STRINGSTRING
LOC102730789 LOC102730789 SAP30L SAP30L LOC102735415 LOC102735415 PSMD11 PSMD11 CIR1 CIR1 OSBPL2 OSBPL2 ADRM1 ADRM1 CCND1 CCND1 CASP3 CASP3 PIK3CD PIK3CD LOC102725545 LOC102725545 PIK3CA PIK3CA ICAM1 ICAM1 MAP2K3 MAP2K3 TYK2 TYK2 GADD45G GADD45G LOC102736516 LOC102736516 E2F3 E2F3 NFKBIE NFKBIE LOC102735127 LOC102735127 LOC102737749 LOC102737749 LOC102726062 LOC102726062 CASP9 CASP9 IFNAR1 IFNAR1 CASP8 CASP8 JAK3 JAK3 LOC102738254 LOC102738254 GADD45B GADD45B LOC102731237 LOC102731237 LOC102733853 LOC102733853 LOC102734456 LOC102734456 MYD88 MYD88 LOC102726381 LOC102726381 LOC102729504 LOC102729504 SIN3B SIN3B STAT3 STAT3 RUNX3 RUNX3 PSMD6 PSMD6 LOC102727494 LOC102727494 CDKN1A CDKN1A NFKB2 NFKB2 LOC102735556 LOC102735556 LOC102748833 LOC102748833 LOC102729219 LOC102729219 LOC102749847 LOC102749847 MAPK11 MAPK11 LOC102751021 LOC102751021 LOC102734861 LOC102734861 IFNA14 IFNA14 LOC102746125 LOC102746125 B2M B2M LOC102733223 LOC102733223 LOC102732823 LOC102732823 LOC102726446 LOC102726446 PSMD4 PSMD4 CDK2 CDK2 PIK3R3 PIK3R3 CCND3 CCND3 MAPK10 MAPK10 CCNE2 CCNE2 APAF1 APAF1 DDB2 DDB2 IRAK4 IRAK4 CALR CALR LOC102743896 LOC102743896 PSMC2 PSMC2 NEDD4 NEDD4 MAP2K6 MAP2K6 NFKBIA NFKBIA ISG15 ISG15 NFKB1 NFKB1 LOC102737670 LOC102737670 LOC102747757 LOC102747757 LOC102747471 LOC102747471 IFNB1 IFNB1 CDKN1B CDKN1B LOC102725978 LOC102725978 MAP2K7 MAP2K7 CD19 CD19 HDAC1 HDAC1 LOC102734657 LOC102734657 TNFAIP3 TNFAIP3 RBPJL RBPJL MAPK12 MAPK12 GADD45A GADD45A PSMC6 PSMC6 CD247 CD247 CC2D2B CC2D2B MAP3K14 MAP3K14 PSMD14 PSMD14 LOC102740784 LOC102740784 LOC102741082 LOC102741082 LOC102750923 LOC102750923 SHFM1 SHFM1 TRAF6 TRAF6 FADD FADD EIF2AK2 EIF2AK2 E2F2 E2F2 PSMC5 PSMC5 BTK BTK ITGAL ITGAL TAP1 TAP1 LOC102748462 LOC102748462 LOC102750454 LOC102750454 BAK1 BAK1 LOC102750166 LOC102750166 LOC102733981 LOC102733981 MAPK8 MAPK8 AKT1 AKT1 TNF TNF LOC102745161 LOC102745161 LOC102746195 LOC102746195 IRF9 IRF9 ENTPD3 ENTPD3 TP53 TP53 CCNE1 CCNE1 IKBKG IKBKG PSMD8 PSMD8 NFKBIB NFKBIB JUN JUN OAS2 OAS2 OAS1 OAS1 CD40 CD40 AKT3 AKT3 CDK4 CDK4 MDM2 MDM2 LOC102728244 LOC102728244 RB1 RB1 STAT2 STAT2 CHUK CHUK TRADD TRADD LOC102749081 LOC102749081 LOC102730162 LOC102730162 LOC102734398 LOC102734398 CC2D2A CC2D2A CD3D CD3D IRF7 IRF7 LOC102748381 LOC102748381 PSMD7 PSMD7 MAVS MAVS LOC102729256 LOC102729256 IL6 IL6 LOC102728857 LOC102728857 LOC102746004 LOC102746004 HDAC2 HDAC2 IKBKB IKBKB LOC102740611 LOC102740611 CXCL10 CXCL10
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LOC102730789TNF receptor-associated factor 3-like. (295 aa)
SAP30LHistone deacetylase complex subunit SAP30L isoform X1. (182 aa)
LOC102735415Phosphoinositide phospholipase C. (309 aa)
PSMD1126S proteasome non-ATPase regulatory subunit 11. (422 aa)
CIR1Corepressor interacting with RBPJ 1. (463 aa)
OSBPL2Oxysterol-binding protein; Belongs to the OSBP family. (480 aa)
ADRM1Proteasomal ubiquitin receptor ADRM1 isoform X1. (406 aa)
CCND1G1/S-specific cyclin-D1; Belongs to the cyclin family. (214 aa)
CASP3Caspase-3; Belongs to the peptidase C14A family. (302 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1043 aa)
