STRINGSTRING
GLS GLS SOX12 SOX12 KRAS KRAS LOC102732823 LOC102732823 LOC102726446 LOC102726446 MCL1 MCL1 NRAS NRAS CSDE1 CSDE1 LOC102740025 LOC102740025 ITGA5 ITGA5 ERBB3 ERBB3 PIK3R3 PIK3R3 IGF2BP3 IGF2BP3 MAP2K1 MAP2K1 BMI1 BMI1 CCNE2 CCNE2 EP300 EP300 LOC102728392 LOC102728392 EZH2 EZH2 PTGS2 PTGS2 DDIT4 DDIT4 ST14 ST14 HMGA2 HMGA2 MDM4 MDM4 MAPK7 MAPK7 NFKB1 NFKB1 LOC102737670 LOC102737670 PTEN PTEN DNMT3A DNMT3A LOC102734862 LOC102734862 CDKN1B CDKN1B MMP16 MMP16 PIM1 PIM1 HDAC1 HDAC1 FSCN1 FSCN1 ITGB3 ITGB3 BMPR2 BMPR2 EFNA1 EFNA1 SHC1 SHC1 ADAM15 ADAM15 FZD3 FZD3 MTOR MTOR TRIM71 TRIM71 IRS1 IRS1 GPSM3 GPSM3 NOTCH4 NOTCH4 TIMP3 TIMP3 FGFR3 FGFR3 SHC4 SHC4 CEP152 CEP152 SLC45A3 SLC45A3 LOC102739805 LOC102739805 CDC25C CDC25C RASSF1 RASSF1 E2F2 E2F2 CCNG1 CCNG1 BAK1 BAK1 TGFB2 TGFB2 ERAS ERAS LOC102745161 LOC102745161 HDAC5 HDAC5 MAP2K2 MAP2K2 TP53 TP53 CCNE1 CCNE1 PAK4 PAK4 HOXD10 HOXD10 MMP9 MMP9 ZEB2 ZEB2 LOC102734979 LOC102734979 MDM2 MDM2 RAF1 RAF1 DNMT3B DNMT3B GLS2 GLS2 HDAC4 HDAC4 IGF2BP1 IGF2BP1 LOC102740606 LOC102740606 THBS1 THBS1 CDC25B CDC25B LOC102745380 LOC102745380 FSCN2 FSCN2 LOC102746004 LOC102746004 HDAC2 HDAC2 WNT3A WNT3A MAPK1 MAPK1 WNT3 WNT3 IKBKB IKBKB ATM ATM HNRNPK HNRNPK LOC102735415 LOC102735415 CRKL CRKL CCND1 CCND1 CASP3 CASP3 SERPINB5 SERPINB5 PIK3CD PIK3CD PIK3CA PIK3CA DNMT1 DNMT1 CREBBP CREBBP PDGFB PDGFB LOC102737030 LOC102737030 LOC102736516 LOC102736516 E2F3 E2F3 PDGFRA PDGFRA STMN1 STMN1 LOC102741543 LOC102741543 NOTCH2 NOTCH2 ABL1 ABL1 BCL2L2 BCL2L2 LOC102738254 LOC102738254 LOC102740057 LOC102740057 RDX RDX LOC102739775 LOC102739775 LOC102734950 LOC102734950 STAT3 STAT3 LOC102750604 LOC102750604 CDKN1A CDKN1A SLC7A1 SLC7A1 LOC102733359 LOC102733359 LOC102733867 LOC102733867 LOC102751021 LOC102751021 LOC102730129 LOC102730129
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
GLSGlutaminase kidney isoform, mitochondrial isoform X1. (671 aa)
SOX12Transcription factor SOX. (314 aa)
KRASGTPase KRas isoform X2. (188 aa)
LOC102732823Vimentin-like isoform X1; Belongs to the intermediate filament family. (466 aa)
LOC102726446Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform-like; Belongs to the PI3/PI4-kinase family. (235 aa)
MCL1Induced myeloid leukemia cell differentiation protein Mcl-1 homolog isoform X1. (350 aa)
NRASGTPase NRas. (189 aa)
CSDE1Cold shock domain-containing protein E1 isoform X1. (845 aa)
LOC102740025Protein sprouty homolog 2-like isoform X1. (315 aa)
ITGA5Integrin alpha-5; Belongs to the integrin alpha chain family. (1054 aa)
ERBB3Receptor tyrosine-protein kinase erbB-3. (1339 aa)
PIK3R3Phosphatidylinositol 3-kinase regulatory subunit gamma. (461 aa)
IGF2BP3Insulin-like growth factor 2 mRNA-binding protein 3 isoform X2. (580 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1 isoform X1; Belongs to the protein kinase superfamily. (393 aa)
BMI1Polycomb complex protein BMI-1 isoform X1. (326 aa)
CCNE2G1/S-specific cyclin-E2; Belongs to the cyclin family. (344 aa)
EP300Histone acetyltransferase p300. (2425 aa)
LOC102728392ephrin-A5-like; Belongs to the ephrin family. (191 aa)
EZH2Histone-lysine N-methyltransferase EZH2. (144 aa)
PTGS2Prostaglandin G/H synthase 2. (470 aa)
DDIT4DNA damage-inducible transcript 4 protein. (231 aa)
