STRINGSTRING
LOC102729504 LOC102729504 LOC102751021 LOC102751021 LOC102731864 LOC102731864 LOC102736146 LOC102736146 CDKN1A CDKN1A STAT3 STAT3 STAT5A STAT5A HGF HGF KRAS KRAS LOC102726446 LOC102726446 TGFA TGFA RASSF5 RASSF5 NRAS NRAS CSDE1 CSDE1 PIK3R3 PIK3R3 FOXO3 FOXO3 MAP2K1 MAP2K1 DDB2 DDB2 LOC102737670 LOC102737670 STK4 STK4 GADD45A GADD45A RARB RARB LTK LTK RASSF1 RASSF1 E2F2 E2F2 RXRB RXRB BAK1 BAK1 AKT1 AKT1 ERAS ERAS LOC102745161 LOC102745161 STAT5B STAT5B MAP2K2 MAP2K2 TP53 TP53 AKT3 AKT3 CDK4 CDK4 RAF1 RAF1 RB1 RB1 LOC102737096 LOC102737096 LOC102740715 LOC102740715 MAPK1 MAPK1 LOC102735415 LOC102735415 CCND1 CCND1 PIK3CD PIK3CD LOC102725545 LOC102725545 PIK3CA PIK3CA LOC102737030 LOC102737030 GADD45G GADD45G LOC102736516 LOC102736516 E2F3 E2F3 RXRA RXRA CASP9 CASP9 JAK3 JAK3 GADD45B GADD45B
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LOC102729504Apoptosis regulator BAX-like. (212 aa)
LOC102751021Phosphatidylinositol 3-kinase regulatory subunit alpha-like isoform X1. (454 aa)
LOC102731864Signal transducer and activator of transcription 5B-like. (353 aa)
LOC1027361463-phosphoinositide-dependent protein kinase 1-like. (216 aa)
CDKN1ACyclin-dependent kinase inhibitor 1 isoform X1. (161 aa)
STAT3Signal transducer and activator of transcription 3-like. (424 aa)
STAT5ASignal transducer and activator of transcription 5A. (464 aa)
HGFHepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. (730 aa)
KRASGTPase KRas isoform X2. (188 aa)
LOC102726446Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform-like; Belongs to the PI3/PI4-kinase family. (235 aa)
TGFAProtransforming growth factor alpha. (160 aa)
RASSF5Ras association domain-containing protein 5. (194 aa)
NRASGTPase NRas. (189 aa)
CSDE1Cold shock domain-containing protein E1 isoform X1. (845 aa)
PIK3R3Phosphatidylinositol 3-kinase regulatory subunit gamma. (461 aa)
FOXO3Forkhead box protein O3. (672 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1 isoform X1; Belongs to the protein kinase superfamily. (393 aa)
DDB2DNA damage-binding protein 2 isoform X1. (426 aa)
LOC102737670Cyclin-dependent kinase 6-like. (322 aa)
STK4Serine/threonine-protein kinase 4. (487 aa)
GADD45AGrowth arrest and DNA damage-inducible protein GADD45 alpha isoform X1. (165 aa)
RARBRetinoic acid receptor beta. (172 aa)
LTKLOW QUALITY PROTEIN: leukocyte tyrosine kinase receptor. (841 aa)
RASSF1Ras association domain-containing protein 1. (189 aa)
E2F2Transcription factor E2F2. (440 aa)
RXRBRetinoic acid receptor RXR-beta isoform X1. (536 aa)
BAK1Bcl-2 homologous antagonist/killer. (211 aa)
AKT1Non-specific serine/threonine protein kinase. (518 aa)
ERASGTPase ERas. (233 aa)
LOC102745161Signal transducer and activator of transcription 3-like. (301 aa)
STAT5BSignal transducer and activator of transcription 5B. (508 aa)
MAP2K2Dual specificity mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (381 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (418 aa)
CDK4Cyclin-dependent kinase 4; Belongs to the protein kinase superfamily. (303 aa)
RAF1RAF proto-oncogene serine/threonine-protein kinase isoform X1. (648 aa)
RB1Retinoblastoma-associated protein. (846 aa)
LOC102737096Retinoic acid receptor beta-like. (262 aa)
LOC102740715Bis(5'-adenosyl)-triphosphatase-like. (163 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (326 aa)
LOC102735415Phosphoinositide phospholipase C. (309 aa)
CCND1G1/S-specific cyclin-D1; Belongs to the cyclin family. (214 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1043 aa)
LOC102725545Caspase-9-like; Belongs to the peptidase C14A family. (275 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
LOC102737030Receptor tyrosine-protein kinase erbB-2-like; Belongs to the protein kinase superfamily. Tyr protein kinase family. (627 aa)
GADD45GGrowth arrest and DNA damage-inducible protein GADD45 gamma. (159 aa)
LOC102736516Phosphatidylinositol 3-kinase regulatory subunit alpha-like. (138 aa)
E2F3Transcription factor E2F3-like isoform X1. (465 aa)
RXRARetinoic acid receptor RXR-alpha. (439 aa)
CASP9Caspase-9. (171 aa)
JAK3Tyrosine-protein kinase. (1139 aa)
GADD45BGrowth arrest and DNA damage-inducible protein GADD45 beta isoform X2. (160 aa)
Your Current Organism:
Leptonychotes weddellii
NCBI taxonomy Id: 9713
Other names: L. weddellii, Leptonychotes weddelli, Weddell seal
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