STRINGSTRING
LOC102738071 LOC102738071 IFNA14 IFNA14 CUL4A CUL4A CALML4 CALML4 LOC102750030 LOC102750030 LOC102734861 LOC102734861 LOC102751021 LOC102751021 MAPK11 MAPK11 LOC102733954 LOC102733954 RPS6KB2 RPS6KB2 LOC102735556 LOC102735556 CCR5 CCR5 LOC102728297 LOC102728297 LOC102748147 LOC102748147 LOC102729504 LOC102729504 MYD88 MYD88 LOC102733853 LOC102733853 GNB4 GNB4 PAK6 PAK6 CASP8 CASP8 CASP9 CASP9 LOC102726062 LOC102726062 LOC102738640 LOC102738640 GNAO1 GNAO1 BST2 BST2 LOC102736516 LOC102736516 GNG2 GNG2 MAP2K3 MAP2K3 GNG4 GNG4 LOC102725943 LOC102725943 NFATC1 NFATC1 PIK3CA PIK3CA LOC102736718 LOC102736718 FOS FOS LOC102725545 LOC102725545 PIK3CD PIK3CD LOC102749983 LOC102749983 CALM3 CALM3 GNG8 GNG8 GNA11 GNA11 CASP3 CASP3 CRKL CRKL LOC102735415 LOC102735415 WEE2 WEE2 LOC102740611 LOC102740611 ATM ATM IKBKB IKBKB ITPR3 ITPR3 MAPK1 MAPK1 PAK2 PAK2 LOC102747594 LOC102747594 AP1G1 AP1G1 RAC2 RAC2 ITPR1 ITPR1 CD3D CD3D LOC102734398 LOC102734398 LOC102730162 LOC102730162 TRADD TRADD GNGT2 GNGT2 CHUK CHUK AP1M2 AP1M2 CCNB2 CCNB2 LOC102728244 LOC102728244 RPS6KB1 RPS6KB1 RAF1 RAF1 CFL1 CFL1 AKT3 AKT3 LOC102745475 LOC102745475 PAK1 PAK1 JUN JUN PAK4 PAK4 IKBKG IKBKG GNG13 GNG13 CCDC125 CCDC125 CCNB1 CCNB1 MAP2K2 MAP2K2 AP1G2 AP1G2 LOC102746195 LOC102746195 TNF TNF ERAS ERAS AKT1 AKT1 MAPK8 MAPK8 BAK1 BAK1 TAP1 TAP1 ITPR2 ITPR2 CD4 CD4 TNFRSF1A TNFRSF1A GNB3 GNB3 FASLG FASLG RNF7 RNF7 GNAI2 GNAI2 CDC25C CDC25C TCEB1 TCEB1 GNG5 GNG5 FADD FADD TRAF6 TRAF6 LOC102750923 LOC102750923 AP1M1 AP1M1 AP1S2 AP1S2 CD247 CD247 MTOR MTOR MAPK12 MAPK12 LOC102745146 LOC102745146 MAP2K7 MAP2K7 GNB2 GNB2 AP1S1 AP1S1 SAMHD1 SAMHD1 GNG10 GNG10 LIMK2 LIMK2 GNB5 GNB5 LOC102725978 LOC102725978 IFNB1 IFNB1 PAK7 PAK7 LOC102726697 LOC102726697 LOC102747471 LOC102747471 LOC102747757 LOC102747757 GNG11 GNG11 GNGT1 GNGT1 TRIM6 TRIM6 NFKB1 NFKB1 CFL2 CFL2 NFKBIA NFKBIA MAP2K6 MAP2K6 LOC102743896 LOC102743896 SKP1 SKP1 TMEM173 TMEM173 CALR CALR GNG3 GNG3 IRAK4 IRAK4 NFATC3 NFATC3 PPP3R1 PPP3R1 RBX1 RBX1 MAP2K1 MAP2K1 MAPK10 MAPK10 PIK3R3 PIK3R3 MB21D1 MB21D1 CSDE1 CSDE1 WEE1 WEE1 LPXN LPXN NRAS NRAS LOC102726446 LOC102726446 KRAS KRAS PPP3R2 PPP3R2 BCL2L1 BCL2L1 LOC102733223 LOC102733223 B2M B2M LOC102725945 LOC102725945 LOC102736922 LOC102736922
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LOC102738071Calmodulin-like; Belongs to the calmodulin family. (113 aa)
IFNA14LOW QUALITY PROTEIN: interferon, alpha 14. (182 aa)
CUL4ALOW QUALITY PROTEIN: cullin 4A; Belongs to the cullin family. (326 aa)
CALML4LOW QUALITY PROTEIN: calmodulin-like 4. (199 aa)
LOC102750030Protein-tyrosine kinase 2-beta-like. (125 aa)
LOC102734861BH3-interacting domain death agonist-like. (83 aa)
LOC102751021Phosphatidylinositol 3-kinase regulatory subunit alpha-like isoform X1. (454 aa)
MAPK11Mitogen-activated protein kinase. (254 aa)
LOC102733954Calmodulin-like protein 4-like. (119 aa)
RPS6KB2Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (482 aa)
LOC102735556Mitogen-activated protein kinase 9-like. (134 aa)
CCR5c-C chemokine receptor type 5; Belongs to the G-protein coupled receptor 1 family. (352 aa)
LOC102728297Serine/threonine-protein kinase PAK 7-like. (225 aa)
LOC102748147Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (72 aa)
LOC102729504Apoptosis regulator BAX-like. (212 aa)
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (296 aa)
LOC102733853Antigen peptide transporter 2-like. (411 aa)
GNB4Guanine nucleotide-binding protein subunit beta-4. (340 aa)
PAK6Non-specific serine/threonine protein kinase. (681 aa)
CASP8Caspase-8 isoform X1; Belongs to the peptidase C14A family. (486 aa)
CASP9Caspase-9. (171 aa)
LOC102726062Uncharacterized protein C7orf31 homolog. (590 aa)
LOC102738640AP complex subunit beta. (683 aa)
GNAO1Guanine nucleotide-binding protein G(O) subunit alpha. (311 aa)
BST2Bone marrow stromal antigen 2. (188 aa)
LOC102736516Phosphatidylinositol 3-kinase regulatory subunit alpha-like. (138 aa)
GNG2Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (71 aa)
MAP2K3Dual specificity mitogen-activated protein kinase kinase 3; Belongs to the protein kinase superfamily. (347 aa)
