STRINGSTRING
LOC102726171 LOC102726171 LYL1 LYL1 SIX4 SIX4 SPI1 SPI1 DDB2 DDB2 SIX1 SIX1 ITGAM ITGAM FUS FUS IL8 IL8 BMI1 BMI1 AFF1 AFF1 HPGD HPGD CCNT1 CCNT1 PAX5 PAX5 HOXC11 HOXC11 WNT16 WNT16 BCL2L1 BCL2L1 LOC102746125 LOC102746125 DUSP6 DUSP6 TP53 TP53 LOC102747288 LOC102747288 ETV4 ETV4 MAX MAX TFE3 TFE3 IGF1R IGF1R LOC102726297 LOC102726297 BAK1 BAK1 RXRB RXRB CCNT2 CCNT2 IL1R2 IL1R2 BCL6 BCL6 MEN1 MEN1 SLC45A3 SLC45A3 ELK4 ELK4 LOC102750159 LOC102750159 PTCRA PTCRA LOC102737083 LOC102737083 LOC102728321 LOC102728321 SIX2 SIX2 ETV7 ETV7 PBX2 PBX2 NCOR1 NCOR1 TLX3 TLX3 GADD45A GADD45A LOC102732274 LOC102732274 ZBTB16 ZBTB16 ATF1 ATF1 SUPT3H SUPT3H MEIS2 MEIS2 HDAC1 HDAC1 NUPR1 NUPR1 TGFBR2 TGFBR2 HHEX HHEX ETV5 ETV5 REL REL MLLT3 MLLT3 CDKN1B CDKN1B TAF15 TAF15 HOXD11 HOXD11 MMP9 MMP9 CD40 CD40 LOC102749673 LOC102749673 BCL2A1 BCL2A1 ARNT2 ARNT2 LOC102736905 LOC102736905 MDM2 MDM2 ELANE ELANE PML PML MMP3 MMP3 SP1 SP1 ITGB7 ITGB7 CSF1R CSF1R IL2RB IL2RB SPINT1 SPINT1 IL6 IL6 FEV FEV ASPSCR1 ASPSCR1 HDAC2 HDAC2 PAX3 PAX3 EYA1 EYA1 ATM ATM PLAT PLAT SMAD1 SMAD1 CDK9 CDK9 JUP JUP MEF2C MEF2C SS18 SS18 TCF3 TCF3 RARA RARA FLT3 FLT3 CEBPE CEBPE LOC102732330 LOC102732330 GADD45G GADD45G LOC102735329 LOC102735329 LOC102749709 LOC102749709 BIRC3 BIRC3 LOC102743667 LOC102743667 LOC102738536 LOC102738536 RXRA RXRA NTRK1 NTRK1 MPO MPO SPIB SPIB WT1 WT1 ERG ERG LOC102747932 LOC102747932 GADD45B GADD45B BIRC2 BIRC2 LOC102731850 LOC102731850 LOC102727485 LOC102727485 LOC102730819 LOC102730819 LOC102745013 LOC102745013 LOC102729504 LOC102729504 SIN3B SIN3B DDIT3 DDIT3 FOXO1 FOXO1 IL3 IL3 LOC102729819 LOC102729819 CDKN1A CDKN1A CSF2 CSF2 LOC102726484 LOC102726484 LOC102749849 LOC102749849 LOC102741963 LOC102741963 NFKB1 NFKB1 KLF3 KLF3 LOC102731039 LOC102731039 CDKN2C CDKN2C CEBPB CEBPB HOXA10 HOXA10 HOXA9 HOXA9 HOXA11 HOXA11 MLF1 MLF1 HMGA2 HMGA2 IGF1 IGF1 LOC102732851 LOC102732851 TLX1 TLX1
Nodes:
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LOC102726171LIM domain-binding protein 1-like. (190 aa)
LYL1Protein lyl-1. (245 aa)
SIX4Homeobox protein SIX4. (778 aa)
SPI1Transcription factor PU.1. (250 aa)
DDB2DNA damage-binding protein 2 isoform X1. (426 aa)
SIX1Homeobox protein SIX1. (284 aa)
ITGAMIntegrin alpha-M isoform X1; Belongs to the integrin alpha chain family. (1154 aa)
FUSRNA-binding protein FUS isoform X1. (517 aa)
IL8Multifunctional fusion protein; Belongs to the intercrine alpha (chemokine CxC) family. (104 aa)
BMI1Polycomb complex protein BMI-1 isoform X1. (326 aa)
AFF1AF4/FMR2 family member 1-like. (395 aa)
HPGD15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform X1; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (266 aa)
CCNT1cyclin-T1 isoform X1; Belongs to the cyclin family. (726 aa)
PAX5Paired box protein Pax-5 isoform X1. (362 aa)
HOXC11Homeobox protein Hox-C11. (304 aa)
WNT16Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (149 aa)
BCL2L1Bcl-2-like protein 1 isoform X1. (233 aa)
LOC102746125LOW QUALITY PROTEIN: cyclin-A1-like; Belongs to the cyclin family. (463 aa)
DUSP6Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (381 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (381 aa)
LOC102747288CCAAT/enhancer-binding protein alpha-like. (178 aa)
ETV4ETS translocation variant 4 isoform X2. (485 aa)
MAXProtein max isoform X1. (160 aa)
