STRINGSTRING
LEF1 LEF1 KRAS KRAS LOC102726446 LOC102726446 TGFA TGFA NRAS NRAS CSDE1 CSDE1 PIK3R3 PIK3R3 MAPK10 MAPK10 MAP2K1 MAP2K1 EREG EREG EPGN EPGN LOC102741253 LOC102741253 DDB2 DDB2 PMAIP1 PMAIP1 AXIN1 AXIN1 LOC102725978 LOC102725978 TGFBR2 TGFBR2 SMAD4 SMAD4 GADD45A GADD45A MTOR MTOR LOC102750923 LOC102750923 RALA RALA MSH6 MSH6 MSH2 MSH2 LOC102745156 LOC102745156 BAK1 BAK1 MAPK8 MAPK8 TGFB2 TGFB2 AKT1 AKT1 ERAS ERAS LOC102730764 LOC102730764 MAP2K2 MAP2K2 TCF7L1 TCF7L1 TP53 TP53 JUN JUN AKT3 AKT3 RAF1 RAF1 RPS6KB1 RPS6KB1 LOC102735556 LOC102735556 GSK3B GSK3B RAC2 RAC2 LOC102746004 LOC102746004 MAPK1 MAPK1 RALGDS RALGDS RPS6KB2 RPS6KB2 BIRC5 BIRC5 LOC102751021 LOC102751021 DCC DCC CCND1 CCND1 CASP3 CASP3 PIK3CD PIK3CD LOC102725545 LOC102725545 FOS FOS PIK3CA PIK3CA GADD45G GADD45G LOC102736516 LOC102736516 TGFB1 TGFB1 TGFB3 TGFB3 MSH3 MSH3 LOC102726062 LOC102726062 CASP9 CASP9 GADD45B GADD45B LOC102730318 LOC102730318 LOC102740060 LOC102740060 LOC102729504 LOC102729504 CDKN1A CDKN1A
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LEF1Lymphoid enhancer-binding factor 1 isoform X1. (399 aa)
KRASGTPase KRas isoform X2. (188 aa)
LOC102726446Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform-like; Belongs to the PI3/PI4-kinase family. (235 aa)
TGFAProtransforming growth factor alpha. (160 aa)
NRASGTPase NRas. (189 aa)
CSDE1Cold shock domain-containing protein E1 isoform X1. (845 aa)
PIK3R3Phosphatidylinositol 3-kinase regulatory subunit gamma. (461 aa)
MAPK10Mitogen-activated protein kinase. (464 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1 isoform X1; Belongs to the protein kinase superfamily. (393 aa)
EREGProepiregulin. (292 aa)
EPGNEpigen isoform X1. (153 aa)
LOC102741253Amphiregulin-like. (253 aa)
DDB2DNA damage-binding protein 2 isoform X1. (426 aa)
PMAIP1Phorbol-12-myristate-13-acetate-induced protein 1. (54 aa)
AXIN1Axin-1 isoform X1. (867 aa)
LOC102725978Cytochrome c 2-like; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (109 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (564 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
GADD45AGrowth arrest and DNA damage-inducible protein GADD45 alpha isoform X1. (165 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2550 aa)
LOC102750923Cytochrome c-like; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
RALARas-related protein Ral-A. (206 aa)
MSH6DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1362 aa)
MSH2DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (951 aa)
LOC102745156Catenin beta-1-like isoform X1. (216 aa)
BAK1Bcl-2 homologous antagonist/killer. (211 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
AKT1Non-specific serine/threonine protein kinase. (518 aa)
ERASGTPase ERas. (233 aa)
LOC102730764Mothers against decapentaplegic homolog 2-like. (227 aa)
MAP2K2Dual specificity mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa)
TCF7L1Transcription factor 7-like 1. (438 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (381 aa)
JUNTranscription factor AP-1; Belongs to the bZIP family. (335 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (418 aa)
RAF1RAF proto-oncogene serine/threonine-protein kinase isoform X1. (648 aa)
RPS6KB1Non-specific serine/threonine protein kinase. (445 aa)
LOC102735556Mitogen-activated protein kinase 9-like. (134 aa)
GSK3BGlycogen synthase kinase-3 beta isoform X1; Belongs to the protein kinase superfamily. (433 aa)
RAC2Ras-related C3 botulinum toxin substrate 2. (192 aa)
LOC102746004Bcl-2-like protein 11-like isoform X2. (140 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (326 aa)
RALGDSRal guanine nucleotide dissociation stimulator. (518 aa)
RPS6KB2Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (482 aa)
BIRC5Baculoviral IAP repeat-containing protein 5. (74 aa)
LOC102751021Phosphatidylinositol 3-kinase regulatory subunit alpha-like isoform X1. (454 aa)
DCCNetrin receptor DCC-like. (307 aa)
CCND1G1/S-specific cyclin-D1; Belongs to the cyclin family. (214 aa)
CASP3Caspase-3; Belongs to the peptidase C14A family. (302 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1043 aa)
LOC102725545Caspase-9-like; Belongs to the peptidase C14A family. (275 aa)
FOSProto-oncogene c-Fos isoform X1. (380 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
GADD45GGrowth arrest and DNA damage-inducible protein GADD45 gamma. (159 aa)
LOC102736516Phosphatidylinositol 3-kinase regulatory subunit alpha-like. (138 aa)
TGFB1Transforming growth factor beta-1. (261 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
MSH3DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1126 aa)
LOC102726062Uncharacterized protein C7orf31 homolog. (590 aa)
CASP9Caspase-9. (171 aa)
GADD45BGrowth arrest and DNA damage-inducible protein GADD45 beta isoform X2. (160 aa)
LOC102730318Mothers against decapentaplegic homolog. (415 aa)
LOC102740060Ral guanine nucleotide dissociation stimulator-like. (256 aa)
LOC102729504Apoptosis regulator BAX-like. (212 aa)
CDKN1ACyclin-dependent kinase inhibitor 1 isoform X1. (161 aa)
Your Current Organism:
Leptonychotes weddellii
NCBI taxonomy Id: 9713
Other names: L. weddellii, Leptonychotes weddelli, Weddell seal
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