LOC102725545Caspase-9-like; Belongs to the peptidase C14A family. (275 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
ICAM1Intercellular adhesion molecule 1. (533 aa)
MAP2K3Dual specificity mitogen-activated protein kinase kinase 3; Belongs to the protein kinase superfamily. (347 aa)
TYK2Non-receptor tyrosine-protein kinase TYK2-like. (767 aa)
GADD45GGrowth arrest and DNA damage-inducible protein GADD45 gamma. (159 aa)
LOC102736516Phosphatidylinositol 3-kinase regulatory subunit alpha-like. (138 aa)
E2F3Transcription factor E2F3-like isoform X1. (465 aa)
NFKBIENF-kappa-B inhibitor epsilon. (361 aa)
LOC10273512726S protease regulatory subunit 4-like isoform X1; Belongs to the AAA ATPase family. (440 aa)
LOC102737749Transcription factor RelB-like. (167 aa)
LOC102726062Uncharacterized protein C7orf31 homolog. (590 aa)
CASP9Caspase-9. (171 aa)
IFNAR1Interferon alpha/beta receptor 1. (560 aa)
CASP8Caspase-8 isoform X1; Belongs to the peptidase C14A family. (486 aa)
JAK3Tyrosine-protein kinase. (1139 aa)
LOC102738254Vimentin-like; Belongs to the intermediate filament family. (209 aa)
GADD45BGrowth arrest and DNA damage-inducible protein GADD45 beta isoform X2. (160 aa)
LOC102731237SNW domain-containing protein 1-like. (340 aa)
LOC102733853Antigen peptide transporter 2-like. (411 aa)
LOC102734456HLA class II histocompatibility antigen, DO alpha chain-like; Belongs to the MHC class II family. (250 aa)
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (296 aa)
LOC10272638126S proteasome non-ATPase regulatory subunit 1-like. (574 aa)
LOC102729504Apoptosis regulator BAX-like. (212 aa)
SIN3BPaired amphipathic helix protein Sin3b. (875 aa)
STAT3Signal transducer and activator of transcription 3-like. (424 aa)
RUNX3Runt-related transcription factor 3-like. (283 aa)
PSMD626S proteasome non-ATPase regulatory subunit 6 isoform X1. (389 aa)
LOC102727494Nuclear receptor corepressor 2-like. (227 aa)
CDKN1ACyclin-dependent kinase inhibitor 1 isoform X1. (161 aa)
NFKB2Nuclear factor NF-kappa-B p100 subunit. (900 aa)
LOC102735556Mitogen-activated protein kinase 9-like. (134 aa)
LOC102748833Tyrosine-protein kinase. (375 aa)
LOC10272921926S proteasome non-ATPase regulatory subunit 2; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S2 family. (778 aa)
LOC102749847Tyrosine-protein kinase JAK1-like. (444 aa)
MAPK11Mitogen-activated protein kinase. (254 aa)
LOC102751021Phosphatidylinositol 3-kinase regulatory subunit alpha-like isoform X1. (454 aa)
LOC102734861BH3-interacting domain death agonist-like. (83 aa)
IFNA14LOW QUALITY PROTEIN: interferon, alpha 14. (182 aa)
LOC102746125LOW QUALITY PROTEIN: cyclin-A1-like; Belongs to the cyclin family. (463 aa)
B2MBeta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. (118 aa)
LOC102733223Protein disulfide-isomerase A3-like; Belongs to the protein disulfide isomerase family. (294 aa)
LOC102732823Vimentin-like isoform X1; Belongs to the intermediate filament family. (466 aa)
LOC102726446Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform-like; Belongs to the PI3/PI4-kinase family. (235 aa)
