STRINGSTRING
IL6 IL6 MAPK1 MAPK1 ITPR3 ITPR3 IKBKB IKBKB LOC102740611 LOC102740611 LOC102740920 LOC102740920 IL10RA IL10RA ADCY9 ADCY9 CRKL CRKL CCND1 CCND1 CASP3 CASP3 IL1B IL1B GNA11 GNA11 GNG8 GNG8 CALM3 CALM3 LOC102746012 LOC102746012 PIK3CD PIK3CD LOC102725545 LOC102725545 LOC102736718 LOC102736718 PIK3CA PIK3CA NFATC1 NFATC1 LOC102725943 LOC102725943 GNG4 GNG4 PLCB3 PLCB3 GNG2 GNG2 LOC102736516 LOC102736516 E2F3 E2F3 PDGFRA PDGFRA GNAO1 GNAO1 RUFY4 RUFY4 CREB3L1 CREB3L1 LOC102735431 LOC102735431 ARHGEF12 ARHGEF12 PTGER2 PTGER2 MTOR MTOR MAPK12 MAPK12 LOC102745146 LOC102745146 ITGB3 ITGB3 LOC102735079 LOC102735079 GNB2 GNB2 SRC SRC GNG10 GNG10 CREB1 CREB1 GNB5 GNB5 PTGER4 PTGER4 LOC102725978 LOC102725978 IFNB1 IFNB1 LOC102734862 LOC102734862 LOC102726697 LOC102726697 CX3CL1 CX3CL1 LOC102726062 LOC102726062 CASP9 CASP9 IL10RB IL10RB IFNA14 IFNA14 CALML4 CALML4 LOC102750030 LOC102750030 LOC102734861 LOC102734861 LOC102730129 LOC102730129 LOC102751021 LOC102751021 LOC102747754 LOC102747754 LOC102726881 LOC102726881 MAPK11 MAPK11 LOC102731038 LOC102731038 LOC102749847 LOC102749847 LOC102733954 LOC102733954 PRKACA PRKACA LOC102733354 LOC102733354 RPS6KB2 RPS6KB2 CDKN1A CDKN1A CASP8 CASP8 LOC102730715 LOC102730715 LOC102740057 LOC102740057 GNB4 GNB4 LOC102733853 LOC102733853 LOC102729504 LOC102729504 CCR3 CCR3 LOC102748147 LOC102748147 STAT3 STAT3 CCR1 CCR1 CCR5 CCR5 LOC102742564 LOC102742564 LOC102747471 LOC102747471 LOC102747757 LOC102747757 GNG11 GNG11 GNGT1 GNGT1 LOC102737670 LOC102737670 NFKB1 NFKB1 LOC102738071 LOC102738071 NFKBIA NFKBIA MAP2K6 MAP2K6 ARHGEF1 ARHGEF1 LOC102743896 LOC102743896 PTGS2 PTGS2 LOC102739066 LOC102739066 TMEM173 TMEM173 CALR CALR GNG3 GNG3 NFATC3 NFATC3 GNA12 GNA12 PPP3R1 PPP3R1 ITPR2 ITPR2 ATF4 ATF4 IL8 IL8 MAP2K1 MAP2K1 TNFRSF1A TNFRSF1A GNB3 GNB3 E2F2 E2F2 FASLG FASLG GNAI2 GNAI2 LOC102745156 LOC102745156 GNG5 GNG5 PRKACB PRKACB FADD FADD LOC102750923 LOC102750923 ADCY6 ADCY6 RHEBL1 RHEBL1 PIK3R3 PIK3R3 MB21D1 MB21D1 CSDE1 CSDE1 LPXN LPXN NRAS NRAS CXCL12 CXCL12 LOC102726446 LOC102726446 KRAS KRAS PPP3R2 PPP3R2 LOC102733223 LOC102733223 B2M B2M LOC102736922 LOC102736922 TAP1 TAP1 BAK1 BAK1 PTGER1 PTGER1 AKT1 AKT1 ERAS ERAS TNF TNF ATF6B ATF6B LOC102745161 LOC102745161 LOC102746195 LOC102746195 CREB3L3 CREB3L3 MAP2K2 MAP2K2 TP53 TP53 GNG13 GNG13 LOC102730047 LOC102730047 IKBKG IKBKG ROCK2 ROCK2 LOC102745475 LOC102745475 AKT3 AKT3 CDK4 CDK4 MDM2 MDM2 RAF1 RAF1 RPS6KB1 RPS6KB1 RB1 RB1 CHUK CHUK PTRHD1 PTRHD1 GNGT2 GNGT2 TRADD TRADD SP1 SP1 ITPR1 ITPR1 ATF2 ATF2 GSK3B GSK3B RAC2 RAC2 LOC102747594 LOC102747594 LOC102742813 LOC102742813
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
IL6Interleukin-6 isoform X1. (212 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (326 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3. (557 aa)
IKBKBInhibitor of nuclear factor kappa-B kinase subunit beta isoform X1. (756 aa)
LOC102740611TNF receptor-associated factor. (490 aa)
LOC102740920C-C motif chemokine. (91 aa)
IL10RAInterleukin-10 receptor subunit alpha. (575 aa)
ADCY9Adenylate cyclase type 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (790 aa)
CRKLCrk-like protein. (303 aa)
CCND1G1/S-specific cyclin-D1; Belongs to the cyclin family. (214 aa)
CASP3Caspase-3; Belongs to the peptidase C14A family. (302 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (270 aa)
