STRINGSTRING
IL6 IL6 ANAPC11 ANAPC11 CRTC2 CRTC2 ZFP36 ZFP36 MAPK1 MAPK1 TLN1 TLN1 VDAC3 VDAC3 IKBKB IKBKB MSX1 MSX1 ATM ATM POLB POLB ANAPC10 ANAPC10 ADCY9 ADCY9 TBP TBP CCND1 CCND1 LOC102731598 LOC102731598 LOC102746012 LOC102746012 CDKN2B CDKN2B CDKN2A CDKN2A PIK3CD PIK3CD FOS FOS PIK3CA PIK3CA TCF3 TCF3 NFATC1 NFATC1 LOC102725943 LOC102725943 ICAM1 ICAM1 CREBBP CREBBP TBPL1 TBPL1 LOC102736516 LOC102736516 E2F3 E2F3 TGFB1 TGFB1 TGFB3 TGFB3 CREB3L1 CREB3L1 LOC102737749 LOC102737749 LOC102747537 LOC102747537 RANBP1 RANBP1 RANBP3 RANBP3 SPIB SPIB BUB1B BUB1B JAK3 JAK3 CDC16 CDC16 VDAC2 VDAC2 LOC102730318 LOC102730318 LOC102734456 LOC102734456 LOC102730108 LOC102730108 LOC102729504 LOC102729504 TSPO2 TSPO2 STAT5A STAT5A CDKN1A CDKN1A NFKB2 NFKB2 LOC102735556 LOC102735556 ANAPC7 ANAPC7 CSF2 CSF2 PRKACA PRKACA LOC102751019 LOC102751019 LOC102749847 LOC102749847 LOC102744718 LOC102744718 LOC102731038 LOC102731038 LOC102731864 LOC102731864 LOC102751021 LOC102751021 LOC102726273 LOC102726273 LOC102746125 LOC102746125 B2M B2M BCL2L1 BCL2L1 PPP3R2 PPP3R2 LOC102746922 LOC102746922 KRAS KRAS LOC102726446 LOC102726446 NRAS NRAS CSDE1 CSDE1 CDK2 CDK2 PIK3R3 PIK3R3 CCND3 CCND3 ADCY6 ADCY6 LOC102738950 LOC102738950 MAPK10 MAPK10 MAP2K1 MAP2K1 CCNE2 CCNE2 ATF4 ATF4 PPP3R1 PPP3R1 EP300 EP300 NFATC3 NFATC3 KAT2B KAT2B SPI1 SPI1 PTTG1 PTTG1 CALR CALR CDKN2C CDKN2C NFKBIA NFKBIA TSPO TSPO NFKB1 NFKB1 CDC20B CDC20B PTEN PTEN XPO1 XPO1 CREB1 CREB1 TGFBR2 TGFBR2 LOC102751218 LOC102751218 SMAD4 SMAD4 FDPS FDPS EGR2 EGR2 SLC25A4 SLC25A4 CDC26 CDC26 MAP3K14 MAP3K14 LTBR LTBR LOC102740784 LOC102740784 LOC102741082 LOC102741082 ETS2 ETS2 TBPL2 TBPL2 SRF SRF PTK7 PTK7 PRKACB PRKACB ANAPC5 ANAPC5 ELK4 ELK4 ANAPC4 ANAPC4 CDC23 CDC23 EGR1 EGR1 ANAPC2 ANAPC2 IL1R2 IL1R2 E2F2 E2F2 TNFRSF1A TNFRSF1A CD4 CD4 ITGAL ITGAL LOC102748462 LOC102748462 LOC102750454 LOC102750454 LOC102750166 LOC102750166 IL2 IL2 MAPK8 MAPK8 TGFB2 TGFB2 AKT1 AKT1 ERAS ERAS LTA LTA TNF TNF ATF6B ATF6B KAT2A KAT2A STAT5B STAT5B LOC102746195 LOC102746195 CREB3L3 CREB3L3 LOC102730764 LOC102730764 MAP2K2 MAP2K2 TP53 TP53 GPS2 GPS2 CCNE1 CCNE1 IKBKG IKBKG JUN JUN CD40 CD40 CANX CANX CDC20 CDC20 AKT3 AKT3 CDK4 CDK4 NFYB NFYB MAP3K1 MAP3K1 RAN RAN ETS1 ETS1 RB1 RB1 MAP3K3 MAP3K3 CHUK CHUK LOC102734300 LOC102734300 PTRHD1 PTRHD1 MESDC1 MESDC1 SLC25A5 SLC25A5 CHEK2 CHEK2 LOC102730162 LOC102730162 LOC102734398 LOC102734398 ESPL1 ESPL1 CD3D CD3D ATF2 ATF2 TLN2 TLN2 IL2RB IL2RB XIAP XIAP LOC102743741 LOC102743741
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
IL6Interleukin-6 isoform X1. (212 aa)
ANAPC11Anaphase-promoting complex subunit 11 isoform X1. (84 aa)
CRTC2CREB-regulated transcription coactivator 2. (695 aa)
ZFP36Tristetraprolin. (325 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (326 aa)
TLN1Talin-1. (549 aa)
VDAC3Voltage-dependent anion-selective channel protein 3 isoform X1. (284 aa)
IKBKBInhibitor of nuclear factor kappa-B kinase subunit beta isoform X1. (756 aa)
MSX1Homeobox protein MSX-1. (303 aa)
ATMSerine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3054 aa)
POLBDNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. (335 aa)
ANAPC10Anaphase-promoting complex subunit 10; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle. (185 aa)
ADCY9Adenylate cyclase type 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (790 aa)
TBPTATA-box-binding protein. (322 aa)