ST14Suppressor of tumorigenicity 14 protein homolog; Degrades extracellular matrix. Belongs to the peptidase S1 family. (827 aa)
HMGA2High mobility group protein HMGI-C. (109 aa)
MDM4Protein Mdm4; Inhibits p53- and p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Belongs to the MDM2/MDM4 family. (492 aa)
MAPK7Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (814 aa)
NFKB1Nuclear factor NF-kappa-B p105 subunit. (254 aa)
LOC102737670Cyclin-dependent kinase 6-like. (322 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
DNMT3ADNA (Cytosine-5)-methyltransferase 3A; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (835 aa)
LOC102734862Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1354 aa)
CDKN1BCyclin-dependent kinase inhibitor 1B. (198 aa)
MMP16Matrix metalloproteinase-16. (613 aa)
PIM1Serine/threonine-protein kinase; Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily. (313 aa)
HDAC1Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (482 aa)
FSCN1Fascin. (493 aa)
ITGB3Integrin beta; Belongs to the integrin beta chain family. (852 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (974 aa)
EFNA1ephrin-A1 isoform X1; Belongs to the ephrin family. (205 aa)
SHC1SHC-transforming protein 1 isoform X2. (583 aa)
ADAM15Disintegrin and metalloproteinase domain-containing protein 15 isoform X1. (867 aa)
FZD3Frizzled-3 isoform X2; Belongs to the G-protein coupled receptor Fz/Smo family. (666 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2550 aa)
TRIM71E3 ubiquitin-protein ligase TRIM71. (369 aa)
IRS1Insulin receptor substrate 1-like isoform X1. (1236 aa)
GPSM3G-protein-signaling modulator 3 isoform X1. (162 aa)
NOTCH4Neurogenic locus notch homolog protein 4 isoform X1. (1996 aa)
TIMP3Metalloproteinase inhibitor 3. (143 aa)
FGFR3Fibroblast growth factor receptor. (809 aa)
SHC4SHC-transforming protein 4. (630 aa)
CEP152Centrosomal protein of 152 kDa isoform X1. (1723 aa)
SLC45A3Solute carrier family 45 member 3. (552 aa)
LOC102739805Sororin-like. (253 aa)
CDC25CM-phase inducer phosphatase 3 isoform X1. (473 aa)
RASSF1Ras association domain-containing protein 1. (189 aa)
E2F2Transcription factor E2F2. (440 aa)
CCNG1cyclin-G1; Belongs to the cyclin family. (295 aa)
BAK1Bcl-2 homologous antagonist/killer. (211 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
ERASGTPase ERas. (233 aa)
LOC102745161Signal transducer and activator of transcription 3-like. (301 aa)
HDAC5Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1116 aa)
MAP2K2Dual specificity mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (381 aa)
CCNE1G1/S-specific cyclin-E1; Belongs to the cyclin family. (410 aa)
PAK4Non-specific serine/threonine protein kinase. (441 aa)
HOXD10Homeobox protein Hox-D10. (340 aa)
MMP9Matrix metalloproteinase-9. (704 aa)
ZEB2Zinc finger E-box-binding homeobox 2 isoform X1. (1214 aa)
LOC102734979Cytochrome P450 1B1-like; Belongs to the cytochrome P450 family. (543 aa)
MDM2E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. (487 aa)
RAF1RAF proto-oncogene serine/threonine-protein kinase isoform X1. (648 aa)
DNMT3BDNA (Cytosine-5)-methyltransferase 3B isoform X1; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (856 aa)
GLS2Glutaminase liver isoform, mitochondrial isoform X1. (602 aa)
