STRINGSTRING
BCL2L1 BCL2L1 LOC102731213 LOC102731213 LOC102726446 LOC102726446 CBLB CBLB CDK2 CDK2 PIK3R3 PIK3R3 LOC102739252 LOC102739252 CCND3 CCND3 LOC102750498 LOC102750498 MAPK10 MAPK10 CCNE2 CCNE2 APAF1 APAF1 IRAK4 IRAK4 LOC102749335 LOC102749335 NFKBIA NFKBIA NFKB1 NFKB1 LOC102737670 LOC102737670 LOC102747757 LOC102747757 LOC102747471 LOC102747471 IFNB1 IFNB1 CDKN1B CDKN1B LOC102725978 LOC102725978 MSN MSN TLR7 TLR7 CLEC4G CLEC4G LOC102743181 LOC102743181 EIF3H EIF3H ADAR ADAR LOC102745146 LOC102745146 TNFAIP3 TNFAIP3 LOC102750923 LOC102750923 TRAF6 TRAF6 FADD FADD EIF2AK2 EIF2AK2 FASLG FASLG BAK1 BAK1 IL2 IL2 MAPK8 MAPK8 AKT1 AKT1 HSPA1L HSPA1L LY6G5B LY6G5B CSNK2B CSNK2B LOC102734190 LOC102734190 LOC102745161 LOC102745161 STAT5B STAT5B HSPA2 HSPA2 IRF9 IRF9 FCGR2B FCGR2B TP53 TP53 CCNE1 CCNE1 IKBKG IKBKG NFKBIB NFKBIB JUN JUN OAS2 OAS2 OAS1 OAS1 AKT3 AKT3 CDK4 CDK4 RCHY1 RCHY1 LOC102728244 LOC102728244 MX1 MX1 STAT2 STAT2 EIF2AK3 EIF2AK3 CHUK CHUK TRADD TRADD LOC102730162 LOC102730162 IL12B IL12B LOC102734398 LOC102734398 CD3D CD3D IRF7 IRF7 LOC102748381 LOC102748381 EIF2AK4 EIF2AK4 IL12A IL12A GSK3B GSK3B IL2RB IL2RB MAVS MAVS LOC102729256 LOC102729256 IL6 IL6 LOC102728857 LOC102728857 SLAMF1 SLAMF1 IKBKB IKBKB LOC102730789 LOC102730789 CCND1 CCND1 CASP3 CASP3 IL1B IL1B IL1A IL1A LOC102730286 LOC102730286 PIK3CD PIK3CD LOC102725545 LOC102725545 FOS FOS PIK3CA PIK3CA GNB2L1 GNB2L1 TYK2 TYK2 CD28 CD28 EIF2AK1 EIF2AK1 LOC102736516 LOC102736516 RAB9A RAB9A TP73 TP73 LOC102726062 LOC102726062 CASP9 CASP9 RAB9B RAB9B IFNAR1 IFNAR1 CASP8 CASP8 JAK3 JAK3 MYD88 MYD88 LOC102729504 LOC102729504 STAT5A STAT5A STAT3 STAT3 TWF2 TWF2 LOC102735556 LOC102735556 LOC102749847 LOC102749847 LOC102731864 LOC102731864 LOC102751021 LOC102751021 LOC102739283 LOC102739283 LOC102734861 LOC102734861 IFNA14 IFNA14
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
BCL2L1Bcl-2-like protein 1 isoform X1. (233 aa)
LOC102731213Heat shock cognate 71 kDa protein-like isoform X1; Belongs to the heat shock protein 70 family. (646 aa)
LOC102726446Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform-like; Belongs to the PI3/PI4-kinase family. (235 aa)
CBLBE3 ubiquitin-protein ligase CBL-B-like. (832 aa)
CDK2Cyclin-dependent kinase 2 isoform X1; Belongs to the protein kinase superfamily. (346 aa)
PIK3R3Phosphatidylinositol 3-kinase regulatory subunit gamma. (461 aa)
LOC102739252Heat shock cognate 71 kDa protein-like. (395 aa)
CCND3G1/S-specific cyclin-D3 isoform X1; Belongs to the cyclin family. (291 aa)
LOC102750498Casein kinase II subunit alpha-like isoform X1; Belongs to the protein kinase superfamily. (391 aa)
MAPK10Mitogen-activated protein kinase. (464 aa)
CCNE2G1/S-specific cyclin-E2; Belongs to the cyclin family. (344 aa)
APAF1Apoptotic protease-activating factor 1. (511 aa)
IRAK4Interleukin-1 receptor-associated kinase 4 isoform X1. (459 aa)
LOC102749335E3 ubiquitin-protein ligase CBL-B-like. (139 aa)
NFKBIANF-kappa-B inhibitor alpha isoform X2. (314 aa)
NFKB1Nuclear factor NF-kappa-B p105 subunit. (254 aa)
LOC102737670Cyclin-dependent kinase 6-like. (322 aa)
LOC102747757Interferon alpha-1/2-like. (187 aa)
LOC102747471Interferon alpha-1/2-like. (187 aa)
IFNB1Interferon beta. (182 aa)
CDKN1BCyclin-dependent kinase inhibitor 1B. (198 aa)
