STRINGSTRING
LOC102726367 LOC102726367 CASP9 CASP9 ERG ERG LOC102731850 LOC102731850 INS INS FOXO1 FOXO1 CDKN1A CDKN1A LOC102736146 LOC102736146 LOC102751021 LOC102751021 KRAS KRAS PDGFC PDGFC NRAS NRAS CSDE1 CSDE1 CDK2 CDK2 PIK3R3 PIK3R3 LOC102742552 LOC102742552 NKX3-1 NKX3-1 MAP2K1 MAP2K1 CCNE2 CCNE2 ATF4 ATF4 EP300 EP300 IGF1 IGF1 SRD5A2 SRD5A2 NFKBIA NFKBIA NFKB1 NFKB1 PTEN PTEN CDKN1B CDKN1B CREB1 CREB1 ETV5 ETV5 MTOR MTOR LOC102745156 LOC102745156 IL1R2 IL1R2 E2F2 E2F2 IGF1R IGF1R AKT1 AKT1 ERAS ERAS CREB3L3 CREB3L3 MAP2K2 MAP2K2 TCF7L1 TCF7L1 FGFR2 FGFR2 TP53 TP53 CCNE1 CCNE1 IKBKG IKBKG MMP9 MMP9 LOC102749673 LOC102749673 AKT3 AKT3 MDM2 MDM2 HSP90B1 HSP90B1 RAF1 RAF1 RB1 RB1 LEF1 LEF1 TGFA TGFA INSRR INSRR CCND1 CCND1 PIK3CD PIK3CD LOC102725545 LOC102725545 LOC102726446 LOC102726446 PIK3CA PIK3CA CREBBP CREBBP PDGFB PDGFB LOC102737030 LOC102737030 LOC102736516 LOC102736516 E2F3 E2F3 PDGFRA PDGFRA CREB3L1 CREB3L1 HSP90AB1 HSP90AB1 LOC102743667 LOC102743667 CHUK CHUK MMP3 MMP3 GSK3B GSK3B SPINT1 SPINT1 MAPK1 MAPK1 LOC102730785 LOC102730785 IKBKB IKBKB PLAT PLAT
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LOC102726367Heat shock protein HSP 90-alpha-like. (262 aa)
CASP9Caspase-9. (171 aa)
ERGTranscriptional regulator ERG-like. (356 aa)
LOC102731850Tyrosine-protein kinase receptor. (757 aa)
INSInsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (110 aa)
FOXO1Forkhead box protein O1-like. (418 aa)
CDKN1ACyclin-dependent kinase inhibitor 1 isoform X1. (161 aa)
LOC1027361463-phosphoinositide-dependent protein kinase 1-like. (216 aa)
LOC102751021Phosphatidylinositol 3-kinase regulatory subunit alpha-like isoform X1. (454 aa)
KRASGTPase KRas isoform X2. (188 aa)
PDGFCPlatelet-derived growth factor C-like; Belongs to the PDGF/VEGF growth factor family. (345 aa)
NRASGTPase NRas. (189 aa)
CSDE1Cold shock domain-containing protein E1 isoform X1. (845 aa)
CDK2Cyclin-dependent kinase 2 isoform X1; Belongs to the protein kinase superfamily. (346 aa)
PIK3R3Phosphatidylinositol 3-kinase regulatory subunit gamma. (461 aa)
LOC102742552Platelet-derived growth factor D-like isoform X1. (370 aa)
NKX3-1Homeobox protein Nkx-3.1 isoform X1. (231 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1 isoform X1; Belongs to the protein kinase superfamily. (393 aa)
CCNE2G1/S-specific cyclin-E2; Belongs to the cyclin family. (344 aa)
ATF4Cyclic AMP-dependent transcription factor ATF-4. (351 aa)
EP300Histone acetyltransferase p300. (2425 aa)
IGF1Insulin-like growth factor I isoform X1. (153 aa)
SRD5A23-oxo-5-alpha-steroid 4-dehydrogenase (NADP(+)). (254 aa)
NFKBIANF-kappa-B inhibitor alpha isoform X2. (314 aa)
NFKB1Nuclear factor NF-kappa-B p105 subunit. (254 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
CDKN1BCyclin-dependent kinase inhibitor 1B. (198 aa)
CREB1Cyclic AMP-responsive element-binding protein 1 isoform X1. (341 aa)
ETV5ETS translocation variant 5 isoform X1. (510 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2550 aa)
LOC102745156Catenin beta-1-like isoform X1. (216 aa)