GNA11Guanine nucleotide-binding protein subunit alpha-11. (359 aa)
GNG8Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (70 aa)
CALM3Calmodulin isoform X1; Belongs to the calmodulin family. (149 aa)
LOC102746012Adenylate cyclase type 3-like; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (311 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1043 aa)
LOC102725545Caspase-9-like; Belongs to the peptidase C14A family. (275 aa)
LOC102736718Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (72 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
NFATC1Nuclear factor of activated T-cells, cytoplasmic 1. (221 aa)
LOC102725943Nuclear factor of activated T-cells, cytoplasmic 2-like. (160 aa)
GNG4Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1100 aa)
GNG2Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (71 aa)
LOC102736516Phosphatidylinositol 3-kinase regulatory subunit alpha-like. (138 aa)
E2F3Transcription factor E2F3-like isoform X1. (465 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1090 aa)
GNAO1Guanine nucleotide-binding protein G(O) subunit alpha. (311 aa)
RUFY4RUN and FYVE domain-containing protein 4-like. (563 aa)
CREB3L1Cyclic AMP-responsive element-binding protein 3-like protein 1. (474 aa)
LOC102735431C-C motif chemokine. (93 aa)
ARHGEF12Rho guanine nucleotide exchange factor 12-like. (932 aa)
PTGER2Prostaglandin E2 receptor EP2 subtype; Belongs to the G-protein coupled receptor 1 family. (353 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2550 aa)
MAPK12Mitogen-activated protein kinase. (367 aa)
LOC102745146Tumor necrosis factor ligand superfamily member 6-like; Belongs to the tumor necrosis factor family. (173 aa)
ITGB3Integrin beta; Belongs to the integrin beta chain family. (852 aa)
LOC102735079Rho guanine nucleotide exchange factor 12-like. (163 aa)
GNB2Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 isoform X1. (340 aa)
SRCTyrosine-protein kinase. (536 aa)
GNG10Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
CREB1Cyclic AMP-responsive element-binding protein 1 isoform X1. (341 aa)
GNB5Guanine nucleotide-binding protein subunit beta-5. (345 aa)
PTGER4Prostaglandin E2 receptor EP4 subtype; Belongs to the G-protein coupled receptor 1 family. (489 aa)
LOC102725978Cytochrome c 2-like; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (109 aa)
IFNB1Interferon beta. (182 aa)
LOC102734862Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1354 aa)
LOC102726697Guanine nucleotide-binding protein G(I) subunit alpha-1-like isoform X1. (354 aa)
CX3CL1Fractalkine. (181 aa)
LOC102726062Uncharacterized protein C7orf31 homolog. (590 aa)
CASP9Caspase-9. (171 aa)
IL10RBInterleukin-10 receptor subunit beta. (375 aa)
IFNA14LOW QUALITY PROTEIN: interferon, alpha 14. (182 aa)
CALML4LOW QUALITY PROTEIN: calmodulin-like 4. (199 aa)
LOC102750030Protein-tyrosine kinase 2-beta-like. (125 aa)
LOC102734861BH3-interacting domain death agonist-like. (83 aa)
LOC102730129Uncharacterized protein LOC102730129. (471 aa)
LOC102751021Phosphatidylinositol 3-kinase regulatory subunit alpha-like isoform X1. (454 aa)
LOC102747754Fractalkine-like. (221 aa)
LOC102726881Breast cancer anti-estrogen resistance protein 1-like. (695 aa)
MAPK11Mitogen-activated protein kinase. (254 aa)
LOC102731038Adenylate cyclase type 9-like; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (564 aa)
LOC102749847Tyrosine-protein kinase JAK1-like. (444 aa)