CCND1G1/S-specific cyclin-D1; Belongs to the cyclin family. (214 aa)
LOC102731598Homeobox protein MSX-3-like. (208 aa)
LOC102746012Adenylate cyclase type 3-like; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (311 aa)
CDKN2BCyclin-dependent kinase 4 inhibitor B. (138 aa)
CDKN2ACyclin-dependent kinase inhibitor 2A, isoforms 1/2/3. (152 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1043 aa)
FOSProto-oncogene c-Fos isoform X1. (380 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
TCF3Transcription factor E2-alpha isoform X1. (654 aa)
NFATC1Nuclear factor of activated T-cells, cytoplasmic 1. (221 aa)
LOC102725943Nuclear factor of activated T-cells, cytoplasmic 2-like. (160 aa)
ICAM1Intercellular adhesion molecule 1. (533 aa)
CREBBPCREB-binding protein-like. (1411 aa)
TBPL1TATA box-binding protein-like protein 1. (186 aa)
LOC102736516Phosphatidylinositol 3-kinase regulatory subunit alpha-like. (138 aa)
E2F3Transcription factor E2F3-like isoform X1. (465 aa)
TGFB1Transforming growth factor beta-1. (261 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
CREB3L1Cyclic AMP-responsive element-binding protein 3-like protein 1. (474 aa)
LOC102737749Transcription factor RelB-like. (167 aa)
LOC102747537Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] (549 aa)
RANBP1Ran-specific GTPase-activating protein. (158 aa)
RANBP3Ran-binding protein 3 isoform X1. (557 aa)
SPIBTranscription factor Spi-B isoform X1. (262 aa)
BUB1BMitotic checkpoint serine/threonine-protein kinase BUB1 beta. (986 aa)
JAK3Tyrosine-protein kinase. (1139 aa)
CDC16Cell division cycle protein 16 homolog isoform X1. (620 aa)
VDAC2Voltage-dependent anion-selective channel protein 2 isoform X1. (294 aa)
LOC102730318Mothers against decapentaplegic homolog. (415 aa)
LOC102734456HLA class II histocompatibility antigen, DO alpha chain-like; Belongs to the MHC class II family. (250 aa)
LOC102730108Neuropilin-1-like. (465 aa)
LOC102729504Apoptosis regulator BAX-like. (212 aa)
TSPO2Translocator protein 2 isoform X1. (171 aa)
STAT5ASignal transducer and activator of transcription 5A. (464 aa)
CDKN1ACyclin-dependent kinase inhibitor 1 isoform X1. (161 aa)
NFKB2Nuclear factor NF-kappa-B p100 subunit. (900 aa)
LOC102735556Mitogen-activated protein kinase 9-like. (134 aa)
ANAPC7Anaphase-promoting complex subunit 7. (461 aa)
CSF2Granulocyte-macrophage colony-stimulating factor. (153 aa)
PRKACAcAMP-dependent protein kinase catalytic subunit alpha isoform X1; Belongs to the protein kinase superfamily. (351 aa)
LOC102751019Talin-1-like. (2016 aa)
LOC102749847Tyrosine-protein kinase JAK1-like. (444 aa)
LOC102744718Transformation/transcription domain-associated protein-like. (206 aa)
LOC102731038Adenylate cyclase type 9-like; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (564 aa)
LOC102731864Signal transducer and activator of transcription 5B-like. (353 aa)
LOC102751021Phosphatidylinositol 3-kinase regulatory subunit alpha-like isoform X1. (454 aa)
LOC102726273Homeobox protein MSX-2-like. (267 aa)
LOC102746125LOW QUALITY PROTEIN: cyclin-A1-like; Belongs to the cyclin family. (463 aa)
B2MBeta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. (118 aa)
BCL2L1Bcl-2-like protein 1 isoform X1. (233 aa)
PPP3R2Calcineurin subunit B type 2. (170 aa)
LOC102746922Mitotic checkpoint protein BUB3-like. (142 aa)
KRASGTPase KRas isoform X2. (188 aa)