IL1R2Interleukin-1 receptor type 2. (414 aa)
E2F2Transcription factor E2F2. (440 aa)
IGF1RInsulin-like growth factor 1 receptor-like. (291 aa)
AKT1Non-specific serine/threonine protein kinase. (518 aa)
ERASGTPase ERas. (233 aa)
CREB3L3Cyclic AMP-responsive element-binding protein 3-like protein 3. (466 aa)
MAP2K2Dual specificity mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa)
TCF7L1Transcription factor 7-like 1. (438 aa)
FGFR2Fibroblast growth factor receptor 2. (658 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (381 aa)
CCNE1G1/S-specific cyclin-E1; Belongs to the cyclin family. (410 aa)
IKBKGNF-kappa-B essential modulator isoform X2. (419 aa)
MMP9Matrix metalloproteinase-9. (704 aa)
LOC102749673Insulin-like growth factor 1 receptor-like. (143 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (418 aa)
MDM2E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. (487 aa)
HSP90B1Endoplasmin isoform X1. (803 aa)
RAF1RAF proto-oncogene serine/threonine-protein kinase isoform X1. (648 aa)
RB1Retinoblastoma-associated protein. (846 aa)
LEF1Lymphoid enhancer-binding factor 1 isoform X1. (399 aa)
TGFAProtransforming growth factor alpha. (160 aa)
INSRRTyrosine-protein kinase receptor. (1380 aa)
CCND1G1/S-specific cyclin-D1; Belongs to the cyclin family. (214 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1043 aa)
LOC102725545Caspase-9-like; Belongs to the peptidase C14A family. (275 aa)
LOC102726446Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform-like; Belongs to the PI3/PI4-kinase family. (235 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
CREBBPCREB-binding protein-like. (1411 aa)
PDGFBPlatelet-derived growth factor subunit B isoform X1; Belongs to the PDGF/VEGF growth factor family. (241 aa)
LOC102737030Receptor tyrosine-protein kinase erbB-2-like; Belongs to the protein kinase superfamily. Tyr protein kinase family. (627 aa)
LOC102736516Phosphatidylinositol 3-kinase regulatory subunit alpha-like. (138 aa)
E2F3Transcription factor E2F3-like isoform X1. (465 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1090 aa)
CREB3L1Cyclic AMP-responsive element-binding protein 3-like protein 1. (474 aa)
HSP90AB1Heat shock protein HSP 90-beta. (464 aa)
LOC102743667Transcriptional regulator ERG-like. (184 aa)
CHUKInhibitor of nuclear factor kappa-B kinase subunit alpha. (745 aa)
MMP3Stromelysin-1. (476 aa)
GSK3BGlycogen synthase kinase-3 beta isoform X1; Belongs to the protein kinase superfamily. (433 aa)
SPINT1Kunitz-type protease inhibitor 1. (511 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (326 aa)
LOC102730785Glutathione S-transferase P-like; Belongs to the GST superfamily. (210 aa)
IKBKBInhibitor of nuclear factor kappa-B kinase subunit beta isoform X1. (756 aa)
PLATPlasminogen activator; Belongs to the peptidase S1 family. (560 aa)
Your Current Organism:
Leptonychotes weddellii
NCBI taxonomy Id: 9713
Other names: L. weddellii, Leptonychotes weddelli, Weddell seal
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