LOC102733954Calmodulin-like protein 4-like. (119 aa)
PRKACAcAMP-dependent protein kinase catalytic subunit alpha isoform X1; Belongs to the protein kinase superfamily. (351 aa)
LOC102733354c-X-C chemokine receptor type 2-like; Belongs to the G-protein coupled receptor 1 family. (356 aa)
RPS6KB2Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (482 aa)
CDKN1ACyclin-dependent kinase inhibitor 1 isoform X1. (161 aa)
CASP8Caspase-8 isoform X1; Belongs to the peptidase C14A family. (486 aa)
LOC1027307151-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2-like. (231 aa)
LOC102740057Vascular endothelial growth factor A-like isoform X1; Belongs to the PDGF/VEGF growth factor family. (186 aa)
GNB4Guanine nucleotide-binding protein subunit beta-4. (340 aa)
LOC102733853Antigen peptide transporter 2-like. (411 aa)
LOC102729504Apoptosis regulator BAX-like. (212 aa)
CCR3c-C chemokine receptor type 3; Belongs to the G-protein coupled receptor 1 family. (359 aa)
LOC102748147Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (72 aa)
STAT3Signal transducer and activator of transcription 3-like. (424 aa)
CCR1c-C chemokine receptor type 1; Belongs to the G-protein coupled receptor 1 family. (355 aa)
CCR5c-C chemokine receptor type 5; Belongs to the G-protein coupled receptor 1 family. (352 aa)
LOC102742564Rho-associated protein kinase 2-like. (530 aa)
LOC102747471Interferon alpha-1/2-like. (187 aa)
LOC102747757Interferon alpha-1/2-like. (187 aa)
GNG11Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (73 aa)
GNGT1Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (74 aa)
LOC102737670Cyclin-dependent kinase 6-like. (322 aa)
NFKB1Nuclear factor NF-kappa-B p105 subunit. (254 aa)
LOC102738071Calmodulin-like; Belongs to the calmodulin family. (113 aa)
NFKBIANF-kappa-B inhibitor alpha isoform X2. (314 aa)
MAP2K6Dual specificity mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (334 aa)
ARHGEF1Rho guanine nucleotide exchange factor 1. (912 aa)
LOC102743896Thioredoxin; Belongs to the thioredoxin family. (121 aa)
PTGS2Prostaglandin G/H synthase 2. (470 aa)
LOC102739066GTP-binding protein Rheb-like. (142 aa)
TMEM173Stimulator of interferon genes protein. (378 aa)
CALRCalreticulin. (417 aa)
GNG3Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
NFATC3Nuclear factor of activated T-cells, cytoplasmic 3 isoform X1. (1075 aa)
GNA12Guanine nucleotide-binding protein subunit alpha-12 isoform X1. (305 aa)
PPP3R1Calcineurin subunit B type 1 isoform X1. (170 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2-like. (2701 aa)
ATF4Cyclic AMP-dependent transcription factor ATF-4. (351 aa)
IL8Multifunctional fusion protein; Belongs to the intercrine alpha (chemokine CxC) family. (104 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1 isoform X1; Belongs to the protein kinase superfamily. (393 aa)
TNFRSF1ATumor necrosis factor receptor superfamily member 1A. (358 aa)
GNB3Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3. (340 aa)
E2F2Transcription factor E2F2. (440 aa)
FASLGTumor necrosis factor ligand superfamily member 6. (130 aa)
GNAI2Guanine nucleotide-binding protein G(I) subunit alpha-2. (303 aa)
LOC102745156Catenin beta-1-like isoform X1. (216 aa)
GNG5Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
PRKACBcAMP-dependent protein kinase catalytic subunit beta isoform X1; Belongs to the protein kinase superfamily. (397 aa)
FADDFAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (218 aa)
LOC102750923Cytochrome c-like; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
ADCY6Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1161 aa)
RHEBL1GTPase RhebL1. (183 aa)
PIK3R3Phosphatidylinositol 3-kinase regulatory subunit gamma. (461 aa)
MB21D1Cyclic GMP-AMP synthase. (522 aa)
CSDE1Cold shock domain-containing protein E1 isoform X1. (845 aa)
LPXNLeupaxin; Belongs to the paxillin family. (386 aa)
NRASGTPase NRas. (189 aa)
CXCL12Stromal cell-derived factor 1 isoform X1; Belongs to the intercrine alpha (chemokine CxC) family. (119 aa)
LOC102726446Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform-like; Belongs to the PI3/PI4-kinase family. (235 aa)
KRASGTPase KRas isoform X2. (188 aa)
PPP3R2Calcineurin subunit B type 2. (170 aa)
LOC102733223Protein disulfide-isomerase A3-like; Belongs to the protein disulfide isomerase family. (294 aa)
B2MBeta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. (118 aa)
LOC102736922Calmodulin-like; Belongs to the calmodulin family. (223 aa)
TAP1Antigen peptide transporter 1. (750 aa)
BAK1Bcl-2 homologous antagonist/killer. (211 aa)
PTGER1Prostaglandin E2 receptor EP1 subtype. (149 aa)
AKT1Non-specific serine/threonine protein kinase. (518 aa)
ERASGTPase ERas. (233 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
ATF6BCyclic AMP-dependent transcription factor ATF-6 beta. (623 aa)
LOC102745161Signal transducer and activator of transcription 3-like. (301 aa)
LOC102746195DLA class I histocompatibility antigen, A9/A9 alpha chain-like. (189 aa)
CREB3L3Cyclic AMP-responsive element-binding protein 3-like protein 3. (466 aa)
MAP2K2Dual specificity mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (381 aa)
GNG13Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13. (67 aa)
LOC102730047Tuberin-like. (353 aa)
IKBKGNF-kappa-B essential modulator isoform X2. (419 aa)
ROCK2Rho-associated protein kinase 2. (850 aa)
LOC102745475Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1-like isoform X1. (340 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (418 aa)
CDK4Cyclin-dependent kinase 4; Belongs to the protein kinase superfamily. (303 aa)
MDM2E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. (487 aa)
RAF1RAF proto-oncogene serine/threonine-protein kinase isoform X1. (648 aa)
RPS6KB1Non-specific serine/threonine protein kinase. (445 aa)
RB1Retinoblastoma-associated protein. (846 aa)
CHUKInhibitor of nuclear factor kappa-B kinase subunit alpha. (745 aa)
PTRHD1Putative peptidyl-tRNA hydrolase PTRHD1. (140 aa)
GNGT2Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (69 aa)
TRADDTumor necrosis factor receptor type 1-associated DEATH domain protein. (312 aa)
SP1Transcription factor Sp1 isoform X1. (786 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1. (1244 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2 isoform X2. (505 aa)
GSK3BGlycogen synthase kinase-3 beta isoform X1; Belongs to the protein kinase superfamily. (433 aa)
RAC2Ras-related C3 botulinum toxin substrate 2. (192 aa)
LOC102747594c-X-C chemokine receptor type 4-like; Belongs to the G-protein coupled receptor 1 family. (353 aa)
LOC102742813Neuroendocrine secretory protein 55-like. (246 aa)
Your Current Organism:
Leptonychotes weddellii
NCBI taxonomy Id: 9713
Other names: L. weddellii, Leptonychotes weddelli, Weddell seal
Server load: low (32%) [HD]