LOC102726446Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform-like; Belongs to the PI3/PI4-kinase family. (235 aa)
NRASGTPase NRas. (189 aa)
CSDE1Cold shock domain-containing protein E1 isoform X1. (845 aa)
CDK2Cyclin-dependent kinase 2 isoform X1; Belongs to the protein kinase superfamily. (346 aa)
PIK3R3Phosphatidylinositol 3-kinase regulatory subunit gamma. (461 aa)
CCND3G1/S-specific cyclin-D3 isoform X1; Belongs to the cyclin family. (291 aa)
ADCY6Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1161 aa)
LOC102738950GTP-binding nuclear protein Ran; GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle. Belongs to the small GTPase superfamily. Ran family. (215 aa)
MAPK10Mitogen-activated protein kinase. (464 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1 isoform X1; Belongs to the protein kinase superfamily. (393 aa)
CCNE2G1/S-specific cyclin-E2; Belongs to the cyclin family. (344 aa)
ATF4Cyclic AMP-dependent transcription factor ATF-4. (351 aa)
PPP3R1Calcineurin subunit B type 1 isoform X1. (170 aa)
EP300Histone acetyltransferase p300. (2425 aa)
NFATC3Nuclear factor of activated T-cells, cytoplasmic 3 isoform X1. (1075 aa)
KAT2BHistone acetyltransferase KAT2B. (735 aa)
SPI1Transcription factor PU.1. (250 aa)
PTTG1Securin isoform X1. (201 aa)
CALRCalreticulin. (417 aa)
CDKN2CCyclin-dependent kinase 4 inhibitor C. (168 aa)
NFKBIANF-kappa-B inhibitor alpha isoform X2. (314 aa)
TSPOTranslocator protein. (170 aa)
NFKB1Nuclear factor NF-kappa-B p105 subunit. (254 aa)
CDC20BCell division cycle protein 20 homolog B. (454 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
XPO1Exportin-1. (384 aa)
CREB1Cyclic AMP-responsive element-binding protein 1 isoform X1. (341 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (564 aa)
LOC102751218Voltage-dependent anion-selective channel protein 1-like. (280 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
FDPSFarnesyl pyrophosphate synthase. (248 aa)
EGR2E3 SUMO-protein ligase EGR2 isoform X1. (469 aa)
SLC25A4ADP/ATP translocase 1; Belongs to the mitochondrial carrier (TC 2.A.29) family. (298 aa)
CDC26Anaphase-promoting complex subunit CDC26. (85 aa)
MAP3K14Mitogen-activated protein kinase kinase kinase 14. (955 aa)
LTBRTumor necrosis factor receptor superfamily member 3 isoform X1. (421 aa)
LOC102740784HLA class II histocompatibility antigen, DR alpha chain-like; Belongs to the MHC class II family. (254 aa)
LOC102741082DLA class II histocompatibility antigen, DR-1 beta chain-like. (266 aa)
ETS2Protein C-ets-2; Transcription factor; Belongs to the ETS family. (469 aa)
TBPL2TATA box-binding protein-like protein 2. (344 aa)
SRFSerum response factor. (508 aa)
PTK7Inactive tyrosine-protein kinase 7 isoform X1; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1070 aa)
PRKACBcAMP-dependent protein kinase catalytic subunit beta isoform X1; Belongs to the protein kinase superfamily. (397 aa)
ANAPC5Anaphase-promoting complex subunit 5 isoform X1. (755 aa)
ELK4ETS domain-containing protein Elk-4. (430 aa)
ANAPC4Anaphase-promoting complex subunit 4-like. (280 aa)
CDC23Cell division cycle protein 23 homolog. (597 aa)
EGR1Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (542 aa)
ANAPC2Anaphase-promoting complex subunit 2; Belongs to the cullin family. (818 aa)
IL1R2Interleukin-1 receptor type 2. (414 aa)
E2F2Transcription factor E2F2. (440 aa)