LOC102725978Cytochrome c 2-like; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (109 aa)
MSNLOW QUALITY PROTEIN: moesin. (546 aa)
TLR7Toll-like receptor 7; Belongs to the Toll-like receptor family. (1050 aa)
CLEC4GC-type lectin domain family 4 member G. (293 aa)
LOC102743181CD209 antigen-like protein 2-like isoform X1. (246 aa)
EIF3HEukaryotic translation initiation factor 3 subunit H. (235 aa)
ADARDouble-stranded RNA-specific adenosine deaminase. (1145 aa)
LOC102745146Tumor necrosis factor ligand superfamily member 6-like; Belongs to the tumor necrosis factor family. (173 aa)
TNFAIP3Tumor necrosis factor alpha-induced protein 3. (790 aa)
LOC102750923Cytochrome c-like; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (541 aa)
FADDFAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (218 aa)
EIF2AK2Interferon-induced, double-stranded RNA-activated protein kinase. (541 aa)
FASLGTumor necrosis factor ligand superfamily member 6. (130 aa)
BAK1Bcl-2 homologous antagonist/killer. (211 aa)
IL2Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family. (154 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
AKT1Non-specific serine/threonine protein kinase. (518 aa)
HSPA1LHeat shock 70 kDa protein 1-like; Belongs to the heat shock protein 70 family. (641 aa)
LY6G5BLymphocyte antigen 6 complex locus protein G5b. (195 aa)
CSNK2BCasein kinase II subunit beta; Plays a complex role in regulating the basal catalytic activity of the alpha subunit; Belongs to the casein kinase 2 subunit beta family. (215 aa)
LOC102734190Heat shock 70 kDa protein 1-like; Belongs to the heat shock protein 70 family. (641 aa)
LOC102745161Signal transducer and activator of transcription 3-like. (301 aa)
STAT5BSignal transducer and activator of transcription 5B. (508 aa)
HSPA2Heat shock-related 70 kDa protein 2; Belongs to the heat shock protein 70 family. (636 aa)
IRF9Interferon regulatory factor 9 isoform X1. (445 aa)
FCGR2BLow affinity immunoglobulin gamma Fc region receptor II-b isoform X1. (314 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (381 aa)
CCNE1G1/S-specific cyclin-E1; Belongs to the cyclin family. (410 aa)
IKBKGNF-kappa-B essential modulator isoform X2. (419 aa)
NFKBIBNF-kappa-B inhibitor beta isoform X2. (354 aa)
JUNTranscription factor AP-1; Belongs to the bZIP family. (335 aa)
OAS22'-5'-oligoadenylate synthase 2. (685 aa)
OAS12'-5'-oligoadenylate synthase 1. (420 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (418 aa)
CDK4Cyclin-dependent kinase 4; Belongs to the protein kinase superfamily. (303 aa)
RCHY1RING finger and CHY zinc finger domain-containing protein 1 isoform X1. (261 aa)
LOC102728244Interleukin-1 receptor-associated kinase 1-like. (299 aa)
MX1Interferon-induced GTP-binding protein Mx1. (291 aa)
STAT2Signal transducer and activator of transcription. (854 aa)
EIF2AK3Eukaryotic translation initiation factor 2-alpha kinase 3 isoform X1. (1114 aa)
CHUKInhibitor of nuclear factor kappa-B kinase subunit alpha. (745 aa)
TRADDTumor necrosis factor receptor type 1-associated DEATH domain protein. (312 aa)
LOC102730162T-cell surface glycoprotein CD3 gamma chain-like. (182 aa)
IL12BInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (279 aa)
LOC102734398T-cell surface glycoprotein CD3 gamma chain-like. (167 aa)
