STRINGSTRING
GADD45A GADD45A CDKN1A CDKN1A LOC102729504 LOC102729504 GADD45B GADD45B NTRK1 NTRK1 RXRA RXRA GADD45G GADD45G CCND1 CCND1 MAPK1 MAPK1 TP53 TP53 TCF7L1 TCF7L1 MAP2K2 MAP2K2 ERAS ERAS BAK1 BAK1 RXRB RXRB LOC102745156 LOC102745156 LOC102728321 LOC102728321 LOC102732863 LOC102732863 TPR TPR DDB2 DDB2 CDH1 CDH1 MAP2K1 MAP2K1 TFG TFG CSDE1 CSDE1 NRAS NRAS RET RET KRAS KRAS LEF1 LEF1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
GADD45AGrowth arrest and DNA damage-inducible protein GADD45 alpha isoform X1. (165 aa)
CDKN1ACyclin-dependent kinase inhibitor 1 isoform X1. (161 aa)
LOC102729504Apoptosis regulator BAX-like. (212 aa)
GADD45BGrowth arrest and DNA damage-inducible protein GADD45 beta isoform X2. (160 aa)
NTRK1Tyrosine-protein kinase receptor. (592 aa)
RXRARetinoic acid receptor RXR-alpha. (439 aa)
GADD45GGrowth arrest and DNA damage-inducible protein GADD45 gamma. (159 aa)
CCND1G1/S-specific cyclin-D1; Belongs to the cyclin family. (214 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (326 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (381 aa)
TCF7L1Transcription factor 7-like 1. (438 aa)
MAP2K2Dual specificity mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa)
ERASGTPase ERas. (233 aa)
BAK1Bcl-2 homologous antagonist/killer. (211 aa)
RXRBRetinoic acid receptor RXR-beta isoform X1. (536 aa)
LOC102745156Catenin beta-1-like isoform X1. (216 aa)
LOC102728321High affinity nerve growth factor receptor-like. (109 aa)
LOC102732863Coiled-coil domain-containing protein 6-like. (163 aa)
TPRNucleoprotein TPR-like isoform X1. (2439 aa)
DDB2DNA damage-binding protein 2 isoform X1. (426 aa)
CDH1Cadherin-1; Cadherins are calcium-dependent cell adhesion proteins. (879 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1 isoform X1; Belongs to the protein kinase superfamily. (393 aa)
TFGProtein TFG isoform X2. (398 aa)
CSDE1Cold shock domain-containing protein E1 isoform X1. (845 aa)
NRASGTPase NRas. (189 aa)
RETProto-oncogene tyrosine-protein kinase receptor Ret; Belongs to the protein kinase superfamily. Tyr protein kinase family. (819 aa)
KRASGTPase KRas isoform X2. (188 aa)
LEF1Lymphoid enhancer-binding factor 1 isoform X1. (399 aa)
Your Current Organism:
Leptonychotes weddellii
NCBI taxonomy Id: 9713
Other names: L. weddellii, Leptonychotes weddelli, Weddell seal
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