TFE3Transcription factor E3 isoform X1. (571 aa)
IGF1RInsulin-like growth factor 1 receptor-like. (291 aa)
LOC102726297Alpha-(1,6)-fucosyltransferase-like isoform X2; Belongs to the glycosyltransferase 23 family. (412 aa)
BAK1Bcl-2 homologous antagonist/killer. (211 aa)
RXRBRetinoic acid receptor RXR-beta isoform X1. (536 aa)
CCNT2cyclin-T2 isoform X1; Belongs to the cyclin family. (730 aa)
IL1R2Interleukin-1 receptor type 2. (414 aa)
BCL6B-cell lymphoma 6 protein. (706 aa)
MEN1Menin. (616 aa)
SLC45A3Solute carrier family 45 member 3. (552 aa)
ELK4ETS domain-containing protein Elk-4. (430 aa)
LOC102750159Junction plakoglobin-like. (503 aa)
PTCRAPre T-cell antigen receptor alpha. (214 aa)
LOC102737083Histone H3; Belongs to the histone H3 family. (136 aa)
LOC102728321High affinity nerve growth factor receptor-like. (109 aa)
SIX2Homeobox protein SIX2. (294 aa)
ETV7Transcription factor ETV7 isoform X1. (255 aa)
PBX2pre-B-cell leukemia transcription factor 2. (430 aa)
NCOR1Nuclear receptor corepressor 1 isoform X1. (2435 aa)
TLX3T-cell leukemia homeobox protein 3. (291 aa)
GADD45AGrowth arrest and DNA damage-inducible protein GADD45 alpha isoform X1. (165 aa)
LOC102732274Homeobox protein Meis1-like. (104 aa)
ZBTB16Zinc finger and BTB domain-containing protein 16 isoform X1. (673 aa)
ATF1Cyclic AMP-dependent transcription factor ATF-1 isoform X2. (270 aa)
SUPT3HTranscription initiation protein SPT3 homolog. (377 aa)
MEIS2Homeobox protein Meis2-like isoform X5. (464 aa)
HDAC1Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (482 aa)
NUPR1Nuclear protein 1 isoform X1. (82 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (564 aa)
HHEXHematopoietically-expressed homeobox protein HHEX. (270 aa)
ETV5ETS translocation variant 5 isoform X1. (510 aa)
RELProto-oncogene c-Rel. (594 aa)
MLLT3Protein AF-9. (518 aa)
CDKN1BCyclin-dependent kinase inhibitor 1B. (198 aa)
TAF15TATA-binding protein-associated factor 2N-like. (312 aa)
HOXD11Homeobox protein Hox-D11. (147 aa)
MMP9Matrix metalloproteinase-9. (704 aa)
CD40Tumor necrosis factor receptor superfamily member 5. (272 aa)
LOC102749673Insulin-like growth factor 1 receptor-like. (143 aa)
BCL2A1Bcl-2-related protein A1. (174 aa)
ARNT2Aryl hydrocarbon receptor nuclear translocator 2. (628 aa)
LOC102736905Glutamate receptor 3-like. (89 aa)
MDM2E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. (487 aa)
ELANELOW QUALITY PROTEIN: neutrophil elastase; Belongs to the peptidase S1 family. (284 aa)
PMLProtein PML. (880 aa)
MMP3Stromelysin-1. (476 aa)
SP1Transcription factor Sp1 isoform X1. (786 aa)
ITGB7Integrin beta; Belongs to the integrin beta chain family. (763 aa)
CSF1RMacrophage colony-stimulating factor 1 receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (961 aa)
IL2RBInterleukin-2 receptor subunit beta. (552 aa)
SPINT1Kunitz-type protease inhibitor 1. (511 aa)
IL6Interleukin-6 isoform X1. (212 aa)
FEVProtein FEV. (181 aa)
ASPSCR1Tether containing UBX domain for GLUT4. (539 aa)
HDAC2Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (488 aa)
PAX3Paired box protein Pax-3 isoform X1. (505 aa)
EYA1Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (592 aa)
ATMSerine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3054 aa)
PLATPlasminogen activator; Belongs to the peptidase S1 family. (560 aa)
SMAD1Mothers against decapentaplegic homolog. (465 aa)