PSMD426S proteasome non-ATPase regulatory subunit 4. (377 aa)
CDK2Cyclin-dependent kinase 2 isoform X1; Belongs to the protein kinase superfamily. (346 aa)
PIK3R3Phosphatidylinositol 3-kinase regulatory subunit gamma. (461 aa)
CCND3G1/S-specific cyclin-D3 isoform X1; Belongs to the cyclin family. (291 aa)
MAPK10Mitogen-activated protein kinase. (464 aa)
CCNE2G1/S-specific cyclin-E2; Belongs to the cyclin family. (344 aa)
APAF1Apoptotic protease-activating factor 1. (511 aa)
DDB2DNA damage-binding protein 2 isoform X1. (426 aa)
IRAK4Interleukin-1 receptor-associated kinase 4 isoform X1. (459 aa)
CALRCalreticulin. (417 aa)
LOC102743896Thioredoxin; Belongs to the thioredoxin family. (121 aa)
PSMC226S protease regulatory subunit 7; Belongs to the AAA ATPase family. (433 aa)
NEDD4E3 ubiquitin-protein ligase NEDD4 isoform X1. (1323 aa)
MAP2K6Dual specificity mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (334 aa)
NFKBIANF-kappa-B inhibitor alpha isoform X2. (314 aa)
ISG15Ubiquitin-like protein ISG15. (169 aa)
NFKB1Nuclear factor NF-kappa-B p105 subunit. (254 aa)
LOC102737670Cyclin-dependent kinase 6-like. (322 aa)
LOC102747757Interferon alpha-1/2-like. (187 aa)
LOC102747471Interferon alpha-1/2-like. (187 aa)
IFNB1Interferon beta. (182 aa)
CDKN1BCyclin-dependent kinase inhibitor 1B. (198 aa)
LOC102725978Cytochrome c 2-like; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (109 aa)
MAP2K7Dual specificity mitogen-activated protein kinase kinase 7 isoform X1. (435 aa)
CD19B-lymphocyte antigen CD19. (559 aa)
HDAC1Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (482 aa)
LOC10273465726S proteasome non-ATPase regulatory subunit 1-like. (279 aa)
TNFAIP3Tumor necrosis factor alpha-induced protein 3. (790 aa)
RBPJLRecombining binding protein suppressor of hairless-like protein. (517 aa)
MAPK12Mitogen-activated protein kinase. (367 aa)
GADD45AGrowth arrest and DNA damage-inducible protein GADD45 alpha isoform X1. (165 aa)
PSMC626S protease regulatory subunit 10B. (291 aa)
CD247T-cell surface glycoprotein CD3 zeta chain. (166 aa)
CC2D2BProtein CC2D2B. (341 aa)
MAP3K14Mitogen-activated protein kinase kinase kinase 14. (955 aa)
PSMD1426S proteasome non-ATPase regulatory subunit 14. (310 aa)
LOC102740784HLA class II histocompatibility antigen, DR alpha chain-like; Belongs to the MHC class II family. (254 aa)
LOC102741082DLA class II histocompatibility antigen, DR-1 beta chain-like. (266 aa)
LOC102750923Cytochrome c-like; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
SHFM126S proteasome complex subunit DSS1. (70 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (541 aa)
FADDFAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (218 aa)
EIF2AK2Interferon-induced, double-stranded RNA-activated protein kinase. (541 aa)
E2F2Transcription factor E2F2. (440 aa)
PSMC526S protease regulatory subunit 8; Belongs to the AAA ATPase family. (406 aa)
BTKTyrosine-protein kinase. (659 aa)
ITGALIntegrin alpha-L; Belongs to the integrin alpha chain family. (1168 aa)
TAP1Antigen peptide transporter 1. (750 aa)
LOC102748462HLA class II histocompatibility antigen, DO beta chain-like. (273 aa)
