFB1Transforming growth factor beta-1. (261 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
ARHGEF12Rho guanine nucleotide exchange factor 12-like. (932 aa)
LOC102726062Uncharacterized protein C7orf31 homolog. (590 aa)
CASP9Caspase-9. (171 aa)
LOC102751087Nitric oxide synthase, inducible-like. (430 aa)
ATP6V0BV-type proton ATPase 21 kDa proteolipid subunit isoform X1; Belongs to the V-ATPase proteolipid subunit family. (205 aa)
IL10RBInterleukin-10 receptor subunit beta. (375 aa)
CASP8Caspase-8 isoform X1; Belongs to the peptidase C14A family. (486 aa)
LOC102734456HLA class II histocompatibility antigen, DO alpha chain-like; Belongs to the MHC class II family. (250 aa)
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (296 aa)
LOC102729504Apoptosis regulator BAX-like. (212 aa)
CAMK2ACalcium/calmodulin-dependent protein kinase type II subunit alpha. (476 aa)
ARSIArylsulfatase I. (575 aa)
TWF2Toll-like receptor 9-like isoform X1. (1331 aa)
CTSDCathepsin D; Belongs to the peptidase A1 family. (410 aa)
LOC102735556Mitogen-activated protein kinase 9-like. (134 aa)
LOC102733954Calmodulin-like protein 4-like. (119 aa)
LOC102749847Tyrosine-protein kinase JAK1-like. (444 aa)
MAPK11Mitogen-activated protein kinase. (254 aa)
LOC102726878V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (393 aa)
LOC102740172Lipopolysaccharide-binding protein-like. (97 aa)
LOC102734861BH3-interacting domain death agonist-like. (83 aa)
CALML4LOW QUALITY PROTEIN: calmodulin-like 4. (199 aa)
LOC102749739Ankyrin repeat family A protein 2-like. (135 aa)
IFNA14LOW QUALITY PROTEIN: interferon, alpha 14. (182 aa)
EFCAB13LOW QUALITY PROTEIN: EF-hand calcium binding domain 13. (905 aa)
Your Current Organism:
Leptonychotes weddellii
NCBI taxonomy Id: 9713
Other names: L. weddellii, Leptonychotes weddelli, Weddell seal
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