CDK9Cyclin-dependent kinase 9; Belongs to the protein kinase superfamily. (372 aa)
JUPJunction plakoglobin. (307 aa)
MEF2CMyocyte-specific enhancer factor 2C-like isoform X2. (473 aa)
SS18Protein SSXT isoform X1. (418 aa)
TCF3Transcription factor E2-alpha isoform X1. (654 aa)
RARARetinoic acid receptor alpha isoform X1. (462 aa)
FLT3Receptor-type tyrosine-protein kinase FLT3; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (984 aa)
CEBPECCAAT/enhancer-binding protein. (281 aa)
LOC102732330Histone H3; Belongs to the histone H3 family. (136 aa)
GADD45GGrowth arrest and DNA damage-inducible protein GADD45 gamma. (159 aa)
LOC102735329Vascular endothelial growth factor receptor 1-like. (351 aa)
LOC102749709CCAAT/enhancer-binding protein alpha-like. (165 aa)
BIRC3Baculoviral IAP repeat-containing protein 3. (604 aa)
LOC102743667Transcriptional regulator ERG-like. (184 aa)
LOC102738536Insulin-like growth factor-binding protein 3-like. (120 aa)
RXRARetinoic acid receptor RXR-alpha. (439 aa)
NTRK1Tyrosine-protein kinase receptor. (592 aa)
MPOMyeloperoxidase isoform X2. (718 aa)
SPIBTranscription factor Spi-B isoform X1. (262 aa)
WT1Wilms tumor protein-like. (413 aa)
ERGTranscriptional regulator ERG-like. (356 aa)
LOC102747932Friend leukemia integration 1 transcription factor-like. (196 aa)
GADD45BGrowth arrest and DNA damage-inducible protein GADD45 beta isoform X2. (160 aa)
BIRC2Baculoviral IAP repeat-containing protein 2-like. (619 aa)
LOC102731850Tyrosine-protein kinase receptor. (757 aa)
LOC102727485Homeobox protein Meis1-like. (210 aa)
LOC102730819Histone H3; Belongs to the histone H3 family. (136 aa)
LOC102745013Histone H3; Belongs to the histone H3 family. (136 aa)
LOC102729504Apoptosis regulator BAX-like. (212 aa)
SIN3BPaired amphipathic helix protein Sin3b. (875 aa)
DDIT3DNA damage-inducible transcript 3 protein; Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer- binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression [...] (168 aa)
FOXO1Forkhead box protein O1-like. (418 aa)
IL3Interleukin-3. (143 aa)
LOC102729819Protein CBFA2T1-like. (287 aa)
CDKN1ACyclin-dependent kinase inhibitor 1 isoform X1. (161 aa)
CSF2Granulocyte-macrophage colony-stimulating factor. (153 aa)
LOC102726484Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (207 aa)
LOC102749849Microphthalmia-associated transcription factor-like. (181 aa)
LOC102741963RNA-binding protein EWS-like. (268 aa)
NFKB1Nuclear factor NF-kappa-B p105 subunit. (254 aa)
KLF3Krueppel-like factor 3. (284 aa)
LOC102731039Histone H3.3-like. (128 aa)
CDKN2CCyclin-dependent kinase 4 inhibitor C. (168 aa)
CEBPBCCAAT/enhancer-binding protein. (345 aa)
HOXA10Homeobox protein Hox-A10. (414 aa)
HOXA9Homeobox protein; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Belongs to the Abd-B homeobox family. (272 aa)
HOXA11Homeobox protein Hox-A11. (321 aa)
MLF1Myeloid leukemia factor 1 isoform X1. (270 aa)
HMGA2High mobility group protein HMGI-C. (109 aa)
IGF1Insulin-like growth factor I isoform X1. (153 aa)
LOC102732851LIM domain-binding protein 1-like. (227 aa)
TLX1T-cell leukemia homeobox protein 1. (262 aa)
Your Current Organism:
Leptonychotes weddellii
NCBI taxonomy Id: 9713
Other names: L. weddellii, Leptonychotes weddelli, Weddell seal
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