GNG4Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
LOC102725943Nuclear factor of activated T-cells, cytoplasmic 2-like. (160 aa)
NFATC1Nuclear factor of activated T-cells, cytoplasmic 1. (221 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
LOC102736718Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (72 aa)
FOSProto-oncogene c-Fos isoform X1. (380 aa)
LOC102725545Caspase-9-like; Belongs to the peptidase C14A family. (275 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1043 aa)
LOC102749983F-box/WD repeat-containing protein 11-like. (264 aa)
CALM3Calmodulin isoform X1; Belongs to the calmodulin family. (149 aa)
GNG8Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (70 aa)
GNA11Guanine nucleotide-binding protein subunit alpha-11. (359 aa)
CASP3Caspase-3; Belongs to the peptidase C14A family. (302 aa)
CRKLCrk-like protein. (303 aa)
LOC102735415Phosphoinositide phospholipase C. (309 aa)
WEE2Wee1-like protein kinase. (566 aa)
LOC102740611TNF receptor-associated factor. (490 aa)
ATMSerine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3054 aa)
IKBKBInhibitor of nuclear factor kappa-B kinase subunit beta isoform X1. (756 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3. (557 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (326 aa)
PAK2Non-specific serine/threonine protein kinase. (524 aa)
LOC102747594c-X-C chemokine receptor type 4-like; Belongs to the G-protein coupled receptor 1 family. (353 aa)
AP1G1AP-1 complex subunit gamma. (825 aa)
RAC2Ras-related C3 botulinum toxin substrate 2. (192 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1. (1244 aa)
CD3DT-cell surface glycoprotein CD3 delta chain. (171 aa)
LOC102734398T-cell surface glycoprotein CD3 gamma chain-like. (167 aa)
LOC102730162T-cell surface glycoprotein CD3 gamma chain-like. (182 aa)
TRADDTumor necrosis factor receptor type 1-associated DEATH domain protein. (312 aa)
GNGT2Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (69 aa)
CHUKInhibitor of nuclear factor kappa-B kinase subunit alpha. (745 aa)
AP1M2AP-1 complex subunit mu-2 isoform X1; Belongs to the adaptor complexes medium subunit family. (425 aa)
CCNB2G2/mitotic-specific cyclin-B2; Belongs to the cyclin family. (299 aa)
LOC102728244Interleukin-1 receptor-associated kinase 1-like. (299 aa)
RPS6KB1Non-specific serine/threonine protein kinase. (445 aa)
RAF1RAF proto-oncogene serine/threonine-protein kinase isoform X1. (648 aa)
CFL1Cofilin-1 isoform X2; Belongs to the actin-binding proteins ADF family. (219 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (418 aa)
LOC102745475Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1-like isoform X1. (340 aa)
PAK1Non-specific serine/threonine protein kinase. (544 aa)
JUNTranscription factor AP-1; Belongs to the bZIP family. (335 aa)
PAK4Non-specific serine/threonine protein kinase. (441 aa)
IKBKGNF-kappa-B essential modulator isoform X2. (419 aa)
GNG13Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13. (67 aa)
CCDC125Coiled-coil domain-containing protein 125. (513 aa)
CCNB1G2/mitotic-specific cyclin-B1; Belongs to the cyclin family. (427 aa)
MAP2K2Dual specificity mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa)
AP1G2AP-1 complex subunit gamma. (783 aa)
LOC102746195DLA class I histocompatibility antigen, A9/A9 alpha chain-like. (189 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
ERASGTPase ERas. (233 aa)
AKT1Non-specific serine/threonine protein kinase. (518 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
BAK1Bcl-2 homologous antagonist/killer. (211 aa)
TAP1Antigen peptide transporter 1. (750 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2-like. (2701 aa)
CD4T-cell surface glycoprotein CD4. (462 aa)
TNFRSF1ATumor necrosis factor receptor superfamily member 1A. (358 aa)
GNB3Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3. (340 aa)
FASLGTumor necrosis factor ligand superfamily member 6. (130 aa)
RNF7RING-box protein 2 isoform X1. (113 aa)
GNAI2Guanine nucleotide-binding protein G(I) subunit alpha-2. (303 aa)