LOC102750454HLA class II histocompatibility antigen, DM alpha chain-like; Belongs to the MHC class II family. (261 aa)
BAK1Bcl-2 homologous antagonist/killer. (211 aa)
LOC102750166HLA class II histocompatibility antigen, DM beta chain-like. (263 aa)
LOC10273398126S proteasome non-ATPase regulatory subunit 2-like. (125 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
AKT1Non-specific serine/threonine protein kinase. (518 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
LOC102745161Signal transducer and activator of transcription 3-like. (301 aa)
LOC102746195DLA class I histocompatibility antigen, A9/A9 alpha chain-like. (189 aa)
IRF9Interferon regulatory factor 9 isoform X1. (445 aa)
ENTPD3Ectonucleoside triphosphate diphosphohydrolase 3 isoform X1; Belongs to the GDA1/CD39 NTPase family. (529 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (381 aa)
CCNE1G1/S-specific cyclin-E1; Belongs to the cyclin family. (410 aa)
IKBKGNF-kappa-B essential modulator isoform X2. (419 aa)
PSMD8LOW QUALITY PROTEIN: 26S proteasome non-ATPase regulatory subunit 8. (351 aa)
NFKBIBNF-kappa-B inhibitor beta isoform X2. (354 aa)
JUNTranscription factor AP-1; Belongs to the bZIP family. (335 aa)
OAS22'-5'-oligoadenylate synthase 2. (685 aa)
OAS12'-5'-oligoadenylate synthase 1. (420 aa)
CD40Tumor necrosis factor receptor superfamily member 5. (272 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (418 aa)
CDK4Cyclin-dependent kinase 4; Belongs to the protein kinase superfamily. (303 aa)
MDM2E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. (487 aa)
LOC102728244Interleukin-1 receptor-associated kinase 1-like. (299 aa)
RB1Retinoblastoma-associated protein. (846 aa)
STAT2Signal transducer and activator of transcription. (854 aa)
CHUKInhibitor of nuclear factor kappa-B kinase subunit alpha. (745 aa)
TRADDTumor necrosis factor receptor type 1-associated DEATH domain protein. (312 aa)
LOC102749081Nuclear receptor corepressor 2-like. (252 aa)
LOC102730162T-cell surface glycoprotein CD3 gamma chain-like. (182 aa)
LOC102734398T-cell surface glycoprotein CD3 gamma chain-like. (167 aa)
CC2D2ACoiled-coil and C2 domain-containing protein 2A. (1617 aa)
CD3DT-cell surface glycoprotein CD3 delta chain. (171 aa)
IRF7Interferon regulatory factor 7. (470 aa)
LOC102748381Inhibitor of nuclear factor kappa-B kinase subunit epsilon-like. (618 aa)
PSMD726S proteasome non-ATPase regulatory subunit 7-like. (324 aa)
MAVSLOW QUALITY PROTEIN: mitochondrial antiviral-signaling protein. (522 aa)
LOC102729256TNF receptor-associated factor 3-like. (283 aa)
IL6Interleukin-6 isoform X1. (212 aa)
LOC102728857Probable ATP-dependent RNA helicase DDX58-like. (294 aa)
LOC102746004Bcl-2-like protein 11-like isoform X2. (140 aa)
HDAC2Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (488 aa)
IKBKBInhibitor of nuclear factor kappa-B kinase subunit beta isoform X1. (756 aa)
LOC102740611TNF receptor-associated factor. (490 aa)
CXCL10C-X-C motif chemokine. (98 aa)
Your Current Organism:
Leptonychotes weddellii
NCBI taxonomy Id: 9713
Other names: L. weddellii, Leptonychotes weddelli, Weddell seal
Server load: low (34%) [HD]