CD3DT-cell surface glycoprotein CD3 delta chain. (171 aa)
IRF7Interferon regulatory factor 7. (470 aa)
LOC102748381Inhibitor of nuclear factor kappa-B kinase subunit epsilon-like. (618 aa)
EIF2AK4Eukaryotic translation initiation factor 2-alpha kinase 4. (1653 aa)
IL12AInterleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC. (222 aa)
GSK3BGlycogen synthase kinase-3 beta isoform X1; Belongs to the protein kinase superfamily. (433 aa)
IL2RBInterleukin-2 receptor subunit beta. (552 aa)
MAVSLOW QUALITY PROTEIN: mitochondrial antiviral-signaling protein. (522 aa)
LOC102729256TNF receptor-associated factor 3-like. (283 aa)
IL6Interleukin-6 isoform X1. (212 aa)
LOC102728857Probable ATP-dependent RNA helicase DDX58-like. (294 aa)
SLAMF1Signaling lymphocytic activation molecule. (312 aa)
IKBKBInhibitor of nuclear factor kappa-B kinase subunit beta isoform X1. (756 aa)
LOC102730789TNF receptor-associated factor 3-like. (295 aa)
CCND1G1/S-specific cyclin-D1; Belongs to the cyclin family. (214 aa)
CASP3Caspase-3; Belongs to the peptidase C14A family. (302 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (270 aa)
IL1AInterleukin-1; Belongs to the IL-1 family. (265 aa)
LOC102730286Interferon-induced GTP-binding protein Mx1-like; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (349 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1043 aa)
LOC102725545Caspase-9-like; Belongs to the peptidase C14A family. (275 aa)
FOSProto-oncogene c-Fos isoform X1. (380 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
GNB2L1Guanine nucleotide-binding protein subunit beta-2-like 1 isoform X1. (317 aa)
TYK2Non-receptor tyrosine-protein kinase TYK2-like. (767 aa)
CD28T-cell-specific surface glycoprotein CD28. (209 aa)
EIF2AK1Eukaryotic translation initiation factor 2-alpha kinase 1 isoform X1. (630 aa)
LOC102736516Phosphatidylinositol 3-kinase regulatory subunit alpha-like. (138 aa)
RAB9ARas-related protein Rab-9A isoform X1. (201 aa)
TP73Tumor protein p73; Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein. (636 aa)
LOC102726062Uncharacterized protein C7orf31 homolog. (590 aa)
CASP9Caspase-9. (171 aa)
RAB9BRas-related protein Rab-9B isoform X1. (201 aa)
IFNAR1Interferon alpha/beta receptor 1. (560 aa)
CASP8Caspase-8 isoform X1; Belongs to the peptidase C14A family. (486 aa)
JAK3Tyrosine-protein kinase. (1139 aa)
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (296 aa)
LOC102729504Apoptosis regulator BAX-like. (212 aa)
STAT5ASignal transducer and activator of transcription 5A. (464 aa)
STAT3Signal transducer and activator of transcription 3-like. (424 aa)
TWF2Toll-like receptor 9-like isoform X1. (1331 aa)
LOC102735556Mitogen-activated protein kinase 9-like. (134 aa)
LOC102749847Tyrosine-protein kinase JAK1-like. (444 aa)
LOC102731864Signal transducer and activator of transcription 5B-like. (353 aa)
LOC102751021Phosphatidylinositol 3-kinase regulatory subunit alpha-like isoform X1. (454 aa)
LOC102739283Heat shock cognate 71 kDa protein-like. (196 aa)
LOC102734861BH3-interacting domain death agonist-like. (83 aa)
IFNA14LOW QUALITY PROTEIN: interferon, alpha 14. (182 aa)
Your Current Organism:
Leptonychotes weddellii
NCBI taxonomy Id: 9713
Other names: L. weddellii, Leptonychotes weddelli, Weddell seal
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