STRINGSTRING
FGF20 FGF20 KRAS KRAS NRAS NRAS FGF9 FGF9 LOC102726446 LOC102726446 FGF16 FGF16 HGF HGF PDGFC PDGFC LOC102751021 LOC102751021 LOC102749849 LOC102749849 CDKN1A CDKN1A LOC102744822 LOC102744822 FGF22 FGF22 LOC102729504 LOC102729504 FGF2 FGF2 FGF23 FGF23 FGF6 FGF6 LOC102731850 LOC102731850 GADD45B GADD45B FGF21 FGF21 PDGFRA PDGFRA E2F3 E2F3 LOC102736516 LOC102736516 GADD45G GADD45G PDGFB PDGFB PIK3CA PIK3CA LOC102733219 LOC102733219 PIK3CD PIK3CD FGF18 FGF18 FGF4 FGF4 FGF3 FGF3 LOC102737823 LOC102737823 FGF17 FGF17 CCND1 CCND1 LOC102747801 LOC102747801 MAPK1 MAPK1 RB1 RB1 RAF1 RAF1 MDM2 MDM2 CDK4 CDK4 AKT3 AKT3 LOC102749673 LOC102749673 TP53 TP53 MAP2K2 MAP2K2 ERAS ERAS AKT1 AKT1 IGF1R IGF1R BAK1 BAK1 E2F2 E2F2 FGF5 FGF5 GALK2 GALK2 FGF7 FGF7 GADD45A GADD45A PTEN PTEN LOC102737670 LOC102737670 IGF1 IGF1 FGF8 FGF8 DDB2 DDB2 CDH1 CDH1 MAP2K1 MAP2K1 FGF10 FGF10 LOC102742552 LOC102742552 PIK3R3 PIK3R3 CSDE1 CSDE1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
FGF20Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (211 aa)
KRASGTPase KRas isoform X2. (188 aa)
NRASGTPase NRas. (189 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
LOC102726446Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform-like; Belongs to the PI3/PI4-kinase family. (235 aa)
FGF16Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
HGFHepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. (730 aa)
PDGFCPlatelet-derived growth factor C-like; Belongs to the PDGF/VEGF growth factor family. (345 aa)
LOC102751021Phosphatidylinositol 3-kinase regulatory subunit alpha-like isoform X1. (454 aa)
LOC102749849Microphthalmia-associated transcription factor-like. (181 aa)
CDKN1ACyclin-dependent kinase inhibitor 1 isoform X1. (161 aa)
LOC102744822Fibroblast growth factor 1; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integrins [...] (56 aa)
FGF22Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (170 aa)
LOC102729504Apoptosis regulator BAX-like. (212 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (113 aa)
FGF23Fibroblast growth factor 23. (177 aa)
FGF6Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (182 aa)
LOC102731850Tyrosine-protein kinase receptor. (757 aa)
GADD45BGrowth arrest and DNA damage-inducible protein GADD45 beta isoform X2. (160 aa)
FGF21Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (210 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1090 aa)
E2F3Transcription factor E2F3-like isoform X1. (465 aa)
LOC102736516Phosphatidylinositol 3-kinase regulatory subunit alpha-like. (138 aa)
GADD45GGrowth arrest and DNA damage-inducible protein GADD45 gamma. (159 aa)
PDGFBPlatelet-derived growth factor subunit B isoform X1; Belongs to the PDGF/VEGF growth factor family. (241 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
LOC102733219Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (147 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1043 aa)
FGF18Fibroblast growth factor 18. (116 aa)
FGF4Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (172 aa)
FGF3Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (200 aa)
LOC102737823Fibroblast growth factor 19-like; Belongs to the heparin-binding growth factors family. (115 aa)
FGF17Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (216 aa)
CCND1G1/S-specific cyclin-D1; Belongs to the cyclin family. (214 aa)
LOC102747801Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (219 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (326 aa)
RB1Retinoblastoma-associated protein. (846 aa)
RAF1RAF proto-oncogene serine/threonine-protein kinase isoform X1. (648 aa)
MDM2E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. (487 aa)
CDK4Cyclin-dependent kinase 4; Belongs to the protein kinase superfamily. (303 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (418 aa)
LOC102749673Insulin-like growth factor 1 receptor-like. (143 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (381 aa)
MAP2K2Dual specificity mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa)
ERASGTPase ERas. (233 aa)
AKT1Non-specific serine/threonine protein kinase. (518 aa)
IGF1RInsulin-like growth factor 1 receptor-like. (291 aa)
BAK1Bcl-2 homologous antagonist/killer. (211 aa)
E2F2Transcription factor E2F2. (440 aa)
FGF5Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (275 aa)
GALK2N-acetylgalactosamine kinase. (332 aa)
FGF7Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
GADD45AGrowth arrest and DNA damage-inducible protein GADD45 alpha isoform X1. (165 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
LOC102737670Cyclin-dependent kinase 6-like. (322 aa)
IGF1Insulin-like growth factor I isoform X1. (153 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (140 aa)
DDB2DNA damage-binding protein 2 isoform X1. (426 aa)
CDH1Cadherin-1; Cadherins are calcium-dependent cell adhesion proteins. (879 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1 isoform X1; Belongs to the protein kinase superfamily. (393 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (218 aa)
LOC102742552Platelet-derived growth factor D-like isoform X1. (370 aa)
PIK3R3Phosphatidylinositol 3-kinase regulatory subunit gamma. (461 aa)
CSDE1Cold shock domain-containing protein E1 isoform X1. (845 aa)
Your Current Organism:
Leptonychotes weddellii
NCBI taxonomy Id: 9713
Other names: L. weddellii, Leptonychotes weddelli, Weddell seal
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