CDC25CM-phase inducer phosphatase 3 isoform X1. (473 aa)
TCEB1Transcription elongation factor B polypeptide 1; Belongs to the SKP1 family. (112 aa)
GNG5Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
FADDFAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (218 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (541 aa)
LOC102750923Cytochrome c-like; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
AP1M1AP-1 complex subunit mu-1 isoform X1; Belongs to the adaptor complexes medium subunit family. (435 aa)
AP1S2AP complex subunit sigma; Belongs to the adaptor complexes small subunit family. (157 aa)
CD247T-cell surface glycoprotein CD3 zeta chain. (166 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2550 aa)
MAPK12Mitogen-activated protein kinase. (367 aa)
LOC102745146Tumor necrosis factor ligand superfamily member 6-like; Belongs to the tumor necrosis factor family. (173 aa)
MAP2K7Dual specificity mitogen-activated protein kinase kinase 7 isoform X1. (435 aa)
GNB2Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 isoform X1. (340 aa)
AP1S1AP complex subunit sigma; Belongs to the adaptor complexes small subunit family. (158 aa)
SAMHD1Deoxynucleoside triphosphate triphosphohydrolase SAMHD1. (627 aa)
GNG10Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
LIMK2LIM domain kinase 2 isoform X1. (638 aa)
GNB5Guanine nucleotide-binding protein subunit beta-5. (345 aa)
LOC102725978Cytochrome c 2-like; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (109 aa)
IFNB1Interferon beta. (182 aa)
PAK7Serine/threonine-protein kinase PAK 7. (474 aa)
LOC102726697Guanine nucleotide-binding protein G(I) subunit alpha-1-like isoform X1. (354 aa)
LOC102747471Interferon alpha-1/2-like. (187 aa)
LOC102747757Interferon alpha-1/2-like. (187 aa)
GNG11Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (73 aa)
GNGT1Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (74 aa)
TRIM6Tripartite motif-containing protein 6 isoform X1. (487 aa)
NFKB1Nuclear factor NF-kappa-B p105 subunit. (254 aa)
CFL2Cofilin-2; Belongs to the actin-binding proteins ADF family. (166 aa)
NFKBIANF-kappa-B inhibitor alpha isoform X2. (314 aa)
MAP2K6Dual specificity mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (334 aa)
LOC102743896Thioredoxin; Belongs to the thioredoxin family. (121 aa)
SKP1S-phase kinase-associated protein 1 isoform X1; Belongs to the SKP1 family. (163 aa)
TMEM173Stimulator of interferon genes protein. (378 aa)
CALRCalreticulin. (417 aa)
GNG3Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
IRAK4Interleukin-1 receptor-associated kinase 4 isoform X1. (459 aa)
NFATC3Nuclear factor of activated T-cells, cytoplasmic 3 isoform X1. (1075 aa)
PPP3R1Calcineurin subunit B type 1 isoform X1. (170 aa)
RBX1E3 ubiquitin-protein ligase RBX1 isoform X3. (108 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1 isoform X1; Belongs to the protein kinase superfamily. (393 aa)
MAPK10Mitogen-activated protein kinase. (464 aa)
PIK3R3Phosphatidylinositol 3-kinase regulatory subunit gamma. (461 aa)
MB21D1Cyclic GMP-AMP synthase. (522 aa)
CSDE1Cold shock domain-containing protein E1 isoform X1. (845 aa)
WEE1Wee1-like protein kinase. (646 aa)
LPXNLeupaxin; Belongs to the paxillin family. (386 aa)
NRASGTPase NRas. (189 aa)
LOC102726446Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform-like; Belongs to the PI3/PI4-kinase family. (235 aa)
KRASGTPase KRas isoform X2. (188 aa)
PPP3R2Calcineurin subunit B type 2. (170 aa)
BCL2L1Bcl-2-like protein 1 isoform X1. (233 aa)
LOC102733223Protein disulfide-isomerase A3-like; Belongs to the protein disulfide isomerase family. (294 aa)
B2MBeta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. (118 aa)
LOC102725945Cyclin-dependent kinase 1-like isoform X1; Belongs to the protein kinase superfamily. (297 aa)
LOC102736922Calmodulin-like; Belongs to the calmodulin family. (223 aa)
Your Current Organism:
Leptonychotes weddellii
NCBI taxonomy Id: 9713
Other names: L. weddellii, Leptonychotes weddelli, Weddell seal
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