TNFRSF1ATumor necrosis factor receptor superfamily member 1A. (358 aa)
CD4T-cell surface glycoprotein CD4. (462 aa)
ITGALIntegrin alpha-L; Belongs to the integrin alpha chain family. (1168 aa)
LOC102748462HLA class II histocompatibility antigen, DO beta chain-like. (273 aa)
LOC102750454HLA class II histocompatibility antigen, DM alpha chain-like; Belongs to the MHC class II family. (261 aa)
LOC102750166HLA class II histocompatibility antigen, DM beta chain-like. (263 aa)
IL2Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family. (154 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
AKT1Non-specific serine/threonine protein kinase. (518 aa)
ERASGTPase ERas. (233 aa)
LTALymphotoxin-alpha; Belongs to the tumor necrosis factor family. (204 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
ATF6BCyclic AMP-dependent transcription factor ATF-6 beta. (623 aa)
KAT2AHistone acetyltransferase KAT2A isoform X2. (838 aa)
STAT5BSignal transducer and activator of transcription 5B. (508 aa)
LOC102746195DLA class I histocompatibility antigen, A9/A9 alpha chain-like. (189 aa)
CREB3L3Cyclic AMP-responsive element-binding protein 3-like protein 3. (466 aa)
LOC102730764Mothers against decapentaplegic homolog 2-like. (227 aa)
MAP2K2Dual specificity mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (381 aa)
GPS2G protein pathway suppressor 2 isoform X1. (327 aa)
CCNE1G1/S-specific cyclin-E1; Belongs to the cyclin family. (410 aa)
IKBKGNF-kappa-B essential modulator isoform X2. (419 aa)
JUNTranscription factor AP-1; Belongs to the bZIP family. (335 aa)
CD40Tumor necrosis factor receptor superfamily member 5. (272 aa)
CANXCalnexin isoform X1. (594 aa)
CDC20Cell division cycle protein 20 homolog. (499 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (418 aa)
CDK4Cyclin-dependent kinase 4; Belongs to the protein kinase superfamily. (303 aa)
NFYBNuclear transcription factor Y subunit beta. (169 aa)
MAP3K1Mitogen-activated protein kinase kinase kinase 1. (1345 aa)
RANGTP-binding nuclear protein Ran; GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle. Belongs to the small GTPase superfamily. Ran family. (216 aa)
ETS1Protein C-ets-1-like isoform X1. (441 aa)
RB1Retinoblastoma-associated protein. (846 aa)
MAP3K3Mitogen-activated protein kinase kinase kinase 3. (600 aa)
CHUKInhibitor of nuclear factor kappa-B kinase subunit alpha. (745 aa)
LOC102734300Matrilysin-like. (274 aa)
PTRHD1Putative peptidyl-tRNA hydrolase PTRHD1. (140 aa)
MESDC1Mesoderm development candidate 1. (362 aa)
SLC25A5ADP/ATP translocase 2; Belongs to the mitochondrial carrier (TC 2.A.29) family. (298 aa)
CHEK2Serine/threonine-protein kinase Chk2 isoform X1. (544 aa)
LOC102730162T-cell surface glycoprotein CD3 gamma chain-like. (182 aa)
LOC102734398T-cell surface glycoprotein CD3 gamma chain-like. (167 aa)
ESPL1Separin. (2105 aa)
CD3DT-cell surface glycoprotein CD3 delta chain. (171 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2 isoform X2. (505 aa)
TLN2Talin-2-like isoform X1. (2542 aa)
IL2RBInterleukin-2 receptor subunit beta. (552 aa)
XIAPE3 ubiquitin-protein ligase XIAP-like isoform X1. (497 aa)
LOC102743741Interleukin; Belongs to the IL-15/IL-21 family. (162 aa)
Your Current Organism:
Leptonychotes weddellii
NCBI taxonomy Id: 9713
Other names: L. weddellii, Leptonychotes weddelli, Weddell seal
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