HDAC4Histone deacetylase 4-like. (667 aa)
IGF2BP1Insulin-like growth factor 2 mRNA-binding protein 1 isoform X1. (577 aa)
LOC102740606SUMO-conjugating enzyme UBC9-like; Belongs to the ubiquitin-conjugating enzyme family. (123 aa)
THBS1Thrombospondin-1 isoform X1. (1170 aa)
CDC25BM-phase inducer phosphatase 2 isoform X1. (516 aa)
LOC102745380Histone-lysine N-methyltransferase EZH2-like. (556 aa)
FSCN2Fascin-2 isoform X1. (513 aa)
LOC102746004Bcl-2-like protein 11-like isoform X2. (140 aa)
HDAC2Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (488 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (326 aa)
WNT3Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (338 aa)
IKBKBInhibitor of nuclear factor kappa-B kinase subunit beta isoform X1. (756 aa)
ATMSerine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3054 aa)
HNRNPKHeterogeneous nuclear ribonucleoprotein K isoform X1. (464 aa)
LOC102735415Phosphoinositide phospholipase C. (309 aa)
CRKLCrk-like protein. (303 aa)
CCND1G1/S-specific cyclin-D1; Belongs to the cyclin family. (214 aa)
CASP3Caspase-3; Belongs to the peptidase C14A family. (302 aa)
SERPINB5Serpin B5; Belongs to the serpin family. (242 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1043 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
DNMT1DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (1613 aa)
CREBBPCREB-binding protein-like. (1411 aa)
PDGFBPlatelet-derived growth factor subunit B isoform X1; Belongs to the PDGF/VEGF growth factor family. (241 aa)
LOC102737030Receptor tyrosine-protein kinase erbB-2-like; Belongs to the protein kinase superfamily. Tyr protein kinase family. (627 aa)
LOC102736516Phosphatidylinositol 3-kinase regulatory subunit alpha-like. (138 aa)
E2F3Transcription factor E2F3-like isoform X1. (465 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1090 aa)
STMN1Stathmin; Belongs to the stathmin family. (149 aa)
LOC102741543Zinc finger protein ZFPM2-like. (827 aa)
NOTCH2Neurogenic locus notch homolog protein 2. (1238 aa)
ABL1Tyrosine-protein kinase ABL1-like. (312 aa)
BCL2L2Bcl-2-like protein 2 isoform X1. (193 aa)
LOC102738254Vimentin-like; Belongs to the intermediate filament family. (209 aa)
LOC102740057Vascular endothelial growth factor A-like isoform X1; Belongs to the PDGF/VEGF growth factor family. (186 aa)
RDXRadixin isoform X1. (572 aa)
LOC102739775Breast cancer type 1 susceptibility protein homolog. (471 aa)
LOC102734950Forkhead box protein P1-like. (351 aa)
STAT3Signal transducer and activator of transcription 3-like. (424 aa)
LOC102750604E3 ubiquitin-protein ligase TRIM71-like. (536 aa)
CDKN1ACyclin-dependent kinase inhibitor 1 isoform X1. (161 aa)
SLC7A1High affinity cationic amino acid transporter 1. (229 aa)
LOC102733359ephrin-A4-like; Belongs to the ephrin family. (166 aa)
LOC102733867Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (235 aa)
LOC102751021Phosphatidylinositol 3-kinase regulatory subunit alpha-like isoform X1. (454 aa)
LOC102730129Uncharacterized protein LOC102730129. (471 aa)
Your Current Organism:
Leptonychotes weddellii
NCBI taxonomy Id: 9713
Other names: L. weddellii, Leptonychotes weddelli, Weddell seal
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